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P38803

- IPI1_YEAST

UniProt

P38803 - IPI1_YEAST

Protein

Pre-rRNA-processing protein IPI1

Gene

IPI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

    GO - Molecular functioni

    1. chromatin binding Source: SGD

    GO - Biological processi

    1. pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
    2. regulation of DNA-dependent DNA replication initiation Source: SGD
    3. ribosomal large subunit assembly Source: SGD
    4. rRNA processing Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31132-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-rRNA-processing protein IPI1
    Alternative name(s):
    Involved in processing IST2 protein 1
    Gene namesi
    Name:IPI1
    Ordered Locus Names:YHR085W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR085w.
    SGDiS000001127. IPI1.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleoplasm Source: SGD
    3. nucleus Source: SGD
    4. Rix1 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Pre-rRNA-processing protein IPI1PRO_0000202904Add
    BLAST

    Proteomic databases

    MaxQBiP38803.
    PaxDbiP38803.

    Expressioni

    Gene expression databases

    GenevestigatoriP38803.

    Interactioni

    Subunit structurei

    Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles.4 Publications

    Protein-protein interaction databases

    BioGridi36520. 28 interactions.
    DIPiDIP-4665N.
    IntActiP38803. 28 interactions.
    MINTiMINT-481995.
    STRINGi4932.YHR085W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38803.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IPI1 family.Curated

    Phylogenomic databases

    eggNOGiNOG315171.
    HOGENOMiHOG000094409.
    KOiK14827.
    OMAiSAMTHIQ.
    OrthoDBiEOG735489.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR024679. IPI1/TEX10.
    [Graphical view]
    PfamiPF12333. Ipi1_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38803-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSRKQKQK KQDFLRKKLK VGKPKEKARN ATDTSFVSKT ISIRNQHLDQ    50
    NPHDLTKRLT LLKHHNINVR KETLTTFQKS IPSIIKSRLM TPLLTQSIPL 100
    ICDESQQVRQ GLIDLVDEIG SHDAEILKLH CNIFVLYINM AMTHIVTQIQ 150
    ADSTKFLSHL LKYCGDEVVR KSWVKLLNGV FGVLGWGQVG KNDSASIVQT 200
    KKRNAKYVTI HLNALYTLVE YGCQDERARS DGDTAETTED SGTLRNPYLI 250
    PDYPQPFEHL KLFTRELKVQ DATSSGVNAT LLSLATQDID TRKAVFIEQF 300
    LPIVRKKIEV IIKEGGECGK SANKLKTLLA KIFD 334
    Length:334
    Mass (Da):37,867
    Last modified:February 1, 1995 - v1
    Checksum:i1AB0B318BBFC8096
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68883.1.
    BK006934 Genomic DNA. Translation: DAA06780.1.
    PIRiS46805.
    RefSeqiNP_011953.1. NM_001179215.1.

    Genome annotation databases

    EnsemblFungiiYHR085W; YHR085W; YHR085W.
    GeneIDi856485.
    KEGGisce:YHR085W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68883.1 .
    BK006934 Genomic DNA. Translation: DAA06780.1 .
    PIRi S46805.
    RefSeqi NP_011953.1. NM_001179215.1.

    3D structure databases

    ProteinModelPortali P38803.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36520. 28 interactions.
    DIPi DIP-4665N.
    IntActi P38803. 28 interactions.
    MINTi MINT-481995.
    STRINGi 4932.YHR085W.

    Proteomic databases

    MaxQBi P38803.
    PaxDbi P38803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR085W ; YHR085W ; YHR085W .
    GeneIDi 856485.
    KEGGi sce:YHR085W.

    Organism-specific databases

    CYGDi YHR085w.
    SGDi S000001127. IPI1.

    Phylogenomic databases

    eggNOGi NOG315171.
    HOGENOMi HOG000094409.
    KOi K14827.
    OMAi SAMTHIQ.
    OrthoDBi EOG735489.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31132-MONOMER.

    Miscellaneous databases

    NextBioi 982179.
    PROi P38803.

    Gene expression databases

    Genevestigatori P38803.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR024679. IPI1/TEX10.
    [Graphical view ]
    Pfami PF12333. Ipi1_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
      Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
      J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
    8. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
      Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
      Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiIPI1_YEAST
    AccessioniPrimary (citable) accession number: P38803
    Secondary accession number(s): D3DL36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4420 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3