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P38776 (YHK8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable drug/proton antiporter YHK8
Gene names
Name:YHK8
Ordered Locus Names:YHR048W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable drug/proton antiporter. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein.

Induction

Up-regulated in cells exhibiting reduced susceptibility to azoles. Ref.3

Sequence similarities

Belongs to the major facilitator superfamily. CAR1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Probable drug/proton antiporter YHK8
PRO_0000173440

Regions

Topological domain1 – 7474Cytoplasmic Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 11116Extracellular Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 1419Cytoplasmic Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 1708Extracellular Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 2009Cytoplasmic Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 2276Extracellular Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 30759Cytoplasmic Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 34214Extracellular Potential
Transmembrane343 – 36321Helical; Potential
Topological domain364 – 38623Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 4125Extracellular Potential
Transmembrane413 – 43321Helical; Potential
Topological domain434 – 44714Cytoplasmic Potential
Transmembrane448 – 46821Helical; Potential
Topological domain469 – 4779Extracellular Potential
Transmembrane478 – 49821Helical; Potential
Topological domain499 – 51416Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38776 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2CAAD39047F1BBCB

FASTA51457,838
        10         20         30         40         50         60 
MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE VTFNEDIADP 

        70         80         90        100        110        120 
EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI IEHFHISHEV STLGITLYVF 

       130        140        150        160        170        180 
GLGIGPLFLS PLSELYGRRI TFLYALTLSI IWQCLTIWSK TITGVMFGRF LSGFFGSAFL 

       190        200        210        220        230        240 
SVAGGAIADI FDKDQIGIPM AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC 

       250        260        270        280        290        300 
LVMIIFTIPE TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 

       310        320        330        340        350        360 
LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI MVGMILSAPT 

       370        380        390        400        410        420 
CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF IFAFTCYKHV HWIAPIIGSA 

       430        440        450        460        470        480 
IFGSGVYFVF TGVFAYTVDA YRRYAASGMA CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG 

       490        500        510 
FLLAMVTVAM IPVPFLFTKY GARLRAKSPY AWDD 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae."
Barker K.S., Pearson M.M., Rogers P.D.
J. Antimicrob. Chemother. 51:1131-1140(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[4]"Evolution of gene families: the multidrug resistance transporter genes in five related yeast species."
Gbelska Y., Krijger J.J., Breunig K.D.
FEMS Yeast Res. 6:345-355(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION OF FUNCTION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00062 Genomic DNA. Translation: AAB68902.1.
BK006934 Genomic DNA. Translation: DAA06740.1.
PIRS46733.
RefSeqNP_011914.1. NM_001179178.1.

3D structure databases

ProteinModelPortalP38776.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36480. 8 interactions.
DIPDIP-8197N.
IntActP38776. 1 interaction.
MINTMINT-1354294.
STRING4932.YHR048W.

Protein family/group databases

TCDB2.A.1.2.63. the major facilitator superfamily (mfs).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR048W; YHR048W; YHR048W.
GeneID856444.
KEGGsce:YHR048W.

Organism-specific databases

CYGDYHR048w.
SGDS000001090. YHK8.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000088227.
HOGENOMHOG000160689.
OMAFATHISV.
OrthoDBEOG77M8XK.

Enzyme and pathway databases

BioCycYEAST:G3O-31103-MONOMER.

Gene expression databases

GenevestigatorP38776.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982060.

Entry information

Entry nameYHK8_YEAST
AccessionPrimary (citable) accession number: P38776
Secondary accession number(s): D3DKZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families