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P38789

- SSF1_YEAST

UniProt

P38789 - SSF1_YEAST

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Protein

Ribosome biogenesis protein SSF1

Gene
SSF1, YHR066W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.2 Publications

GO - Molecular functioni

  1. rRNA binding Source: SGD

GO - Biological processi

  1. conjugation with cellular fusion Source: SGD
  2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein SSF1
Gene namesi
Name:SSF1
Ordered Locus Names:YHR066W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR066w.
SGDiS000001108. SSF1.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Ribosome biogenesis protein SSF1PRO_0000120259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei301 – 3011Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38789.
PeptideAtlasiP38789.

Expressioni

Gene expression databases

GenevestigatoriP38789.

Interactioni

Subunit structurei

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Protein-protein interaction databases

BioGridi36498. 195 interactions.
DIPiDIP-6501N.
IntActiP38789. 47 interactions.
MINTiMINT-612836.
STRINGi4932.YHR066W.

Structurei

3D structure databases

ProteinModelPortaliP38789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 348323BrixAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.

Phylogenomic databases

GeneTreeiENSGT00530000064158.
HOGENOMiHOG000210038.
KOiK14859.
OMAiPGHKPKG.
OrthoDBiEOG7HHX3R.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38789-1 [UniParc]FASTAAdd to Basket

« Hide

MAKRRQKKRT HAQLTPEQEQ GIPKSMVIRV GQTSLANHSL NQLVKDFRQI    50
MQPHTAIKLK ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR 100
TPQGPTVTFQ VLDYSLGRDI KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK 150
RSGEDDQDVN VEKVIVSMFQ NIFPPLNPAR TSLNSIKRVF MINKDRETGE 200
ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE DISSLILDHD 250
LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ SLKSQRTPVE KKDNKEREKE 300
TEEEDVEMEE PKPSENLQPT PRKKAIKLTE LGPRLTLKLV KIEEGICSGK 350
VLHHEFVQKS SEEIKALEKR HAAKMRLKEQ RKKEQEENIA KKKAVKDAKK 400
QRKLERRKAR AAEGGEGQGK DDAMSDDESS SSDSEHYGSV PEDLDSDLFS 450
EVE 453
Length:453
Mass (Da):51,764
Last modified:February 1, 1995 - v1
Checksum:i6F0344993BEF2217
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18113 Genomic DNA. Translation: AAA79980.1.
U00061 Genomic DNA. Translation: AAB68379.1.
BK006934 Genomic DNA. Translation: DAA06759.1.
PIRiS46700.
RefSeqiNP_011933.1. NM_001179196.1.

Genome annotation databases

EnsemblFungiiYHR066W; YHR066W; YHR066W.
GeneIDi856463.
KEGGisce:YHR066W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18113 Genomic DNA. Translation: AAA79980.1 .
U00061 Genomic DNA. Translation: AAB68379.1 .
BK006934 Genomic DNA. Translation: DAA06759.1 .
PIRi S46700.
RefSeqi NP_011933.1. NM_001179196.1.

3D structure databases

ProteinModelPortali P38789.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36498. 195 interactions.
DIPi DIP-6501N.
IntActi P38789. 47 interactions.
MINTi MINT-612836.
STRINGi 4932.YHR066W.

Proteomic databases

MaxQBi P38789.
PeptideAtlasi P38789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR066W ; YHR066W ; YHR066W .
GeneIDi 856463.
KEGGi sce:YHR066W.

Organism-specific databases

CYGDi YHR066w.
SGDi S000001108. SSF1.

Phylogenomic databases

GeneTreei ENSGT00530000064158.
HOGENOMi HOG000210038.
KOi K14859.
OMAi PGHKPKG.
OrthoDBi EOG7HHX3R.

Enzyme and pathway databases

BioCyci YEAST:G3O-31117-MONOMER.

Miscellaneous databases

NextBioi 982114.

Gene expression databases

Genevestigatori P38789.

Family and domain databases

InterProi IPR007109. Brix.
[Graphical view ]
Pfami PF04427. Brix. 1 hit.
[Graphical view ]
SMARTi SM00879. Brix. 1 hit.
[Graphical view ]
PROSITEi PS50833. BRIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An essential gene pair in Saccharomyces cerevisiae with a potential role in mating."
    Yu Y., Hirsch J.P.
    DNA Cell Biol. 14:411-418(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Ssf1p prevents premature processing of an early pre-60S ribosomal particle."
    Fatica A., Cronshaw A.D., Dlakic M., Tollervey D.
    Mol. Cell 9:341-351(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
    Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
    FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSF1_YEAST
AccessioniPrimary (citable) accession number: P38789
Secondary accession number(s): D3DL15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8150 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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