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P38848

- PEX28_YEAST

UniProt

P38848 - PEX28_YEAST

Protein

Peroxisomal membrane protein PEX28

Gene

PEX28

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the regulation of peroxisome number, size and distribution.1 Publication

    GO - Biological processi

    1. peroxisome organization Source: SGD

    Keywords - Biological processi

    Peroxisome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31185-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX28
    Alternative name(s):
    Peroxin-28
    Gene namesi
    Name:PEX28
    Ordered Locus Names:YHR150W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR150w.
    SGDiS000001193. PEX28.

    Subcellular locationi

    Peroxisome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Peroxisomal membrane protein PEX28PRO_0000202925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP38848.
    PaxDbiP38848.
    PeptideAtlasiP38848.

    Expressioni

    Gene expression databases

    GenevestigatoriP38848.

    Interactioni

    Protein-protein interaction databases

    BioGridi36584. 12 interactions.
    STRINGi4932.YHR150W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38848.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 243243CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 392128PeroxisomalSequence AnalysisAdd
    BLAST
    Topological domaini414 – 579166CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 114113Ser-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77645.
    GeneTreeiENSGT00530000069406.
    HOGENOMiHOG000115507.
    OMAiWRLIFIQ.
    OrthoDBiEOG78WM3Q.

    Family and domain databases

    InterProiIPR010482. Peroxin/Dysferlin.
    [Graphical view]
    PfamiPF06398. Pex24p. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38848-1 [UniParc]FASTAAdd to Basket

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    MSETSSSRRS ASKDAVKSYF AGKYNKVLDS ILEAEAAISK SPTVAEDLSG    50
    SSSSGNSEMS HPSLTASSAT SQGISKKELL QQIAGSLFST SIERLKTAHS 100
    SEVSSTPEYS VNDSYGEQEC RECDGVFKCS AHFEGAPEYY DDETESGPAL 150
    EPMTSNSEKD PFIDVFLDKL ISRLVPEKLP EREHFSSKTT IEHDLDTGRV 200
    PVFSATTLGS NFKKLSKKMG SIFELQDSIV RLLTWRNPTG TVTSLILFTL 250
    ICFNPMYLVI LPIFRFVYGI VVPGYVRKHP LQRSIYPLKR NHGSSLLYDV 300
    CYEGKNEYSY GQQFFSKSFM DTLESRNQEI DEISELDKRT ENTGELKQGM 350
    KVLINLRDMQ NMTSGTLHVI EAINSFLRKS SSFQNEECST KRFFTGFLLI 400
    VFLKILSPFV NWSYVCSIFA WCLLIYMHPR AHPKIISFFK TGTMGKEYKN 450
    LKKREHQALN MIFDEQPETK FIEIFEIYKK ALLPNDWKFF RYSNRIFDPQ 500
    DPYRRAQQFP PGVDSLADVI PPTGWSFDPN FEWKIDNDVD RWVVERGLNL 550
    PITGEFLFDP MFKRRRLIHR VIKNATPVA 579
    Length:579
    Mass (Da):66,148
    Last modified:February 1, 1995 - v1
    Checksum:i2A6A73999C54C19E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68980.1.
    BK006934 Genomic DNA. Translation: DAA06843.1.
    PIRiS46757.
    RefSeqiNP_012020.1. NM_001179281.1.

    Genome annotation databases

    EnsemblFungiiYHR150W; YHR150W; YHR150W.
    GeneIDi856555.
    KEGGisce:YHR150W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68980.1 .
    BK006934 Genomic DNA. Translation: DAA06843.1 .
    PIRi S46757.
    RefSeqi NP_012020.1. NM_001179281.1.

    3D structure databases

    ProteinModelPortali P38848.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36584. 12 interactions.
    STRINGi 4932.YHR150W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P38848.
    PaxDbi P38848.
    PeptideAtlasi P38848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR150W ; YHR150W ; YHR150W .
    GeneIDi 856555.
    KEGGi sce:YHR150W.

    Organism-specific databases

    CYGDi YHR150w.
    SGDi S000001193. PEX28.

    Phylogenomic databases

    eggNOGi NOG77645.
    GeneTreei ENSGT00530000069406.
    HOGENOMi HOG000115507.
    OMAi WRLIFIQ.
    OrthoDBi EOG78WM3Q.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31185-MONOMER.

    Miscellaneous databases

    NextBioi 982369.

    Gene expression databases

    Genevestigatori P38848.

    Family and domain databases

    InterProi IPR010482. Peroxin/Dysferlin.
    [Graphical view ]
    Pfami PF06398. Pex24p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae."
      Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D., Rachubinski R.A.
      J. Cell Biol. 161:321-332(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiPEX28_YEAST
    AccessioniPrimary (citable) accession number: P38848
    Secondary accession number(s): D3DL99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3