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Protein

Protein phosphatase 2C homolog 7, mitochondrial

Gene

PTC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Manganese 1By similarity1
Metal bindingi109Manganese 2By similarity1
Metal bindingi110Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi265Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: SGD
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 7, mitochondrial (EC:3.1.3.16)
Short name:
PP2C-7
Gene namesi
Name:PTC7
Ordered Locus Names:YHR076W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR076W.
SGDiS000001118. PTC7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000005777940 – 343Protein phosphatase 2C homolog 7, mitochondrialAdd BLAST304

Proteomic databases

MaxQBiP38797.
PRIDEiP38797.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC14P242806EBI-24588,EBI-16535

Protein-protein interaction databases

BioGridi36510. 47 interactors.
DIPiDIP-6369N.
IntActiP38797. 9 interactors.
MINTiMINT-700436.
STRINGi4932.YHR076W.

Structurei

3D structure databases

ProteinModelPortaliP38797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 342PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST267

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000011937.
HOGENOMiHOG000248058.
InParanoidiP38797.
KOiK17508.
OMAiNLGDSWC.
OrthoDBiEOG092C43IW.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR001932. PPM-type_phosphatase_dom.
PfamiView protein in Pfam
PF07228. SpoIIE. 1 hit.
SMARTiView protein in SMART
SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY
60 70 80 90 100
SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV
110 120 130 140 150
HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT
160 170 180 190 200
PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR
210 220 230 240 250
DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY
260 270 280 290 300
SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD
310 320 330 340
NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD
Length:343
Mass (Da):37,782
Last modified:June 26, 2007 - v2
Checksum:iFCCC729800371B24
GO

Sequence cautioni

The sequence AAB68888 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
EF123135 mRNA. Translation: ABM97479.1.
DQ881450 mRNA. Translation: ABI95877.1.
BK006934 Genomic DNA. Translation: DAA06770.1.
PIRiS46810.
RefSeqiNP_011943.2. NM_001179206.1.

Genome annotation databases

EnsemblFungiiYHR076W; YHR076W; YHR076W.
GeneIDi856475.
KEGGisce:YHR076W.

Similar proteinsi

Entry informationi

Entry nameiPP2C7_YEAST
AccessioniPrimary (citable) accession number: P38797
Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: September 27, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names