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Protein

Pre-rRNA-processing protein IPI1

Gene

IPI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein IPI1
Alternative name(s):
Involved in processing IST2 protein 1
Gene namesi
Name:IPI1
Ordered Locus Names:YHR085W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR085w.
EuPathDBiFungiDB:YHR085W.
SGDiS000001127. IPI1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleoplasm Source: SGD
  • nucleus Source: SGD
  • Rix1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Pre-rRNA-processing protein IPI1PRO_0000202904Add
BLAST

Proteomic databases

MaxQBiP38803.
PaxDbiP38803.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles.4 Publications

Protein-protein interaction databases

BioGridi36520. 28 interactions.
DIPiDIP-4665N.
IntActiP38803. 28 interactions.
MINTiMINT-481995.
STRINGi4932.YHR085W.

Structurei

3D structure databases

ProteinModelPortaliP38803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IPI1 family.Curated

Phylogenomic databases

eggNOGiNOG315171.
HOGENOMiHOG000094409.
InParanoidiP38803.
KOiK14827.
OMAiSAMTHIQ.
OrthoDBiEOG735489.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamiPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P38803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSRKQKQK KQDFLRKKLK VGKPKEKARN ATDTSFVSKT ISIRNQHLDQ
60 70 80 90 100
NPHDLTKRLT LLKHHNINVR KETLTTFQKS IPSIIKSRLM TPLLTQSIPL
110 120 130 140 150
ICDESQQVRQ GLIDLVDEIG SHDAEILKLH CNIFVLYINM AMTHIVTQIQ
160 170 180 190 200
ADSTKFLSHL LKYCGDEVVR KSWVKLLNGV FGVLGWGQVG KNDSASIVQT
210 220 230 240 250
KKRNAKYVTI HLNALYTLVE YGCQDERARS DGDTAETTED SGTLRNPYLI
260 270 280 290 300
PDYPQPFEHL KLFTRELKVQ DATSSGVNAT LLSLATQDID TRKAVFIEQF
310 320 330
LPIVRKKIEV IIKEGGECGK SANKLKTLLA KIFD
Length:334
Mass (Da):37,867
Last modified:February 1, 1995 - v1
Checksum:i1AB0B318BBFC8096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68883.1.
BK006934 Genomic DNA. Translation: DAA06780.1.
PIRiS46805.
RefSeqiNP_011953.1. NM_001179215.1.

Genome annotation databases

EnsemblFungiiYHR085W; YHR085W; YHR085W.
GeneIDi856485.
KEGGisce:YHR085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68883.1.
BK006934 Genomic DNA. Translation: DAA06780.1.
PIRiS46805.
RefSeqiNP_011953.1. NM_001179215.1.

3D structure databases

ProteinModelPortaliP38803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36520. 28 interactions.
DIPiDIP-4665N.
IntActiP38803. 28 interactions.
MINTiMINT-481995.
STRINGi4932.YHR085W.

Proteomic databases

MaxQBiP38803.
PaxDbiP38803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR085W; YHR085W; YHR085W.
GeneIDi856485.
KEGGisce:YHR085W.

Organism-specific databases

CYGDiYHR085w.
EuPathDBiFungiDB:YHR085W.
SGDiS000001127. IPI1.

Phylogenomic databases

eggNOGiNOG315171.
HOGENOMiHOG000094409.
InParanoidiP38803.
KOiK14827.
OMAiSAMTHIQ.
OrthoDBiEOG735489.

Enzyme and pathway databases

BioCyciYEAST:G3O-31132-MONOMER.

Miscellaneous databases

NextBioi982179.
PROiP38803.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamiPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
    Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
    J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
  8. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
    Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
    Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiIPI1_YEAST
AccessioniPrimary (citable) accession number: P38803
Secondary accession number(s): D3DL36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.