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P38789

- SSF1_YEAST

UniProt

P38789 - SSF1_YEAST

Protein

Ribosome biogenesis protein SSF1

Gene

SSF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for biogenesis of the 60S ribosomal subunit.2 Publications

    GO - Molecular functioni

    1. rRNA binding Source: SGD

    GO - Biological processi

    1. conjugation with cellular fusion Source: SGD
    2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. ribosomal large subunit assembly Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31117-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome biogenesis protein SSF1
    Gene namesi
    Name:SSF1
    Ordered Locus Names:YHR066W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR066w.
    SGDiS000001108. SSF1.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. preribosome, large subunit precursor Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Ribosome biogenesis protein SSF1PRO_0000120259Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei301 – 3011Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38789.
    PeptideAtlasiP38789.

    Expressioni

    Gene expression databases

    GenevestigatoriP38789.

    Interactioni

    Subunit structurei

    Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

    Protein-protein interaction databases

    BioGridi36498. 196 interactions.
    DIPiDIP-6501N.
    IntActiP38789. 47 interactions.
    MINTiMINT-612836.
    STRINGi4932.YHR066W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38789.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 348323BrixPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Brix domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000064158.
    HOGENOMiHOG000210038.
    KOiK14859.
    OMAiPGHKPKG.
    OrthoDBiEOG7HHX3R.

    Family and domain databases

    InterProiIPR007109. Brix.
    [Graphical view]
    PfamiPF04427. Brix. 1 hit.
    [Graphical view]
    SMARTiSM00879. Brix. 1 hit.
    [Graphical view]
    PROSITEiPS50833. BRIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38789-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRRQKKRT HAQLTPEQEQ GIPKSMVIRV GQTSLANHSL NQLVKDFRQI    50
    MQPHTAIKLK ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR 100
    TPQGPTVTFQ VLDYSLGRDI KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK 150
    RSGEDDQDVN VEKVIVSMFQ NIFPPLNPAR TSLNSIKRVF MINKDRETGE 200
    ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE DISSLILDHD 250
    LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ SLKSQRTPVE KKDNKEREKE 300
    TEEEDVEMEE PKPSENLQPT PRKKAIKLTE LGPRLTLKLV KIEEGICSGK 350
    VLHHEFVQKS SEEIKALEKR HAAKMRLKEQ RKKEQEENIA KKKAVKDAKK 400
    QRKLERRKAR AAEGGEGQGK DDAMSDDESS SSDSEHYGSV PEDLDSDLFS 450
    EVE 453
    Length:453
    Mass (Da):51,764
    Last modified:February 1, 1995 - v1
    Checksum:i6F0344993BEF2217
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18113 Genomic DNA. Translation: AAA79980.1.
    U00061 Genomic DNA. Translation: AAB68379.1.
    BK006934 Genomic DNA. Translation: DAA06759.1.
    PIRiS46700.
    RefSeqiNP_011933.1. NM_001179196.1.

    Genome annotation databases

    EnsemblFungiiYHR066W; YHR066W; YHR066W.
    GeneIDi856463.
    KEGGisce:YHR066W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18113 Genomic DNA. Translation: AAA79980.1 .
    U00061 Genomic DNA. Translation: AAB68379.1 .
    BK006934 Genomic DNA. Translation: DAA06759.1 .
    PIRi S46700.
    RefSeqi NP_011933.1. NM_001179196.1.

    3D structure databases

    ProteinModelPortali P38789.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36498. 196 interactions.
    DIPi DIP-6501N.
    IntActi P38789. 47 interactions.
    MINTi MINT-612836.
    STRINGi 4932.YHR066W.

    Proteomic databases

    MaxQBi P38789.
    PeptideAtlasi P38789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR066W ; YHR066W ; YHR066W .
    GeneIDi 856463.
    KEGGi sce:YHR066W.

    Organism-specific databases

    CYGDi YHR066w.
    SGDi S000001108. SSF1.

    Phylogenomic databases

    GeneTreei ENSGT00530000064158.
    HOGENOMi HOG000210038.
    KOi K14859.
    OMAi PGHKPKG.
    OrthoDBi EOG7HHX3R.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31117-MONOMER.

    Miscellaneous databases

    NextBioi 982114.

    Gene expression databases

    Genevestigatori P38789.

    Family and domain databases

    InterProi IPR007109. Brix.
    [Graphical view ]
    Pfami PF04427. Brix. 1 hit.
    [Graphical view ]
    SMARTi SM00879. Brix. 1 hit.
    [Graphical view ]
    PROSITEi PS50833. BRIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An essential gene pair in Saccharomyces cerevisiae with a potential role in mating."
      Yu Y., Hirsch J.P.
      DNA Cell Biol. 14:411-418(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Ssf1p prevents premature processing of an early pre-60S ribosomal particle."
      Fatica A., Cronshaw A.D., Dlakic M., Tollervey D.
      Mol. Cell 9:341-351(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
      Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
      FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSSF1_YEAST
    AccessioniPrimary (citable) accession number: P38789
    Secondary accession number(s): D3DL15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 8150 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3