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Protein

2-deoxyglucose-6-phosphate phosphatase 1

Gene

DOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active on 2-DOG-6P, also very active on fructose-1P.

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactori

Mg2+By similarity

pH dependencei

Optimum pH is 6.

Temperature dependencei

Optimum temperature is 30 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12NucleophileBy similarity1
Metal bindingi12MagnesiumBy similarity1
Active sitei14Proton donorBy similarity1
Metal bindingi14MagnesiumBy similarity1
Metal bindingi183MagnesiumBy similarity1

GO - Molecular functioni

  • 2-deoxyglucose-6-phosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • glucose metabolic process Source: SGD

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR044C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxyglucose-6-phosphate phosphatase 1 (EC:3.1.3.68)
Short name:
2-DOG-6-P 1
Short name:
2-deoxyglucose-6-phosphatase 1
Gene namesi
Name:DOG1
Ordered Locus Names:YHR044C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR044C
SGDiS000001086 DOG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799741 – 2462-deoxyglucose-6-phosphate phosphatase 1Add BLAST246

Proteomic databases

MaxQBiP38774
PaxDbiP38774
PRIDEiP38774

Interactioni

Protein-protein interaction databases

BioGridi36476, 61 interactors
DIPiDIP-6336N
IntActiP38774, 10 interactors
STRINGi4932.YHR044C

Structurei

3D structure databases

ProteinModelPortaliP38774
SMRiP38774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000065392
HOGENOMiHOG000248341
InParanoidiP38774
KOiK01111
OrthoDBiEOG092C47K9

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01509 HAD-SF-IA-v3, 1 hit

Sequencei

Sequence statusi: Complete.

P38774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR
60 70 80 90 100
TQEVLRRFFP KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV
110 120 130 140 150
DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG
160 170 180 190 200
KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG
210 220 230 240
ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA
Length:246
Mass (Da):27,100
Last modified:February 1, 1995 - v1
Checksum:i0682527802373EAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03107 Genomic DNA Translation: AAC48923.1
U00062 Genomic DNA Translation: AAB68917.1
AY558516 Genomic DNA Translation: AAS56842.1
BK006934 Genomic DNA Translation: DAA06736.1
PIRiS46604
RefSeqiNP_011910.1, NM_001179174.1

Genome annotation databases

EnsemblFungiiYHR044C; YHR044C; YHR044C
GeneIDi856440
KEGGisce:YHR044C

Similar proteinsi

Entry informationi

Entry nameiDOG1_YEAST
AccessioniPrimary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health