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P38786

- RPP1_YEAST

UniProt

P38786 - RPP1_YEAST

Protein

Ribonuclease P/MRP protein subunit RPP1

Gene

RPP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.2 Publications

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. RNA binding Source: SGD

    GO - Biological processi

    1. intronic box C/D snoRNA processing Source: SGD
    2. mRNA cleavage Source: SGD
    3. RNA phosphodiester bond hydrolysis Source: GOC
    4. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    5. rRNA processing Source: SGD
    6. tRNA processing Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    rRNA processing, tRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:YHR062C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P/MRP protein subunit RPP1 (EC:3.1.26.5)
    Alternative name(s):
    RNA-processing protein RPP1
    RNaseP/MRP 32.2 kDa subunit
    Gene namesi
    Name:RPP1
    Ordered Locus Names:YHR062C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR062c.
    SGDiS000001104. RPP1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleolar ribonuclease P complex Source: SGD
    3. nucleus Source: SGD
    4. ribonuclease MRP complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Ribonuclease P/MRP protein subunit RPP1PRO_0000140034Add
    BLAST

    Proteomic databases

    MaxQBiP38786.
    PaxDbiP38786.

    Expressioni

    Gene expression databases

    GenevestigatoriP38786.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.3 Publications

    Protein-protein interaction databases

    BioGridi36494. 20 interactions.
    DIPiDIP-5590N.
    IntActiP38786. 6 interactions.
    MINTiMINT-501586.
    STRINGi4932.YHR062C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1603.
    GeneTreeiENSGT00390000000883.
    HOGENOMiHOG000157793.
    KOiK03539.
    OMAiRLYDIIA.
    OrthoDBiEOG7X3R34.

    Family and domain databases

    InterProiIPR016195. Pol/histidinol_Pase-like.
    IPR002738. RNase_P_p30.
    [Graphical view]
    PANTHERiPTHR13031. PTHR13031. 1 hit.
    PfamiPF01876. RNase_P_p30. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38786-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVDLNVPWP QNSYADKVTS QAVNNLIKTL STLHMLGYTH IAINFTVNHS    50
    EKFPNDVKLL NPIDIKRRFG ELMDRTGLKL YSRITLIIDD PSKGQSLSKI 100
    SQAFDIVAAL PISEKGLTLS TTNLDIDLLT FQYGSRLPTF LKHKSICSCV 150
    NRGVKLEIVY GYALRDVQAR RQFVSNVRSV IRSSRSRGIV IGSGAMSPLE 200
    CRNILGVTSL IKNLGLPSDR CSKAMGDLAS LVLLNGRLRN KSHKQTIVTG 250
    GGSGNGDDVV NDVQGIDDVQ TIKVVKRSMD AEQLGHASKR HKP 293
    Length:293
    Mass (Da):32,224
    Last modified:February 1, 1995 - v1
    Checksum:iE9C775D8C646B5C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95757 Genomic DNA. Translation: AAB96559.1.
    U00061 Genomic DNA. Translation: AAB68389.1.
    BK006934 Genomic DNA. Translation: DAA06755.1.
    PIRiS46710.
    RefSeqiNP_011929.1. NM_001179192.1.

    Genome annotation databases

    EnsemblFungiiYHR062C; YHR062C; YHR062C.
    GeneIDi856459.
    KEGGisce:YHR062C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95757 Genomic DNA. Translation: AAB96559.1 .
    U00061 Genomic DNA. Translation: AAB68389.1 .
    BK006934 Genomic DNA. Translation: DAA06755.1 .
    PIRi S46710.
    RefSeqi NP_011929.1. NM_001179192.1.

    3D structure databases

    ProteinModelPortali P38786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36494. 20 interactions.
    DIPi DIP-5590N.
    IntActi P38786. 6 interactions.
    MINTi MINT-501586.
    STRINGi 4932.YHR062C.

    Proteomic databases

    MaxQBi P38786.
    PaxDbi P38786.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR062C ; YHR062C ; YHR062C .
    GeneIDi 856459.
    KEGGi sce:YHR062C.

    Organism-specific databases

    CYGDi YHR062c.
    SGDi S000001104. RPP1.

    Phylogenomic databases

    eggNOGi COG1603.
    GeneTreei ENSGT00390000000883.
    HOGENOMi HOG000157793.
    KOi K03539.
    OMAi RLYDIIA.
    OrthoDBi EOG7X3R34.

    Enzyme and pathway databases

    BioCyci YEAST:YHR062C-MONOMER.

    Miscellaneous databases

    NextBioi 982102.
    PROi P38786.

    Gene expression databases

    Genevestigatori P38786.

    Family and domain databases

    InterProi IPR016195. Pol/histidinol_Pase-like.
    IPR002738. RNase_P_p30.
    [Graphical view ]
    PANTHERi PTHR13031. PTHR13031. 1 hit.
    Pfami PF01876. RNase_P_p30. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae."
      Stolc V., Altman S.
      Genes Dev. 11:2414-2425(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
      Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
      Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
      Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
      J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiRPP1_YEAST
    AccessioniPrimary (citable) accession number: P38786
    Secondary accession number(s): D3DL11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3