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P38844 (DSE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein DSE2
Alternative name(s):
Daughter-specific expression protein 2
Gene names
Name:DSE2
Ordered Locus Names:YHR143W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in pseudohyphal growth, cell wall metabolism and required for the separation of the mother and daughter cells. Ref.4

Subcellular location

Secretedcell wall. Membrane; Lipid-anchorGPI-anchor. Note: GPI-anchored cell wall protein (GPI-CWP). Ref.5

Developmental stage

Expressed in daughter cells. Ref.3

Induction

Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions. Ref.3 Ref.4 Ref.7 Ref.8

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the DSE2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 308287Protein DSE2
PRO_0000014328
Propeptide309 – 32517Removed in mature form Potential
PRO_0000285355

Regions

Compositional bias72 – 281210Ser-rich

Amino acid modifications

Lipidation3081GPI-anchor amidated aspartate Potential

Sequences

Sequence LengthMass (Da)Tools
P38844 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 72FD171D5C919A1F

FASTA32533,417
        10         20         30         40         50         60 
MKFNFSTIFN ILFFLFTLIE ANSNGETVKL ITSDGIVYSY AVYTKTLAPA RVVVKTISYT 

        70         80         90        100        110        120 
TTRVYPITLA NSVVSSTTEK ITEVSTVSAS EQVSATQTNS LVSTSTVSTI SPTISSGSST 

       130        140        150        160        170        180 
SSSSTYDIES SQSIESSGTS SATAEPSASS GFRLTSSSAF VSSTAPFSSQ LSSSSSSETS 

       190        200        210        220        230        240 
SSSFSTSSSS APLSLTSSSS SSSSFATIIT LAPSSSKSGN SQLTLASSSS TSAVESSQTG 

       250        260        270        280        290        300 
STIARTTSTL VPSSSVDTTS RATTSMPLES SSTQSISVSS SDGTCYVFYD DDDYYSTVYL 

       310        320 
TNPSQSVDAA TTITSTNTIY ATVTI 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates."
Colman-Lerner A., Chin T.E., Brent R.
Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, DEVELOPMENTAL STAGE.
[4]"Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p."
Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.
Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, FUNCTION.
[5]"Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae."
Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N., Kitada K.
Curr. Genet. 40:311-316(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae."
Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.
J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae."
Purevdorj-Gage B., Sheehan K.B., Hyman L.E.
Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10397 Genomic DNA. Translation: AAB68983.1.
BK006934 Genomic DNA. Translation: DAA06836.1.
PIRS46760.
RefSeqNP_012012.1. NM_001179274.1.

3D structure databases

ProteinModelPortalP38844.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36576. 19 interactions.
IntActP38844. 2 interactions.
MINTMINT-7266789.
STRING4932.YHR143W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR143W; YHR143W; YHR143W.
GeneID856546.
KEGGsce:YHR143W.

Organism-specific databases

CYGDYHR143w.
SGDS000001186. DSE2.

Phylogenomic databases

eggNOGNOG78578.
HOGENOMHOG000000887.
OMATSTNTIY.
OrthoDBEOG7XDBTT.

Enzyme and pathway databases

BioCycYEAST:G3O-31180-MONOMER.

Gene expression databases

GenevestigatorP38844.

Family and domain databases

InterProIPR026225. DSE2.
[Graphical view]
PRINTSPR02066. DSEPROTEIN2.
ProtoNetSearch...

Other

NextBio982346.

Entry information

Entry nameDSE2_YEAST
AccessionPrimary (citable) accession number: P38844
Secondary accession number(s): D3DL92
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families