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Protein

Pre-rRNA-processing protein IPI1

Gene

IPI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein IPI1
Alternative name(s):
Involved in processing IST2 protein 1
Gene namesi
Name:IPI1
Ordered Locus Names:YHR085W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR085W.
SGDiS000001127. IPI1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029041 – 334Pre-rRNA-processing protein IPI1Add BLAST334

Proteomic databases

MaxQBiP38803.
PRIDEiP38803.

PTM databases

iPTMnetiP38803.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.4 Publications

Protein-protein interaction databases

BioGridi36520. 229 interactors.
DIPiDIP-4665N.
IntActiP38803. 28 interactors.
MINTiMINT-481995.
STRINGi4932.YHR085W.

Structurei

3D structure databases

ProteinModelPortaliP38803.
SMRiP38803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IPI1/TEX10 family.Curated

Phylogenomic databases

HOGENOMiHOG000094409.
InParanoidiP38803.
KOiK14827.
OMAiGQPRDEE.
OrthoDBiEOG092C2WI7.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
PfamiView protein in Pfam
PF12333. Ipi1_N. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P38803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSRKQKQK KQDFLRKKLK VGKPKEKARN ATDTSFVSKT ISIRNQHLDQ
60 70 80 90 100
NPHDLTKRLT LLKHHNINVR KETLTTFQKS IPSIIKSRLM TPLLTQSIPL
110 120 130 140 150
ICDESQQVRQ GLIDLVDEIG SHDAEILKLH CNIFVLYINM AMTHIVTQIQ
160 170 180 190 200
ADSTKFLSHL LKYCGDEVVR KSWVKLLNGV FGVLGWGQVG KNDSASIVQT
210 220 230 240 250
KKRNAKYVTI HLNALYTLVE YGCQDERARS DGDTAETTED SGTLRNPYLI
260 270 280 290 300
PDYPQPFEHL KLFTRELKVQ DATSSGVNAT LLSLATQDID TRKAVFIEQF
310 320 330
LPIVRKKIEV IIKEGGECGK SANKLKTLLA KIFD
Length:334
Mass (Da):37,867
Last modified:February 1, 1995 - v1
Checksum:i1AB0B318BBFC8096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68883.1.
BK006934 Genomic DNA. Translation: DAA06780.1.
PIRiS46805.
RefSeqiNP_011953.1. NM_001179215.1.

Genome annotation databases

EnsemblFungiiYHR085W; YHR085W; YHR085W.
GeneIDi856485.
KEGGisce:YHR085W.

Similar proteinsi

Entry informationi

Entry nameiIPI1_YEAST
AccessioniPrimary (citable) accession number: P38803
Secondary accession number(s): D3DL36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names