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Protein

Ribosome production factor 1

Gene

RPF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential protein. Required for biogenesis of the 60S ribosomal subunit.2 Publications

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA primary transcript binding Source: SGD

GO - Biological processi

  • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • ribosomal large subunit export from nucleus Source: SGD

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31135-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 1
Alternative name(s):
Ribosome biogenesis protein RPF1
Gene namesi
Name:RPF1
Ordered Locus Names:YHR088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR088W
SGDiS000001130 RPF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202551 – 295Ribosome production factor 1Add BLAST295

Proteomic databases

MaxQBiP38805
PaxDbiP38805
PRIDEiP38805
TopDownProteomicsiP38805

Interactioni

Subunit structurei

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36523, 253 interactors
DIPiDIP-6511N
IntActiP38805, 33 interactors
MINTiP38805
STRINGi4932.YHR088W

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 43Combined sources32
Helixi46 – 54Combined sources9
Turni60 – 63Combined sources4
Helixi79 – 84Combined sources6
Beta strandi94 – 99Combined sources6
Helixi105 – 117Combined sources13
Beta strandi118 – 124Combined sources7
Helixi133 – 141Combined sources9
Beta strandi145 – 167Combined sources23
Beta strandi170 – 174Combined sources5
Helixi205 – 217Combined sources13
Beta strandi228 – 230Combined sources3
Beta strandi235 – 240Combined sources6
Beta strandi243 – 249Combined sources7
Turni250 – 252Combined sources3
Beta strandi253 – 260Combined sources8
Beta strandi265 – 268Combined sources4
Beta strandi272 – 276Combined sources5
Beta strandi288 – 290Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z3Gelectron microscopy3.65O1-295[»]
6C0Felectron microscopy3.70I1-295[»]
6EM1electron microscopy3.60x1-295[»]
6EM3electron microscopy3.20x1-295[»]
6EM4electron microscopy4.10x1-295[»]
6EM5electron microscopy4.30x1-295[»]
ProteinModelPortaliP38805
SMRiP38805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 276BrixPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 271RNA-bindingAdd BLAST18

Phylogenomic databases

GeneTreeiENSGT00550000074691
HOGENOMiHOG000172062
InParanoidiP38805
KOiK14846
OMAiAWIISNK
OrthoDBiEOG092C3ODK

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequencei

Sequence statusi: Complete.

P38805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGNEINIT NKLKRQEIFA DIKHEKNKER HTMRRKRAKE ERENPELREQ
60 70 80 90 100
RLKENVTQTI ENTRVYDETI NKEVEGDEDD LMRYFNSNSN EPPKIFLTTN
110 120 130 140 150
VNAKKSAYEF ANILIEILPN VTFVKRKFGY KLKEISDICI KRNFTDIVII
160 170 180 190 200
NEDKKKVTGL TFIHLPEGPT FYFKLSSFVE VKKIVGHGRP TSHIPELILN
210 220 230 240 250
NFQTRLGQTV GRLFQSILPQ NPDIEGRQVI TLHNQRDYIF FRRHRYVFKD
260 270 280 290
NERVGLQELG PQFTLKLKRL QRGIKEETEW EHKPEMDKEK KKFYL
Length:295
Mass (Da):35,121
Last modified:February 1, 1995 - v1
Checksum:iEC6EDB2FCE252D4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00060 Genomic DNA Translation: AAB68926.1
BK006934 Genomic DNA Translation: DAA06784.1
PIRiS46718
RefSeqiNP_011956.1, NM_001179218.1

Genome annotation databases

EnsemblFungiiYHR088W; YHR088W; YHR088W
GeneIDi856488
KEGGisce:YHR088W

Similar proteinsi

Entry informationi

Entry nameiRPF1_YEAST
AccessioniPrimary (citable) accession number: P38805
Secondary accession number(s): D3DL40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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