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Protein

PX domain-containing protein YPT35

Gene

YPT35

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31149-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
PX domain-containing protein YPT35
Gene namesi
Name:YPT35
Ordered Locus Names:YHR105W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR105W
SGDiS000001147 YPT35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi123Y → A: Abolishes partially PtdIns(3)P-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029101 – 214PX domain-containing protein YPT35Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38815
PaxDbiP38815
PRIDEiP38815

PTM databases

iPTMnetiP38815

Interactioni

Subunit structurei

Interacts with RBD2, YIF1, YIP1 and YIP4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36538, 51 interactors
DIPiDIP-1881N
IntActiP38815, 18 interactors
MINTiP38815
STRINGi4932.YHR105W

Structurei

3D structure databases

ProteinModelPortaliP38815
SMRiP38815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 213PXPROSITE-ProRule annotationAdd BLAST141

Domaini

The PX domain binds phosphatidylinositol 3-phosphate (PtdIns3P) which is necessary for peripheral membrane localization.1 Publication

Sequence similaritiesi

Belongs to the YPT35 family.Curated

Phylogenomic databases

InParanoidiP38815
OMAiFAVWRIT
OrthoDBiEOG092C4QIV

Family and domain databases

CDDicd07280 PX_YPT35, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR037917 Ypt35_PX
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

P38815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKISFLPP EPIQLLDEDS TEPELDIDSQ QENEGPISAS NSNDSTSHSN
60 70 80 90 100
DCGATITRTR PRRSSSINAN FSFQKAHVSD CTIVNGDHGT KFAVWRITVF
110 120 130 140 150
LEPNLKAFAA KRESYKIQTY KRYSDFVRLR ENLLTRIKTA KPEKLNCLQI
160 170 180 190 200
PHLPPSVQWY SSWKYQEVNL NKDWLAKRQR GLEYFLNHII LNSSLVEMTK
210
DILIQFLEPS KRVA
Length:214
Mass (Da):24,646
Last modified:February 1, 1995 - v1
Checksum:i2ADD21AF107094DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00059 Genomic DNA Translation: AAB68857.1
AY557854 Genomic DNA Translation: AAS56180.1
BK006934 Genomic DNA Translation: DAA06799.1
PIRiS48947
RefSeqiNP_011973.1, NM_001179235.1

Genome annotation databases

EnsemblFungiiYHR105W; YHR105W; YHR105W
GeneIDi856505
KEGGisce:YHR105W

Similar proteinsi

Entry informationi

Entry nameiYPT35_YEAST
AccessioniPrimary (citable) accession number: P38815
Secondary accession number(s): D3DL55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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