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P38789 (SSF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosome biogenesis protein SSF1
Gene names
Name:SSF1
Ordered Locus Names:YHR066W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for biogenesis of the 60S ribosomal subunit. Ref.4 Ref.5

Subunit structure

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Subcellular location

Nucleusnucleolus Ref.5.

Miscellaneous

Present with 8150 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 Brix domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Ribosome biogenesis protein SSF1
PRO_0000120259

Regions

Domain26 – 348323Brix

Amino acid modifications

Modified residue3011Phosphothreonine Ref.7 Ref.8

Sequences

Sequence LengthMass (Da)Tools
P38789 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 6F0344993BEF2217

FASTA45351,764
        10         20         30         40         50         60 
MAKRRQKKRT HAQLTPEQEQ GIPKSMVIRV GQTSLANHSL NQLVKDFRQI MQPHTAIKLK 

        70         80         90        100        110        120 
ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR TPQGPTVTFQ VLDYSLGRDI 

       130        140        150        160        170        180 
KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK RSGEDDQDVN VEKVIVSMFQ NIFPPLNPAR 

       190        200        210        220        230        240 
TSLNSIKRVF MINKDRETGE ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE 

       250        260        270        280        290        300 
DISSLILDHD LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ SLKSQRTPVE KKDNKEREKE 

       310        320        330        340        350        360 
TEEEDVEMEE PKPSENLQPT PRKKAIKLTE LGPRLTLKLV KIEEGICSGK VLHHEFVQKS 

       370        380        390        400        410        420 
SEEIKALEKR HAAKMRLKEQ RKKEQEENIA KKKAVKDAKK QRKLERRKAR AAEGGEGQGK 

       430        440        450 
DDAMSDDESS SSDSEHYGSV PEDLDSDLFS EVE 

« Hide

References

« Hide 'large scale' references
[1]"An essential gene pair in Saccharomyces cerevisiae with a potential role in mating."
Yu Y., Hirsch J.P.
DNA Cell Biol. 14:411-418(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Ssf1p prevents premature processing of an early pre-60S ribosomal particle."
Fatica A., Cronshaw A.D., Dlakic M., Tollervey D.
Mol. Cell 9:341-351(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18113 Genomic DNA. Translation: AAA79980.1.
U00061 Genomic DNA. Translation: AAB68379.1.
BK006934 Genomic DNA. Translation: DAA06759.1.
PIRS46700.
RefSeqNP_011933.1. NM_001179196.1.

3D structure databases

ProteinModelPortalP38789.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36498. 195 interactions.
DIPDIP-6501N.
IntActP38789. 47 interactions.
MINTMINT-612836.
STRING4932.YHR066W.

Proteomic databases

MaxQBP38789.
PeptideAtlasP38789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR066W; YHR066W; YHR066W.
GeneID856463.
KEGGsce:YHR066W.

Organism-specific databases

CYGDYHR066w.
SGDS000001108. SSF1.

Phylogenomic databases

GeneTreeENSGT00530000064158.
HOGENOMHOG000210038.
KOK14859.
OMAPGHKPKG.
OrthoDBEOG7HHX3R.

Enzyme and pathway databases

BioCycYEAST:G3O-31117-MONOMER.

Gene expression databases

GenevestigatorP38789.

Family and domain databases

InterProIPR007109. Brix.
[Graphical view]
PfamPF04427. Brix. 1 hit.
[Graphical view]
SMARTSM00879. Brix. 1 hit.
[Graphical view]
PROSITEPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982114.

Entry information

Entry nameSSF1_YEAST
AccessionPrimary (citable) accession number: P38789
Secondary accession number(s): D3DL15
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families