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Protein

2-dehydropantoate 2-reductase

Gene

PAN5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Miscellaneous

Present with 2600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (ECM31)
  2. 2-dehydropantoate 2-reductase (PAN5)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119NADP; via amide nitrogenBy similarity1
Binding sitei119SubstrateBy similarity1
Active sitei224Proton donorBy similarity1
Binding sitei228SubstrateBy similarity1
Binding sitei232SubstrateBy similarity1
Binding sitei316SubstrateBy similarity1
Binding sitei328NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADPBy similarity6

GO - Molecular functioni

  • 2-dehydropantoate 2-reductase activity Source: SGD

GO - Biological processi

  • pantothenate biosynthetic process Source: SGD
  • pantothenate biosynthetic process from valine Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-214
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:PAN5
Ordered Locus Names:YHR063C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR063C
SGDiS000001105 PAN5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573281 – 3792-dehydropantoate 2-reductaseAdd BLAST379

Proteomic databases

MaxQBiP38787
PaxDbiP38787
PRIDEiP38787

Interactioni

Protein-protein interaction databases

BioGridi36495, 46 interactors
DIPiDIP-5591N
IntActiP38787, 5 interactors
MINTiP38787
STRINGi4932.YHR063C

Structurei

3D structure databases

ProteinModelPortaliP38787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

HOGENOMiHOG000000875
InParanoidiP38787
KOiK00077
OMAiNGEIMEN
OrthoDBiEOG092C5SUP

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

P38787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN
60 70 80 90 100
GNNISIRKLY LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA
110 120 130 140 150
LAPYLPYINK NTNLILIQNG LGVLELLREE IFTDSKNRPH LFQGVISHGV
160 170 180 190 200
YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ KKSVVEDDAA NNSLVKLLTE
210 220 230 240 250
PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC VNGEMKASCG
260 270 280 290 300
PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS
310 320 330 340 350
EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC
360 370
KVNKTIGELA TMRLALNRSR SINGDWRKD
Length:379
Mass (Da):42,821
Last modified:February 1, 1995 - v1
Checksum:i22BCAB56B2AE1AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00061 Genomic DNA Translation: AAB68390.1
BK006934 Genomic DNA Translation: DAA06756.1
PIRiS46711
RefSeqiNP_011930.1, NM_001179193.1

Genome annotation databases

EnsemblFungiiYHR063C; YHR063C; YHR063C
GeneIDi856460
KEGGisce:YHR063C

Similar proteinsi

Entry informationi

Entry nameiPANE_YEAST
AccessioniPrimary (citable) accession number: P38787
Secondary accession number(s): D3DL12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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