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P38843 (CHS7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chitin synthase export chaperone
Gene names
Name:CHS7
Ordered Locus Names:YHR142W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. Ref.4 Ref.5 Ref.6 Ref.7

Subunit structure

Interacts with CHS3. Ref.8

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the CHS7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Chitin synthase export chaperone
PRO_0000202922

Regions

Transmembrane62 – 8221Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane266 – 28621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P38843 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9DA1EAFA181B2409

FASTA31634,898
        10         20         30         40         50         60 
MAFSDFAAIC SKTPLPLCSV IKSKTHLILS NSTIIHDFDP LNLNVGVLPR CYARSIDLAN 

        70         80         90        100        110        120 
TVIFDVGNAF INIGALGVIL IILYNIRQKY TAIGRSEYLY FFQLTLLLII FTLVVDCGVS 

       130        140        150        160        170        180 
PPGSGSYPYF VAIQIGLAGA CCWALLIIGF LGFNLWEDGT TKSMLLVRGT SMLGFIANFL 

       190        200        210        220        230        240 
ASILTFKAWI TDHKVATMNA SGMIVVVYII NAIFLFVFVI CQLLVSLLVV RNLWVTGAIF 

       250        260        270        280        290        300 
LGLFFFVAGQ VLVYAFSTQI CEGFKHYLDG LFFGSICNVF TLMMVYKTWD MTTDDDLEFG 

       310 
VSVSKDGDVV YDNGFM 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae."
Trilla J.A., Duran A., Roncero C.
J. Cell Biol. 145:1153-1163(1999) [PubMed: 10366589] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Involvement of GFA1, which encodes glutamine-fructose-6-phosphate amidotransferase, in the activation of the chitin synthesis pathway in response to cell-wall defects in Saccharomyces cerevisiae."
Lagorce A., Le Berre-Anton V., Aguilar-Uscanga B., Martin-Yken H., Dagkessamanskaia A., Francois J.
Eur. J. Biochem. 269:1697-1707(2002) [PubMed: 11895440] [Abstract]
Cited for: FUNCTION.
[6]"Maintenance of cell integrity in the gas1 mutant of Saccharomyces cerevisiae requires the Chs3p-targeting and activation pathway and involves an unusual Chs3p localization."
Carotti C., Ferrario L., Roncero C., Valdivieso M.-H., Duran A., Popolo L.
Yeast 19:1113-1124(2002) [PubMed: 12237852] [Abstract]
Cited for: FUNCTION.
[7]"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER."
Kota J., Ljungdahl P.O.
J. Cell Biol. 168:79-88(2005) [PubMed: 15623581] [Abstract]
Cited for: FUNCTION.
[8]"Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3."
Lam K.K.Y., Davey M., Sun B., Roth A.F., Davis N.G., Conibear E.
J. Cell Biol. 174:19-25(2006) [PubMed: 16818716] [Abstract]
Cited for: INTERACTION WITH CHS3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10397 Genomic DNA. Translation: AAB68984.1.
AY692978 Genomic DNA. Translation: AAT92997.1.
BK006934 Genomic DNA. Translation: DAA06835.1.
PIRS46761.
RefSeqNP_012011.1. NM_001179272.1.

3D structure databases

ProteinModelPortalP38843.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5238N.
IntActP38843. 8 interactions.
MINTMINT-491582.
STRINGP38843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR142W; YHR142W; YHR142W.
GeneID856545.
KEGGsce:YHR142W.
NMPDRfig|4932.3.peg.3175.

Organism-specific databases

CYGDYHR142w.
SGDS000001184. CHS7.

Phylogenomic databases

eggNOGfuNOG04121.
GeneTreeEFGT00050000003557.
HOGENOMHBG333395.
OMAEDLEFSV.
OrthoDBEOG47WRXN.

Gene expression databases

ArrayExpressP38843.
GenevestigatorP38843.
GermOnlineYHR142W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR022057. Chs3p.
[Graphical view]
PfamPF12271. Chs3p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982343.

Entry information

Entry nameCHS7_YEAST
AccessionPrimary (citable) accession number: P38843
Secondary accession number(s): D3DL91
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families