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P38776

- YHK8_YEAST

UniProt

P38776 - YHK8_YEAST

Protein

Probable drug/proton antiporter YHK8

Gene

YHK8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Probable drug/proton antiporter.

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. drug transport Source: SGD
    2. proton transport Source: UniProtKB-KW

    Keywords - Biological processi

    Antiport, Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31103-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.2.63. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable drug/proton antiporter YHK8
    Gene namesi
    Name:YHK8
    Ordered Locus Names:YHR048W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR048w.
    SGDiS000001090. YHK8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Probable drug/proton antiporter YHK8PRO_0000173440Add
    BLAST

    Expressioni

    Inductioni

    Up-regulated in cells exhibiting reduced susceptibility to azoles.1 Publication

    Gene expression databases

    GenevestigatoriP38776.

    Interactioni

    Protein-protein interaction databases

    BioGridi36480. 8 interactions.
    DIPiDIP-8197N.
    IntActiP38776. 1 interaction.
    MINTiMINT-1354294.
    STRINGi4932.YHR048W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38776.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1419CytoplasmicSequence Analysis
    Topological domaini163 – 1708ExtracellularSequence Analysis
    Topological domaini192 – 2009CytoplasmicSequence Analysis
    Topological domaini222 – 2276ExtracellularSequence Analysis
    Topological domaini249 – 30759CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 34214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini364 – 38623CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 4125ExtracellularSequence Analysis
    Topological domaini434 – 44714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini469 – 4779ExtracellularSequence Analysis
    Topological domaini499 – 51416CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei448 – 46821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088227.
    HOGENOMiHOG000160689.
    OMAiARRYYIS.
    OrthoDBiEOG77M8XK.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38776-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE    50
    VTFNEDIADP EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI 100
    IEHFHISHEV STLGITLYVF GLGIGPLFLS PLSELYGRRI TFLYALTLSI 150
    IWQCLTIWSK TITGVMFGRF LSGFFGSAFL SVAGGAIADI FDKDQIGIPM 200
    AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC LVMIIFTIPE 250
    TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 300
    LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI 350
    MVGMILSAPT CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF 400
    IFAFTCYKHV HWIAPIIGSA IFGSGVYFVF TGVFAYTVDA YRRYAASGMA 450
    CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG FLLAMVTVAM IPVPFLFTKY 500
    GARLRAKSPY AWDD 514
    Length:514
    Mass (Da):57,838
    Last modified:February 1, 1995 - v1
    Checksum:i2CAAD39047F1BBCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68902.1.
    BK006934 Genomic DNA. Translation: DAA06740.1.
    PIRiS46733.
    RefSeqiNP_011914.1. NM_001179178.1.

    Genome annotation databases

    EnsemblFungiiYHR048W; YHR048W; YHR048W.
    GeneIDi856444.
    KEGGisce:YHR048W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68902.1 .
    BK006934 Genomic DNA. Translation: DAA06740.1 .
    PIRi S46733.
    RefSeqi NP_011914.1. NM_001179178.1.

    3D structure databases

    ProteinModelPortali P38776.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36480. 8 interactions.
    DIPi DIP-8197N.
    IntActi P38776. 1 interaction.
    MINTi MINT-1354294.
    STRINGi 4932.YHR048W.

    Protein family/group databases

    TCDBi 2.A.1.2.63. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR048W ; YHR048W ; YHR048W .
    GeneIDi 856444.
    KEGGi sce:YHR048W.

    Organism-specific databases

    CYGDi YHR048w.
    SGDi S000001090. YHK8.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088227.
    HOGENOMi HOG000160689.
    OMAi ARRYYIS.
    OrthoDBi EOG77M8XK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31103-MONOMER.

    Miscellaneous databases

    NextBioi 982060.

    Gene expression databases

    Genevestigatori P38776.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae."
      Barker K.S., Pearson M.M., Rogers P.D.
      J. Antimicrob. Chemother. 51:1131-1140(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. "Evolution of gene families: the multidrug resistance transporter genes in five related yeast species."
      Gbelska Y., Krijger J.J., Breunig K.D.
      FEMS Yeast Res. 6:345-355(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PREDICTION OF FUNCTION.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiYHK8_YEAST
    AccessioniPrimary (citable) accession number: P38776
    Secondary accession number(s): D3DKZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3