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P38778 (SMF2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Manganese transporter SMF2
Gene names
Name:SMF2
Ordered Locus Names:YHR050W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

High-affinity manganese transporter involved in mobilizing manganese from vesicular stores iin conditions of low manganese ion concentrations. Ref.4 Ref.5

Subcellular location

Vacuole membrane; Multi-pass membrane protein. Note: Targeted to the vacuolar lumen in presence of excess manganese, where it is degraded. Ref.5

Sequence similarities

Belongs to the NRAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Manganese transporter SMF2 HAMAP-Rule MF_00221
PRO_0000212606

Regions

Transmembrane91 – 10919Helical; Potential
Transmembrane130 – 14718Helical; Potential
Transmembrane161 – 18525Helical; Potential
Transmembrane196 – 21419Helical; Potential
Transmembrane312 – 33221Helical; Potential
Transmembrane350 – 37223Helical; Potential
Transmembrane432 – 45221Helical; Potential
Transmembrane521 – 54121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P38778 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4C200057B82D65E3

FASTA54959,768
        10         20         30         40         50         60 
MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM IGTLRKYARF 

        70         80         90        100        110        120 
IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF MAAFWQYLCA RLGAVTGLDL 

       130        140        150        160        170        180 
AQNCKKHLPF GLNITLYILA EMAIIATDLA EVVGTAISLN ILFHIPLALG VILTVVDVLI 

       190        200        210        220        230        240 
VLLAYKPNGS MKGIRIFEAF VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG 

       250        260        270        280        290        300 
DGLYLSLAIL GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA 

       310        320        330        340        350        360 
ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI YNLLCSTLSK 

       370        380        390        400        410        420 
GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA LRRSATRAVA ITPCLILVLV 

       430        440        450        460        470        480 
AGRSGLSGAL NASQVVLSLL LPFVSAPLLY FTSSKKIMRV QLNRTKELSR TTDKKPVADR 

       490        500        510        520        530        540 
TEDDETIELE EMGIGSSSQE RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG 


FTTGKEVHL 

« Hide

References

« Hide 'large scale' references
[1]"Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein."
West A.H., Clark D.J., Martin J., Neupert W., Hartl F.-U., Horwich A.L.
J. Biol. Chem. 267:24625-24633(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The family of SMF metal ion transporters in yeast cells."
Cohen A., Nelson H., Nelson N.
J. Biol. Chem. 275:33388-33394(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters."
Portnoy M.E., Liu X.F., Culotta V.C.
Mol. Cell. Biol. 20:7893-7902(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00062 Genomic DNA. Translation: AAB68900.1.
BK006934 Genomic DNA. Translation: DAA06742.1.
PIRB45154.
RefSeqNP_011917.1. NM_001179180.1.

3D structure databases

ProteinModelPortalP38778.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36482. 31 interactions.
DIPDIP-4171N.
MINTMINT-497357.
STRING4932.YHR050W.

Protein family/group databases

TCDB2.A.55.1.2. the metal ion (mn(2+)-iron) transporter (nramp) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR050W; YHR050W; YHR050W.
GeneID856447.
KEGGsce:YHR050W.

Organism-specific databases

CYGDYHR050w.
SGDS000001092. SMF2.

Phylogenomic databases

eggNOGCOG1914.
GeneTreeENSGT00390000006526.
HOGENOMHOG000152204.
KOK12346.
OMAAYKPNGS.
OrthoDBEOG7NSBBM.

Enzyme and pathway databases

BioCycYEAST:G3O-31105-MONOMER.

Gene expression databases

GenevestigatorP38778.

Family and domain databases

HAMAPMF_00221. NRAMP.
InterProIPR001046. NRAMP-like.
[Graphical view]
PANTHERPTHR11706. PTHR11706. 1 hit.
PfamPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSPR00447. NATRESASSCMP.
TIGRFAMsTIGR01197. nramp. 1 hit.
ProtoNetSearch...

Other

NextBio982066.

Entry information

Entry nameSMF2_YEAST
AccessionPrimary (citable) accession number: P38778
Secondary accession number(s): D3DKZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families