GTPase-interacting component 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38785 (GIC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GTPase-interacting component 1

Gene names

Name:	GIC1
Ordered Locus Names:	YHR061C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
Subunit structure	Interacts with GTP-bound CDC42.
Subcellular location	Bud neck. Bud tip. Cytoplasm › cell cortex. Cytoplasm › cytoskeleton. Note: Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud sites in the two progeny cells.
Miscellaneous	Present with 1100 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the BORG/CEP family. Contains 1 CRIB domain.

Ontologies

Keywords
Biological process	Cell shape
Cellular component	Cytoplasm Cytoskeleton
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Traceable author statement PubMed 10652251. Source: SGD axial cellular bud site selection Traceable author statement PubMed 10652251. Source: SGD regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW regulation of exit from mitosis Inferred from mutant phenotype PubMed 14734533. Source: SGD
Cellular_component	actin cap Traceable author statement PubMed 10652251. Source: SGD cellular bud neck Inferred from direct assay Ref.3. Source: SGD cellular bud tip Inferred from direct assay PubMed 22842922 Ref.3. Source: SGD incipient cellular bud site Inferred from direct assay Ref.3. Source: SGD mating projection tip Inferred from direct assay Ref.4. Source: SGD nucleus Inferred from direct assay PubMed 22842922. Source: SGD
Molecular_function	Rho GTPase activator activity Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
BFA1	P47113	2	EBI-7575,EBI-3586
BUB2	P26448	5	EBI-7575,EBI-3824
CDC11	P32458	2	EBI-7575,EBI-4178
CDC12	P32468	5	EBI-7575,EBI-4182
CDC14	Q00684	2	EBI-7575,EBI-4192
CDC3	P32457	2	EBI-7575,EBI-4429

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 314

314

GTPase-interacting component 1

PRO_0000212659

Regions

Domain

126 – 139

CRIB

Sequences

Sequence

Length

Mass (Da)

Tools

P38785 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C6B2FE253799500B
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FASTA

314

35,238

        10         20         30         40         50         60 
MTEGKRLQQM ELPQMKSIWI DEDQEMEKLY GFQVRQRFMN GPSTDSDEDA DEDLGIVLVD 

        70         80         90        100        110        120 
SKKLALPNKN NIKLPPLPNY MTINPNINSN HKSLTNKKKN FLGMFKKKDL LSRRHGSAKT 

       130        140        150        160        170        180 
AKQSSISTPF DFHHISHANG KREDNPLESH EEKHDVESLV KFTSLAPQPR PDSNVSSKYS 

       190        200        210        220        230        240 
NVVMNDSSRI VSSSTIATTM DSHHDGNETN NTPNGNKQLD SPTDLEMTLE DLRNYTFPSV 

       250        260        270        280        290        300 
LGDSVSEKTN PSSPSVSSFS GKFKPRELSA LHTPELGNCF NVDQSLNSPG NRISVDDVLK 

       310 
FYYQCSETST PRNT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae." Chen G.C., Kim Y.J., Chan C.S. Genes Dev. 11:2958-2971(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[4]	"Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast." Brown J.L., Jaquenoud M., Gulli M.P., Chant J., Peter M. Genes Dev. 11:2972-2982(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00061 Genomic DNA. Translation: AAB68388.1. BK006934 Genomic DNA. Translation: DAA06754.1.
PIR	S46709.
RefSeq	NP_011928.1. NM_001179191.1.
3D structure databases
ProteinModelPortal	P38785.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1217N.
IntAct	P38785. 28 interactions.
MINT	MINT-395115.
STRING	4932.YHR061C.
Proteomic databases
PaxDb	P38785.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR061C; YHR061C; YHR061C.
GeneID	856458.
KEGG	sce:YHR061C.
Organism-specific databases
CYGD	YHR061c.
SGD	S000001103. GIC1.
Phylogenomic databases
eggNOG	NOG42654.
GeneTree	ENSGT00530000066862.
HOGENOM	HOG000000874.
OMA	HISHANG.
OrthoDB	EOG40S3R8.
Gene expression databases
Genevestigator	P38785.
GermOnline	YHR061C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000095. PAK_box_Rho-bd. [Graphical view]
PROSITE	PS50108. CRIB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982099.

Entry information

Entry name

GIC1_YEAST

Accession

Primary (citable) accession number: P38785
Secondary accession number(s): D3DL10

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents