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P38803 (IPI1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-rRNA-processing protein IPI1
Alternative name(s):
Involved in processing IST2 protein 1
Gene names
Name:IPI1
Ordered Locus Names:YHR085W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. Ref.6 Ref.7

Subunit structure

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles. Ref.3 Ref.6 Ref.7 Ref.8

Subcellular location

Nucleus Ref.4 Ref.6.

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the IPI1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Pre-rRNA-processing protein IPI1
PRO_0000202904

Sequences

Sequence LengthMass (Da)Tools
P38803 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1AB0B318BBFC8096

FASTA33437,867
        10         20         30         40         50         60 
MTKSRKQKQK KQDFLRKKLK VGKPKEKARN ATDTSFVSKT ISIRNQHLDQ NPHDLTKRLT 

        70         80         90        100        110        120 
LLKHHNINVR KETLTTFQKS IPSIIKSRLM TPLLTQSIPL ICDESQQVRQ GLIDLVDEIG 

       130        140        150        160        170        180 
SHDAEILKLH CNIFVLYINM AMTHIVTQIQ ADSTKFLSHL LKYCGDEVVR KSWVKLLNGV 

       190        200        210        220        230        240 
FGVLGWGQVG KNDSASIVQT KKRNAKYVTI HLNALYTLVE YGCQDERARS DGDTAETTED 

       250        260        270        280        290        300 
SGTLRNPYLI PDYPQPFEHL KLFTRELKVQ DATSSGVNAT LLSLATQDID TRKAVFIEQF 

       310        320        330 
LPIVRKKIEV IIKEGGECGK SANKLKTLLA KIFD 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Assigning function to yeast proteins by integration of technologies."
Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M., Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E., Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.
Mol. Cell 12:1353-1365(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"High-definition macromolecular composition of yeast RNA-processing complexes."
Krogan N.J., Peng W.-T., Cagney G., Robinson M.D., Haw R., Zhong G., Guo X., Zhang X., Canadien V., Richards D.P., Beattie B.K., Lalev A., Zhang W., Davierwala A.P., Mnaimneh S., Starostine A., Tikuisis A.P., Grigull J. expand/collapse author list , Datta N., Bray J.E., Hughes T.R., Emili A., Greenblatt J.F.
Mol. Cell 13:225-239(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
[8]"A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10556 Genomic DNA. Translation: AAB68883.1.
BK006934 Genomic DNA. Translation: DAA06780.1.
PIRS46805.
RefSeqNP_011953.1. NM_001179215.1.

3D structure databases

ProteinModelPortalP38803.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36520. 28 interactions.
DIPDIP-4665N.
IntActP38803. 28 interactions.
MINTMINT-481995.
STRING4932.YHR085W.

Proteomic databases

MaxQBP38803.
PaxDbP38803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR085W; YHR085W; YHR085W.
GeneID856485.
KEGGsce:YHR085W.

Organism-specific databases

CYGDYHR085w.
SGDS000001127. IPI1.

Phylogenomic databases

eggNOGNOG315171.
HOGENOMHOG000094409.
KOK14827.
OMASAMTHIQ.
OrthoDBEOG735489.

Enzyme and pathway databases

BioCycYEAST:G3O-31132-MONOMER.

Gene expression databases

GenevestigatorP38803.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

NextBio982179.
PROP38803.

Entry information

Entry nameIPI1_YEAST
AccessionPrimary (citable) accession number: P38803
Secondary accession number(s): D3DL36
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families