P38800 (YHO0_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein YHR080C

Gene names

Ordered Locus Names:

YHR080C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	1345 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the YSP2 family. Contains 1 GRAM domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 14576278PubMed 16823961. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1345	1345	Uncharacterized protein YHR080C		PRO_0000202901
Regions
	Transmembrane	1198 – 1218	21	Helical; Potential
	Domain	548 – 617	70	GRAM
	Compositional bias	679 – 711	33	Asp-rich
Amino acid modifications
	Modified residue	355	1	Phosphoserine Ref.4
	Modified residue	747	1	Phosphoserine Ref.3 Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P38800 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2FDAB94A686564C2	FASTA	1,345	149,680
	10 20 30 40 50 60 MTRDSKKKHH WGTAFLRTIG VKRKHKKDRN FLNNTTGENV STTASAERFR RVGGNPDIPS 70 80 90 100 110 120 LLKPETFTES PAKGSQKAAA SSLAHSQGVF NIPIVIDPME TNRLEKTNTN LTAGSLKGRF 130 140 150 160 170 180 QDGNSNSNSV PSLSVQALEK EKLQSGKREG SSNQAEEKTP DGHDEHTAFE TFLSFAHNAV 190 200 210 220 230 240 SHIPKINVQD ADNGTISRNE PKDRKKNSSN ISGALSENST NNKNTSSTKE SDGPFLKNLD 250 260 270 280 290 300 NILAASKSST PSNQQLNTTE AGSKSKPSSL SRLAFGNLKG HIHSNSHSSS NAISGDDTSL 310 320 330 340 350 360 DDTRKMTDDM ARKVVFEPIR HSHDKPTPGV GNLKLEHFDD SQATLEGLEA MSAESLPEAD 370 380 390 400 410 420 HLDSRGPVQQ SNLERKTVPS KWSVVSSSTT DGVKPRRRAK SMISAMADKQ NTSSDVLQDC 430 440 450 460 470 480 KKRLSFNSSN GLTNNDPEYE DREPREMSKK FLNRRSFSPG SISMGMKVLP STALKYSLNK 490 500 510 520 530 540 VKNSTDIAST IIPRPSMSNG RPSSGLRRSS SKSFSSTPVN IIEPSEENGR QSSIRIKGVE 550 560 570 580 590 600 YASEKKDAEF HAIFKDSGVS PNERLILDHS CALSRDILLQ GRMYISDQHI GFYSNILGWV 610 620 630 640 650 660 STVFIPFKTI VQIEKRATAG IFPNGIVIDT LHTKYTFASF TSRDATYDLI TEVWNQIILG 670 680 690 700 710 720 KRFRSNSNNT NSSSNSISDD ENDDYDDDYD DYGDDDDDLY DNSNNISDST DMTSSVSIGK 730 740 750 760 770 780 PEDLPMPLQT DTPYGTGIPP LGPKIHSPTE TVYKPAPNEK LVNESTIHAS LGRVVNILFG 790 800 810 820 830 840 KDVSYIMAIL KAQKNSDISP IPVLVDSPTV SEGKKRDYSY VKTTPGAIGP GKTKCMITET 850 860 870 880 890 900 IQHFNLEEYV QVLQTTKTPD VPSGNSFYVR TVYLLSWANN NETKLKLYVS VEWTGKSLIK 910 920 930 940 950 960 SPIEKGTFDG VTDATKILVE ELGNILTRSA TKRKRSSKEN TVTVSTLPKM EPSSHAPTEP 970 980 990 1000 1010 1020 DIQKDKDDSI IRENENIPAP LGTVVQLLFG SNTEYMQKVI TRDKNNVNVE TIPKFTPSLV 1030 1040 1050 1060 1070 1080 EGGSRHYEYT KKLNNSIGPK QTKCLLTESI EHMDINNYVL VTQTTKTPDV PSGSNFAVES 1090 1100 1110 1120 1130 1140 KIFLFWGQHD TTNMTVITKI NWTSKSFLKG AIEKGSVEGQ KVSVDYMLSE LRDIISRAKS 1150 1160 1170 1180 1190 1200 KKPVKKVMKS HDKHRPFHSK VEQKSSESRK SDDNKDILTH ILDFVQNNFS SEIFMNKLLS 1210 1220 1230 1240 1250 1260 PQKLFLILGL TIMLFWSPRL HVFQEKNNLQ IIKPGRLLID GQEYNYVPSF GTLYNSYENA 1270 1280 1290 1300 1310 1320 ISSKKKRENV NYARDKSPIV GRESDIWDWI SNRGSAISPR GRAMLRNDDE HKLQQLSESI 1330 1340 KITEMQLNHM KTMLDNIERD ANDLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747, MASS SPECTROMETRY. Strain: ADR376.
[4]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355 AND SER-747, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10556 Genomic DNA. Translation: AAB68895.1. BK006934 Genomic DNA. Translation: DAA06775.1.
PIR	S46817.
RefSeq	NP_011948.1. NM_001179210.1.
3D structure databases
ProteinModelPortal	P38800.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5282N.
IntAct	P38800. 1 interaction.
MINT	MINT-499642.
STRING	4932.YHR080C.
Proteomic databases
PaxDb	P38800.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR080C; YHR080C; YHR080C.
GeneID	856480.
KEGG	sce:YHR080C.
Organism-specific databases
CYGD	YHR080c.
SGD	S000001122. YHR080C.
Phylogenomic databases
eggNOG	NOG304071.
GeneTree	ENSGT00580000081380.
HOGENOM	HOG000001060.
OrthoDB	EOG42FWSS.
Gene expression databases
Genevestigator	P38800.
GermOnline	YHR080C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004182. GRAM. [Graphical view]
Pfam	PF02893. GRAM. 1 hit. [Graphical view]
SMART	SM00568. GRAM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982164.

Entry information

Entry name

YHO0_YEAST

Accession

Primary (citable) accession number: P38800
Secondary accession number(s): D3DL31

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program