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P38805 (RPF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosome production factor 1
Alternative name(s):
Ribosome biogenesis protein RPF1
Gene names
Name:RPF1
Ordered Locus Names:YHR088W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential protein. Required for biogenesis of the 60S ribosomal subunit. Ref.3 Ref.4

Subunit structure

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Subcellular location

Nucleusnucleolus Ref.3 Ref.4.

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 Brix domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Ribosome production factor 1
PRO_0000120255

Regions

Domain93 – 276184Brix
Region254 – 27118RNA-binding

Sequences

Sequence LengthMass (Da)Tools
P38805 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: EC6EDB2FCE252D4A

FASTA29535,121
        10         20         30         40         50         60 
MALGNEINIT NKLKRQEIFA DIKHEKNKER HTMRRKRAKE ERENPELREQ RLKENVTQTI 

        70         80         90        100        110        120 
ENTRVYDETI NKEVEGDEDD LMRYFNSNSN EPPKIFLTTN VNAKKSAYEF ANILIEILPN 

       130        140        150        160        170        180 
VTFVKRKFGY KLKEISDICI KRNFTDIVII NEDKKKVTGL TFIHLPEGPT FYFKLSSFVE 

       190        200        210        220        230        240 
VKKIVGHGRP TSHIPELILN NFQTRLGQTV GRLFQSILPQ NPDIEGRQVI TLHNQRDYIF 

       250        260        270        280        290 
FRRHRYVFKD NERVGLQELG PQFTLKLKRL QRGIKEETEW EHKPEMDKEK KKFYL 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis."
Wehner K.A., Baserga S.J.
Mol. Cell 9:329-339(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, POSSIBLE COMPLEX COMPOSITION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00060 Genomic DNA. Translation: AAB68926.1.
BK006934 Genomic DNA. Translation: DAA06784.1.
PIRS46718.
RefSeqNP_011956.1. NM_001179218.1.

3D structure databases

ProteinModelPortalP38805.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36523. 84 interactions.
DIPDIP-6511N.
IntActP38805. 26 interactions.
MINTMINT-8285251.
STRING4932.YHR088W.

Proteomic databases

PaxDbP38805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR088W; YHR088W; YHR088W.
GeneID856488.
KEGGsce:YHR088W.

Organism-specific databases

CYGDYHR088w.
SGDS000001130. RPF1.

Phylogenomic databases

eggNOGCOG2136.
GeneTreeENSGT00550000074691.
HOGENOMHOG000172062.
KOK14846.
OMADRKIPNG.
OrthoDBEOG757D7K.

Enzyme and pathway databases

BioCycYEAST:G3O-31135-MONOMER.

Gene expression databases

GenevestigatorP38805.

Family and domain databases

Gene3D3.40.50.10480. 1 hit.
InterProIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamPF04427. Brix. 1 hit.
[Graphical view]
SMARTSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMSSF52954. SSF52954. 1 hit.
PROSITEPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982188.
PROP38805.

Entry information

Entry nameRPF1_YEAST
AccessionPrimary (citable) accession number: P38805
Secondary accession number(s): D3DL40
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families