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P38803

- IPI1_YEAST

UniProt

P38803 - IPI1_YEAST

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Protein

Pre-rRNA-processing protein IPI1

Gene

IPI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

GO - Molecular functioni

  1. chromatin binding Source: SGD

GO - Biological processi

  1. pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  2. regulation of DNA-dependent DNA replication initiation Source: SGD
  3. ribosomal large subunit assembly Source: SGD
  4. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein IPI1
Alternative name(s):
Involved in processing IST2 protein 1
Gene namesi
Name:IPI1
Ordered Locus Names:YHR085W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR085w.
SGDiS000001127. IPI1.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleoplasm Source: SGD
  3. nucleus Source: SGD
  4. Rix1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Pre-rRNA-processing protein IPI1PRO_0000202904Add
BLAST

Proteomic databases

MaxQBiP38803.
PaxDbiP38803.

Expressioni

Gene expression databases

GenevestigatoriP38803.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles.4 Publications

Protein-protein interaction databases

BioGridi36520. 28 interactions.
DIPiDIP-4665N.
IntActiP38803. 28 interactions.
MINTiMINT-481995.
STRINGi4932.YHR085W.

Structurei

3D structure databases

ProteinModelPortaliP38803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IPI1 family.Curated

Phylogenomic databases

eggNOGiNOG315171.
HOGENOMiHOG000094409.
InParanoidiP38803.
KOiK14827.
OMAiSAMTHIQ.
OrthoDBiEOG735489.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamiPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P38803-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKSRKQKQK KQDFLRKKLK VGKPKEKARN ATDTSFVSKT ISIRNQHLDQ
60 70 80 90 100
NPHDLTKRLT LLKHHNINVR KETLTTFQKS IPSIIKSRLM TPLLTQSIPL
110 120 130 140 150
ICDESQQVRQ GLIDLVDEIG SHDAEILKLH CNIFVLYINM AMTHIVTQIQ
160 170 180 190 200
ADSTKFLSHL LKYCGDEVVR KSWVKLLNGV FGVLGWGQVG KNDSASIVQT
210 220 230 240 250
KKRNAKYVTI HLNALYTLVE YGCQDERARS DGDTAETTED SGTLRNPYLI
260 270 280 290 300
PDYPQPFEHL KLFTRELKVQ DATSSGVNAT LLSLATQDID TRKAVFIEQF
310 320 330
LPIVRKKIEV IIKEGGECGK SANKLKTLLA KIFD
Length:334
Mass (Da):37,867
Last modified:February 1, 1995 - v1
Checksum:i1AB0B318BBFC8096
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10556 Genomic DNA. Translation: AAB68883.1.
BK006934 Genomic DNA. Translation: DAA06780.1.
PIRiS46805.
RefSeqiNP_011953.1. NM_001179215.1.

Genome annotation databases

EnsemblFungiiYHR085W; YHR085W; YHR085W.
GeneIDi856485.
KEGGisce:YHR085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10556 Genomic DNA. Translation: AAB68883.1 .
BK006934 Genomic DNA. Translation: DAA06780.1 .
PIRi S46805.
RefSeqi NP_011953.1. NM_001179215.1.

3D structure databases

ProteinModelPortali P38803.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36520. 28 interactions.
DIPi DIP-4665N.
IntActi P38803. 28 interactions.
MINTi MINT-481995.
STRINGi 4932.YHR085W.

Proteomic databases

MaxQBi P38803.
PaxDbi P38803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR085W ; YHR085W ; YHR085W .
GeneIDi 856485.
KEGGi sce:YHR085W.

Organism-specific databases

CYGDi YHR085w.
SGDi S000001127. IPI1.

Phylogenomic databases

eggNOGi NOG315171.
HOGENOMi HOG000094409.
InParanoidi P38803.
KOi K14827.
OMAi SAMTHIQ.
OrthoDBi EOG735489.

Enzyme and pathway databases

BioCyci YEAST:G3O-31132-MONOMER.

Miscellaneous databases

NextBioi 982179.
PROi P38803.

Gene expression databases

Genevestigatori P38803.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
[Graphical view ]
Pfami PF12333. Ipi1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
    Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
    J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
  8. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
    Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
    Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiIPI1_YEAST
AccessioniPrimary (citable) accession number: P38803
Secondary accession number(s): D3DL36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3