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P38786 (RPP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P/MRP protein subunit RPP1

EC=3.1.26.5
Alternative name(s):
RNA-processing protein RPP1
RNaseP/MRP 32.2 kDa subunit
Gene names
Name:RPP1
Ordered Locus Names:YHR062C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences. Ref.1 Ref.5

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. Ref.1 Ref.5 Ref.8

Subcellular location

Nucleus Ref.6.

Miscellaneous

Present with 6300 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Ribonuclease P/MRP protein subunit RPP1
PRO_0000140034

Sequences

Sequence LengthMass (Da)Tools
P38786 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: E9C775D8C646B5C7

FASTA29332,224
        10         20         30         40         50         60 
MLVDLNVPWP QNSYADKVTS QAVNNLIKTL STLHMLGYTH IAINFTVNHS EKFPNDVKLL 

        70         80         90        100        110        120 
NPIDIKRRFG ELMDRTGLKL YSRITLIIDD PSKGQSLSKI SQAFDIVAAL PISEKGLTLS 

       130        140        150        160        170        180 
TTNLDIDLLT FQYGSRLPTF LKHKSICSCV NRGVKLEIVY GYALRDVQAR RQFVSNVRSV 

       190        200        210        220        230        240 
IRSSRSRGIV IGSGAMSPLE CRNILGVTSL IKNLGLPSDR CSKAMGDLAS LVLLNGRLRN 

       250        260        270        280        290 
KSHKQTIVTG GGSGNGDDVV NDVQGIDDVQ TIKVVKRSMD AEQLGHASKR HKP 

« Hide

References

« Hide 'large scale' references
[1]"Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae."
Stolc V., Altman S.
Genes Dev. 11:2414-2425(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
[2]Erratum
Stolc V., Altman S.
Genes Dev. 11:2926-2937(1997) [PubMed] [Europe PMC] [Abstract]
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95757 Genomic DNA. Translation: AAB96559.1.
U00061 Genomic DNA. Translation: AAB68389.1.
BK006934 Genomic DNA. Translation: DAA06755.1.
PIRS46710.
RefSeqNP_011929.1. NM_001179192.1.

3D structure databases

ProteinModelPortalP38786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36494. 20 interactions.
DIPDIP-5590N.
IntActP38786. 6 interactions.
MINTMINT-501586.
STRING4932.YHR062C.

Proteomic databases

PaxDbP38786.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR062C; YHR062C; YHR062C.
GeneID856459.
KEGGsce:YHR062C.

Organism-specific databases

CYGDYHR062c.
SGDS000001104. RPP1.

Phylogenomic databases

eggNOGCOG1603.
GeneTreeENSGT00390000000883.
HOGENOMHOG000157793.
KOK03539.
OMARLYDIIA.
OrthoDBEOG7X3R34.

Enzyme and pathway databases

BioCycYEAST:YHR062C-MONOMER.

Gene expression databases

GenevestigatorP38786.

Family and domain databases

InterProIPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view]
PANTHERPTHR13031. PTHR13031. 1 hit.
PfamPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMSSF89550. SSF89550. 1 hit.
ProtoNetSearch...

Other

NextBio982102.
PROP38786.

Entry information

Entry nameRPP1_YEAST
AccessionPrimary (citable) accession number: P38786
Secondary accession number(s): D3DL11
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families