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P38778

- SMF2_YEAST

UniProt

P38778 - SMF2_YEAST

Protein

Manganese transporter SMF2

Gene

SMF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    High-affinity manganese transporter involved in mobilizing manganese from vesicular stores iin conditions of low manganese ion concentrations.2 Publications

    GO - Molecular functioni

    1. inorganic cation transmembrane transporter activity Source: SGD
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular cobalt ion homeostasis Source: SGD
    2. cellular manganese ion homeostasis Source: SGD
    3. cobalt ion transport Source: SGD
    4. manganese ion transport Source: SGD

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31105-MONOMER.

    Protein family/group databases

    TCDBi2.A.55.1.2. the metal ion (mn(2+)-iron) transporter (nramp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Manganese transporter SMF2
    Gene namesi
    Name:SMF2
    Ordered Locus Names:YHR050W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR050w.
    SGDiS000001092. SMF2.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Targeted to the vacuolar lumen in presence of excess manganese, where it is degraded.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Manganese transporter SMF2PRO_0000212606Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP38778.

    Interactioni

    Protein-protein interaction databases

    BioGridi36482. 31 interactions.
    DIPiDIP-4171N.
    MINTiMINT-497357.
    STRINGi4932.YHR050W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38778.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 10919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 14718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18525HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NRAMP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1914.
    GeneTreeiENSGT00390000006526.
    HOGENOMiHOG000152204.
    KOiK12346.
    OMAiCMSEAAT.
    OrthoDBiEOG7NSBBM.

    Family and domain databases

    HAMAPiMF_00221. NRAMP.
    InterProiIPR001046. NRAMP_fam.
    [Graphical view]
    PANTHERiPTHR11706. PTHR11706. 1 hit.
    PfamiPF01566. Nramp. 1 hit.
    [Graphical view]
    PRINTSiPR00447. NATRESASSCMP.
    TIGRFAMsiTIGR01197. nramp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38778-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM    50
    IGTLRKYARF IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF 100
    MAAFWQYLCA RLGAVTGLDL AQNCKKHLPF GLNITLYILA EMAIIATDLA 150
    EVVGTAISLN ILFHIPLALG VILTVVDVLI VLLAYKPNGS MKGIRIFEAF 200
    VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG DGLYLSLAIL 250
    GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA 300
    ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI 350
    YNLLCSTLSK GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA 400
    LRRSATRAVA ITPCLILVLV AGRSGLSGAL NASQVVLSLL LPFVSAPLLY 450
    FTSSKKIMRV QLNRTKELSR TTDKKPVADR TEDDETIELE EMGIGSSSQE 500
    RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG FTTGKEVHL 549
    Length:549
    Mass (Da):59,768
    Last modified:February 1, 1995 - v1
    Checksum:i4C200057B82D65E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68900.1.
    BK006934 Genomic DNA. Translation: DAA06742.1.
    PIRiB45154.
    RefSeqiNP_011917.1. NM_001179180.1.

    Genome annotation databases

    EnsemblFungiiYHR050W; YHR050W; YHR050W.
    GeneIDi856447.
    KEGGisce:YHR050W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68900.1 .
    BK006934 Genomic DNA. Translation: DAA06742.1 .
    PIRi B45154.
    RefSeqi NP_011917.1. NM_001179180.1.

    3D structure databases

    ProteinModelPortali P38778.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36482. 31 interactions.
    DIPi DIP-4171N.
    MINTi MINT-497357.
    STRINGi 4932.YHR050W.

    Protein family/group databases

    TCDBi 2.A.55.1.2. the metal ion (mn(2+)-iron) transporter (nramp) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR050W ; YHR050W ; YHR050W .
    GeneIDi 856447.
    KEGGi sce:YHR050W.

    Organism-specific databases

    CYGDi YHR050w.
    SGDi S000001092. SMF2.

    Phylogenomic databases

    eggNOGi COG1914.
    GeneTreei ENSGT00390000006526.
    HOGENOMi HOG000152204.
    KOi K12346.
    OMAi CMSEAAT.
    OrthoDBi EOG7NSBBM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31105-MONOMER.

    Miscellaneous databases

    NextBioi 982066.

    Gene expression databases

    Genevestigatori P38778.

    Family and domain databases

    HAMAPi MF_00221. NRAMP.
    InterProi IPR001046. NRAMP_fam.
    [Graphical view ]
    PANTHERi PTHR11706. PTHR11706. 1 hit.
    Pfami PF01566. Nramp. 1 hit.
    [Graphical view ]
    PRINTSi PR00447. NATRESASSCMP.
    TIGRFAMsi TIGR01197. nramp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein."
      West A.H., Clark D.J., Martin J., Neupert W., Hartl F.-U., Horwich A.L.
      J. Biol. Chem. 267:24625-24633(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The family of SMF metal ion transporters in yeast cells."
      Cohen A., Nelson H., Nelson N.
      J. Biol. Chem. 275:33388-33394(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters."
      Portnoy M.E., Liu X.F., Culotta V.C.
      Mol. Cell. Biol. 20:7893-7902(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSMF2_YEAST
    AccessioniPrimary (citable) accession number: P38778
    Secondary accession number(s): D3DKZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3