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Protein

Manganese transporter SMF2

Gene

SMF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

High-affinity manganese transporter involved in mobilizing manganese from vesicular stores iin conditions of low manganese ion concentrations.2 Publications

GO - Molecular functioni

  • inorganic cation transmembrane transporter activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cation transmembrane transport Source: GOC
  • cellular cobalt ion homeostasis Source: SGD
  • cellular manganese ion homeostasis Source: SGD
  • cobalt ion transport Source: SGD
  • manganese ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31105-MONOMER.
ReactomeiREACT_304838. Iron uptake and transport.
REACT_324446. Phagosomal maturation (early endosomal stage).
REACT_342711. Metal ion SLC transporters.

Protein family/group databases

TCDBi2.A.55.1.2. the metal ion (mn(2+)-iron) transporter (nramp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese transporter SMF2
Gene namesi
Name:SMF2
Ordered Locus Names:YHR050W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR050w.
EuPathDBiFungiDB:YHR050W.
SGDiS000001092. SMF2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei91 – 10919HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 14718HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 18525HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21419HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37223HelicalSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: SGD
  • trans-Golgi network Source: SGD
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Manganese transporter SMF2PRO_0000212606Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi36482. 31 interactions.
DIPiDIP-4171N.
MINTiMINT-497357.

Structurei

3D structure databases

ProteinModelPortaliP38778.
SMRiP38778. Positions 69-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1914.
GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152204.
InParanoidiP38778.
KOiK12346.
OMAiYNLLCST.
OrthoDBiEOG7NSBBM.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

P38778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM
60 70 80 90 100
IGTLRKYARF IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF
110 120 130 140 150
MAAFWQYLCA RLGAVTGLDL AQNCKKHLPF GLNITLYILA EMAIIATDLA
160 170 180 190 200
EVVGTAISLN ILFHIPLALG VILTVVDVLI VLLAYKPNGS MKGIRIFEAF
210 220 230 240 250
VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG DGLYLSLAIL
260 270 280 290 300
GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA
310 320 330 340 350
ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI
360 370 380 390 400
YNLLCSTLSK GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA
410 420 430 440 450
LRRSATRAVA ITPCLILVLV AGRSGLSGAL NASQVVLSLL LPFVSAPLLY
460 470 480 490 500
FTSSKKIMRV QLNRTKELSR TTDKKPVADR TEDDETIELE EMGIGSSSQE
510 520 530 540
RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG FTTGKEVHL
Length:549
Mass (Da):59,768
Last modified:February 1, 1995 - v1
Checksum:i4C200057B82D65E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68900.1.
BK006934 Genomic DNA. Translation: DAA06742.1.
PIRiB45154.
RefSeqiNP_011917.1. NM_001179180.1.

Genome annotation databases

EnsemblFungiiYHR050W; YHR050W; YHR050W.
GeneIDi856447.
KEGGisce:YHR050W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68900.1.
BK006934 Genomic DNA. Translation: DAA06742.1.
PIRiB45154.
RefSeqiNP_011917.1. NM_001179180.1.

3D structure databases

ProteinModelPortaliP38778.
SMRiP38778. Positions 69-536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36482. 31 interactions.
DIPiDIP-4171N.
MINTiMINT-497357.

Protein family/group databases

TCDBi2.A.55.1.2. the metal ion (mn(2+)-iron) transporter (nramp) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR050W; YHR050W; YHR050W.
GeneIDi856447.
KEGGisce:YHR050W.

Organism-specific databases

CYGDiYHR050w.
EuPathDBiFungiDB:YHR050W.
SGDiS000001092. SMF2.

Phylogenomic databases

eggNOGiCOG1914.
GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152204.
InParanoidiP38778.
KOiK12346.
OMAiYNLLCST.
OrthoDBiEOG7NSBBM.

Enzyme and pathway databases

BioCyciYEAST:G3O-31105-MONOMER.
ReactomeiREACT_304838. Iron uptake and transport.
REACT_324446. Phagosomal maturation (early endosomal stage).
REACT_342711. Metal ion SLC transporters.

Miscellaneous databases

NextBioi982066.
PROiP38778.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein."
    West A.H., Clark D.J., Martin J., Neupert W., Hartl F.-U., Horwich A.L.
    J. Biol. Chem. 267:24625-24633(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The family of SMF metal ion transporters in yeast cells."
    Cohen A., Nelson H., Nelson N.
    J. Biol. Chem. 275:33388-33394(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters."
    Portnoy M.E., Liu X.F., Culotta V.C.
    Mol. Cell. Biol. 20:7893-7902(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSMF2_YEAST
AccessioniPrimary (citable) accession number: P38778
Secondary accession number(s): D3DKZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.