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Protein

Protein BZZ1

Gene

BZZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.2 Publications

Miscellaneous

Present with 5440 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • enzyme activator activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • actin nucleation Source: SGD
  • endocytosis Source: SGD
  • response to salt stress Source: SGD

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31156-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BZZ1
Alternative name(s):
LAS17-binding protein 7
Gene namesi
Name:BZZ1
Synonyms:LSB7
Ordered Locus Names:YHR114W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR114W
SGDiS000001156 BZZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000650331 – 633Protein BZZ1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei476PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38822
PaxDbiP38822
PRIDEiP38822

PTM databases

iPTMnetiP38822

Interactioni

Subunit structurei

Interacts with LAS17 and MYO5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36547, 190 interactors
DIPiDIP-2143N
IntActiP38822, 90 interactors
MINTiP38822
STRINGi4932.YHR114W

Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi520 – 524Combined sources5
Beta strandi527 – 536Combined sources10
Turni537 – 540Combined sources4
Beta strandi541 – 546Combined sources6
Helixi547 – 549Combined sources3
Beta strandi581 – 584Combined sources4
Beta strandi603 – 608Combined sources6
Beta strandi612 – 620Combined sources9
Beta strandi623 – 628Combined sources6
Helixi629 – 631Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUUX-ray0.97A498-552[»]
2A28X-ray1.07A/B/C/D582-633[»]
ProteinModelPortaliP38822
SMRiP38822
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38822

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 271F-BARPROSITE-ProRule annotationAdd BLAST267
Domaini493 – 555SH3 1PROSITE-ProRule annotationAdd BLAST63
Domaini577 – 633SH3 2PROSITE-ProRule annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 210Sequence analysisAdd BLAST73

Sequence similaritiesi

Belongs to the BZZ1 family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

HOGENOMiHOG000185865
InParanoidiP38822
KOiK20121
OMAiTPWMREI
OrthoDBiEOG092C3MIC

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

P38822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADLSIGNE IKDSFKETHK WVQNNLKWLK DIEQFYRERA KLEKDYSERL
60 70 80 90 100
SRLSAEYFNK KSSTSVPISV GDTPTTTPGS IEAAGVVAWN EILSQTDMIS
110 120 130 140 150
KDHDQLSTDF ENHVANQLSG LFTKLDMTLS KINGFNNDMV NKKDNIYHEL
160 170 180 190 200
EKAKKDYDEA CSTMEMARNR YTKASNDRNK KKLDEKEMEM NKCKNEYLIK
210 220 230 240 250
INQANRTKDK YYFQDVPEVL DLLQDVNEAK TLFLNDLWLK AASVENDLGA
260 270 280 290 300
NVSKRLQAAN SVVKQNKPSL NTAIFIKHNL KNWKEPQDFV YKPSPVWHDD
310 320 330 340 350
EKFAVPSSLE VEDLRIKLAK AENDYNSLQD KTQNELSKLS TLNKIKHEMK
360 370 380 390 400
TNEDNINATK FYDTLKEYLN VVSPFTSHET LKLQAEVQIE SIQNNVPEEY
410 420 430 440 450
DLSTDNIDLS KTKKKSGIFS KFKHNILNVD SKPSSGGSTG NGNGGPLHIT
460 470 480 490 500
SLFNTSRRTR LGSAPNNAGE DSDNNSIRTT STNNTKKTTQ NSSDDGKNKV
510 520 530 540 550
LYAYVQKDDD EITITPGDKI SLVARDTGSG WTKINNDTTG ETGLVPTTYI
560 570 580 590 600
RISSAATVKA NDRGPAPEVP PPRRSTLPVR TMEAIYAYEA QGDDEISIDP
610 620 630
GDIITVIRGD DGSGWTYGEC DGLKGLFPTS YCK
Length:633
Mass (Da):71,171
Last modified:February 1, 1995 - v1
Checksum:i5C73DACC69611B41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196E → G in AAS56434 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA Translation: AAB68850.1
AY558108 Genomic DNA Translation: AAS56434.1
BK006934 Genomic DNA Translation: DAA06808.1
PIRiS48956
RefSeqiNP_011982.1, NM_001179244.1

Genome annotation databases

EnsemblFungiiYHR114W; YHR114W; YHR114W
GeneIDi856514
KEGGisce:YHR114W

Similar proteinsi

Entry informationi

Entry nameiBZZ1_YEAST
AccessioniPrimary (citable) accession number: P38822
Secondary accession number(s): D3DL64, E9P8V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health