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P38826 (ORC6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Origin recognition complex subunit 6
Alternative name(s):
ACS-associated protein 1
Origin recognition complex 50 kDa subunit
Gene names
Name:ORC6
Synonyms:AAP1
Ordered Locus Names:YHR118C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication. Ref.5 Ref.6

Subunit structure

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC3, ORC5 and TAH11. Ref.5 Ref.6

Subcellular location

Nucleus.

Miscellaneous

Present with 2970 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ORC6 family.

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.

Sequence caution

The sequence AAB68869.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Origin recognition complex subunit 6
PRO_0000127102

Amino acid modifications

Modified residue1461Phosphothreonine Ref.8

Sequences

Sequence LengthMass (Da)Tools
P38826 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 22803C70378B7E85

FASTA43550,296
        10         20         30         40         50         60 
MSMQQVQHCV AEVLRLDPQE KPDWSSGYLK KLTNATSILY NTSLNKVMLK QDEEVARCHI 

        70         80         90        100        110        120 
CAYIASQKMN EKHMPDLCYY IDSIPLEPKK AKHLMNLFRQ SLSNSSPMKQ FAWTPSPKKN 

       130        140        150        160        170        180 
KRSPVKNGGR FTSSDPKELR NQLFGTPTKV RKSQNNDSFV IPELPPMQTN ESPSITRRKL 

       190        200        210        220        230        240 
AFEEDEDEDE EEPGNDGLSL KSHSNKSITG TRNVDSDEYE NHESDPTSEE EPLGVQESRS 

       250        260        270        280        290        300 
GRTKQNKAVG KPQSELKTAK ALRKRGRIPN SLLVKKYCKM TTEEIIRLCN DFELPREVAY 

       310        320        330        340        350        360 
KIVDEYNINA SRLVCPWQLV CGLVLNCTFI VFNERRRKDP RIDHFIVSKM CSLMLTSKVD 

       370        380        390        400        410        420 
DVIECVKLVK ELIIGEKWFR DLQIRYDDFD GIRYDEIIFR KLGSMLQTTN ILVTDDQYNI 

       430 
WKKRIEMDLA LTEPL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system."
Li J.J., Herskowitz I.
Science 262:1870-1874(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Interaction between ORC and Cdt1p of Saccharomyces cerevisiae."
Asano T., Makise M., Takehara M., Mizushima T.
FEMS Yeast Res. 7:1256-1262(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TAH11.
[6]"Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading."
Chen S., de Vries M.A., Bell S.P.
Genes Dev. 21:2897-2907(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ORC3; ORC5 AND TAH11.
[7]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23323 Genomic DNA. Translation: AAA21822.1.
U00059 Genomic DNA. Translation: AAB68869.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06812.1.
PIRA49387.
RefSeqNP_011986.1. NM_001179248.1.

3D structure databases

ProteinModelPortalP38826.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36551. 68 interactions.
DIPDIP-2289N.
IntActP38826. 19 interactions.
MINTMINT-662807.
STRING4932.YHR118C.

Proteomic databases

PaxDbP38826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR118C; YHR118C; YHR118C.
GeneID856518.
KEGGsce:YHR118C.

Organism-specific databases

CYGDYHR118c.
SGDS000001160. ORC6.

Phylogenomic databases

eggNOGNOG38934.
HOGENOMHOG000000884.
KOK02608.
OMAARCHICA.
OrthoDBEOG7PS1S0.

Enzyme and pathway databases

BioCycYEAST:G3O-31160-MONOMER.

Gene expression databases

GenevestigatorP38826.

Family and domain databases

InterProIPR008721. ORC6.
IPR016811. ORC6_fun.
[Graphical view]
PfamPF05460. ORC6. 1 hit.
[Graphical view]
PIRSFPIRSF022941. ORC6_fun. 1 hit.
ProtoNetSearch...

Other

NextBio982272.

Entry information

Entry nameORC6_YEAST
AccessionPrimary (citable) accession number: P38826
Secondary accession number(s): D3DL68
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: March 19, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families