Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38787

- PANE_YEAST

UniProt

P38787 - PANE_YEAST

Protein

2-dehydropantoate 2-reductase

Gene

PAN5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191NADP; via amide nitrogenBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Active sitei224 – 2241Proton donorBy similarity
    Binding sitei228 – 2281SubstrateBy similarity
    Binding sitei232 – 2321SubstrateBy similarity
    Binding sitei316 – 3161SubstrateBy similarity
    Binding sitei328 – 3281NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: SGD
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciYEAST:MONOMER3O-214.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:PAN5
    Ordered Locus Names:YHR063C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR063c.
    SGDiS000001105. PAN5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3793792-dehydropantoate 2-reductasePRO_0000157328Add
    BLAST

    Proteomic databases

    MaxQBiP38787.
    PaxDbiP38787.
    PeptideAtlasiP38787.

    Expressioni

    Gene expression databases

    GenevestigatoriP38787.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-12913,EBI-12913
    AUS1Q084091EBI-12913,EBI-35723
    PRP40P332031EBI-12913,EBI-701
    SSM4P403181EBI-12913,EBI-18208

    Protein-protein interaction databases

    BioGridi36495. 32 interactions.
    DIPiDIP-5591N.
    IntActiP38787. 5 interactions.
    MINTiMINT-502833.
    STRINGi4932.YHR063C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38787.
    SMRiP38787. Positions 86-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000000875.
    KOiK00077.
    OMAiYMIKHLV.
    OrthoDBiEOG7VQJPR.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38787-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN    50
    GNNISIRKLY LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA 100
    LAPYLPYINK NTNLILIQNG LGVLELLREE IFTDSKNRPH LFQGVISHGV 150
    YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ KKSVVEDDAA NNSLVKLLTE 200
    PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC VNGEMKASCG 250
    PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS 300
    EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC 350
    KVNKTIGELA TMRLALNRSR SINGDWRKD 379
    Length:379
    Mass (Da):42,821
    Last modified:February 1, 1995 - v1
    Checksum:i22BCAB56B2AE1AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00061 Genomic DNA. Translation: AAB68390.1.
    BK006934 Genomic DNA. Translation: DAA06756.1.
    PIRiS46711.
    RefSeqiNP_011930.1. NM_001179193.1.

    Genome annotation databases

    EnsemblFungiiYHR063C; YHR063C; YHR063C.
    GeneIDi856460.
    KEGGisce:YHR063C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00061 Genomic DNA. Translation: AAB68390.1 .
    BK006934 Genomic DNA. Translation: DAA06756.1 .
    PIRi S46711.
    RefSeqi NP_011930.1. NM_001179193.1.

    3D structure databases

    ProteinModelPortali P38787.
    SMRi P38787. Positions 86-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36495. 32 interactions.
    DIPi DIP-5591N.
    IntActi P38787. 5 interactions.
    MINTi MINT-502833.
    STRINGi 4932.YHR063C.

    Proteomic databases

    MaxQBi P38787.
    PaxDbi P38787.
    PeptideAtlasi P38787.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR063C ; YHR063C ; YHR063C .
    GeneIDi 856460.
    KEGGi sce:YHR063C.

    Organism-specific databases

    CYGDi YHR063c.
    SGDi S000001105. PAN5.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000000875.
    KOi K00077.
    OMAi YMIKHLV.
    OrthoDBi EOG7VQJPR.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci YEAST:MONOMER3O-214.

    Miscellaneous databases

    NextBioi 982105.

    Gene expression databases

    Genevestigatori P38787.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPANE_YEAST
    AccessioniPrimary (citable) accession number: P38787
    Secondary accession number(s): D3DL12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2600 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3