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Protein

Ribonuclease P/MRP protein subunit RPP1

Gene

RPP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.2 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: SGD

GO - Biological processi

  • intronic box C/D snoRNA processing Source: SGD
  • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay Source: SGD
  • rRNA processing Source: SGD
  • tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

rRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YHR062C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P/MRP protein subunit RPP1 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein RPP1
RNaseP/MRP 32.2 kDa subunit
Gene namesi
Name:RPP1
Ordered Locus Names:YHR062C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR062C.
SGDiS000001104. RPP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleolar ribonuclease P complex Source: SGD
  • nucleus Source: SGD
  • ribonuclease MRP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001400341 – 293Ribonuclease P/MRP protein subunit RPP1Add BLAST293

Proteomic databases

MaxQBiP38786.
PRIDEiP38786.
TopDownProteomicsiP38786.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POP1P418122EBI-15968,EBI-13621
POP4P383363EBI-15968,EBI-13646

Protein-protein interaction databases

BioGridi36494. 21 interactors.
DIPiDIP-5590N.
IntActiP38786. 7 interactors.
MINTiMINT-501586.

Structurei

3D structure databases

ProteinModelPortaliP38786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000883.
HOGENOMiHOG000157793.
InParanoidiP38786.
KOiK03539.
OMAiTHCCTAF.
OrthoDBiEOG092C4XYN.

Family and domain databases

InterProiIPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view]
PANTHERiPTHR13031. PTHR13031. 1 hit.
PfamiPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.

Sequencei

Sequence statusi: Complete.

P38786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVDLNVPWP QNSYADKVTS QAVNNLIKTL STLHMLGYTH IAINFTVNHS
60 70 80 90 100
EKFPNDVKLL NPIDIKRRFG ELMDRTGLKL YSRITLIIDD PSKGQSLSKI
110 120 130 140 150
SQAFDIVAAL PISEKGLTLS TTNLDIDLLT FQYGSRLPTF LKHKSICSCV
160 170 180 190 200
NRGVKLEIVY GYALRDVQAR RQFVSNVRSV IRSSRSRGIV IGSGAMSPLE
210 220 230 240 250
CRNILGVTSL IKNLGLPSDR CSKAMGDLAS LVLLNGRLRN KSHKQTIVTG
260 270 280 290
GGSGNGDDVV NDVQGIDDVQ TIKVVKRSMD AEQLGHASKR HKP
Length:293
Mass (Da):32,224
Last modified:February 1, 1995 - v1
Checksum:iE9C775D8C646B5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95757 Genomic DNA. Translation: AAB96559.1.
U00061 Genomic DNA. Translation: AAB68389.1.
BK006934 Genomic DNA. Translation: DAA06755.1.
PIRiS46710.
RefSeqiNP_011929.1. NM_001179192.1.

Genome annotation databases

EnsemblFungiiYHR062C; YHR062C; YHR062C.
GeneIDi856459.
KEGGisce:YHR062C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95757 Genomic DNA. Translation: AAB96559.1.
U00061 Genomic DNA. Translation: AAB68389.1.
BK006934 Genomic DNA. Translation: DAA06755.1.
PIRiS46710.
RefSeqiNP_011929.1. NM_001179192.1.

3D structure databases

ProteinModelPortaliP38786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36494. 21 interactors.
DIPiDIP-5590N.
IntActiP38786. 7 interactors.
MINTiMINT-501586.

Proteomic databases

MaxQBiP38786.
PRIDEiP38786.
TopDownProteomicsiP38786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR062C; YHR062C; YHR062C.
GeneIDi856459.
KEGGisce:YHR062C.

Organism-specific databases

EuPathDBiFungiDB:YHR062C.
SGDiS000001104. RPP1.

Phylogenomic databases

GeneTreeiENSGT00390000000883.
HOGENOMiHOG000157793.
InParanoidiP38786.
KOiK03539.
OMAiTHCCTAF.
OrthoDBiEOG092C4XYN.

Enzyme and pathway databases

BioCyciYEAST:YHR062C-MONOMER.

Miscellaneous databases

PROiP38786.

Family and domain databases

InterProiIPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view]
PANTHERiPTHR13031. PTHR13031. 1 hit.
PfamiPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPP1_YEAST
AccessioniPrimary (citable) accession number: P38786
Secondary accession number(s): D3DL11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.