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P38785 (GIC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase-interacting component 1
Gene names
Name:GIC1
Ordered Locus Names:YHR061C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

Subunit structure

Interacts with GTP-bound CDC42.

Subcellular location

Bud neck. Bud tip. Cytoplasmcell cortex. Cytoplasmcytoskeleton. Note: Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud sites in the two progeny cells.

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the BORG/CEP family.

Contains 1 CRIB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314GTPase-interacting component 1
PRO_0000212659

Regions

Domain126 – 13914CRIB

Sequences

Sequence LengthMass (Da)Tools
P38785 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C6B2FE253799500B

FASTA31435,238
        10         20         30         40         50         60 
MTEGKRLQQM ELPQMKSIWI DEDQEMEKLY GFQVRQRFMN GPSTDSDEDA DEDLGIVLVD 

        70         80         90        100        110        120 
SKKLALPNKN NIKLPPLPNY MTINPNINSN HKSLTNKKKN FLGMFKKKDL LSRRHGSAKT 

       130        140        150        160        170        180 
AKQSSISTPF DFHHISHANG KREDNPLESH EEKHDVESLV KFTSLAPQPR PDSNVSSKYS 

       190        200        210        220        230        240 
NVVMNDSSRI VSSSTIATTM DSHHDGNETN NTPNGNKQLD SPTDLEMTLE DLRNYTFPSV 

       250        260        270        280        290        300 
LGDSVSEKTN PSSPSVSSFS GKFKPRELSA LHTPELGNCF NVDQSLNSPG NRISVDDVLK 

       310 
FYYQCSETST PRNT 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae."
Chen G.C., Kim Y.J., Chan C.S.
Genes Dev. 11:2958-2971(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast."
Brown J.L., Jaquenoud M., Gulli M.P., Chant J., Peter M.
Genes Dev. 11:2972-2982(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00061 Genomic DNA. Translation: AAB68388.1.
BK006934 Genomic DNA. Translation: DAA06754.1.
PIRS46709.
RefSeqNP_011928.1. NM_001179191.1.

3D structure databases

ProteinModelPortalP38785.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36493. 60 interactions.
DIPDIP-1217N.
IntActP38785. 28 interactions.
MINTMINT-395115.
STRING4932.YHR061C.

Proteomic databases

PaxDbP38785.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR061C; YHR061C; YHR061C.
GeneID856458.
KEGGsce:YHR061C.

Organism-specific databases

CYGDYHR061c.
SGDS000001103. GIC1.

Phylogenomic databases

eggNOGNOG42654.
GeneTreeENSGT00530000066862.
HOGENOMHOG000000874.
OMAHHISHAN.
OrthoDBEOG7Q2NGK.

Enzyme and pathway databases

BioCycYEAST:G3O-31114-MONOMER.

Gene expression databases

GenevestigatorP38785.

Family and domain databases

InterProIPR000095. CRIB_dom.
[Graphical view]
PROSITEPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982099.

Entry information

Entry nameGIC1_YEAST
AccessionPrimary (citable) accession number: P38785
Secondary accession number(s): D3DL10
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families