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Protein

Chromatin modification-related protein YNG2

Gene

YNG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224Histone H3K4me3By similarity1
Metal bindingi225Zinc 1By similarity1
Metal bindingi227Zinc 1By similarity1
Binding sitei235Histone H3K4me3By similarity1
Metal bindingi238Zinc 2By similarity1
Binding sitei239Histone H3K4me3By similarity1
Metal bindingi243Zinc 2By similarity1
Binding sitei247Histone H3K4me3By similarity1
Metal bindingi249Zinc 1; via pros nitrogenBy similarity1
Metal bindingi252Zinc 1By similarity1
Metal bindingi265Zinc 2By similarity1
Metal bindingi268Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 271PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: UniProtKB

GO - Biological processi

  • covalent chromatin modification Source: SGD
  • DNA repair Source: SGD
  • histone acetylation Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processCell cycle, DNA damage, DNA repair, Meiosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31137-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein YNG2
Alternative name(s):
ESA1-associated factor 4
ING1 homolog 2
Gene namesi
Name:YNG2
Synonyms:EAF4, NBN1
Ordered Locus Names:YHR090C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR090C
SGDiS000001132 YNG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126791 – 282Chromatin modification-related protein YNG2Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineCombined sources1
Modified residuei185PhosphothreonineCombined sources1
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38806
PaxDbiP38806
PRIDEiP38806

PTM databases

iPTMnetiP38806

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EPL1P4357210EBI-24622,EBI-22792

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi36525, 594 interactors
DIPiDIP-2095N
IntActiP38806, 19 interactors
MINTiP38806
STRINGi4932.YHR090C

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Turni14 – 16Combined sources3
Helixi17 – 56Combined sources40
Beta strandi58 – 60Combined sources3
Helixi65 – 113Combined sources49
Beta strandi225 – 227Combined sources3
Turni250 – 254Combined sources5
Helixi266 – 270Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUMNMR-A222-271[»]
5J9QX-ray3.25D/H/K1-120[»]
5J9TX-ray2.70D/H/L1-120[»]
5J9UX-ray2.95D/H/K1-120[»]
5J9WX-ray2.80D/H/L1-120[»]
ProteinModelPortaliP38806
SMRiP38806
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 86Sequence analysisAdd BLAST52

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 271PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00900000142451
HOGENOMiHOG000000883
InParanoidiP38806
KOiK11396
OMAiWSCVGIT
OrthoDBiEOG092C2K1R

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR024610 ING_N_histone_binding
IPR037996 Yng2/Png1
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF88 PTHR10333:SF88, 2 hits
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSLVLEQT IQDVSNLPSE FRYLLEEIGS NDLKLIEEKK KYEQKESQIH
60 70 80 90 100
KFIRQQGSIP KHPQEDGLDK EIKESLLKCQ SLQREKCVLA NTALFLIARH
110 120 130 140 150
LNKLEKNIAL LEEDGVLAPV EEDGDMDSAA EASRESSVVS NSSVKKRRAA
160 170 180 190 200
SSSGSVPPTL KKKKTSRTSK LQNEIDVSSR EKSVTPVSPS IEKKIARTKE
210 220 230 240 250
FKNSRNGKGQ NGSPENEEED KTLYCFCQRV SFGEMVACDG PNCKYEWFHY
260 270 280
DCVNLKEPPK GTWYCPECKI EMEKNKLKRK RN
Length:282
Mass (Da):32,086
Last modified:February 1, 1995 - v1
Checksum:i110E0A2536547D03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68930.1
BK006934 Genomic DNA Translation: DAA06786.1
PIRiS46722
RefSeqiNP_011958.1, NM_001179220.1

Genome annotation databases

EnsemblFungiiYHR090C; YHR090C; YHR090C
GeneIDi856490
KEGGisce:YHR090C

Similar proteinsi

Entry informationi

Entry nameiYNG2_YEAST
AccessioniPrimary (citable) accession number: P38806
Secondary accession number(s): D3DL42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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