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P38797

- PP2C7_YEAST

UniProt

P38797 - PP2C7_YEAST

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Protein
Protein phosphatase 2C homolog 7, mitochondrial
Gene
PTC7, YHR076W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Manganese 1 By similarity
Metal bindingi109 – 1091Manganese 2 By similarity
Metal bindingi110 – 1101Manganese 1; via carbonyl oxygen By similarity
Metal bindingi265 – 2651Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: SGD
  3. protein binding Source: IntAct
  4. protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  1. protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 7, mitochondrial (EC:3.1.3.16)
Short name:
PP2C-7
Gene namesi
Name:PTC7
Ordered Locus Names:YHR076W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR076w.
SGDiS000001118. PTC7.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: SGD
  2. nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion Reviewed prediction
Add
BLAST
Chaini40 – 343304Protein phosphatase 2C homolog 7, mitochondrial
PRO_0000057779Add
BLAST

Proteomic databases

MaxQBiP38797.
PaxDbiP38797.

Expressioni

Gene expression databases

GenevestigatoriP38797.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC14P242803EBI-24588,EBI-16535

Protein-protein interaction databases

BioGridi36510. 32 interactions.
DIPiDIP-6369N.
IntActiP38797. 4 interactions.
MINTiMINT-700436.

Structurei

3D structure databases

ProteinModelPortaliP38797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 342272PP2C-like
Add
BLAST

Sequence similaritiesi

Contains 1 PP2C-like domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000248058.
KOiK17508.
OMAiFGEDAWF.
OrthoDBiEOG7RZ624.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38797-1 [UniParc]FASTAAdd to Basket

« Hide

MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY    50
SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV 100
HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT 150
PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR 200
DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY 250
SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD 300
NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD 343
Length:343
Mass (Da):37,782
Last modified:June 26, 2007 - v2
Checksum:iFCCC729800371B24
GO

Sequence cautioni

The sequence AAB68888.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
EF123135 mRNA. Translation: ABM97479.1.
DQ881450 mRNA. Translation: ABI95877.1.
BK006934 Genomic DNA. Translation: DAA06770.1.
PIRiS46810.
RefSeqiNP_011943.2. NM_001179206.1.

Genome annotation databases

EnsemblFungiiYHR076W; YHR076W; YHR076W.
GeneIDi856475.
KEGGisce:YHR076W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10556 Genomic DNA. Translation: AAB68888.1 . Sequence problems.
EF123135 mRNA. Translation: ABM97479.1 .
DQ881450 mRNA. Translation: ABI95877.1 .
BK006934 Genomic DNA. Translation: DAA06770.1 .
PIRi S46810.
RefSeqi NP_011943.2. NM_001179206.1.

3D structure databases

ProteinModelPortali P38797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36510. 32 interactions.
DIPi DIP-6369N.
IntActi P38797. 4 interactions.
MINTi MINT-700436.

Proteomic databases

MaxQBi P38797.
PaxDbi P38797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR076W ; YHR076W ; YHR076W .
GeneIDi 856475.
KEGGi sce:YHR076W.

Organism-specific databases

CYGDi YHR076w.
SGDi S000001118. PTC7.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00390000011937.
HOGENOMi HOG000248058.
KOi K17508.
OMAi FGEDAWF.
OrthoDBi EOG7RZ624.

Enzyme and pathway databases

BioCyci YEAST:G3O-31123-MONOMER.

Miscellaneous databases

NextBioi 982149.
PROi P38797.

Gene expression databases

Genevestigatori P38797.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
[Graphical view ]
Pfami PF07228. SpoIIE. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
    Juneau K., Palm C., Miranda M., Davis R.W.
    Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125.
    Strain: ATCC 201390 / BY4743.
  4. "Genome-wide identification of spliced introns using a tiling microarray."
    Zhang Z., Hesselberth J.R., Fields S.
    Genome Res. 17:503-509(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-113.
    Strain: ATCC 201390 / BY4743.
  5. "Molecular analysis of the Saccharomyces cerevisiae YHR076w gene."
    Ramos C.W., Gueldener U., Klein S., Hegemann J.H., Gonzalez S., Rodriguez-Medina J.R.
    IUBMB Life 50:371-377(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast."
    Jiang L., Whiteway M., Ramos C.W., Rodriguez-Medina J.R., Shen S.-H.
    FEBS Lett. 527:323-325(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C7_YEAST
AccessioniPrimary (citable) accession number: P38797
Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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