Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P38848 (PEX28_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PEX28
Alternative name(s):
Peroxin-28
Gene names
Name:PEX28
Ordered Locus Names:YHR150W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of peroxisome number, size and distribution. Ref.3

Subcellular location

Peroxisome membrane; Multi-pass membrane protein Ref.3.

Sequence similarities

Belongs to the peroxin-2832 family. Peroxin-28 subfamily.

Ontologies

Keywords
   Biological processPeroxisome biogenesis
   Cellular componentMembrane
Peroxisome
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processperoxisome organization

Inferred from direct assay Ref.3. Source: SGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

peroxisomal membrane

Inferred from direct assay Ref.3. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 579579Peroxisomal membrane protein PEX28
PRO_0000202925

Regions

Topological domain1 – 243243Cytoplasmic Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 392128Peroxisomal Potential
Transmembrane393 – 41321Helical; Potential
Topological domain414 – 579166Cytoplasmic Potential
Compositional bias2 – 114113Ser-rich

Amino acid modifications

Glycosylation3611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38848 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2A6A73999C54C19E

FASTA57966,148
        10         20         30         40         50         60 
MSETSSSRRS ASKDAVKSYF AGKYNKVLDS ILEAEAAISK SPTVAEDLSG SSSSGNSEMS 

        70         80         90        100        110        120 
HPSLTASSAT SQGISKKELL QQIAGSLFST SIERLKTAHS SEVSSTPEYS VNDSYGEQEC 

       130        140        150        160        170        180 
RECDGVFKCS AHFEGAPEYY DDETESGPAL EPMTSNSEKD PFIDVFLDKL ISRLVPEKLP 

       190        200        210        220        230        240 
EREHFSSKTT IEHDLDTGRV PVFSATTLGS NFKKLSKKMG SIFELQDSIV RLLTWRNPTG 

       250        260        270        280        290        300 
TVTSLILFTL ICFNPMYLVI LPIFRFVYGI VVPGYVRKHP LQRSIYPLKR NHGSSLLYDV 

       310        320        330        340        350        360 
CYEGKNEYSY GQQFFSKSFM DTLESRNQEI DEISELDKRT ENTGELKQGM KVLINLRDMQ 

       370        380        390        400        410        420 
NMTSGTLHVI EAINSFLRKS SSFQNEECST KRFFTGFLLI VFLKILSPFV NWSYVCSIFA 

       430        440        450        460        470        480 
WCLLIYMHPR AHPKIISFFK TGTMGKEYKN LKKREHQALN MIFDEQPETK FIEIFEIYKK 

       490        500        510        520        530        540 
ALLPNDWKFF RYSNRIFDPQ DPYRRAQQFP PGVDSLADVI PPTGWSFDPN FEWKIDNDVD 

       550        560        570 
RWVVERGLNL PITGEFLFDP MFKRRRLIHR VIKNATPVA 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae."
Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D., Rachubinski R.A.
J. Cell Biol. 161:321-332(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10397 Genomic DNA. Translation: AAB68980.1.
BK006934 Genomic DNA. Translation: DAA06843.1.
PIRS46757.
RefSeqNP_012020.1. NM_001179281.1.

3D structure databases

ProteinModelPortalP38848.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36584. 12 interactions.
STRING4932.YHR150W.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBP38848.
PaxDbP38848.
PeptideAtlasP38848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR150W; YHR150W; YHR150W.
GeneID856555.
KEGGsce:YHR150W.

Organism-specific databases

CYGDYHR150w.
SGDS000001193. PEX28.

Phylogenomic databases

eggNOGNOG77645.
GeneTreeENSGT00530000069406.
HOGENOMHOG000115507.
OMAWRLIFIQ.
OrthoDBEOG78WM3Q.

Enzyme and pathway databases

BioCycYEAST:G3O-31185-MONOMER.

Gene expression databases

GenevestigatorP38848.

Family and domain databases

InterProIPR010482. Peroxin/Dysferlin.
[Graphical view]
PfamPF06398. Pex24p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982369.

Entry information

Entry namePEX28_YEAST
AccessionPrimary (citable) accession number: P38848
Secondary accession number(s): D3DL99
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families