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Protein

Probable drug/proton antiporter YHK8

Gene

YHK8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable drug/proton antiporter.

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW

GO - Biological processi

  1. drug transport Source: SGD
  2. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31103-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.63. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable drug/proton antiporter YHK8
Gene namesi
Name:YHK8
Ordered Locus Names:YHR048W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR048w.
SGDiS000001090. YHK8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 11116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Topological domaini133 – 1419CytoplasmicSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1708ExtracellularSequence Analysis
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 2009CytoplasmicSequence Analysis
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Topological domaini222 – 2276ExtracellularSequence Analysis
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 30759CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 34214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Topological domaini364 – 38623CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Topological domaini408 – 4125ExtracellularSequence Analysis
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Topological domaini434 – 44714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence AnalysisAdd
BLAST
Topological domaini469 – 4779ExtracellularSequence Analysis
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Topological domaini499 – 51416CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Probable drug/proton antiporter YHK8PRO_0000173440Add
BLAST

Expressioni

Inductioni

Up-regulated in cells exhibiting reduced susceptibility to azoles.1 Publication

Gene expression databases

GenevestigatoriP38776.

Interactioni

Protein-protein interaction databases

BioGridi36480. 8 interactions.
DIPiDIP-8197N.
IntActiP38776. 1 interaction.
MINTiMINT-1354294.
STRINGi4932.YHR048W.

Structurei

3D structure databases

ProteinModelPortaliP38776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38776.
OMAiFATHISV.
OrthoDBiEOG77M8XK.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38776-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE
60 70 80 90 100
VTFNEDIADP EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI
110 120 130 140 150
IEHFHISHEV STLGITLYVF GLGIGPLFLS PLSELYGRRI TFLYALTLSI
160 170 180 190 200
IWQCLTIWSK TITGVMFGRF LSGFFGSAFL SVAGGAIADI FDKDQIGIPM
210 220 230 240 250
AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC LVMIIFTIPE
260 270 280 290 300
TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL
310 320 330 340 350
LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI
360 370 380 390 400
MVGMILSAPT CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF
410 420 430 440 450
IFAFTCYKHV HWIAPIIGSA IFGSGVYFVF TGVFAYTVDA YRRYAASGMA
460 470 480 490 500
CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG FLLAMVTVAM IPVPFLFTKY
510
GARLRAKSPY AWDD
Length:514
Mass (Da):57,838
Last modified:February 1, 1995 - v1
Checksum:i2CAAD39047F1BBCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68902.1.
BK006934 Genomic DNA. Translation: DAA06740.1.
PIRiS46733.
RefSeqiNP_011914.1. NM_001179178.1.

Genome annotation databases

EnsemblFungiiYHR048W; YHR048W; YHR048W.
GeneIDi856444.
KEGGisce:YHR048W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68902.1.
BK006934 Genomic DNA. Translation: DAA06740.1.
PIRiS46733.
RefSeqiNP_011914.1. NM_001179178.1.

3D structure databases

ProteinModelPortaliP38776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36480. 8 interactions.
DIPiDIP-8197N.
IntActiP38776. 1 interaction.
MINTiMINT-1354294.
STRINGi4932.YHR048W.

Protein family/group databases

TCDBi2.A.1.2.63. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR048W; YHR048W; YHR048W.
GeneIDi856444.
KEGGisce:YHR048W.

Organism-specific databases

CYGDiYHR048w.
SGDiS000001090. YHK8.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38776.
OMAiFATHISV.
OrthoDBiEOG77M8XK.

Enzyme and pathway databases

BioCyciYEAST:G3O-31103-MONOMER.

Miscellaneous databases

NextBioi982060.

Gene expression databases

GenevestigatoriP38776.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae."
    Barker K.S., Pearson M.M., Rogers P.D.
    J. Antimicrob. Chemother. 51:1131-1140(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Evolution of gene families: the multidrug resistance transporter genes in five related yeast species."
    Gbelska Y., Krijger J.J., Breunig K.D.
    FEMS Yeast Res. 6:345-355(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiYHK8_YEAST
AccessioniPrimary (citable) accession number: P38776
Secondary accession number(s): D3DKZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.