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P38785

- GIC1_YEAST

UniProt

P38785 - GIC1_YEAST

Protein

GTPase-interacting component 1

Gene

GIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. Rho GTPase activator activity Source: SGD
    3. Rho GTPase binding Source: SGD

    GO - Biological processi

    1. axial cellular bud site selection Source: SGD
    2. establishment of cell polarity Source: SGD
    3. positive regulation of Rho GTPase activity Source: GOC
    4. regulation of cell shape Source: UniProtKB-KW
    5. regulation of exit from mitosis Source: SGD
    6. Rho protein signal transduction Source: SGD

    Keywords - Biological processi

    Cell shape

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31114-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase-interacting component 1
    Gene namesi
    Name:GIC1
    Ordered Locus Names:YHR061C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR061c.
    SGDiS000001103. GIC1.

    Subcellular locationi

    Bud neck. Bud tip. Cytoplasmcell cortex. Cytoplasmcytoskeleton
    Note: Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud sites in the two progeny cells.

    GO - Cellular componenti

    1. actin cap Source: SGD
    2. cellular bud neck Source: SGD
    3. cellular bud tip Source: SGD
    4. incipient cellular bud site Source: SGD
    5. mating projection tip Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314GTPase-interacting component 1PRO_0000212659Add
    BLAST

    Proteomic databases

    PaxDbiP38785.

    Expressioni

    Gene expression databases

    GenevestigatoriP38785.

    Interactioni

    Subunit structurei

    Interacts with GTP-bound CDC42.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BFA1P471132EBI-7575,EBI-3586
    BUB2P264485EBI-7575,EBI-3824
    CDC11P324582EBI-7575,EBI-4178
    CDC12P324685EBI-7575,EBI-4182
    CDC14Q006842EBI-7575,EBI-4192
    CDC3P324572EBI-7575,EBI-4429

    Protein-protein interaction databases

    BioGridi36493. 60 interactions.
    DIPiDIP-1217N.
    IntActiP38785. 28 interactions.
    MINTiMINT-395115.
    STRINGi4932.YHR061C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38785.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 13914CRIBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BORG/CEP family.Curated
    Contains 1 CRIB domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG42654.
    GeneTreeiENSGT00530000066862.
    HOGENOMiHOG000000874.
    OMAiHHISHAN.
    OrthoDBiEOG7Q2NGK.

    Family and domain databases

    InterProiIPR000095. CRIB_dom.
    [Graphical view]
    PROSITEiPS50108. CRIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38785-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEGKRLQQM ELPQMKSIWI DEDQEMEKLY GFQVRQRFMN GPSTDSDEDA    50
    DEDLGIVLVD SKKLALPNKN NIKLPPLPNY MTINPNINSN HKSLTNKKKN 100
    FLGMFKKKDL LSRRHGSAKT AKQSSISTPF DFHHISHANG KREDNPLESH 150
    EEKHDVESLV KFTSLAPQPR PDSNVSSKYS NVVMNDSSRI VSSSTIATTM 200
    DSHHDGNETN NTPNGNKQLD SPTDLEMTLE DLRNYTFPSV LGDSVSEKTN 250
    PSSPSVSSFS GKFKPRELSA LHTPELGNCF NVDQSLNSPG NRISVDDVLK 300
    FYYQCSETST PRNT 314
    Length:314
    Mass (Da):35,238
    Last modified:February 1, 1995 - v1
    Checksum:iC6B2FE253799500B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00061 Genomic DNA. Translation: AAB68388.1.
    BK006934 Genomic DNA. Translation: DAA06754.1.
    PIRiS46709.
    RefSeqiNP_011928.1. NM_001179191.1.

    Genome annotation databases

    EnsemblFungiiYHR061C; YHR061C; YHR061C.
    GeneIDi856458.
    KEGGisce:YHR061C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00061 Genomic DNA. Translation: AAB68388.1 .
    BK006934 Genomic DNA. Translation: DAA06754.1 .
    PIRi S46709.
    RefSeqi NP_011928.1. NM_001179191.1.

    3D structure databases

    ProteinModelPortali P38785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36493. 60 interactions.
    DIPi DIP-1217N.
    IntActi P38785. 28 interactions.
    MINTi MINT-395115.
    STRINGi 4932.YHR061C.

    Proteomic databases

    PaxDbi P38785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR061C ; YHR061C ; YHR061C .
    GeneIDi 856458.
    KEGGi sce:YHR061C.

    Organism-specific databases

    CYGDi YHR061c.
    SGDi S000001103. GIC1.

    Phylogenomic databases

    eggNOGi NOG42654.
    GeneTreei ENSGT00530000066862.
    HOGENOMi HOG000000874.
    OMAi HHISHAN.
    OrthoDBi EOG7Q2NGK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31114-MONOMER.

    Miscellaneous databases

    NextBioi 982099.

    Gene expression databases

    Genevestigatori P38785.

    Family and domain databases

    InterProi IPR000095. CRIB_dom.
    [Graphical view ]
    PROSITEi PS50108. CRIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae."
      Chen G.C., Kim Y.J., Chan C.S.
      Genes Dev. 11:2958-2971(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast."
      Brown J.L., Jaquenoud M., Gulli M.P., Chant J., Peter M.
      Genes Dev. 11:2972-2982(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIC1_YEAST
    AccessioniPrimary (citable) accession number: P38785
    Secondary accession number(s): D3DL10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1100 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3