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P38801

- LRP1_YEAST

UniProt

P38801 - LRP1_YEAST

Protein

Exosome complex protein LRP1

Gene

LRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance.5 Publications

    GO - Molecular functioni

    1. double-stranded DNA binding Source: SGD
    2. double-stranded RNA binding Source: SGD
    3. enzyme regulator activity Source: SGD

    GO - Biological processi

    1. exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. nuclear mRNA surveillance Source: SGD
    3. nuclear polyadenylation-dependent CUT catabolic process Source: SGD
    4. nuclear polyadenylation-dependent rRNA catabolic process Source: SGD
    5. nuclear retention of pre-mRNA at the site of transcription Source: SGD
    6. polyadenylation-dependent snoRNA 3'-end processing Source: SGD
    7. posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
    8. regulation of exoribonuclease activity Source: SGD
    9. U4 snRNA 3'-end processing Source: SGD
    10. U5 snRNA 3'-end processing Source: SGD

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31128-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exosome complex protein LRP1
    Alternative name(s):
    Like an rRNA processing protein 1
    Yeast C1D domain-containing protein
    rRNA processing protein 47
    Gene namesi
    Name:LRP1
    Synonyms:RRP47, YC1D
    Ordered Locus Names:YHR081W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR081w.
    SGDiS000001123. LRP1.

    Subcellular locationi

    Nucleus 3 Publications

    GO - Cellular componenti

    1. exosome (RNase complex) Source: UniProtKB-KW
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Exosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184Exosome complex protein LRP1PRO_0000202902Add
    BLAST

    Proteomic databases

    MaxQBiP38801.
    PaxDbiP38801.

    Expressioni

    Gene expression databases

    GenevestigatoriP38801.

    Interactioni

    Subunit structurei

    Associated with nuclear form of the RNA exosome complex. Interacts with RRP4, RRP6, RRP45 and RRP46.3 Publications

    Protein-protein interaction databases

    BioGridi36516. 261 interactions.
    DIPiDIP-4359N.
    IntActiP38801. 7 interactions.
    MINTiMINT-499454.
    STRINGi4932.YHR081W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38801.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the C1D family.Curated

    Phylogenomic databases

    eggNOGiNOG315595.
    HOGENOMiHOG000000879.
    KOiK12592.
    OMAiFENDELA.
    OrthoDBiEOG7RFTW7.

    Family and domain databases

    InterProiIPR011082. Exosome-assoc_fac/DNA_repair.
    IPR007146. Sas10/Utp3/C1D.
    [Graphical view]
    PANTHERiPTHR15341. PTHR15341. 1 hit.
    PfamiPF04000. Sas10_Utp3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38801-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDIEKIKPY VRSFSKALDE LKPEIEKLTS KSLDEQLLLL SDERAKLELI    50
    NRYAYVLSSL MFANMKVLGV KDMSPILGEL KRVKSYMDKA KQYDNRITKS 100
    NEKSQAEQEK AKNIISNVLD GNKNQFEPSI SRSNFQGKHT KFENDELAES 150
    TTTKIIDSTD HIRKASSKKS KRLDKVGKKK GGKK 184
    Length:184
    Mass (Da):21,045
    Last modified:February 1, 1995 - v1
    Checksum:i27D00668C296CC9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68886.1.
    BK006934 Genomic DNA. Translation: DAA06776.1.
    PIRiS46808.
    RefSeqiNP_011949.1. NM_001179211.1.

    Genome annotation databases

    EnsemblFungiiYHR081W; YHR081W; YHR081W.
    GeneIDi856481.
    KEGGisce:YHR081W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68886.1 .
    BK006934 Genomic DNA. Translation: DAA06776.1 .
    PIRi S46808.
    RefSeqi NP_011949.1. NM_001179211.1.

    3D structure databases

    ProteinModelPortali P38801.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36516. 261 interactions.
    DIPi DIP-4359N.
    IntActi P38801. 7 interactions.
    MINTi MINT-499454.
    STRINGi 4932.YHR081W.

    Proteomic databases

    MaxQBi P38801.
    PaxDbi P38801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR081W ; YHR081W ; YHR081W .
    GeneIDi 856481.
    KEGGi sce:YHR081W.

    Organism-specific databases

    CYGDi YHR081w.
    SGDi S000001123. LRP1.

    Phylogenomic databases

    eggNOGi NOG315595.
    HOGENOMi HOG000000879.
    KOi K12592.
    OMAi FENDELA.
    OrthoDBi EOG7RFTW7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31128-MONOMER.

    Miscellaneous databases

    NextBioi 982167.
    PROi P38801.

    Gene expression databases

    Genevestigatori P38801.

    Family and domain databases

    InterProi IPR011082. Exosome-assoc_fac/DNA_repair.
    IPR007146. Sas10/Utp3/C1D.
    [Graphical view ]
    PANTHERi PTHR15341. PTHR15341. 1 hit.
    Pfami PF04000. Sas10_Utp3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION.
    4. "Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination."
      Erdemir T., Bilican B., Cagatay T., Goding C.R., Yavuzer U.
      Mol. Microbiol. 46:947-957(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: FUNCTION, INTERACTION WITH RRP45 AND RRP46.
    6. "Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs."
      Mitchell P., Petfalski E., Houalla R., Podtelejnikov A., Mann M., Tollervey D.
      Mol. Cell. Biol. 23:6982-6992(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RRP4 AND RRP6, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Genome-wide mRNA surveillance is coupled to mRNA export."
      Hieronymus H., Yu M.C., Silver P.A.
      Genes Dev. 18:2652-2662(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION RRP6, SUBCELLULAR LOCATION.
    8. "A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length."
      Askree S.H., Yehuda T., Smolikov S., Gurevich R., Hawk J., Coker C., Krauskopf A., Kupiec M., McEachern M.J.
      Proc. Natl. Acad. Sci. U.S.A. 101:8658-8663(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLRP1_YEAST
    AccessioniPrimary (citable) accession number: P38801
    Secondary accession number(s): D3DL32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3