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Protein

Ribosome biogenesis protein SSF1

Gene

SSF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.2 Publications

GO - Molecular functioni

  • rRNA binding Source: SGD

GO - Biological processi

  • conjugation with cellular fusion Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein SSF1
Gene namesi
Name:SSF1
Ordered Locus Names:YHR066W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR066W.
SGDiS000001108. SSF1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202591 – 453Ribosome biogenesis protein SSF1Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38789.
PRIDEiP38789.

PTM databases

iPTMnetiP38789.

Interactioni

Subunit structurei

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Binary interactionsi

WithEntry#Exp.IntActNotes
EBP2P360494EBI-18160,EBI-6289
RRP15Q065114EBI-18160,EBI-34602

Protein-protein interaction databases

BioGridi36498. 199 interactors.
DIPiDIP-6501N.
IntActiP38789. 48 interactors.
MINTiMINT-612836.

Structurei

3D structure databases

ProteinModelPortaliP38789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 348BrixPROSITE-ProRule annotationAdd BLAST323

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000210038.
InParanoidiP38789.
KOiK14859.
OMAiEGNVLYH.
OrthoDBiEOG092C3Q2K.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRRQKKRT HAQLTPEQEQ GIPKSMVIRV GQTSLANHSL NQLVKDFRQI
60 70 80 90 100
MQPHTAIKLK ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR
110 120 130 140 150
TPQGPTVTFQ VLDYSLGRDI KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK
160 170 180 190 200
RSGEDDQDVN VEKVIVSMFQ NIFPPLNPAR TSLNSIKRVF MINKDRETGE
210 220 230 240 250
ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE DISSLILDHD
260 270 280 290 300
LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ SLKSQRTPVE KKDNKEREKE
310 320 330 340 350
TEEEDVEMEE PKPSENLQPT PRKKAIKLTE LGPRLTLKLV KIEEGICSGK
360 370 380 390 400
VLHHEFVQKS SEEIKALEKR HAAKMRLKEQ RKKEQEENIA KKKAVKDAKK
410 420 430 440 450
QRKLERRKAR AAEGGEGQGK DDAMSDDESS SSDSEHYGSV PEDLDSDLFS

EVE
Length:453
Mass (Da):51,764
Last modified:February 1, 1995 - v1
Checksum:i6F0344993BEF2217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18113 Genomic DNA. Translation: AAA79980.1.
U00061 Genomic DNA. Translation: AAB68379.1.
BK006934 Genomic DNA. Translation: DAA06759.1.
PIRiS46700.
RefSeqiNP_011933.1. NM_001179196.1.

Genome annotation databases

EnsemblFungiiYHR066W; YHR066W; YHR066W.
GeneIDi856463.
KEGGisce:YHR066W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18113 Genomic DNA. Translation: AAA79980.1.
U00061 Genomic DNA. Translation: AAB68379.1.
BK006934 Genomic DNA. Translation: DAA06759.1.
PIRiS46700.
RefSeqiNP_011933.1. NM_001179196.1.

3D structure databases

ProteinModelPortaliP38789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36498. 199 interactors.
DIPiDIP-6501N.
IntActiP38789. 48 interactors.
MINTiMINT-612836.

PTM databases

iPTMnetiP38789.

Proteomic databases

MaxQBiP38789.
PRIDEiP38789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR066W; YHR066W; YHR066W.
GeneIDi856463.
KEGGisce:YHR066W.

Organism-specific databases

EuPathDBiFungiDB:YHR066W.
SGDiS000001108. SSF1.

Phylogenomic databases

HOGENOMiHOG000210038.
InParanoidiP38789.
KOiK14859.
OMAiEGNVLYH.
OrthoDBiEOG092C3Q2K.

Enzyme and pathway databases

BioCyciYEAST:G3O-31117-MONOMER.

Miscellaneous databases

PROiP38789.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSF1_YEAST
AccessioniPrimary (citable) accession number: P38789
Secondary accession number(s): D3DL15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8150 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.