Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein TOM71

Gene

TOM71

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in MBF1-mediated mitochondrial morphogenesis.1 Publication

GO - Molecular functioni

  • protein channel activity Source: SGD

GO - Biological processi

  • protein targeting to mitochondrion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31159-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TOM71
Alternative name(s):
71 kDa mitochondrial outer membrane protein
Gene namesi
Name:TOM71
Synonyms:TOM72
Ordered Locus Names:YHR117W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR117W.
SGDiS000001159. TOM71.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Mitochondrial intermembraneBy similarityAdd BLAST14
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18
Topological domaini33 – 639CytoplasmicBy similarityAdd BLAST607

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: SGD
  • mitochondrial outer membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064201 – 639Protein TOM71Add BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38825.
PRIDEiP38825.

PTM databases

iPTMnetiP38825.

Interactioni

Subunit structurei

Interacts with TOM40, TOM70 and MBF1.2 Publications

Protein-protein interaction databases

BioGridi36550. 40 interactors.
DIPiDIP-5618N.
IntActiP38825. 23 interactors.
MINTiMINT-512763.

Structurei

Secondary structure

1639
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi112 – 115Combined sources4
Helixi120 – 139Combined sources20
Helixi147 – 156Combined sources10
Helixi161 – 174Combined sources14
Helixi177 – 190Combined sources14
Helixi195 – 208Combined sources14
Helixi211 – 221Combined sources11
Helixi235 – 251Combined sources17
Helixi266 – 274Combined sources9
Helixi278 – 283Combined sources6
Helixi295 – 306Combined sources12
Helixi310 – 331Combined sources22
Helixi338 – 357Combined sources20
Helixi361 – 374Combined sources14
Helixi378 – 387Combined sources10
Helixi395 – 407Combined sources13
Helixi412 – 424Combined sources13
Helixi428 – 441Combined sources14
Helixi447 – 458Combined sources12
Helixi462 – 475Combined sources14
Helixi481 – 492Combined sources12
Helixi496 – 512Combined sources17
Helixi521 – 534Combined sources14
Helixi543 – 559Combined sources17
Helixi564 – 576Combined sources13
Helixi580 – 593Combined sources14
Helixi598 – 617Combined sources20
Helixi620 – 626Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FP2X-ray1.98A107-639[»]
3FP3X-ray1.98A107-639[»]
3FP4X-ray2.14A107-639[»]
3LCAX-ray2.19A107-639[»]
ProteinModelPortaliP38825.
SMRiP38825.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38825.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 160TPR 1Add BLAST34
Repeati162 – 194TPR 2Add BLAST33
Repeati345 – 378TPR 3Add BLAST34
Repeati379 – 411TPR 4Add BLAST33
Repeati412 – 445TPR 5Add BLAST34
Repeati447 – 479TPR 6Add BLAST33
Repeati480 – 513TPR 7Add BLAST34
Repeati530 – 563TPR 8Add BLAST34
Repeati565 – 597TPR 9Add BLAST33

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 9 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000133798.
HOGENOMiHOG000074722.
InParanoidiP38825.
OMAiCELDPRS.
OrthoDBiEOG092C1Q9V.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSLLRFI TKNKVAILAT VSAGTAAVGA YVYYQQIKQQ QQQQLKGTKD
60 70 80 90 100
NRRQSEAFAG QNEDEADLKD DGSVVSGSNK RKKKKNKRKR NNKAKSGEGF
110 120 130 140 150
DYPSLPNGEP DIAQLKGLSP SQRQAYAVQL KNRGNHFFTA KNFNEAIKYY
160 170 180 190 200
QYAIELDPNE PVFYSNISAC YISTGDLEKV IEFTTKALEI KPDHSKALLR
210 220 230 240 250
RASANESLGN FTDAMFDLSV LSLNGDFDGA SIEPMLERNL NKQAMKVLNE
260 270 280 290 300
NLSKDEGRGS QVLPSNTSLA SFFGIFDSHL EVSSVNTSSN YDTAYALLSD
310 320 330 340 350
ALQRLYSATD EGYLVANDLL TKSTDMYHSL LSANTVDDPL RENAALALCY
360 370 380 390 400
TGIFHFLKNN LLDAQVLLQE SINLHPTPNS YIFLALTLAD KENSQEFFKF
410 420 430 440 450
FQKAVDLNPE YPPTYYHRGQ MYFILQDYKN AKEDFQKAQS LNPENVYPYI
460 470 480 490 500
QLACLLYKQG KFTESEAFFN ETKLKFPTLP EVPTFFAEIL TDRGDFDTAI
510 520 530 540 550
KQYDIAKRLE EVQEKIHVGI GPLIGKATIL ARQSSQDPTQ LDEEKFNAAI
560 570 580 590 600
KLLTKACELD PRSEQAKIGL AQLKLQMEKI DEAIELFEDS AILARTMDEK
610 620 630
LQATTFAEAA KIQKRLRADP IISAKMELTL ARYRAKGML
Length:639
Mass (Da):71,856
Last modified:February 1, 1995 - v1
Checksum:iB4AD583BB6CB466B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA. Translation: AAB68868.1.
BK006934 Genomic DNA. Translation: DAA06811.1.
PIRiS48959.
RefSeqiNP_011985.1. NM_001179247.1.

Genome annotation databases

EnsemblFungiiYHR117W; YHR117W; YHR117W.
GeneIDi856517.
KEGGisce:YHR117W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA. Translation: AAB68868.1.
BK006934 Genomic DNA. Translation: DAA06811.1.
PIRiS48959.
RefSeqiNP_011985.1. NM_001179247.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FP2X-ray1.98A107-639[»]
3FP3X-ray1.98A107-639[»]
3FP4X-ray2.14A107-639[»]
3LCAX-ray2.19A107-639[»]
ProteinModelPortaliP38825.
SMRiP38825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36550. 40 interactors.
DIPiDIP-5618N.
IntActiP38825. 23 interactors.
MINTiMINT-512763.

PTM databases

iPTMnetiP38825.

Proteomic databases

MaxQBiP38825.
PRIDEiP38825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR117W; YHR117W; YHR117W.
GeneIDi856517.
KEGGisce:YHR117W.

Organism-specific databases

EuPathDBiFungiDB:YHR117W.
SGDiS000001159. TOM71.

Phylogenomic databases

GeneTreeiENSGT00860000133798.
HOGENOMiHOG000074722.
InParanoidiP38825.
OMAiCELDPRS.
OrthoDBiEOG092C1Q9V.

Enzyme and pathway databases

BioCyciYEAST:G3O-31159-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38825.
PROiP38825.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM71_YEAST
AccessioniPrimary (citable) accession number: P38825
Secondary accession number(s): D3DL67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4110 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.