Regulator of Ty1 transposition protein 107 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38850 (RT107_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Regulator of Ty1 transposition protein 107

Gene names

Name:	RTT107
Synonyms:	ESC4
Ordered Locus Names:	YHR154W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for resumption of chromosome replication after DNA damage, specifically in S phase. Ref.5
Subcellular location	Nucleus Ref.3.
Post-translational modification	Phosphorylated by MEC1. Ref.5
Miscellaneous	Present with 1380 molecules/cell in log phase SD medium.
Sequence similarities	Contains 2 BRCT domains.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	double-strand break repair Inferred from mutant phenotype Ref.5. Source: SGD negative regulation of transposition, RNA-mediated Inferred from mutant phenotype PubMed 11779788. Source: SGD
Cellular_component	Cul8-RING ubiquitin ligase complex Inferred from direct assay PubMed 20139071. Source: SGD nucleus Inferred from direct assay Ref.3 PubMed 22842922. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1070

1070

Regulator of Ty1 transposition protein 107

PRO_0000097502

Regions

Domain

117 – 226

110

BRCT 1

Domain

370 – 466

BRCT 2

Amino acid modifications

Modified residue

184

Phosphoserine Ref.9

Modified residue

187

Phosphoserine Ref.9

Modified residue

188

Phosphoserine Ref.9

Modified residue

190

Phosphothreonine Ref.9

Modified residue

304

Phosphoserine Ref.9

Modified residue

532

Phosphothreonine Ref.6 Ref.8 Ref.9

Modified residue

536

Phosphoserine Ref.9

Modified residue

575

Phosphoserine Ref.9

Modified residue

591

Phosphoserine Ref.9

Modified residue

593

Phosphoserine Ref.9

Modified residue

699

Phosphoserine Ref.9

Modified residue

720

Phosphoserine Ref.7

Modified residue

742

Phosphothreonine Ref.9

Modified residue

800

Phosphoserine Ref.9

Modified residue

804

Phosphoserine Ref.9

Modified residue

806

Phosphoserine Ref.8 Ref.9

Secondary structure

1070

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P38850 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 767931285BB52580
Show »

FASTA

1,070

123,017

        10         20         30         40         50         60 
MSTSLLFEQL NFLILVAAEA ELPIAHSTRK LLMDNSCNNC QIYELYNENL KDVKTDKDWF 

        70         80         90        100        110        120 
MNKFGPQTVH FVISNTINFP FYKIVYFDLL IPVVSHTWVQ DSVKTKRHLR TNMYSPNPFH 

       130        140        150        160        170        180 
LLRDCQVYIS KSSFNKCEYI LYSDLLHLLG GTLVNYISNR TTHVIVQSPQ DPIIATVSKL 

       190        200        210        220        230        240 
TFGSFSSSST NKHTEKPLRE WKFVYPIWIL YHFKMAKPLK GELATLCELD MQDTSEEQLF 

       250        260        270        280        290        300 
AKWEEVIGDK QTSSSQLTLH PNKTLFKNHH FAISPDLNFF TPLYWFLKGF IEDLDGKVTP 

       310        320        330        340        350        360 
LSFSDDLKSV YQAFPDIDCY IGHSANSPIL EKTKSIKPEI HVGNVSWLFY MFALQKFTPV 

       370        380        390        400        410        420 
SQCKLIHQPF HAKLFTSKEL TVAYTNYFGS QRFYIQRLVE ILGGLSTPEL TRKNTHLITK 

       430        440        450        460        470        480 
STIGKKFKVA KKWSLDPQNA IIVTNHMWLE QCYMNNSKLN PKDSRFQNFK LDDNMGWNIG 

       490        500        510        520        530        540 
QIGMDHSSLP TPKNLSMVTY DTQSISEKPP PTNDQMDQIN DNTNVLSKKD GTPISSFENS 

       550        560        570        580        590        600 
IDEKIDKLQK ISGEVAVTHS GDLERSFVSR PSRASFPVVD SKKSNLQKKD SNSDISMETE 

       610        620        630        640        650        660 
VFCEGHEKRE EKEFTKPITE YDAPKKQEIR EQSRKKNDID YKKEEEETEL QVQLGQRTKR 

       670        680        690        700        710        720 
EIKTSKKNEK EKETNECHIE VDQMTNEKQG EESTGKLIST EDVTSKKDTD KFSHLFEGLS 

       730        740        750        760        770        780 
DNDDHINDEK PAVNSKYTTP KTSQNITSGV DTPTTAQTQV FMPSSGNSRL AKTQAAKRLH 

       790        800        810        820        830        840 
TDIESLNEFQ KNFKRKRIDS EEISLSQDVE RSNNNKELAT KAEKILARFN ELPNYDLKAV 

       850        860        870        880        890        900 
CTGCFHDGFN EVDIEILNQL GIKIFDNIKE TDKLNCIFAP KILRTEKFLK SLSFEPLKFA 

       910        920        930        940        950        960 
LKPEFIIDLL KQIHSKKDKL SQININLFDY EINGINESII SKTKLPTKVF ERANIRCINL 

       970        980        990       1000       1010       1020 
VNDIPGGVDT IGSVLKAHGI EKINVLRSKK CTFEDIIPND VSKQENGGIF KYVLIVTKAS 

      1030       1040       1050       1060       1070 
QVKKFTKLIN DRDKNETILI VEWNWCVESI FHLNVDFTSK KNVLYQKKNN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage." Rouse J. EMBO J. 23:1188-1197(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION BY MEC1.
[6]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-532, MASS SPECTROMETRY. Strain: ADR376.
[7]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-720, MASS SPECTROMETRY.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-532 AND SER-806, MASS SPECTROMETRY.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-187; SER-188; THR-190; SER-304; THR-532; SER-536; SER-575; SER-591; SER-593; SER-699; THR-742; SER-800; SER-804 AND SER-806, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U10397 Genomic DNA. Translation: AAB68978.1.
BK006934 Genomic DNA. Translation: DAA06847.1.

PIR

S46755.

RefSeq

NP_012024.1. NM_001179285.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3T7I	X-ray	2.30	A/B	820-1070	[»]
3T7J	X-ray	2.04	A/B	820-1070	[»]
3T7K	X-ray	2.03	A/B	820-1070	[»]

ProteinModelPortal

P38850.

SMR

P38850. Positions 821-1068.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6297N.

IntAct

P38850. 13 interactions.

MINT

MINT-702893.

STRING

4932.YHR154W.

Proteomic databases

PaxDb

P38850.

PeptideAtlas

P38850.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YHR154W; YHR154W; YHR154W.

GeneID

856559.

KEGG

sce:YHR154W.

Organism-specific databases

CYGD

YHR154w.

SGD

S000001197. RTT107.

Phylogenomic databases

eggNOG

NOG248673.

OMA

DVLTKYT.

OrthoDB

EOG4MGWGQ.

Gene expression databases

Genevestigator

P38850.

GermOnline

YHR154W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR001357. BRCT_dom.
[Graphical view]

Pfam

PF00533. BRCT. 2 hits.
[Graphical view]

SMART

SM00292. BRCT. 4 hits.
[Graphical view]

SUPFAM

SSF52113. BRCT. 2 hits.

PROSITE

PS50172. BRCT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

982381.

Entry information

Entry name

RT107_YEAST

Accession

Primary (citable) accession number: P38850
Secondary accession number(s): D3DLA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents