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Protein

Regulator of Ty1 transposition protein 107

Gene

RTT107

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.2 Publications

GO - Biological processi

  • DNA double-strand break attachment to nuclear envelope Source: SGD
  • double-strand break repair Source: SGD
  • negative regulation of transposition, RNA-mediated Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-31189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of Ty1 transposition protein 107
Alternative name(s):
Establishes silent chromatin protein 4
Gene namesi
Name:RTT107
Synonyms:ESC4
Ordered Locus Names:YHR154W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR154W.
SGDiS000001197. RTT107.

Subcellular locationi

GO - Cellular componenti

  • Cul8-RING ubiquitin ligase complex Source: SGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975021 – 1070Regulator of Ty1 transposition protein 107Add BLAST1070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304PhosphoserineCombined sources1
Modified residuei532PhosphothreonineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MEC1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38850.
PRIDEiP38850.

PTM databases

iPTMnetiP38850.

Interactioni

Subunit structurei

Forms a complex with the cullin-RING ligase (CRL) RTT101(MMS1-MMS22). Interacts with MMS22 and RTT101. Interacts with histone H2A; requires H2A to be phosphorylated (gamma-H2A). Interacts with RAD55.4 Publications

Protein-protein interaction databases

BioGridi36588. 358 interactors.
DIPiDIP-6297N.
IntActiP38850. 13 interactors.
MINTiMINT-702893.

Structurei

Secondary structure

11070
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi822 – 827Combined sources6
Beta strandi837 – 844Combined sources8
Helixi851 – 859Combined sources9
Beta strandi862 – 864Combined sources3
Helixi870 – 872Combined sources3
Beta strandi876 – 878Combined sources3
Helixi886 – 891Combined sources6
Beta strandi899 – 901Combined sources3
Helixi904 – 913Combined sources10
Helixi927 – 930Combined sources4
Helixi937 – 942Combined sources6
Beta strandi945 – 947Combined sources3
Helixi949 – 952Combined sources4
Beta strandi957 – 961Combined sources5
Helixi968 – 977Combined sources10
Beta strandi982 – 986Combined sources5
Turni988 – 990Combined sources3
Helixi993 – 995Combined sources3
Beta strandi1011 – 1015Combined sources5
Helixi1019 – 1032Combined sources14
Beta strandi1038 – 1041Combined sources4
Helixi1043 – 1051Combined sources9
Beta strandi1063 – 1067Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T7IX-ray2.30A/B820-1070[»]
3T7JX-ray2.04A/B820-1070[»]
3T7KX-ray2.03A/B820-1070[»]
ProteinModelPortaliP38850.
SMRiP38850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 103BRCT 1PROSITE-ProRule annotationAdd BLAST102
Domaini117 – 213BRCT 2PROSITE-ProRule annotationAdd BLAST97
Domaini260 – 352BRCT 3PROSITE-ProRule annotationAdd BLAST93
Domaini369 – 453BRCT 4PROSITE-ProRule annotationAdd BLAST85
Domaini829 – 910BRCT 5PROSITE-ProRule annotationAdd BLAST82
Domaini934 – 1049BRCT 6PROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 6 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP38850.
OMAiVEWNWCV.
OrthoDBiEOG092C0BFA.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR031906. RTT107_BRCT_6.
[Graphical view]
PfamiPF00533. BRCT. 2 hits.
PF12738. PTCB-BRCT. 1 hit.
PF16770. RTT107_BRCT_5. 1 hit.
PF16771. RTT107_BRCT_6. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 4 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSLLFEQL NFLILVAAEA ELPIAHSTRK LLMDNSCNNC QIYELYNENL
60 70 80 90 100
KDVKTDKDWF MNKFGPQTVH FVISNTINFP FYKIVYFDLL IPVVSHTWVQ
110 120 130 140 150
DSVKTKRHLR TNMYSPNPFH LLRDCQVYIS KSSFNKCEYI LYSDLLHLLG
160 170 180 190 200
GTLVNYISNR TTHVIVQSPQ DPIIATVSKL TFGSFSSSST NKHTEKPLRE
210 220 230 240 250
WKFVYPIWIL YHFKMAKPLK GELATLCELD MQDTSEEQLF AKWEEVIGDK
260 270 280 290 300
QTSSSQLTLH PNKTLFKNHH FAISPDLNFF TPLYWFLKGF IEDLDGKVTP
310 320 330 340 350
LSFSDDLKSV YQAFPDIDCY IGHSANSPIL EKTKSIKPEI HVGNVSWLFY
360 370 380 390 400
MFALQKFTPV SQCKLIHQPF HAKLFTSKEL TVAYTNYFGS QRFYIQRLVE
410 420 430 440 450
ILGGLSTPEL TRKNTHLITK STIGKKFKVA KKWSLDPQNA IIVTNHMWLE
460 470 480 490 500
QCYMNNSKLN PKDSRFQNFK LDDNMGWNIG QIGMDHSSLP TPKNLSMVTY
510 520 530 540 550
DTQSISEKPP PTNDQMDQIN DNTNVLSKKD GTPISSFENS IDEKIDKLQK
560 570 580 590 600
ISGEVAVTHS GDLERSFVSR PSRASFPVVD SKKSNLQKKD SNSDISMETE
610 620 630 640 650
VFCEGHEKRE EKEFTKPITE YDAPKKQEIR EQSRKKNDID YKKEEEETEL
660 670 680 690 700
QVQLGQRTKR EIKTSKKNEK EKETNECHIE VDQMTNEKQG EESTGKLIST
710 720 730 740 750
EDVTSKKDTD KFSHLFEGLS DNDDHINDEK PAVNSKYTTP KTSQNITSGV
760 770 780 790 800
DTPTTAQTQV FMPSSGNSRL AKTQAAKRLH TDIESLNEFQ KNFKRKRIDS
810 820 830 840 850
EEISLSQDVE RSNNNKELAT KAEKILARFN ELPNYDLKAV CTGCFHDGFN
860 870 880 890 900
EVDIEILNQL GIKIFDNIKE TDKLNCIFAP KILRTEKFLK SLSFEPLKFA
910 920 930 940 950
LKPEFIIDLL KQIHSKKDKL SQININLFDY EINGINESII SKTKLPTKVF
960 970 980 990 1000
ERANIRCINL VNDIPGGVDT IGSVLKAHGI EKINVLRSKK CTFEDIIPND
1010 1020 1030 1040 1050
VSKQENGGIF KYVLIVTKAS QVKKFTKLIN DRDKNETILI VEWNWCVESI
1060 1070
FHLNVDFTSK KNVLYQKKNN
Length:1,070
Mass (Da):123,017
Last modified:February 1, 1995 - v1
Checksum:i767931285BB52580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68978.1.
BK006934 Genomic DNA. Translation: DAA06847.1.
PIRiS46755.
RefSeqiNP_012024.1. NM_001179285.1.

Genome annotation databases

EnsemblFungiiYHR154W; YHR154W; YHR154W.
GeneIDi856559.
KEGGisce:YHR154W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68978.1.
BK006934 Genomic DNA. Translation: DAA06847.1.
PIRiS46755.
RefSeqiNP_012024.1. NM_001179285.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T7IX-ray2.30A/B820-1070[»]
3T7JX-ray2.04A/B820-1070[»]
3T7KX-ray2.03A/B820-1070[»]
ProteinModelPortaliP38850.
SMRiP38850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36588. 358 interactors.
DIPiDIP-6297N.
IntActiP38850. 13 interactors.
MINTiMINT-702893.

PTM databases

iPTMnetiP38850.

Proteomic databases

MaxQBiP38850.
PRIDEiP38850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR154W; YHR154W; YHR154W.
GeneIDi856559.
KEGGisce:YHR154W.

Organism-specific databases

EuPathDBiFungiDB:YHR154W.
SGDiS000001197. RTT107.

Phylogenomic databases

InParanoidiP38850.
OMAiVEWNWCV.
OrthoDBiEOG092C0BFA.

Enzyme and pathway databases

BioCyciYEAST:G3O-31189-MONOMER.

Miscellaneous databases

PROiP38850.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR031906. RTT107_BRCT_6.
[Graphical view]
PfamiPF00533. BRCT. 2 hits.
PF12738. PTCB-BRCT. 1 hit.
PF16770. RTT107_BRCT_5. 1 hit.
PF16771. RTT107_BRCT_6. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 4 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT107_YEAST
AccessioniPrimary (citable) accession number: P38850
Secondary accession number(s): D3DLA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.