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Protein

Protein phosphatase 2C homolog 7, mitochondrial

Gene

PTC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Manganese 1By similarity1
Metal bindingi109Manganese 2By similarity1
Metal bindingi110Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi265Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: SGD
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31123-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 7, mitochondrial (EC:3.1.3.16)
Short name:
PP2C-7
Gene namesi
Name:PTC7
Ordered Locus Names:YHR076W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR076W
SGDiS000001118 PTC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000005777940 – 343Protein phosphatase 2C homolog 7, mitochondrialAdd BLAST304

Proteomic databases

MaxQBiP38797
PaxDbiP38797
PRIDEiP38797

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC14P242804EBI-24588,EBI-16535

Protein-protein interaction databases

BioGridi36510, 122 interactors
DIPiDIP-6369N
IntActiP38797, 8 interactors
MINTiP38797
STRINGi4932.YHR076W

Structurei

3D structure databases

ProteinModelPortaliP38797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 342PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST267

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000011937
HOGENOMiHOG000248058
InParanoidiP38797
KOiK17508
OMAiSIYWTGR
OrthoDBiEOG092C43IW

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF07228 SpoIIE, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY
60 70 80 90 100
SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV
110 120 130 140 150
HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT
160 170 180 190 200
PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR
210 220 230 240 250
DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY
260 270 280 290 300
SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD
310 320 330 340
NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD
Length:343
Mass (Da):37,782
Last modified:June 26, 2007 - v2
Checksum:iFCCC729800371B24
GO

Sequence cautioni

The sequence AAB68888 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA Translation: AAB68888.1 Sequence problems.
EF123135 mRNA Translation: ABM97479.1
DQ881450 mRNA Translation: ABI95877.1
BK006934 Genomic DNA Translation: DAA06770.1
PIRiS46810
RefSeqiNP_011943.2, NM_001179206.1

Genome annotation databases

EnsemblFungiiYHR076W; YHR076W; YHR076W
GeneIDi856475
KEGGisce:YHR076W

Similar proteinsi

Entry informationi

Entry nameiPP2C7_YEAST
AccessioniPrimary (citable) accession number: P38797
Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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