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Protein

Protein BZZ1

Gene

BZZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.2 Publications

GO - Molecular functioni

  • enzyme activator activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • actin nucleation Source: SGD
  • endocytosis Source: SGD
  • response to salt stress Source: SGD
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BZZ1
Alternative name(s):
LAS17-binding protein 7
Gene namesi
Name:BZZ1
Synonyms:LSB7
Ordered Locus Names:YHR114W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR114W.
SGDiS000001156. BZZ1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000650331 – 633Protein BZZ1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei476PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38822.
PRIDEiP38822.

PTM databases

iPTMnetiP38822.

Interactioni

Subunit structurei

Interacts with LAS17 and MYO5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AIM21P405637EBI-3889,EBI-25376
AIM3P382662EBI-3889,EBI-21584
APP1P5393314EBI-3889,EBI-28798
LAS17Q1244614EBI-3889,EBI-10022
LDB17Q123423EBI-3889,EBI-38872
MYO5Q044395EBI-3889,EBI-11687
UBP7P404533EBI-3889,EBI-19857
YPL277CQ089892EBI-3889,EBI-38031

Protein-protein interaction databases

BioGridi36547. 128 interactors.
DIPiDIP-2143N.
IntActiP38822. 101 interactors.
MINTiMINT-474480.

Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi520 – 524Combined sources5
Beta strandi527 – 536Combined sources10
Turni537 – 540Combined sources4
Beta strandi541 – 546Combined sources6
Helixi547 – 549Combined sources3
Beta strandi582 – 584Combined sources3
Beta strandi603 – 608Combined sources6
Beta strandi612 – 620Combined sources9
Beta strandi623 – 628Combined sources6
Helixi629 – 631Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUUX-ray0.97A498-552[»]
2A28X-ray1.07A/B/C/D582-633[»]
ProteinModelPortaliP38822.
SMRiP38822.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38822.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 271F-BARPROSITE-ProRule annotationAdd BLAST267
Domaini493 – 555SH3 1PROSITE-ProRule annotationAdd BLAST63
Domaini577 – 633SH3 2PROSITE-ProRule annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 210Sequence analysisAdd BLAST73

Sequence similaritiesi

Belongs to the BZZ1 family.Curated
Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

HOGENOMiHOG000185865.
InParanoidiP38822.
KOiK20121.
OrthoDBiEOG092C3MIC.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADLSIGNE IKDSFKETHK WVQNNLKWLK DIEQFYRERA KLEKDYSERL
60 70 80 90 100
SRLSAEYFNK KSSTSVPISV GDTPTTTPGS IEAAGVVAWN EILSQTDMIS
110 120 130 140 150
KDHDQLSTDF ENHVANQLSG LFTKLDMTLS KINGFNNDMV NKKDNIYHEL
160 170 180 190 200
EKAKKDYDEA CSTMEMARNR YTKASNDRNK KKLDEKEMEM NKCKNEYLIK
210 220 230 240 250
INQANRTKDK YYFQDVPEVL DLLQDVNEAK TLFLNDLWLK AASVENDLGA
260 270 280 290 300
NVSKRLQAAN SVVKQNKPSL NTAIFIKHNL KNWKEPQDFV YKPSPVWHDD
310 320 330 340 350
EKFAVPSSLE VEDLRIKLAK AENDYNSLQD KTQNELSKLS TLNKIKHEMK
360 370 380 390 400
TNEDNINATK FYDTLKEYLN VVSPFTSHET LKLQAEVQIE SIQNNVPEEY
410 420 430 440 450
DLSTDNIDLS KTKKKSGIFS KFKHNILNVD SKPSSGGSTG NGNGGPLHIT
460 470 480 490 500
SLFNTSRRTR LGSAPNNAGE DSDNNSIRTT STNNTKKTTQ NSSDDGKNKV
510 520 530 540 550
LYAYVQKDDD EITITPGDKI SLVARDTGSG WTKINNDTTG ETGLVPTTYI
560 570 580 590 600
RISSAATVKA NDRGPAPEVP PPRRSTLPVR TMEAIYAYEA QGDDEISIDP
610 620 630
GDIITVIRGD DGSGWTYGEC DGLKGLFPTS YCK
Length:633
Mass (Da):71,171
Last modified:February 1, 1995 - v1
Checksum:i5C73DACC69611B41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196E → G in AAS56434 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA. Translation: AAB68850.1.
AY558108 Genomic DNA. Translation: AAS56434.1.
BK006934 Genomic DNA. Translation: DAA06808.1.
PIRiS48956.
RefSeqiNP_011982.1. NM_001179244.1.

Genome annotation databases

EnsemblFungiiYHR114W; YHR114W; YHR114W.
GeneIDi856514.
KEGGisce:YHR114W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA. Translation: AAB68850.1.
AY558108 Genomic DNA. Translation: AAS56434.1.
BK006934 Genomic DNA. Translation: DAA06808.1.
PIRiS48956.
RefSeqiNP_011982.1. NM_001179244.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUUX-ray0.97A498-552[»]
2A28X-ray1.07A/B/C/D582-633[»]
ProteinModelPortaliP38822.
SMRiP38822.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36547. 128 interactors.
DIPiDIP-2143N.
IntActiP38822. 101 interactors.
MINTiMINT-474480.

PTM databases

iPTMnetiP38822.

Proteomic databases

MaxQBiP38822.
PRIDEiP38822.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR114W; YHR114W; YHR114W.
GeneIDi856514.
KEGGisce:YHR114W.

Organism-specific databases

EuPathDBiFungiDB:YHR114W.
SGDiS000001156. BZZ1.

Phylogenomic databases

HOGENOMiHOG000185865.
InParanoidiP38822.
KOiK20121.
OrthoDBiEOG092C3MIC.

Enzyme and pathway databases

BioCyciYEAST:G3O-31156-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38822.
PROiP38822.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZZ1_YEAST
AccessioniPrimary (citable) accession number: P38822
Secondary accession number(s): D3DL64, E9P8V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5440 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.