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Protein

Protein phosphatase 2C homolog 7, mitochondrial

Gene

PTC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Manganese 1By similarity
Metal bindingi109 – 1091Manganese 2By similarity
Metal bindingi110 – 1101Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi265 – 2651Manganese 2By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: SGD
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 7, mitochondrial (EC:3.1.3.16)
Short name:
PP2C-7
Gene namesi
Name:PTC7
Ordered Locus Names:YHR076W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR076w.
EuPathDBiFungiDB:YHR076W.
SGDiS000001118. PTC7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
  • nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 343304Protein phosphatase 2C homolog 7, mitochondrialPRO_0000057779Add
BLAST

Proteomic databases

MaxQBiP38797.
PaxDbiP38797.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC14P242803EBI-24588,EBI-16535

Protein-protein interaction databases

BioGridi36510. 37 interactions.
DIPiDIP-6369N.
IntActiP38797. 4 interactions.
MINTiMINT-700436.
STRINGi4932.YHR076W.

Structurei

3D structure databases

ProteinModelPortaliP38797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 342267PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000248058.
InParanoidiP38797.
KOiK17508.
OMAiAHEMELN.
OrthoDBiEOG7RZ624.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY
60 70 80 90 100
SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV
110 120 130 140 150
HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT
160 170 180 190 200
PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR
210 220 230 240 250
DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY
260 270 280 290 300
SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD
310 320 330 340
NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD
Length:343
Mass (Da):37,782
Last modified:June 26, 2007 - v2
Checksum:iFCCC729800371B24
GO

Sequence cautioni

The sequence AAB68888.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
EF123135 mRNA. Translation: ABM97479.1.
DQ881450 mRNA. Translation: ABI95877.1.
BK006934 Genomic DNA. Translation: DAA06770.1.
PIRiS46810.
RefSeqiNP_011943.2. NM_001179206.1.

Genome annotation databases

EnsemblFungiiYHR076W; YHR076W; YHR076W.
GeneIDi856475.
KEGGisce:YHR076W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
EF123135 mRNA. Translation: ABM97479.1.
DQ881450 mRNA. Translation: ABI95877.1.
BK006934 Genomic DNA. Translation: DAA06770.1.
PIRiS46810.
RefSeqiNP_011943.2. NM_001179206.1.

3D structure databases

ProteinModelPortaliP38797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36510. 37 interactions.
DIPiDIP-6369N.
IntActiP38797. 4 interactions.
MINTiMINT-700436.
STRINGi4932.YHR076W.

Proteomic databases

MaxQBiP38797.
PaxDbiP38797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR076W; YHR076W; YHR076W.
GeneIDi856475.
KEGGisce:YHR076W.

Organism-specific databases

CYGDiYHR076w.
EuPathDBiFungiDB:YHR076W.
SGDiS000001118. PTC7.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000248058.
InParanoidiP38797.
KOiK17508.
OMAiAHEMELN.
OrthoDBiEOG7RZ624.

Enzyme and pathway databases

BioCyciYEAST:G3O-31123-MONOMER.

Miscellaneous databases

NextBioi982149.
PROiP38797.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
    Juneau K., Palm C., Miranda M., Davis R.W.
    Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125.
    Strain: ATCC 201390 / BY4743.
  4. "Genome-wide identification of spliced introns using a tiling microarray."
    Zhang Z., Hesselberth J.R., Fields S.
    Genome Res. 17:503-509(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-113.
    Strain: ATCC 201390 / BY4743.
  5. "Molecular analysis of the Saccharomyces cerevisiae YHR076w gene."
    Ramos C.W., Gueldener U., Klein S., Hegemann J.H., Gonzalez S., Rodriguez-Medina J.R.
    IUBMB Life 50:371-377(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast."
    Jiang L., Whiteway M., Ramos C.W., Rodriguez-Medina J.R., Shen S.-H.
    FEBS Lett. 527:323-325(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C7_YEAST
AccessioniPrimary (citable) accession number: P38797
Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: June 24, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.