Reviewed,
UniProtKB/Swiss-Prot P38843 (CHS7_YEAST)
Last modified
November 24, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Chitin synthase export chaperone | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. Ref.3 Ref.4 Ref.5 Ref.6 |
| Subunit structure | Interacts with CHS3. Ref.7 |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Sequence similarities | Belongs to the CHS7 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell wall biogenesis/degradation Protein transport Transport |
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Transmembrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ER to Golgi vesicle-mediated transport Ref.3 Inferred from direct assay. Source: SGD cell wall chitin biosynthetic process Ref.3Inferred from mutant phenotype. Source: SGD cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW protein folding Ref.6Inferred from mutant phenotype. Source: SGD protein transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Ref.3 Inferred from direct assay. Source: SGD integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | unfolded protein binding Ref.6 Inferred from mutant phenotype. Source: SGD |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| AGP1 | P25376 | 1 | EBI-24756,EBI-2357 | |
| CHS3 | P29465 | 1 | EBI-24756,EBI-4632 | |
| GAP1 | P19145 | 1 | EBI-24756,EBI-7314 | |
| KEX1 | P09620 | 1 | EBI-24756,EBI-9653 | |
| OST1 | P41543 | 1 | EBI-24756,EBI-12651 | |
| PMP2 | P40975 | 1 | EBI-24756,EBI-2043041 | |
| SOP4 | P39543 | 1 | EBI-24756,EBI-26193 | |
| SPF1 | P39986 | 1 | EBI-24756,EBI-3128 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | Chitin synthase export chaperone | PRO_0000202922 | |||||
Regions | |||||||||
| Transmembrane | 62 – 82 | 21 | Potential | ||||||
| Transmembrane | 99 – 119 | 21 | Potential | ||||||
| Transmembrane | 130 – 150 | 21 | Potential | ||||||
| Transmembrane | 170 – 190 | 21 | Potential | ||||||
| Transmembrane | 200 – 220 | 21 | Potential | ||||||
| Transmembrane | 233 – 253 | 21 | Potential | ||||||
| Transmembrane | 266 – 286 | 21 | Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M.Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae." Trilla J.A., Duran A., Roncero C. J. Cell Biol. 145:1153-1163(1999) [PubMed: 10366589] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| [4] | "Involvement of GFA1, which encodes glutamine-fructose-6-phosphate amidotransferase, in the activation of the chitin synthesis pathway in response to cell-wall defects in Saccharomyces cerevisiae." Lagorce A., Le Berre-Anton V., Aguilar-Uscanga B., Martin-Yken H., Dagkessamanskaia A., Francois J. Eur. J. Biochem. 269:1697-1707(2002) [PubMed: 11895440] [Abstract] Cited for: FUNCTION. |
| [5] | "Maintenance of cell integrity in the gas1 mutant of Saccharomyces cerevisiae requires the Chs3p-targeting and activation pathway and involves an unusual Chs3p localization." Carotti C., Ferrario L., Roncero C., Valdivieso M.-H., Duran A., Popolo L. Yeast 19:1113-1124(2002) [PubMed: 12237852] [Abstract] Cited for: FUNCTION. |
| [6] | "Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER." Kota J., Ljungdahl P.O. J. Cell Biol. 168:79-88(2005) [PubMed: 15623581] [Abstract] Cited for: FUNCTION. |
| [7] | "Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3." Lam K.K.Y., Davey M., Sun B., Roth A.F., Davis N.G., Conibear E. J. Cell Biol. 174:19-25(2006) [PubMed: 16818716] [Abstract] Cited for: INTERACTION WITH CHS3. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U10397 Genomic DNA. Translation: AAB68984.1. AY692978 Genomic DNA. Translation: AAT92997.1. | |
| PIR | S46761. |
| RefSeq | NP_012011.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5238N. |
| IntAct | P38843. 16 interactions. |
| STRING | P38843. |
Genome annotation databases | |
| Ensembl | YHR142W; YHR142W; YHR142W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 856545. |
| KEGG | sce:YHR142W. |
| NMPDR | fig|4932.3.peg.3175. |
Organism-specific databases | |
| CYGD | YHR142w. |
| SGD | S000001184. CHS7. |
Phylogenomic databases | |
| HOGENOM | P38843. |
| OMA | EDLEFSV |
| OrthoDB | EOG9C2JTH |
Gene expression databases | |
| ArrayExpress | P38843. |
| Genevestigator | P38843. |
| GermOnline | YHR142W. Saccharomyces cerevisiae. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 982343. |
Entry information
| Entry name | CHS7_YEAST | ||||||||
| Accession | Primary (citable) accession number: P38843 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VIII Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names |

Clusters with


