P38804 (SDO1L_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Restriction of telomere capping protein 3

Gene names

Name:	RTC3
Ordered Locus Names:	YHR087W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping. Ref.6
Subcellular location	Cytoplasm. Nucleus Ref.4.
Miscellaneous	Present with 2430 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the SDO1-like family.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from genetic interaction Ref.8. Source: SGD rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay Ref.4. Source: SGD nucleus Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 111

111

Restriction of telomere capping protein 3

PRO_0000202905

Amino acid modifications

Modified residue

97

1

Phosphoserine Ref.7

Secondary structure

1

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111

Helix Strand Turn

Details...

Beta strand

5 – 10

6

Beta strand

12 – 21

10

Helix

23 – 31

9

Helix

35 – 41

7

Beta strand

52 – 54

3

Beta strand

56 – 58

3

Helix

65 – 72

8

Helix

79 – 87

9

Beta strand

107 – 109

3

Sequences

	Sequence		Length	Mass (Da)
	P38804 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 34A95645CAFB51BD	FASTA	111	12,009
	10 20 30 40 50 60 MSTVTKYFYK GENTDLIVFA ASEELVDEYL KNPSIGKLSE VVELFEVFTP QDGRGAEGEL 70 80 90 100 110 GAASKAQVEN EFGKGKKIEE VIDLILRNGK PNSTTSSLKT KGGNAGTKAY N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae." Addinall S.G., Downey M., Yu M., Zubko M.K., Dewar J., Leake A., Hallinan J., Shaw O., James K., Wilkinson D.J., Wipat A., Durocher D., Lydall D. Genetics 180:2251-2266(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, MASS SPECTROMETRY.
[8]	"The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism." Savchenko A., Krogan N., Cort J.R., Evdokimova E., Lew J.M., Yee A.A., Sanchez-Pulido L., Andrade M.A., Bochkarev A., Watson J.D., Kennedy M.A., Greenblatt J., Hughes T., Arrowsmith C.H., Rommens J.M., Edwards A.M. J. Biol. Chem. 280:19213-19220(2005) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U00060 Genomic DNA. Translation: AAB68927.1.
AY557845 Genomic DNA. Translation: AAS56171.1.
BK006934 Genomic DNA. Translation: DAA06783.1.

PIR

S46719.

RefSeq

NP_011955.1. NM_001179217.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NYN	NMR	-	A	1-111	[»]

ProteinModelPortal

P38804.

SMR

P38804. Positions 1-111.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2925N.

IntAct

P38804. 2 interactions.

MINT

MINT-558198.

STRING

4932.YHR087W.

Proteomic databases

PaxDb

P38804.

PeptideAtlas

P38804.

Protocols and materials databases

DNASU

856487.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YHR087W; YHR087W; YHR087W.

GeneID

856487.

KEGG

sce:YHR087W.

Organism-specific databases

CYGD

YHR087w.

SGD

S000001129. RTC3.

Phylogenomic databases

eggNOG

NOG81974.

HOGENOM

HOG000216667.

OMA

NEFGKGK.

OrthoDB

EOG4V9Z1H.

Enzyme and pathway databases

BioCyc

YEAST:G3O-31134-MONOMER.

Gene expression databases

Genevestigator

P38804.

GermOnline

YHR087W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR019783. Ribosome_mat_SBDS_N.
[Graphical view]

Pfam

PF01172. SBDS. 1 hit.
[Graphical view]

SUPFAM

SSF89895. Ribosome_mat_SBDS_N. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P38804.

NextBio

982185.

Entry information

Entry name

SDO1L_YEAST

Accession

Primary (citable) accession number: P38804
Secondary accession number(s): D3DL39

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program