P38848 (PEX28_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PEX28

Alternative name(s):
Peroxin-28

Gene names

Name:	PEX28
Ordered Locus Names:	YHR150W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of peroxisome number, size and distribution. Ref.3
Subcellular location	Peroxisome membrane; Multi-pass membrane protein Ref.3.
Sequence similarities	Belongs to the peroxin-2832 family. Peroxin-28 subfamily.

Ontologies

Keywords
Biological process	Peroxisome biogenesis
Cellular component	Membrane Peroxisome
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peroxisome organization Inferred from direct assay Ref.3. Source: SGD
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD peroxisomal membrane Inferred from direct assay Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	Peroxisomal membrane protein PEX28		PRO_0000202925
Regions
	Topological domain	1 – 243	243	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Topological domain	265 – 392	128	Peroxisomal Potential
	Transmembrane	393 – 413	21	Helical; Potential
	Topological domain	414 – 579	166	Cytoplasmic Potential
	Compositional bias	2 – 114	113	Ser-rich
Amino acid modifications
	Glycosylation	361	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P38848 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2A6A73999C54C19E	FASTA	579	66,148
	10 20 30 40 50 60 MSETSSSRRS ASKDAVKSYF AGKYNKVLDS ILEAEAAISK SPTVAEDLSG SSSSGNSEMS 70 80 90 100 110 120 HPSLTASSAT SQGISKKELL QQIAGSLFST SIERLKTAHS SEVSSTPEYS VNDSYGEQEC 130 140 150 160 170 180 RECDGVFKCS AHFEGAPEYY DDETESGPAL EPMTSNSEKD PFIDVFLDKL ISRLVPEKLP 190 200 210 220 230 240 EREHFSSKTT IEHDLDTGRV PVFSATTLGS NFKKLSKKMG SIFELQDSIV RLLTWRNPTG 250 260 270 280 290 300 TVTSLILFTL ICFNPMYLVI LPIFRFVYGI VVPGYVRKHP LQRSIYPLKR NHGSSLLYDV 310 320 330 340 350 360 CYEGKNEYSY GQQFFSKSFM DTLESRNQEI DEISELDKRT ENTGELKQGM KVLINLRDMQ 370 380 390 400 410 420 NMTSGTLHVI EAINSFLRKS SSFQNEECST KRFFTGFLLI VFLKILSPFV NWSYVCSIFA 430 440 450 460 470 480 WCLLIYMHPR AHPKIISFFK TGTMGKEYKN LKKREHQALN MIFDEQPETK FIEIFEIYKK 490 500 510 520 530 540 ALLPNDWKFF RYSNRIFDPQ DPYRRAQQFP PGVDSLADVI PPTGWSFDPN FEWKIDNDVD 550 560 570 RWVVERGLNL PITGEFLFDP MFKRRRLIHR VIKNATPVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae." Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D., Rachubinski R.A. J. Cell Biol. 161:321-332(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10397 Genomic DNA. Translation: AAB68980.1. BK006934 Genomic DNA. Translation: DAA06843.1.
PIR	S46757.
RefSeq	NP_012020.1. NM_001179281.1.
3D structure databases
ProteinModelPortal	P38848.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YHR150W.
Proteomic databases
PaxDb	P38848.
PeptideAtlas	P38848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR150W; YHR150W; YHR150W.
GeneID	856555.
KEGG	sce:YHR150W.
Organism-specific databases
CYGD	YHR150w.
SGD	S000001193. PEX28.
Phylogenomic databases
eggNOG	NOG77645.
GeneTree	ENSGT00530000069406.
HOGENOM	HOG000115507.
OMA	YEFRRRR.
OrthoDB	EOG43FM5R.
Gene expression databases
Genevestigator	P38848.
GermOnline	YHR150W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR010482. Peroxin/Dysferlin. [Graphical view]
Pfam	PF06398. Pex24p. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982369.

Entry information

Entry name

PEX28_YEAST

Accession

Primary (citable) accession number: P38848
Secondary accession number(s): D3DL99

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program