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Protein

Thioredoxin reductase 2, mitochondrial

Gene

TRR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress.1 Publication

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68FAD; via amide nitrogenBy similarity1
Binding sitei77FADBy similarity1
Binding sitei110FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei168FADBy similarity1
Binding sitei311FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 37FADBy similarity4
Nucleotide bindingi56 – 68FADBy similarityAdd BLAST13
Nucleotide bindingi63 – 64FADBy similarity2
Nucleotide bindingi311 – 320FADBy similarity10
Nucleotide bindingi318 – 320FADBy similarity3

GO - Molecular functioni

  • thioredoxin-disulfide reductase activity Source: SGD

GO - Biological processi

  • cell redox homeostasis Source: SGD
  • cellular response to oxidative stress Source: SGD
  • removal of superoxide radicals Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:YHR106W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase 2, mitochondrial (EC:1.8.1.9)
Gene namesi
Name:TRR2
Ordered Locus Names:YHR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR106W
SGDiS000001148 TRR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000003030324 – 342Thioredoxin reductase 2, mitochondrialAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi165 ↔ 168Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP38816
PaxDbiP38816
PRIDEiP38816

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRR1P295096EBI-19502,EBI-19497

Protein-protein interaction databases

BioGridi36539, 49 interactors
DIPiDIP-1942N
IntActiP38816, 7 interactors
MINTiP38816
STRINGi4932.YHR106W

Structurei

3D structure databases

ProteinModelPortaliP38816
SMRiP38816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000011774
HOGENOMiHOG000072912
InParanoidiP38816
KOiK00384
OMAiSYCTICD
OrthoDBiEOG092C3AEY

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKHIVSPFR TNFVGISKSV LSRMIHHKVT IIGSGPAAHT AAIYLARAEM
60 70 80 90 100
KPTLYEGMMA NGIAAGGQLT TTTDIENFPG FPESLSGSEL MERMRKQSAK
110 120 130 140 150
FGTNIITETV SKVDLSSKPF RLWTEFNEDA EPVTTDAIIL ATGASAKRMH
160 170 180 190 200
LPGEETYWQQ GISACAVCDG AVPIFRNKPL AVIGGGDSAC EEAEFLTKYA
210 220 230 240 250
SKVYILVRKD HFRASVIMQR RIEKNPNIIV LFNTVALEAK GDGKLLNMLR
260 270 280 290 300
IKNTKSNVEN DLEVNGLFYA IGHSPATDIV KGQVDEEETG YIKTVPGSSL
310 320 330 340
TSVPGFFAAG DVQDSRYRQA VTSAGSGCIA ALDAERYLSA QE
Length:342
Mass (Da):37,087
Last modified:February 1, 1995 - v1
Checksum:i739F302AA0837A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA Translation: AAB68856.1
AY557882 Genomic DNA Translation: AAS56208.1
BK006934 Genomic DNA Translation: DAA06800.1
PIRiS48948
RefSeqiNP_011974.1, NM_001179236.1

Genome annotation databases

EnsemblFungiiYHR106W; YHR106W; YHR106W
GeneIDi856506
KEGGisce:YHR106W

Similar proteinsi

Entry informationi

Entry nameiTRXB2_YEAST
AccessioniPrimary (citable) accession number: P38816
Secondary accession number(s): D3DL56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health