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P38797 (PP2C7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C homolog 7, mitochondrial

Short name=PP2C-7
EC=3.1.3.16
Gene names
Name:PTC7
Ordered Locus Names:YHR076W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Mitochondrion Ref.5 Ref.7.

Sequence similarities

Contains 1 PP2C-like domain.

Sequence caution

The sequence AAB68888.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SEC14P242803EBI-24588,EBI-16535

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 343304Protein phosphatase 2C homolog 7, mitochondrial
PRO_0000057779

Regions

Domain71 – 342272PP2C-like

Sites

Metal binding1091Manganese 1 By similarity
Metal binding1091Manganese 2 By similarity
Metal binding1101Manganese 1; via carbonyl oxygen By similarity
Metal binding2651Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P38797 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: FCCC729800371B24

FASTA34337,782
        10         20         30         40         50         60 
MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY SSGSQSGPFT 

        70         80         90        100        110        120 
YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV HDIFAGVADG VGGWAEHGYD 

       130        140        150        160        170        180 
SSAISRELCK KMDEISTALA ENSSKETLLT PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF 

       190        200        210        220        230        240 
PSNGKLEVAN LGDSWCGVFR DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI 

       250        260        270        280        290        300 
LNTPRDADEY SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD 

       310        320        330        340 
NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
Juneau K., Palm C., Miranda M., Davis R.W.
Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125.
Strain: ATCC 201390 / BY4743.
[4]"Genome-wide identification of spliced introns using a tiling microarray."
Zhang Z., Hesselberth J.R., Fields S.
Genome Res. 17:503-509(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-113.
Strain: ATCC 201390 / BY4743.
[5]"Molecular analysis of the Saccharomyces cerevisiae YHR076w gene."
Ramos C.W., Gueldener U., Klein S., Hegemann J.H., Gonzalez S., Rodriguez-Medina J.R.
IUBMB Life 50:371-377(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast."
Jiang L., Whiteway M., Ramos C.W., Rodriguez-Medina J.R., Shen S.-H.
FEBS Lett. 527:323-325(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: ATCC 76625 / YPH499.
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
EF123135 mRNA. Translation: ABM97479.1.
DQ881450 mRNA. Translation: ABI95877.1.
BK006934 Genomic DNA. Translation: DAA06770.1.
PIRS46810.
RefSeqNP_011943.2. NM_001179206.1.

3D structure databases

ProteinModelPortalP38797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36510. 32 interactions.
DIPDIP-6369N.
IntActP38797. 4 interactions.
MINTMINT-700436.

Proteomic databases

MaxQBP38797.
PaxDbP38797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR076W; YHR076W; YHR076W.
GeneID856475.
KEGGsce:YHR076W.

Organism-specific databases

CYGDYHR076w.
SGDS000001118. PTC7.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00390000011937.
HOGENOMHOG000248058.
KOK17508.
OMAFGEDAWF.
OrthoDBEOG7RZ624.

Enzyme and pathway databases

BioCycYEAST:G3O-31123-MONOMER.

Gene expression databases

GenevestigatorP38797.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
[Graphical view]
PfamPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
ProtoNetSearch...

Other

NextBio982149.
PROP38797.

Entry information

Entry namePP2C7_YEAST
AccessionPrimary (citable) accession number: P38797
Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families