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Reviewed, UniProtKB/Swiss-Prot P38843 (CHS7_YEAST)

Last modified November 24, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Chitin synthase export chaperone
Gene names
Name: CHS7
Ordered Locus Names: YHR142W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. Ref.3 Ref.4 Ref.5 Ref.6

Subunit structure

Interacts with CHS3. Ref.7

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CHS7 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Chitin synthase export chaperone
PRO_0000202922

Regions

Transmembrane62 – 8221 Potential
Transmembrane99 – 11921 Potential
Transmembrane130 – 15021 Potential
Transmembrane170 – 19021 Potential
Transmembrane200 – 22021 Potential
Transmembrane233 – 25321 Potential
Transmembrane266 – 28621 Potential

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Sequences

Sequence LengthMass (Da)Tools
P38843-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9DA1EAFA181B2409

FASTA31634,898
        10         20         30         40         50         60 
MAFSDFAAIC SKTPLPLCSV IKSKTHLILS NSTIIHDFDP LNLNVGVLPR CYARSIDLAN 

        70         80         90        100        110        120 
TVIFDVGNAF INIGALGVIL IILYNIRQKY TAIGRSEYLY FFQLTLLLII FTLVVDCGVS 

       130        140        150        160        170        180 
PPGSGSYPYF VAIQIGLAGA CCWALLIIGF LGFNLWEDGT TKSMLLVRGT SMLGFIANFL 

       190        200        210        220        230        240 
ASILTFKAWI TDHKVATMNA SGMIVVVYII NAIFLFVFVI CQLLVSLLVV RNLWVTGAIF 

       250        260        270        280        290        300 
LGLFFFVAGQ VLVYAFSTQI CEGFKHYLDG LFFGSICNVF TLMMVYKTWD MTTDDDLEFG 

       310 
VSVSKDGDVV YDNGFM

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References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae."
Trilla J.A., Duran A., Roncero C.
J. Cell Biol. 145:1153-1163(1999) [PubMed: 10366589] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Involvement of GFA1, which encodes glutamine-fructose-6-phosphate amidotransferase, in the activation of the chitin synthesis pathway in response to cell-wall defects in Saccharomyces cerevisiae."
Lagorce A., Le Berre-Anton V., Aguilar-Uscanga B., Martin-Yken H., Dagkessamanskaia A., Francois J.
Eur. J. Biochem. 269:1697-1707(2002) [PubMed: 11895440] [Abstract]
Cited for: FUNCTION.
[5]"Maintenance of cell integrity in the gas1 mutant of Saccharomyces cerevisiae requires the Chs3p-targeting and activation pathway and involves an unusual Chs3p localization."
Carotti C., Ferrario L., Roncero C., Valdivieso M.-H., Duran A., Popolo L.
Yeast 19:1113-1124(2002) [PubMed: 12237852] [Abstract]
Cited for: FUNCTION.
[6]"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER."
Kota J., Ljungdahl P.O.
J. Cell Biol. 168:79-88(2005) [PubMed: 15623581] [Abstract]
Cited for: FUNCTION.
[7]"Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3."
Lam K.K.Y., Davey M., Sun B., Roth A.F., Davis N.G., Conibear E.
J. Cell Biol. 174:19-25(2006) [PubMed: 16818716] [Abstract]
Cited for: INTERACTION WITH CHS3.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U10397 Genomic DNA. Translation: AAB68984.1.
AY692978 Genomic DNA. Translation: AAT92997.1.
PIRS46761.
RefSeqNP_012011.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5238N.
IntActP38843. 16 interactions.
STRINGP38843.

Genome annotation databases

EnsemblYHR142W; YHR142W; YHR142W; Saccharomyces cerevisiae. [Genome view]
GeneID856545.
KEGGsce:YHR142W.
NMPDRfig|4932.3.peg.3175.

Organism-specific databases

CYGDYHR142w.
SGDS000001184. CHS7.

Phylogenomic databases

HOGENOMP38843.
OMAEDLEFSV
OrthoDBEOG9C2JTH

Gene expression databases

ArrayExpressP38843.
GenevestigatorP38843.
GermOnlineYHR142W. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio982343.

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Entry information

Entry nameCHS7_YEAST
AccessionPrimary (citable) accession number: P38843
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 24, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents