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Protein

2-deoxyglucose-6-phosphate phosphatase 1

Gene

DOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active on 2-DOG-6P, also very active on fructose-1P.

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactori

Mg2+By similarity

pH dependencei

Optimum pH is 6.

Temperature dependencei

Optimum temperature is 30 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12NucleophileBy similarity1
Metal bindingi12MagnesiumBy similarity1
Active sitei14Proton donorBy similarity1
Metal bindingi14MagnesiumBy similarity1
Metal bindingi183MagnesiumBy similarity1

GO - Molecular functioni

  • 2-deoxyglucose-6-phosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • glucose metabolic process Source: SGD

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR044C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxyglucose-6-phosphate phosphatase 1 (EC:3.1.3.68)
Short name:
2-DOG-6-P 1
Short name:
2-deoxyglucose-6-phosphatase 1
Gene namesi
Name:DOG1
Ordered Locus Names:YHR044C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR044C.
SGDiS000001086. DOG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799741 – 2462-deoxyglucose-6-phosphate phosphatase 1Add BLAST246

Proteomic databases

MaxQBiP38774.
PRIDEiP38774.

Interactioni

Protein-protein interaction databases

BioGridi36476. 61 interactors.
DIPiDIP-6336N.
IntActiP38774. 1 interactor.
MINTiMINT-690583.
STRINGi4932.YHR044C.

Structurei

3D structure databases

ProteinModelPortaliP38774.
SMRiP38774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000065392.
HOGENOMiHOG000248341.
InParanoidiP38774.
KOiK01111.
OrthoDBiEOG092C47K9.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
PfamiView protein in Pfam
PF13419. HAD_2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

P38774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR
60 70 80 90 100
TQEVLRRFFP KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV
110 120 130 140 150
DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG
160 170 180 190 200
KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG
210 220 230 240
ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA
Length:246
Mass (Da):27,100
Last modified:February 1, 1995 - v1
Checksum:i0682527802373EAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03107 Genomic DNA. Translation: AAC48923.1.
U00062 Genomic DNA. Translation: AAB68917.1.
AY558516 Genomic DNA. Translation: AAS56842.1.
BK006934 Genomic DNA. Translation: DAA06736.1.
PIRiS46604.
RefSeqiNP_011910.1. NM_001179174.1.

Genome annotation databases

EnsemblFungiiYHR044C; YHR044C; YHR044C.
GeneIDi856440.
KEGGisce:YHR044C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDOG1_YEAST
AccessioniPrimary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names