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Protein

2-dehydropantoate 2-reductase

Gene

PAN5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADP; via amide nitrogenBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Active sitei224 – 2241Proton donorBy similarity
Binding sitei228 – 2281SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Binding sitei316 – 3161SubstrateBy similarity
Binding sitei328 – 3281NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NADPBy similarity

GO - Molecular functioni

  • 2-dehydropantoate 2-reductase activity Source: SGD
  • NADP binding Source: InterPro

GO - Biological processi

  • pantothenate biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-214.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:PAN5
Ordered Locus Names:YHR063C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR063c.
EuPathDBiFungiDB:YHR063C.
SGDiS000001105. PAN5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3793792-dehydropantoate 2-reductasePRO_0000157328Add
BLAST

Proteomic databases

MaxQBiP38787.
PaxDbiP38787.
PeptideAtlasiP38787.

Expressioni

Gene expression databases

GenevestigatoriP38787.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-12913,EBI-12913
AUS1Q084091EBI-12913,EBI-35723
PRP40P332031EBI-12913,EBI-701
SSM4P403181EBI-12913,EBI-18208

Protein-protein interaction databases

BioGridi36495. 33 interactions.
DIPiDIP-5591N.
IntActiP38787. 5 interactions.
MINTiMINT-502833.
STRINGi4932.YHR063C.

Structurei

3D structure databases

ProteinModelPortaliP38787.
SMRiP38787. Positions 5-42, 86-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000000875.
InParanoidiP38787.
KOiK00077.
OMAiECLIVAV.
OrthoDBiEOG7VQJPR.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

P38787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN
60 70 80 90 100
GNNISIRKLY LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA
110 120 130 140 150
LAPYLPYINK NTNLILIQNG LGVLELLREE IFTDSKNRPH LFQGVISHGV
160 170 180 190 200
YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ KKSVVEDDAA NNSLVKLLTE
210 220 230 240 250
PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC VNGEMKASCG
260 270 280 290 300
PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS
310 320 330 340 350
EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC
360 370
KVNKTIGELA TMRLALNRSR SINGDWRKD
Length:379
Mass (Da):42,821
Last modified:February 1, 1995 - v1
Checksum:i22BCAB56B2AE1AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00061 Genomic DNA. Translation: AAB68390.1.
BK006934 Genomic DNA. Translation: DAA06756.1.
PIRiS46711.
RefSeqiNP_011930.1. NM_001179193.1.

Genome annotation databases

EnsemblFungiiYHR063C; YHR063C; YHR063C.
GeneIDi856460.
KEGGisce:YHR063C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00061 Genomic DNA. Translation: AAB68390.1.
BK006934 Genomic DNA. Translation: DAA06756.1.
PIRiS46711.
RefSeqiNP_011930.1. NM_001179193.1.

3D structure databases

ProteinModelPortaliP38787.
SMRiP38787. Positions 5-42, 86-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36495. 33 interactions.
DIPiDIP-5591N.
IntActiP38787. 5 interactions.
MINTiMINT-502833.
STRINGi4932.YHR063C.

Proteomic databases

MaxQBiP38787.
PaxDbiP38787.
PeptideAtlasiP38787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR063C; YHR063C; YHR063C.
GeneIDi856460.
KEGGisce:YHR063C.

Organism-specific databases

CYGDiYHR063c.
EuPathDBiFungiDB:YHR063C.
SGDiS000001105. PAN5.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000000875.
InParanoidiP38787.
KOiK00077.
OMAiECLIVAV.
OrthoDBiEOG7VQJPR.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.
BioCyciYEAST:MONOMER3O-214.

Miscellaneous databases

NextBioi982105.
PROiP38787.

Gene expression databases

GenevestigatoriP38787.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPANE_YEAST
AccessioniPrimary (citable) accession number: P38787
Secondary accession number(s): D3DL12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.