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Protein

GTPase-interacting component 1

Gene

GIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD
  • Rho GTPase binding Source: SGD

GO - Biological processi

  • establishment of cell polarity Source: SGD
  • heterochromatin organization involved in chromatin silencing Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of exit from mitosis Source: SGD
  • septin ring organization Source: SGD

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciYEAST:G3O-31114-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-interacting component 1
Gene namesi
Name:GIC1
Ordered Locus Names:YHR061C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR061C
SGDiS000001103 GIC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126591 – 314GTPase-interacting component 1Add BLAST314

Proteomic databases

PaxDbiP38785
PRIDEiP38785

Interactioni

Subunit structurei

Interacts with GTP-bound CDC42.

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rho GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi36493, 114 interactors
DIPiDIP-1217N
IntActiP38785, 28 interactors
MINTiP38785
STRINGi4932.YHR061C

Structurei

3D structure databases

ProteinModelPortaliP38785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 139CRIBPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000066862
HOGENOMiHOG000000874
InParanoidiP38785
OMAiHHISHAN
OrthoDBiEOG092C3HOD

Family and domain databases

CDDicd00132 CRIB, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

P38785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEGKRLQQM ELPQMKSIWI DEDQEMEKLY GFQVRQRFMN GPSTDSDEDA
60 70 80 90 100
DEDLGIVLVD SKKLALPNKN NIKLPPLPNY MTINPNINSN HKSLTNKKKN
110 120 130 140 150
FLGMFKKKDL LSRRHGSAKT AKQSSISTPF DFHHISHANG KREDNPLESH
160 170 180 190 200
EEKHDVESLV KFTSLAPQPR PDSNVSSKYS NVVMNDSSRI VSSSTIATTM
210 220 230 240 250
DSHHDGNETN NTPNGNKQLD SPTDLEMTLE DLRNYTFPSV LGDSVSEKTN
260 270 280 290 300
PSSPSVSSFS GKFKPRELSA LHTPELGNCF NVDQSLNSPG NRISVDDVLK
310
FYYQCSETST PRNT
Length:314
Mass (Da):35,238
Last modified:February 1, 1995 - v1
Checksum:iC6B2FE253799500B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00061 Genomic DNA Translation: AAB68388.1
BK006934 Genomic DNA Translation: DAA06754.1
PIRiS46709
RefSeqiNP_011928.1, NM_001179191.1

Genome annotation databases

EnsemblFungiiYHR061C; YHR061C; YHR061C
GeneIDi856458
KEGGisce:YHR061C

Similar proteinsi

Entry informationi

Entry nameiGIC1_YEAST
AccessioniPrimary (citable) accession number: P38785
Secondary accession number(s): D3DL10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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