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P38785

- GIC1_YEAST

UniProt

P38785 - GIC1_YEAST

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Protein

GTPase-interacting component 1

Gene
GIC1, YHR061C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. Rho GTPase activator activity Source: SGD
  3. Rho GTPase binding Source: SGD

GO - Biological processi

  1. axial cellular bud site selection Source: SGD
  2. establishment of cell polarity Source: SGD
  3. positive regulation of Rho GTPase activity Source: GOC
  4. regulation of cell shape Source: UniProtKB-KW
  5. regulation of exit from mitosis Source: SGD
  6. Rho protein signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

BioCyciYEAST:G3O-31114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-interacting component 1
Gene namesi
Name:GIC1
Ordered Locus Names:YHR061C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR061c.
SGDiS000001103. GIC1.

Subcellular locationi

Bud neck. Bud tip. Cytoplasmcell cortex. Cytoplasmcytoskeleton
Note: Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud sites in the two progeny cells.

GO - Cellular componenti

  1. actin cap Source: SGD
  2. cellular bud neck Source: SGD
  3. cellular bud tip Source: SGD
  4. incipient cellular bud site Source: SGD
  5. mating projection tip Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314GTPase-interacting component 1PRO_0000212659Add
BLAST

Proteomic databases

PaxDbiP38785.

Expressioni

Gene expression databases

GenevestigatoriP38785.

Interactioni

Subunit structurei

Interacts with GTP-bound CDC42.

Binary interactionsi

WithEntry#Exp.IntActNotes
BFA1P471132EBI-7575,EBI-3586
BUB2P264485EBI-7575,EBI-3824
CDC11P324582EBI-7575,EBI-4178
CDC12P324685EBI-7575,EBI-4182
CDC14Q006842EBI-7575,EBI-4192
CDC3P324572EBI-7575,EBI-4429

Protein-protein interaction databases

BioGridi36493. 60 interactions.
DIPiDIP-1217N.
IntActiP38785. 28 interactions.
MINTiMINT-395115.
STRINGi4932.YHR061C.

Structurei

3D structure databases

ProteinModelPortaliP38785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 13914CRIBAdd
BLAST

Sequence similaritiesi

Belongs to the BORG/CEP family.
Contains 1 CRIB domain.

Phylogenomic databases

eggNOGiNOG42654.
GeneTreeiENSGT00530000066862.
HOGENOMiHOG000000874.
OMAiHHISHAN.
OrthoDBiEOG7Q2NGK.

Family and domain databases

InterProiIPR000095. CRIB_dom.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38785-1 [UniParc]FASTAAdd to Basket

« Hide

MTEGKRLQQM ELPQMKSIWI DEDQEMEKLY GFQVRQRFMN GPSTDSDEDA    50
DEDLGIVLVD SKKLALPNKN NIKLPPLPNY MTINPNINSN HKSLTNKKKN 100
FLGMFKKKDL LSRRHGSAKT AKQSSISTPF DFHHISHANG KREDNPLESH 150
EEKHDVESLV KFTSLAPQPR PDSNVSSKYS NVVMNDSSRI VSSSTIATTM 200
DSHHDGNETN NTPNGNKQLD SPTDLEMTLE DLRNYTFPSV LGDSVSEKTN 250
PSSPSVSSFS GKFKPRELSA LHTPELGNCF NVDQSLNSPG NRISVDDVLK 300
FYYQCSETST PRNT 314
Length:314
Mass (Da):35,238
Last modified:February 1, 1995 - v1
Checksum:iC6B2FE253799500B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00061 Genomic DNA. Translation: AAB68388.1.
BK006934 Genomic DNA. Translation: DAA06754.1.
PIRiS46709.
RefSeqiNP_011928.1. NM_001179191.1.

Genome annotation databases

EnsemblFungiiYHR061C; YHR061C; YHR061C.
GeneIDi856458.
KEGGisce:YHR061C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00061 Genomic DNA. Translation: AAB68388.1 .
BK006934 Genomic DNA. Translation: DAA06754.1 .
PIRi S46709.
RefSeqi NP_011928.1. NM_001179191.1.

3D structure databases

ProteinModelPortali P38785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36493. 60 interactions.
DIPi DIP-1217N.
IntActi P38785. 28 interactions.
MINTi MINT-395115.
STRINGi 4932.YHR061C.

Proteomic databases

PaxDbi P38785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR061C ; YHR061C ; YHR061C .
GeneIDi 856458.
KEGGi sce:YHR061C.

Organism-specific databases

CYGDi YHR061c.
SGDi S000001103. GIC1.

Phylogenomic databases

eggNOGi NOG42654.
GeneTreei ENSGT00530000066862.
HOGENOMi HOG000000874.
OMAi HHISHAN.
OrthoDBi EOG7Q2NGK.

Enzyme and pathway databases

BioCyci YEAST:G3O-31114-MONOMER.

Miscellaneous databases

NextBioi 982099.

Gene expression databases

Genevestigatori P38785.

Family and domain databases

InterProi IPR000095. CRIB_dom.
[Graphical view ]
PROSITEi PS50108. CRIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae."
    Chen G.C., Kim Y.J., Chan C.S.
    Genes Dev. 11:2958-2971(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast."
    Brown J.L., Jaquenoud M., Gulli M.P., Chant J., Peter M.
    Genes Dev. 11:2972-2982(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIC1_YEAST
AccessioniPrimary (citable) accession number: P38785
Secondary accession number(s): D3DL10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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