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P38774

- DOG1_YEAST

UniProt

P38774 - DOG1_YEAST

Protein

2-deoxyglucose-6-phosphate phosphatase 1

Gene

DOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Active on 2-DOG-6P, also very active on fructose-1P.

    Catalytic activityi

    2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

    Cofactori

    Magnesium.By similarity

    pH dependencei

    Optimum pH is 6.

    Temperature dependencei

    Optimum temperature is 30 degrees Celsius.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei12 – 121NucleophileBy similarity
    Metal bindingi12 – 121MagnesiumBy similarity
    Active sitei14 – 141Proton donorBy similarity
    Metal bindingi14 – 141MagnesiumBy similarity
    Metal bindingi183 – 1831MagnesiumBy similarity

    GO - Molecular functioni

    1. 2-deoxyglucose-6-phosphatase activity Source: SGD
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. glucose metabolic process Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:YHR044C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-deoxyglucose-6-phosphate phosphatase 1 (EC:3.1.3.68)
    Short name:
    2-DOG-6-P 1
    Short name:
    2-deoxyglucose-6-phosphatase 1
    Gene namesi
    Name:DOG1
    Ordered Locus Names:YHR044C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR044c.
    SGDiS000001086. DOG1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2462462-deoxyglucose-6-phosphate phosphatase 1PRO_0000079974Add
    BLAST

    Proteomic databases

    MaxQBiP38774.
    PaxDbiP38774.

    Expressioni

    Gene expression databases

    GenevestigatoriP38774.

    Interactioni

    Protein-protein interaction databases

    BioGridi36476. 26 interactions.
    DIPiDIP-6336N.
    IntActiP38774. 1 interaction.
    MINTiMINT-690583.
    STRINGi4932.YHR044C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38774.
    SMRiP38774. Positions 10-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0637.
    GeneTreeiENSGT00530000065392.
    HOGENOMiHOG000248341.
    KOiK01111.
    OMAiLSKIHIT.
    OrthoDBiEOG72JWT8.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR    50
    TQEVLRRFFP KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV 100
    DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG 150
    KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG 200
    ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA 246
    Length:246
    Mass (Da):27,100
    Last modified:February 1, 1995 - v1
    Checksum:i0682527802373EAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03107 Genomic DNA. Translation: AAC48923.1.
    U00062 Genomic DNA. Translation: AAB68917.1.
    AY558516 Genomic DNA. Translation: AAS56842.1.
    BK006934 Genomic DNA. Translation: DAA06736.1.
    PIRiS46604.
    RefSeqiNP_011910.1. NM_001179174.1.

    Genome annotation databases

    EnsemblFungiiYHR044C; YHR044C; YHR044C.
    GeneIDi856440.
    KEGGisce:YHR044C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03107 Genomic DNA. Translation: AAC48923.1 .
    U00062 Genomic DNA. Translation: AAB68917.1 .
    AY558516 Genomic DNA. Translation: AAS56842.1 .
    BK006934 Genomic DNA. Translation: DAA06736.1 .
    PIRi S46604.
    RefSeqi NP_011910.1. NM_001179174.1.

    3D structure databases

    ProteinModelPortali P38774.
    SMRi P38774. Positions 10-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36476. 26 interactions.
    DIPi DIP-6336N.
    IntActi P38774. 1 interaction.
    MINTi MINT-690583.
    STRINGi 4932.YHR044C.

    Proteomic databases

    MaxQBi P38774.
    PaxDbi P38774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR044C ; YHR044C ; YHR044C .
    GeneIDi 856440.
    KEGGi sce:YHR044C.

    Organism-specific databases

    CYGDi YHR044c.
    SGDi S000001086. DOG1.

    Phylogenomic databases

    eggNOGi COG0637.
    GeneTreei ENSGT00530000065392.
    HOGENOMi HOG000248341.
    KOi K01111.
    OMAi LSKIHIT.
    OrthoDBi EOG72JWT8.

    Enzyme and pathway databases

    BioCyci YEAST:YHR044C-MONOMER.

    Miscellaneous databases

    NextBioi 982048.

    Gene expression databases

    Genevestigatori P38774.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast."
      Sanz P., Randez-Gil F., Prieto J.A.
      Yeast 10:1195-1202(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed."
      Randez-Gil F., Blasco A., Prieto J.A., Sanz P.
      Yeast 11:1233-1240(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDOG1_YEAST
    AccessioniPrimary (citable) accession number: P38774
    Secondary accession number(s): D3DKZ2, P38923
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 752 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3