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Protein

Probable drug/proton antiporter YHK8

Gene

YHK8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable drug/proton antiporter.

GO - Molecular functioni

GO - Biological processi

  • drug transport Source: SGD
  • proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31103-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.63. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable drug/proton antiporter YHK8
Gene namesi
Name:YHK8
Ordered Locus Names:YHR048W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR048W.
SGDiS000001090. YHK8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 111ExtracellularSequence analysisAdd BLAST16
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 141CytoplasmicSequence analysis9
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 170ExtracellularSequence analysis8
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 200CytoplasmicSequence analysis9
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 227ExtracellularSequence analysis6
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 307CytoplasmicSequence analysisAdd BLAST59
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 342ExtracellularSequence analysisAdd BLAST14
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 386CytoplasmicSequence analysisAdd BLAST23
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 412ExtracellularSequence analysis5
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 447CytoplasmicSequence analysisAdd BLAST14
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 477ExtracellularSequence analysis9
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 514CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734401 – 514Probable drug/proton antiporter YHK8Add BLAST514

Proteomic databases

PRIDEiP38776.

Expressioni

Inductioni

Up-regulated in cells exhibiting reduced susceptibility to azoles.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi36480. 8 interactors.
DIPiDIP-8197N.
IntActiP38776. 1 interactor.
MINTiMINT-1354294.

Structurei

3D structure databases

ProteinModelPortaliP38776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38776.
OMAiFATHISV.
OrthoDBiEOG092C2079.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE
60 70 80 90 100
VTFNEDIADP EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI
110 120 130 140 150
IEHFHISHEV STLGITLYVF GLGIGPLFLS PLSELYGRRI TFLYALTLSI
160 170 180 190 200
IWQCLTIWSK TITGVMFGRF LSGFFGSAFL SVAGGAIADI FDKDQIGIPM
210 220 230 240 250
AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC LVMIIFTIPE
260 270 280 290 300
TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL
310 320 330 340 350
LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI
360 370 380 390 400
MVGMILSAPT CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF
410 420 430 440 450
IFAFTCYKHV HWIAPIIGSA IFGSGVYFVF TGVFAYTVDA YRRYAASGMA
460 470 480 490 500
CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG FLLAMVTVAM IPVPFLFTKY
510
GARLRAKSPY AWDD
Length:514
Mass (Da):57,838
Last modified:February 1, 1995 - v1
Checksum:i2CAAD39047F1BBCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68902.1.
BK006934 Genomic DNA. Translation: DAA06740.1.
PIRiS46733.
RefSeqiNP_011914.1. NM_001179178.1.

Genome annotation databases

EnsemblFungiiYHR048W; YHR048W; YHR048W.
GeneIDi856444.
KEGGisce:YHR048W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68902.1.
BK006934 Genomic DNA. Translation: DAA06740.1.
PIRiS46733.
RefSeqiNP_011914.1. NM_001179178.1.

3D structure databases

ProteinModelPortaliP38776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36480. 8 interactors.
DIPiDIP-8197N.
IntActiP38776. 1 interactor.
MINTiMINT-1354294.

Protein family/group databases

TCDBi2.A.1.2.63. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP38776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR048W; YHR048W; YHR048W.
GeneIDi856444.
KEGGisce:YHR048W.

Organism-specific databases

EuPathDBiFungiDB:YHR048W.
SGDiS000001090. YHK8.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38776.
OMAiFATHISV.
OrthoDBiEOG092C2079.

Enzyme and pathway databases

BioCyciYEAST:G3O-31103-MONOMER.

Miscellaneous databases

PROiP38776.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYHK8_YEAST
AccessioniPrimary (citable) accession number: P38776
Secondary accession number(s): D3DKZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.