P38844 (DSE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DSE2

Alternative name(s):
Daughter-specific expression protein 2

Gene names

Name:	DSE2
Ordered Locus Names:	YHR143W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in pseudohyphal growth, cell wall metabolism and required for the separation of the mother and daughter cells. Ref.4
Subcellular location	Secreted › cell wall. Membrane; Lipid-anchor › GPI-anchor. Note: GPI-anchored cell wall protein (GPI-CWP). Ref.5
Developmental stage	Expressed in daughter cells. Ref.3
Induction	Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions. Ref.3 Ref.4 Ref.7 Ref.8
Miscellaneous	Present with 907 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the DSE2 family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell wall Membrane Secreted
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokinesis, completion of separation Inferred from mutant phenotype Ref.4. Source: SGD pseudohyphal growth Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from direct assay Ref.5. Source: SGD fungal-type cell wall Inferred from direct assay Ref.4. Source: SGD
Molecular_function	glucosidase activity Inferred from sequence or structural similarity Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 308	287	Protein DSE2		PRO_0000014328
	Propeptide	309 – 325	17	Removed in mature form Potential		PRO_0000285355
Regions
	Compositional bias	72 – 281	210	Ser-rich
Amino acid modifications
	Lipidation	308	1	GPI-anchor amidated aspartate Potential

Sequences

	Sequence		Length	Mass (Da)
	P38844 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 72FD171D5C919A1F	FASTA	325	33,417
	10 20 30 40 50 60 MKFNFSTIFN ILFFLFTLIE ANSNGETVKL ITSDGIVYSY AVYTKTLAPA RVVVKTISYT 70 80 90 100 110 120 TTRVYPITLA NSVVSSTTEK ITEVSTVSAS EQVSATQTNS LVSTSTVSTI SPTISSGSST 130 140 150 160 170 180 SSSSTYDIES SQSIESSGTS SATAEPSASS GFRLTSSSAF VSSTAPFSSQ LSSSSSSETS 190 200 210 220 230 240 SSSFSTSSSS APLSLTSSSS SSSSFATIIT LAPSSSKSGN SQLTLASSSS TSAVESSQTG 250 260 270 280 290 300 STIARTTSTL VPSSSVDTTS RATTSMPLES SSTQSISVSS SDGTCYVFYD DDDYYSTVYL 310 320 TNPSQSVDAA TTITSTNTIY ATVTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates." Colman-Lerner A., Chin T.E., Brent R. Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, DEVELOPMENTAL STAGE.
[4]	"Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p." Doolin M.-T., Johnson A.L., Johnston L.H., Butler G. Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, FUNCTION.
[5]	"Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae." Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N., Kitada K. Curr. Genet. 40:311-316(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae." Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R. J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[8]	"Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae." Purevdorj-Gage B., Sheehan K.B., Hyman L.E. Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10397 Genomic DNA. Translation: AAB68983.1. BK006934 Genomic DNA. Translation: DAA06836.1.
PIR	S46760.
RefSeq	NP_012012.1. NM_001179274.1.
3D structure databases
ProteinModelPortal	P38844.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38844. 1 interaction.
MINT	MINT-7266789.
STRING	4932.YHR143W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR143W; YHR143W; YHR143W.
GeneID	856546.
KEGG	sce:YHR143W.
Organism-specific databases
CYGD	YHR143w.
SGD	S000001186. DSE2.
Phylogenomic databases
eggNOG	NOG78578.
GeneTree	ENSGT00680000100713.
HOGENOM	HOG000000887.
OMA	ESTQEDE.
OrthoDB	EOG44N230.
Gene expression databases
Genevestigator	P38844.
GermOnline	YHR143W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR026225. DSE2. [Graphical view]
PRINTS	PR02066. DSEPROTEIN2.
ProtoNet	Search...
Other
NextBio	982346.

Entry information

Entry name

DSE2_YEAST

Accession

Primary (citable) accession number: P38844
Secondary accession number(s): D3DL92

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program