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Protein

Protein TOM71

Gene

TOM71

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in MBF1-mediated mitochondrial morphogenesis.1 Publication

Miscellaneous

Present with 4110 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein transmembrane transporter activity Source: SGD

GO - Biological processi

  • protein targeting to mitochondrion Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31159-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TOM71
Alternative name(s):
71 kDa mitochondrial outer membrane protein
Gene namesi
Name:TOM71
Synonyms:TOM72
Ordered Locus Names:YHR117W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR117W
SGDiS000001159 TOM71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Mitochondrial intermembraneBy similarityAdd BLAST14
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18
Topological domaini33 – 639CytoplasmicBy similarityAdd BLAST607

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064201 – 639Protein TOM71Add BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38825
PaxDbiP38825
PRIDEiP38825

PTM databases

iPTMnetiP38825

Interactioni

Subunit structurei

Interacts with TOM40, TOM70 and MBF1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SSB1P114842EBI-24694,EBI-8627

Protein-protein interaction databases

BioGridi36550, 81 interactors
DIPiDIP-5618N
IntActiP38825, 23 interactors
STRINGi4932.YHR117W

Structurei

Secondary structure

1639
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi112 – 115Combined sources4
Helixi120 – 139Combined sources20
Helixi147 – 156Combined sources10
Helixi161 – 174Combined sources14
Helixi177 – 190Combined sources14
Helixi195 – 208Combined sources14
Helixi211 – 221Combined sources11
Helixi235 – 251Combined sources17
Helixi266 – 274Combined sources9
Helixi278 – 283Combined sources6
Helixi295 – 306Combined sources12
Helixi310 – 331Combined sources22
Helixi338 – 357Combined sources20
Helixi361 – 374Combined sources14
Helixi378 – 387Combined sources10
Helixi395 – 407Combined sources13
Helixi412 – 424Combined sources13
Helixi428 – 441Combined sources14
Helixi447 – 458Combined sources12
Helixi462 – 475Combined sources14
Helixi481 – 492Combined sources12
Helixi496 – 512Combined sources17
Helixi521 – 534Combined sources14
Helixi543 – 559Combined sources17
Helixi564 – 576Combined sources13
Helixi580 – 593Combined sources14
Helixi598 – 617Combined sources20
Helixi620 – 626Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FP2X-ray1.98A107-639[»]
3FP3X-ray1.98A107-639[»]
3FP4X-ray2.14A107-639[»]
3LCAX-ray2.19A107-639[»]
ProteinModelPortaliP38825
SMRiP38825
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38825

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 160TPR 1Add BLAST34
Repeati162 – 194TPR 2Add BLAST33
Repeati345 – 378TPR 3Add BLAST34
Repeati379 – 411TPR 4Add BLAST33
Repeati412 – 445TPR 5Add BLAST34
Repeati447 – 479TPR 6Add BLAST33
Repeati480 – 513TPR 7Add BLAST34
Repeati530 – 563TPR 8Add BLAST34
Repeati565 – 597TPR 9Add BLAST33

Sequence similaritiesi

Belongs to the Tom70 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000140844
HOGENOMiHOG000074722
InParanoidiP38825
OMAiHYEEVIP
OrthoDBiEOG092C1Q9V

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

P38825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSLLRFI TKNKVAILAT VSAGTAAVGA YVYYQQIKQQ QQQQLKGTKD
60 70 80 90 100
NRRQSEAFAG QNEDEADLKD DGSVVSGSNK RKKKKNKRKR NNKAKSGEGF
110 120 130 140 150
DYPSLPNGEP DIAQLKGLSP SQRQAYAVQL KNRGNHFFTA KNFNEAIKYY
160 170 180 190 200
QYAIELDPNE PVFYSNISAC YISTGDLEKV IEFTTKALEI KPDHSKALLR
210 220 230 240 250
RASANESLGN FTDAMFDLSV LSLNGDFDGA SIEPMLERNL NKQAMKVLNE
260 270 280 290 300
NLSKDEGRGS QVLPSNTSLA SFFGIFDSHL EVSSVNTSSN YDTAYALLSD
310 320 330 340 350
ALQRLYSATD EGYLVANDLL TKSTDMYHSL LSANTVDDPL RENAALALCY
360 370 380 390 400
TGIFHFLKNN LLDAQVLLQE SINLHPTPNS YIFLALTLAD KENSQEFFKF
410 420 430 440 450
FQKAVDLNPE YPPTYYHRGQ MYFILQDYKN AKEDFQKAQS LNPENVYPYI
460 470 480 490 500
QLACLLYKQG KFTESEAFFN ETKLKFPTLP EVPTFFAEIL TDRGDFDTAI
510 520 530 540 550
KQYDIAKRLE EVQEKIHVGI GPLIGKATIL ARQSSQDPTQ LDEEKFNAAI
560 570 580 590 600
KLLTKACELD PRSEQAKIGL AQLKLQMEKI DEAIELFEDS AILARTMDEK
610 620 630
LQATTFAEAA KIQKRLRADP IISAKMELTL ARYRAKGML
Length:639
Mass (Da):71,856
Last modified:February 1, 1995 - v1
Checksum:iB4AD583BB6CB466B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA Translation: AAB68868.1
BK006934 Genomic DNA Translation: DAA06811.1
PIRiS48959
RefSeqiNP_011985.1, NM_001179247.1

Genome annotation databases

EnsemblFungiiYHR117W; YHR117W; YHR117W
GeneIDi856517
KEGGisce:YHR117W

Similar proteinsi

Entry informationi

Entry nameiTOM71_YEAST
AccessioniPrimary (citable) accession number: P38825
Secondary accession number(s): D3DL67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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