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Protein

Exosome complex protein LRP1

Gene

LRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance.5 Publications

GO - Molecular functioni

  • double-stranded DNA binding Source: SGD
  • double-stranded RNA binding Source: SGD
  • enzyme regulator activity Source: SGD

GO - Biological processi

  • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • nuclear mRNA surveillance Source: SGD
  • nuclear polyadenylation-dependent CUT catabolic process Source: SGD
  • nuclear polyadenylation-dependent rRNA catabolic process Source: SGD
  • nuclear retention of pre-mRNA at the site of transcription Source: SGD
  • polyadenylation-dependent snoRNA 3'-end processing Source: SGD
  • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
  • regulation of exoribonuclease activity Source: SGD
  • U4 snRNA 3'-end processing Source: SGD
  • U5 snRNA 3'-end processing Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31128-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex protein LRP1
Alternative name(s):
Like an rRNA processing protein 1
Yeast C1D domain-containing protein
rRNA processing protein 47
Gene namesi
Name:LRP1
Synonyms:RRP47, YC1D
Ordered Locus Names:YHR081W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR081W
SGDiS000001123 LRP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029021 – 184Exosome complex protein LRP1Add BLAST184

Proteomic databases

MaxQBiP38801
PaxDbiP38801
PRIDEiP38801

Interactioni

Subunit structurei

Associated with nuclear form of the RNA exosome complex. Interacts with RRP4, RRP6, RRP45 and RRP46.3 Publications

Protein-protein interaction databases

BioGridi36516, 440 interactors
DIPiDIP-4359N
IntActiP38801, 7 interactors
MINTiP38801
STRINGi4932.YHR081W

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Helixi8 – 28Combined sources21
Helixi33 – 39Combined sources7
Helixi43 – 67Combined sources25
Helixi74 – 119Combined sources46

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WFCX-ray2.35B/D/F1-133[»]
4WFDX-ray2.40B/E/H1-103[»]
5C0WX-ray4.60L1-184[»]
6FSZelectron microscopy4.60LL1-184[»]
6FT6electron microscopy3.90LL1-184[»]
DisProtiDP00788
ProteinModelPortaliP38801
SMRiP38801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the C1D family.Curated

Phylogenomic databases

HOGENOMiHOG000000879
InParanoidiP38801
KOiK12592
OMAiNFQGKHT
OrthoDBiEOG092C52FJ

Family and domain databases

InterProiView protein in InterPro
IPR011082 Exosome-assoc_fac/DNA_repair
IPR007146 Sas10/Utp3/C1D
PANTHERiPTHR15341 PTHR15341, 1 hit
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit

Sequencei

Sequence statusi: Complete.

P38801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDIEKIKPY VRSFSKALDE LKPEIEKLTS KSLDEQLLLL SDERAKLELI
60 70 80 90 100
NRYAYVLSSL MFANMKVLGV KDMSPILGEL KRVKSYMDKA KQYDNRITKS
110 120 130 140 150
NEKSQAEQEK AKNIISNVLD GNKNQFEPSI SRSNFQGKHT KFENDELAES
160 170 180
TTTKIIDSTD HIRKASSKKS KRLDKVGKKK GGKK
Length:184
Mass (Da):21,045
Last modified:February 1, 1995 - v1
Checksum:i27D00668C296CC9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA Translation: AAB68886.1
BK006934 Genomic DNA Translation: DAA06776.1
PIRiS46808
RefSeqiNP_011949.1, NM_001179211.1

Genome annotation databases

EnsemblFungiiYHR081W; YHR081W; YHR081W
GeneIDi856481
KEGGisce:YHR081W

Similar proteinsi

Entry informationi

Entry nameiLRP1_YEAST
AccessioniPrimary (citable) accession number: P38801
Secondary accession number(s): D3DL32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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