P38774 (DOG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-deoxyglucose-6-phosphate phosphatase 1
Short name=2-DOG-6-P 1
Short name=2-deoxyglucose-6-phosphatase 1
EC=3.1.3.68

Gene names

Name:	DOG1
Ordered Locus Names:	YHR044C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Active on 2-DOG-6P, also very active on fructose-1P.
Catalytic activity	2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
Miscellaneous	Present with 752 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the DOG/GPP family.
Biophysicochemical properties	pH dependence: Optimum pH is 6. Temperature dependence: Optimum temperature is 30 degrees Celsius.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glucose metabolic process Inferred from sequence or structural similarity Ref.5. Source: SGD
Molecular_function	2-deoxyglucose-6-phosphatase activity Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	2-deoxyglucose-6-phosphate phosphatase 1		PRO_0000079974

Sequences

	Sequence		Length	Mass (Da)
	P38774 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 0682527802373EAD	FASTA	246	27,100
	10 20 30 40 50 60 MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR TQEVLRRFFP 70 80 90 100 110 120 KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS 130 140 150 160 170 180 PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV 190 200 210 220 230 240 FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast." Sanz P., Randez-Gil F., Prieto J.A. Yeast 10:1195-1202(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed." Randez-Gil F., Blasco A., Prieto J.A., Sanz P. Yeast 11:1233-1240(1995) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03107 Genomic DNA. Translation: AAC48923.1. U00062 Genomic DNA. Translation: AAB68917.1. AY558516 Genomic DNA. Translation: AAS56842.1. BK006934 Genomic DNA. Translation: DAA06736.1.
PIR	S46604.
RefSeq	NP_011910.1. NM_001179174.1.
3D structure databases
ProteinModelPortal	P38774.
SMR	P38774. Positions 10-231.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6336N.
IntAct	P38774. 5 interactions.
MINT	MINT-690583.
STRING	4932.YHR044C.
Proteomic databases
PaxDb	P38774.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR044C; YHR044C; YHR044C.
GeneID	856440.
KEGG	sce:YHR044C.
Organism-specific databases
CYGD	YHR044c.
SGD	S000001086. DOG1.
Phylogenomic databases
eggNOG	COG0637.
GeneTree	ENSGT00530000065392.
HOGENOM	HOG000248341.
KO	K01111.
OrthoDB	EOG4NGKWQ.
Gene expression databases
Genevestigator	P38774.
GermOnline	YHR044C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.150.240. 1 hit. 3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR006402. HAD-SF_hydro_IA_v3. IPR023198. PGP_dom2. [Graphical view]
Pfam	PF13419. HAD_2. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNet	Search...
Other
NextBio	982048.

Entry information

Entry name

DOG1_YEAST

Accession

Primary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program