ID   YHT1_YEAST              Reviewed;         850 AA.
AC   P38835; D3DL79;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=PH domain-containing protein YHR131C;
GN   OrderedLocusNames=YHR131C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RA   Hong E.L., Cherry J.M.;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   IDENTIFICATION OF FRAMESHIFT.
RX   PubMed=12748633; DOI=10.1038/nature01644;
RA   Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT   "Sequencing and comparison of yeast species to identify genes and
RT   regulatory elements.";
RL   Nature 423:241-254(2003).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
CC   -!- INTERACTION:
CC       P38835; P39940: RSP5; NbExp=3; IntAct=EBI-24724, EBI-16219;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; U10398; AAB68414.2; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06823.1; -; Genomic_DNA.
DR   PIR; S48975; S48975.
DR   RefSeq; NP_011999.2; NM_001179261.1.
DR   AlphaFoldDB; P38835; -.
DR   BioGRID; 36563; 44.
DR   IntAct; P38835; 16.
DR   MINT; P38835; -.
DR   STRING; 4932.YHR131C; -.
DR   iPTMnet; P38835; -.
DR   PaxDb; 4932-YHR131C; -.
DR   PeptideAtlas; P38835; -.
DR   EnsemblFungi; YHR131C_mRNA; YHR131C; YHR131C.
DR   GeneID; 856532; -.
DR   KEGG; sce:YHR131C; -.
DR   AGR; SGD:S000001173; -.
DR   SGD; S000001173; YHR131C.
DR   VEuPathDB; FungiDB:YHR131C; -.
DR   eggNOG; ENOG502QUAB; Eukaryota.
DR   GeneTree; ENSGT00940000176577; -.
DR   HOGENOM; CLU_012105_0_0_1; -.
DR   InParanoid; P38835; -.
DR   OMA; KNFIMEI; -.
DR   OrthoDB; 2735247at2759; -.
DR   BioCyc; YEAST:G3O-31169-MONOMER; -.
DR   BioGRID-ORCS; 856532; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P38835; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38835; Protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005829; C:cytosol; HDA:SGD.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR37283; PH DOMAIN-CONTAINING PROTEIN YHR131C; 1.
DR   PANTHER; PTHR37283:SF1; PH DOMAIN-CONTAINING PROTEIN YHR131C; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..850
FT                   /note="PH domain-containing protein YHR131C"
FT                   /id="PRO_0000202917"
FT   DOMAIN          194..306
FT                   /note="PH"
FT   REGION          324..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          793..850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..339
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..657
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..850
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  96099 MW;  DD63F340A8C736DB CRC64;
     MALPIEGKLS MANNRIERLK SPSSSSTCSM DEVLITSSNN SSSICLETMR QLPREGVSGQ
     INIIKETAAS SSSHAALFIK QDLYEHIDPL PAYPPSYDLV NPNKEVRFPI FGDTAPCPKS
     SLPPLYAPAV YELTLISLKL ERLSPYEISS NRSWRNFIIE INSTQLNFYH IDESLTKHIR
     NYSSGETKSE KEDRIHSDLV HRSDQSQHLH HRLFTLPTRS ASEFKKADQE RISYRVKRDR
     SRYLTDEALY KSFTLQNARF GIPTDYTKKS FVLRMSCESE QFLLRFSHID DMIDWSMYLS
     IGISVSLDLE VREYPDYRIV PRRRRRRRRR RRRRRHTHRS ESSMGSFSQR FIRSNSRPDL
     IQRYSTGSST NNNTTIRERS NTFTAGLLDH YCTGLSKTPT EALISSAASG ESSDNSTLGS
     TRSLSGCSAS RSIASRSLKF KIKNFFRPKN SSRTEKLHRL RSNSSNLNSV IETEEDDEHH
     ESSGGDHPEP GVPVNTTIKV ERPMHRNRAI SMPQRQSLRR AISEEVVPIK FPNSTVGESV
     HSPSPIEHLS VDGCEIMLQS QNAVMKEELR SVASNLVANE RDEASIRPKP QSSSIYLSGL
     APNGESATDL SQSSRSLCLT NRDAEINDDE SATETDEDEN DGETDEYAGD DTNDDTDDSN
     IGYAYGSESD YSCLIEERIR NRRRASSTLS CFSNIPYGTD DIKWKPAIKE ISRRRYLRDS
     LKCIKPFLDS NDCLGKVIYI PVSGPTFETS NKIHFSNRQS LQKQKNHFLK GFIVGPTALI
     ELNCKNKNAI VGTTKDAEDH GEDDGDGDDG EDDDDDDDDD DDDDDDEDDD DDDDDDDDDD
     DDDDDGQITA
//