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P38805

- RPF1_YEAST

UniProt

P38805 - RPF1_YEAST

Protein

Ribosome production factor 1

Gene

RPF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Essential protein. Required for biogenesis of the 60S ribosomal subunit.2 Publications

    GO - Molecular functioni

    1. rRNA primary transcript binding Source: SGD

    GO - Biological processi

    1. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. ribosomal large subunit assembly Source: SGD
    4. ribosomal large subunit export from nucleus Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31135-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome production factor 1
    Alternative name(s):
    Ribosome biogenesis protein RPF1
    Gene namesi
    Name:RPF1
    Ordered Locus Names:YHR088W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR088w.
    SGDiS000001130. RPF1.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. preribosome, large subunit precursor Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Ribosome production factor 1PRO_0000120255Add
    BLAST

    Proteomic databases

    MaxQBiP38805.
    PaxDbiP38805.

    Expressioni

    Gene expression databases

    GenevestigatoriP38805.

    Interactioni

    Subunit structurei

    Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

    Protein-protein interaction databases

    BioGridi36523. 84 interactions.
    DIPiDIP-6511N.
    IntActiP38805. 26 interactions.
    MINTiMINT-8285251.
    STRINGi4932.YHR088W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38805.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 276184BrixPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 27118RNA-bindingAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Brix domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2136.
    GeneTreeiENSGT00550000074691.
    HOGENOMiHOG000172062.
    KOiK14846.
    OMAiKDPTEHV.
    OrthoDBiEOG757D7K.

    Family and domain databases

    Gene3Di3.40.50.10480. 1 hit.
    InterProiIPR004154. Anticodon-bd.
    IPR007109. Brix.
    [Graphical view]
    PfamiPF04427. Brix. 1 hit.
    [Graphical view]
    SMARTiSM00879. Brix. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    PROSITEiPS50833. BRIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38805-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGNEINIT NKLKRQEIFA DIKHEKNKER HTMRRKRAKE ERENPELREQ    50
    RLKENVTQTI ENTRVYDETI NKEVEGDEDD LMRYFNSNSN EPPKIFLTTN 100
    VNAKKSAYEF ANILIEILPN VTFVKRKFGY KLKEISDICI KRNFTDIVII 150
    NEDKKKVTGL TFIHLPEGPT FYFKLSSFVE VKKIVGHGRP TSHIPELILN 200
    NFQTRLGQTV GRLFQSILPQ NPDIEGRQVI TLHNQRDYIF FRRHRYVFKD 250
    NERVGLQELG PQFTLKLKRL QRGIKEETEW EHKPEMDKEK KKFYL 295
    Length:295
    Mass (Da):35,121
    Last modified:February 1, 1995 - v1
    Checksum:iEC6EDB2FCE252D4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00060 Genomic DNA. Translation: AAB68926.1.
    BK006934 Genomic DNA. Translation: DAA06784.1.
    PIRiS46718.
    RefSeqiNP_011956.1. NM_001179218.1.

    Genome annotation databases

    EnsemblFungiiYHR088W; YHR088W; YHR088W.
    GeneIDi856488.
    KEGGisce:YHR088W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00060 Genomic DNA. Translation: AAB68926.1 .
    BK006934 Genomic DNA. Translation: DAA06784.1 .
    PIRi S46718.
    RefSeqi NP_011956.1. NM_001179218.1.

    3D structure databases

    ProteinModelPortali P38805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36523. 84 interactions.
    DIPi DIP-6511N.
    IntActi P38805. 26 interactions.
    MINTi MINT-8285251.
    STRINGi 4932.YHR088W.

    Proteomic databases

    MaxQBi P38805.
    PaxDbi P38805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR088W ; YHR088W ; YHR088W .
    GeneIDi 856488.
    KEGGi sce:YHR088W.

    Organism-specific databases

    CYGDi YHR088w.
    SGDi S000001130. RPF1.

    Phylogenomic databases

    eggNOGi COG2136.
    GeneTreei ENSGT00550000074691.
    HOGENOMi HOG000172062.
    KOi K14846.
    OMAi KDPTEHV.
    OrthoDBi EOG757D7K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31135-MONOMER.

    Miscellaneous databases

    NextBioi 982188.
    PROi P38805.

    Gene expression databases

    Genevestigatori P38805.

    Family and domain databases

    Gene3Di 3.40.50.10480. 1 hit.
    InterProi IPR004154. Anticodon-bd.
    IPR007109. Brix.
    [Graphical view ]
    Pfami PF04427. Brix. 1 hit.
    [Graphical view ]
    SMARTi SM00879. Brix. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    PROSITEi PS50833. BRIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis."
      Wehner K.A., Baserga S.J.
      Mol. Cell 9:329-339(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
      Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
      FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, POSSIBLE COMPLEX COMPOSITION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPF1_YEAST
    AccessioniPrimary (citable) accession number: P38805
    Secondary accession number(s): D3DL40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 784 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3