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Protein

ADP-ribosylation factor-binding protein GGA2

Gene

GGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of membrane traffic through the trans-Golgi network.2 Publications

Miscellaneous

Present with 2270 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-4-phosphate binding Source: SGD
  • ubiquitin binding Source: SGD

GO - Biological processi

  • Golgi to endosome transport Source: SGD
  • Golgi to vacuole transport Source: SGD
  • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31151-MONOMER
ReactomeiR-SCE-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA2
Alternative name(s):
Golgi-localized, gamma ear-containing, ARF-binding protein 2
Gene namesi
Name:GGA2
Ordered Locus Names:YHR108W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR108W
SGDiS000001150 GGA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi560K → Q: Reduced binding to ENT3. 1 Publication1
Mutagenesisi563W → A: Reduced binding to ENT3 and ENT5. 1 Publication1
Mutagenesisi564K → Q: Reduced binding to ENT3 and ENT5. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126871 – 585ADP-ribosylation factor-binding protein GGA2Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38817
PaxDbiP38817
PRIDEiP38817

PTM databases

iPTMnetiP38817

Interactioni

Subunit structurei

Binds to ARF1 and ARF2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi36541, 152 interactors
DIPiDIP-2971N
IntActiP38817, 22 interactors
MINTiP38817
STRINGi4932.YHR108W

Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi472 – 477Combined sources6
Beta strandi479 – 489Combined sources11
Beta strandi491 – 493Combined sources3
Beta strandi495 – 503Combined sources9
Beta strandi505 – 507Combined sources3
Beta strandi509 – 517Combined sources9
Beta strandi522 – 526Combined sources5
Beta strandi546 – 550Combined sources5
Beta strandi560 – 569Combined sources10
Beta strandi572 – 581Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MNMX-ray1.73A/B/C465-585[»]
ProteinModelPortaliP38817
SMRiP38817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 169VHSPROSITE-ProRule annotationAdd BLAST137
Domaini196 – 321GATPROSITE-ProRule annotationAdd BLAST126
Domaini466 – 581GAEPROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00870000136446
HOGENOMiHOG000209783
InParanoidiP38817
KOiK12404
OMAiYKLTFTM
OrthoDBiEOG092C1LW8

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008942 ENTH_VHS
IPR008153 GAE_dom
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR002014 VHS_dom
PfamiView protein in Pfam
PF02883 Alpha_adaptinC2, 1 hit
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequencei

Sequence statusi: Complete.

P38817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPHSHSIY LSELPVRKPQ ALGNPLLRKI QRACRMSLAE PDLALNLDIA
60 70 80 90 100
DYINEKQGAA PRDAAIALAK LINNRESHVA IFALSLLDVL VKNCGYPFHL
110 120 130 140 150
QISRKEFLNE LVKRFPGHPP LRYSKIQRLI LTAIEEWYQT ICKHSSYKND
160 170 180 190 200
MGYIRDMHRL LKYKGYAFPK ISESDLAVLK PSNQLKTASE IQKEQEIAQA
210 220 230 240 250
AKLEELIRRG KPEDLREANK LMKIMAGFKE DNAVQAKQAI SSELNKLKRK
260 270 280 290 300
ADLLNEMLES PDSQNWDNET TQELHSALKV AQPKFQKIIE EEQEDDALVQ
310 320 330 340 350
DLLKFNDTVN QLLEKFNLLK NGDSNAASQI HPSHVSAPLQ QSSGALTNEI
360 370 380 390 400
NLIDFNDLDE APSQGNNNTN GTGTPAAAET SVNDLLGDLT DLSISNPSTA
410 420 430 440 450
NQASFGLGGD IVLGSSQPAP PVTTTNNSNN TLDLLGLSTP QSPTNSQAVN
460 470 480 490 500
SSGFDLLMGF NPTTGTTTAP ARTLVNQSPN LKIEFEISRE SNSVIRIKSF
510 520 530 540 550
FTNLSSSPIS NLVFLLAVPK SMSLKLQPQS SNFMIGNAKD GISQEGTIEN
560 570 580
APANPSKALK VKWKVNYSVN STQAEETAVF TLPNV
Length:585
Mass (Da):64,347
Last modified:February 1, 1995 - v1
Checksum:i7AC3A317AEE302E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA Translation: AAB68854.1
BK006934 Genomic DNA Translation: DAA06802.1
PIRiS48950
RefSeqiNP_011976.1, NM_001179238.1

Genome annotation databases

EnsemblFungiiYHR108W; YHR108W; YHR108W
GeneIDi856508
KEGGisce:YHR108W

Similar proteinsi

Entry informationi

Entry nameiGGA2_YEAST
AccessioniPrimary (citable) accession number: P38817
Secondary accession number(s): D3DL58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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