P38832 (ANS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable GPI-anchored protein ANS1

Gene names

Name:	ANS1
Ordered Locus Names:	YHR126C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Induction	Expression is regulated by AZF1. Ref.4
Sequence similarities	Contains 1 PIR1/2/3 repeat.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural constituent of cell wall Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 137	117	Probable GPI-anchored protein ANS1		PRO_0000203777
	Propeptide	138 – 159	22	Removed in mature form Potential		PRO_0000402190
Regions
	Repeat	101 – 114	14	PIR1/2/3
Amino acid modifications
	Lipidation	137	1	GPI-anchor amidated glycine Potential

Sequences

	Sequence		Length	Mass (Da)
	P38832 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: EFF6F5F5A6DEA211	FASTA	159	16,635
	10 20 30 40 50 60 MKCTLVSTLF AITNILVAHA QVSNSSDTLD VQFANSTNSY IEGKFNSTDE AFNSSASWSL 70 80 90 100 110 120 AAQQKKISNA AVYDVGGWNG SLYRSNRSAV ADHQPGKKQD AAISQISDGQ IQATASGPET 130 140 150 TAATTPSSTA NVSVYEGAGM KVESKNMGYI VGVAALLFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The function and properties of the Azf1 transcriptional regulator change with growth conditions in Saccharomyces cerevisiae." Slattery M.G., Liko D., Heideman W. Eukaryot. Cell 5:313-320(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10398 Genomic DNA. Translation: AAB68411.1. AY692674 Genomic DNA. Translation: AAT92693.1. BK006934 Genomic DNA. Translation: DAA06819.1.
PIR	S48970.
RefSeq	NP_011994.1. NM_001179256.1.
3D structure databases
ProteinModelPortal	P38832.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YHR126C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR126C; YHR126C; YHR126C.
GeneID	856527.
KEGG	sce:YHR126C.
Organism-specific databases
CYGD	YHR126c.
SGD	S000001168. ANS1.
Gene expression databases
Genevestigator	P38832.
GermOnline	YHR126C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000420. Yeast_PIR. [Graphical view]
Pfam	PF00399. PIR. 1 hit. [Graphical view]
PROSITE	PS00929. PIR_REPEAT_1. 1 hit. PS50256. PIR_REPEAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982295.

Entry information

Entry name

ANS1_YEAST

Accession

Primary (citable) accession number: P38832
Secondary accession number(s): D3DL75

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program