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Protein

2-deoxyglucose-6-phosphate phosphatase 1

Gene

DOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active on 2-DOG-6P, also very active on fructose-1P.

Catalytic activityi

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactori

Mg2+By similarity

pH dependencei

Optimum pH is 6.

Temperature dependencei

Optimum temperature is 30 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121NucleophileBy similarity
Metal bindingi12 – 121MagnesiumBy similarity
Active sitei14 – 141Proton donorBy similarity
Metal bindingi14 – 141MagnesiumBy similarity
Metal bindingi183 – 1831MagnesiumBy similarity

GO - Molecular functioni

  • 2-deoxyglucose-6-phosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • dephosphorylation Source: GOC
  • glucose metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR044C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxyglucose-6-phosphate phosphatase 1 (EC:3.1.3.68)
Short name:
2-DOG-6-P 1
Short name:
2-deoxyglucose-6-phosphatase 1
Gene namesi
Name:DOG1
Ordered Locus Names:YHR044C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR044c.
EuPathDBiFungiDB:YHR044C.
SGDiS000001086. DOG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2462462-deoxyglucose-6-phosphate phosphatase 1PRO_0000079974Add
BLAST

Proteomic databases

MaxQBiP38774.
PaxDbiP38774.

Interactioni

Protein-protein interaction databases

BioGridi36476. 27 interactions.
DIPiDIP-6336N.
IntActiP38774. 1 interaction.
MINTiMINT-690583.

Structurei

3D structure databases

ProteinModelPortaliP38774.
SMRiP38774. Positions 10-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0637.
GeneTreeiENSGT00530000065392.
HOGENOMiHOG000248341.
InParanoidiP38774.
KOiK01111.
OMAiDEGFHRI.
OrthoDBiEOG72JWT8.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

P38774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR
60 70 80 90 100
TQEVLRRFFP KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV
110 120 130 140 150
DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG
160 170 180 190 200
KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG
210 220 230 240
ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA
Length:246
Mass (Da):27,100
Last modified:February 1, 1995 - v1
Checksum:i0682527802373EAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03107 Genomic DNA. Translation: AAC48923.1.
U00062 Genomic DNA. Translation: AAB68917.1.
AY558516 Genomic DNA. Translation: AAS56842.1.
BK006934 Genomic DNA. Translation: DAA06736.1.
PIRiS46604.
RefSeqiNP_011910.1. NM_001179174.1.

Genome annotation databases

EnsemblFungiiYHR044C; YHR044C; YHR044C.
GeneIDi856440.
KEGGisce:YHR044C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03107 Genomic DNA. Translation: AAC48923.1.
U00062 Genomic DNA. Translation: AAB68917.1.
AY558516 Genomic DNA. Translation: AAS56842.1.
BK006934 Genomic DNA. Translation: DAA06736.1.
PIRiS46604.
RefSeqiNP_011910.1. NM_001179174.1.

3D structure databases

ProteinModelPortaliP38774.
SMRiP38774. Positions 10-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36476. 27 interactions.
DIPiDIP-6336N.
IntActiP38774. 1 interaction.
MINTiMINT-690583.

Proteomic databases

MaxQBiP38774.
PaxDbiP38774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR044C; YHR044C; YHR044C.
GeneIDi856440.
KEGGisce:YHR044C.

Organism-specific databases

CYGDiYHR044c.
EuPathDBiFungiDB:YHR044C.
SGDiS000001086. DOG1.

Phylogenomic databases

eggNOGiCOG0637.
GeneTreeiENSGT00530000065392.
HOGENOMiHOG000248341.
InParanoidiP38774.
KOiK01111.
OMAiDEGFHRI.
OrthoDBiEOG72JWT8.

Enzyme and pathway databases

BioCyciYEAST:YHR044C-MONOMER.

Miscellaneous databases

NextBioi982048.
PROiP38774.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast."
    Sanz P., Randez-Gil F., Prieto J.A.
    Yeast 10:1195-1202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed."
    Randez-Gil F., Blasco A., Prieto J.A., Sanz P.
    Yeast 11:1233-1240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDOG1_YEAST
AccessioniPrimary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.