Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38806

- YNG2_YEAST

UniProt

P38806 - YNG2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Chromatin modification-related protein YNG2

Gene

YNG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241Histone H3K4me3By similarity
Binding sitei235 – 2351Histone H3K4me3By similarity
Binding sitei239 – 2391Histone H3K4me3By similarity
Binding sitei247 – 2471Histone H3K4me3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 27150PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. methylated histone binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. chromatin modification Source: SGD
  2. DNA repair Source: SGD
  3. histone acetylation Source: SGD
  4. meiotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, DNA damage, DNA repair, Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31137-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein YNG2
Alternative name(s):
ESA1-associated factor 4
ING1 homolog 2
Gene namesi
Name:YNG2
Synonyms:EAF4, NBN1
Ordered Locus Names:YHR090C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR090c.
SGDiS000001132. YNG2.

Subcellular locationi

Nucleus 3 Publications

GO - Cellular componenti

  1. cytosol Source: SGD
  2. NuA4 histone acetyltransferase complex Source: SGD
  3. nucleus Source: SGD
  4. Piccolo NuA4 histone acetyltransferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Chromatin modification-related protein YNG2PRO_0000212679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei185 – 1851Phosphothreonine1 Publication
Modified residuei188 – 1881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38806.
PaxDbiP38806.
PeptideAtlasiP38806.

Expressioni

Gene expression databases

GenevestigatoriP38806.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EPL1P435728EBI-24622,EBI-22792

Protein-protein interaction databases

BioGridi36525. 284 interactions.
DIPiDIP-2095N.
IntActiP38806. 18 interactions.
MINTiMINT-561028.
STRINGi4932.YHR090C.

Structurei

3D structure databases

ProteinModelPortaliP38806.
SMRiP38806. Positions 223-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 8652Sequence AnalysisAdd
BLAST

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication

Sequence similaritiesi

Belongs to the ING family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 27150PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiCOG5034.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000000883.
InParanoidiP38806.
KOiK11396.
OMAiTLTKHPK.
OrthoDBiEOG7G1VHM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PfamiPF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38806-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPSLVLEQT IQDVSNLPSE FRYLLEEIGS NDLKLIEEKK KYEQKESQIH
60 70 80 90 100
KFIRQQGSIP KHPQEDGLDK EIKESLLKCQ SLQREKCVLA NTALFLIARH
110 120 130 140 150
LNKLEKNIAL LEEDGVLAPV EEDGDMDSAA EASRESSVVS NSSVKKRRAA
160 170 180 190 200
SSSGSVPPTL KKKKTSRTSK LQNEIDVSSR EKSVTPVSPS IEKKIARTKE
210 220 230 240 250
FKNSRNGKGQ NGSPENEEED KTLYCFCQRV SFGEMVACDG PNCKYEWFHY
260 270 280
DCVNLKEPPK GTWYCPECKI EMEKNKLKRK RN
Length:282
Mass (Da):32,086
Last modified:February 1, 1995 - v1
Checksum:i110E0A2536547D03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00060 Genomic DNA. Translation: AAB68930.1.
BK006934 Genomic DNA. Translation: DAA06786.1.
PIRiS46722.
RefSeqiNP_011958.1. NM_001179220.1.

Genome annotation databases

EnsemblFungiiYHR090C; YHR090C; YHR090C.
GeneIDi856490.
KEGGisce:YHR090C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00060 Genomic DNA. Translation: AAB68930.1 .
BK006934 Genomic DNA. Translation: DAA06786.1 .
PIRi S46722.
RefSeqi NP_011958.1. NM_001179220.1.

3D structure databases

ProteinModelPortali P38806.
SMRi P38806. Positions 223-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36525. 284 interactions.
DIPi DIP-2095N.
IntActi P38806. 18 interactions.
MINTi MINT-561028.
STRINGi 4932.YHR090C.

Proteomic databases

MaxQBi P38806.
PaxDbi P38806.
PeptideAtlasi P38806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR090C ; YHR090C ; YHR090C .
GeneIDi 856490.
KEGGi sce:YHR090C.

Organism-specific databases

CYGDi YHR090c.
SGDi S000001132. YNG2.

Phylogenomic databases

eggNOGi COG5034.
GeneTreei ENSGT00550000074538.
HOGENOMi HOG000000883.
InParanoidi P38806.
KOi K11396.
OMAi TLTKHPK.
OrthoDBi EOG7G1VHM.

Enzyme and pathway databases

BioCyci YEAST:G3O-31137-MONOMER.

Miscellaneous databases

NextBioi 982194.
PROi P38806.

Gene expression databases

Genevestigatori P38806.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10333. PTHR10333. 1 hit.
Pfami PF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities."
    Loewith R., Meijer M., Lees-Miller S.P., Riabowol K., Young D.
    Mol. Cell. Biol. 20:3807-3816(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE NUA4 COMPLEX.
  4. "Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression."
    Choy J.S., Tobe B.T.D., Huh J.H., Kron S.J.
    J. Biol. Chem. 276:43653-43662(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex."
    Nourani A., Doyon Y., Utley R.T., Allard S., Lane W.S., Cote J.
    Mol. Cell. Biol. 21:7629-7640(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-34; 62-70; 107-161; 171-180 AND 184-193, IDENTIFICATION IN THE NUA4 COMPLEX, FUNCTION.
  6. "NuA4 subunit Yng2 function in intra-S-phase DNA damage response."
    Choy J.S., Kron S.J.
    Mol. Cell. Biol. 22:8215-8225(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres."
    Zhang H., Richardson D.O., Roberts D.N., Utley R.T., Erdjument-Bromage H., Tempst P., Cote J., Cairns B.R.
    Mol. Cell. Biol. 24:9424-9436(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
    Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
    PLoS Biol. 2:587-599(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
    Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  11. Cited for: DOMAIN PHD-TYPE ZINC-FINGER, INTERACTION WITH HISTONES H3K4ME3 AND H3K4ME2.
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; THR-185 AND SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYNG2_YEAST
AccessioniPrimary (citable) accession number: P38806
Secondary accession number(s): D3DL42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3