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P38797

- PP2C7_YEAST

UniProt

P38797 - PP2C7_YEAST

Protein

Protein phosphatase 2C homolog 7, mitochondrial

Gene

PTC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091Manganese 1By similarity
    Metal bindingi109 – 1091Manganese 2By similarity
    Metal bindingi110 – 1101Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi265 – 2651Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: SGD
    3. protein binding Source: IntAct
    4. protein serine/threonine phosphatase activity Source: SGD

    GO - Biological processi

    1. protein dephosphorylation Source: SGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31123-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 7, mitochondrial (EC:3.1.3.16)
    Short name:
    PP2C-7
    Gene namesi
    Name:PTC7
    Ordered Locus Names:YHR076W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR076w.
    SGDiS000001118. PTC7.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: SGD
    2. nuclear envelope Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 343304Protein phosphatase 2C homolog 7, mitochondrialPRO_0000057779Add
    BLAST

    Proteomic databases

    MaxQBiP38797.
    PaxDbiP38797.

    Expressioni

    Gene expression databases

    GenevestigatoriP38797.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SEC14P242803EBI-24588,EBI-16535

    Protein-protein interaction databases

    BioGridi36510. 32 interactions.
    DIPiDIP-6369N.
    IntActiP38797. 4 interactions.
    MINTiMINT-700436.

    Structurei

    3D structure databases

    ProteinModelPortaliP38797.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 342272PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00390000011937.
    HOGENOMiHOG000248058.
    KOiK17508.
    OMAiFGEDAWF.
    OrthoDBiEOG7RZ624.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF07228. SpoIIE. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38797-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY    50
    SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV 100
    HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT 150
    PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR 200
    DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY 250
    SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD 300
    NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD 343
    Length:343
    Mass (Da):37,782
    Last modified:June 26, 2007 - v2
    Checksum:iFCCC729800371B24
    GO

    Sequence cautioni

    The sequence AAB68888.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68888.1. Sequence problems.
    EF123135 mRNA. Translation: ABM97479.1.
    DQ881450 mRNA. Translation: ABI95877.1.
    BK006934 Genomic DNA. Translation: DAA06770.1.
    PIRiS46810.
    RefSeqiNP_011943.2. NM_001179206.1.

    Genome annotation databases

    EnsemblFungiiYHR076W; YHR076W; YHR076W.
    GeneIDi856475.
    KEGGisce:YHR076W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10556 Genomic DNA. Translation: AAB68888.1 . Sequence problems.
    EF123135 mRNA. Translation: ABM97479.1 .
    DQ881450 mRNA. Translation: ABI95877.1 .
    BK006934 Genomic DNA. Translation: DAA06770.1 .
    PIRi S46810.
    RefSeqi NP_011943.2. NM_001179206.1.

    3D structure databases

    ProteinModelPortali P38797.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36510. 32 interactions.
    DIPi DIP-6369N.
    IntActi P38797. 4 interactions.
    MINTi MINT-700436.

    Proteomic databases

    MaxQBi P38797.
    PaxDbi P38797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR076W ; YHR076W ; YHR076W .
    GeneIDi 856475.
    KEGGi sce:YHR076W.

    Organism-specific databases

    CYGDi YHR076w.
    SGDi S000001118. PTC7.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00390000011937.
    HOGENOMi HOG000248058.
    KOi K17508.
    OMAi FGEDAWF.
    OrthoDBi EOG7RZ624.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31123-MONOMER.

    Miscellaneous databases

    NextBioi 982149.
    PROi P38797.

    Gene expression databases

    Genevestigatori P38797.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF07228. SpoIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
      Juneau K., Palm C., Miranda M., Davis R.W.
      Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125.
      Strain: ATCC 201390 / BY4743.
    4. "Genome-wide identification of spliced introns using a tiling microarray."
      Zhang Z., Hesselberth J.R., Fields S.
      Genome Res. 17:503-509(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-113.
      Strain: ATCC 201390 / BY4743.
    5. "Molecular analysis of the Saccharomyces cerevisiae YHR076w gene."
      Ramos C.W., Gueldener U., Klein S., Hegemann J.H., Gonzalez S., Rodriguez-Medina J.R.
      IUBMB Life 50:371-377(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast."
      Jiang L., Whiteway M., Ramos C.W., Rodriguez-Medina J.R., Shen S.-H.
      FEBS Lett. 527:323-325(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPP2C7_YEAST
    AccessioniPrimary (citable) accession number: P38797
    Secondary accession number(s): A2TBN2, D3DL26, Q06HN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3