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Protein

Peroxisomal membrane protein PEX28

Gene

PEX28

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of peroxisome number, size and distribution.1 Publication

GO - Biological processi

  1. peroxisome organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31185-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX28
Alternative name(s):
Peroxin-28
Gene namesi
Name:PEX28
Ordered Locus Names:YHR150W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR150w.
SGDiS000001193. PEX28.

Subcellular locationi

Peroxisome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 243243CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 392128PeroxisomalSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Topological domaini414 – 579166CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Peroxisomal membrane protein PEX28PRO_0000202925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38848.
PaxDbiP38848.
PeptideAtlasiP38848.

Expressioni

Gene expression databases

GenevestigatoriP38848.

Interactioni

Protein-protein interaction databases

BioGridi36584. 12 interactions.
STRINGi4932.YHR150W.

Structurei

3D structure databases

ProteinModelPortaliP38848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 114113Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77645.
GeneTreeiENSGT00530000069406.
HOGENOMiHOG000115507.
InParanoidiP38848.
OMAiWRLIFIQ.
OrthoDBiEOG78WM3Q.

Family and domain databases

InterProiIPR010482. Peroxin/Dysferlin.
[Graphical view]
PfamiPF06398. Pex24p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETSSSRRS ASKDAVKSYF AGKYNKVLDS ILEAEAAISK SPTVAEDLSG
60 70 80 90 100
SSSSGNSEMS HPSLTASSAT SQGISKKELL QQIAGSLFST SIERLKTAHS
110 120 130 140 150
SEVSSTPEYS VNDSYGEQEC RECDGVFKCS AHFEGAPEYY DDETESGPAL
160 170 180 190 200
EPMTSNSEKD PFIDVFLDKL ISRLVPEKLP EREHFSSKTT IEHDLDTGRV
210 220 230 240 250
PVFSATTLGS NFKKLSKKMG SIFELQDSIV RLLTWRNPTG TVTSLILFTL
260 270 280 290 300
ICFNPMYLVI LPIFRFVYGI VVPGYVRKHP LQRSIYPLKR NHGSSLLYDV
310 320 330 340 350
CYEGKNEYSY GQQFFSKSFM DTLESRNQEI DEISELDKRT ENTGELKQGM
360 370 380 390 400
KVLINLRDMQ NMTSGTLHVI EAINSFLRKS SSFQNEECST KRFFTGFLLI
410 420 430 440 450
VFLKILSPFV NWSYVCSIFA WCLLIYMHPR AHPKIISFFK TGTMGKEYKN
460 470 480 490 500
LKKREHQALN MIFDEQPETK FIEIFEIYKK ALLPNDWKFF RYSNRIFDPQ
510 520 530 540 550
DPYRRAQQFP PGVDSLADVI PPTGWSFDPN FEWKIDNDVD RWVVERGLNL
560 570
PITGEFLFDP MFKRRRLIHR VIKNATPVA
Length:579
Mass (Da):66,148
Last modified:February 1, 1995 - v1
Checksum:i2A6A73999C54C19E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68980.1.
BK006934 Genomic DNA. Translation: DAA06843.1.
PIRiS46757.
RefSeqiNP_012020.1. NM_001179281.1.

Genome annotation databases

EnsemblFungiiYHR150W; YHR150W; YHR150W.
GeneIDi856555.
KEGGisce:YHR150W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68980.1.
BK006934 Genomic DNA. Translation: DAA06843.1.
PIRiS46757.
RefSeqiNP_012020.1. NM_001179281.1.

3D structure databases

ProteinModelPortaliP38848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36584. 12 interactions.
STRINGi4932.YHR150W.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP38848.
PaxDbiP38848.
PeptideAtlasiP38848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR150W; YHR150W; YHR150W.
GeneIDi856555.
KEGGisce:YHR150W.

Organism-specific databases

CYGDiYHR150w.
SGDiS000001193. PEX28.

Phylogenomic databases

eggNOGiNOG77645.
GeneTreeiENSGT00530000069406.
HOGENOMiHOG000115507.
InParanoidiP38848.
OMAiWRLIFIQ.
OrthoDBiEOG78WM3Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-31185-MONOMER.

Miscellaneous databases

NextBioi982369.

Gene expression databases

GenevestigatoriP38848.

Family and domain databases

InterProiIPR010482. Peroxin/Dysferlin.
[Graphical view]
PfamiPF06398. Pex24p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae."
    Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D., Rachubinski R.A.
    J. Cell Biol. 161:321-332(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiPEX28_YEAST
AccessioniPrimary (citable) accession number: P38848
Secondary accession number(s): D3DL99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.