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P38774

- DOG1_YEAST

UniProt

P38774 - DOG1_YEAST

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Protein

2-deoxyglucose-6-phosphate phosphatase 1

Gene
DOG1, YHR044C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Active on 2-DOG-6P, also very active on fructose-1P.

Catalytic activityi

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactori

Magnesium By similarity.

pH dependencei

Optimum pH is 6.

Temperature dependencei

Optimum temperature is 30 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121Nucleophile By similarity
Metal bindingi12 – 121Magnesium By similarity
Active sitei14 – 141Proton donor By similarity
Metal bindingi14 – 141Magnesium By similarity
Metal bindingi183 – 1831Magnesium By similarity

GO - Molecular functioni

  1. 2-deoxyglucose-6-phosphatase activity Source: SGD
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. glucose metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR044C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxyglucose-6-phosphate phosphatase 1 (EC:3.1.3.68)
Short name:
2-DOG-6-P 1
Short name:
2-deoxyglucose-6-phosphatase 1
Gene namesi
Name:DOG1
Ordered Locus Names:YHR044C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR044c.
SGDiS000001086. DOG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2462462-deoxyglucose-6-phosphate phosphatase 1PRO_0000079974Add
BLAST

Proteomic databases

MaxQBiP38774.
PaxDbiP38774.

Expressioni

Gene expression databases

GenevestigatoriP38774.

Interactioni

Protein-protein interaction databases

BioGridi36476. 26 interactions.
DIPiDIP-6336N.
IntActiP38774. 1 interaction.
MINTiMINT-690583.
STRINGi4932.YHR044C.

Structurei

3D structure databases

ProteinModelPortaliP38774.
SMRiP38774. Positions 10-231.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0637.
GeneTreeiENSGT00530000065392.
HOGENOMiHOG000248341.
KOiK01111.
OMAiLSKIHIT.
OrthoDBiEOG72JWT8.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

P38774-1 [UniParc]FASTAAdd to Basket

« Hide

MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR    50
TQEVLRRFFP KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV 100
DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG 150
KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG 200
ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA 246
Length:246
Mass (Da):27,100
Last modified:February 1, 1995 - v1
Checksum:i0682527802373EAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03107 Genomic DNA. Translation: AAC48923.1.
U00062 Genomic DNA. Translation: AAB68917.1.
AY558516 Genomic DNA. Translation: AAS56842.1.
BK006934 Genomic DNA. Translation: DAA06736.1.
PIRiS46604.
RefSeqiNP_011910.1. NM_001179174.1.

Genome annotation databases

EnsemblFungiiYHR044C; YHR044C; YHR044C.
GeneIDi856440.
KEGGisce:YHR044C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03107 Genomic DNA. Translation: AAC48923.1 .
U00062 Genomic DNA. Translation: AAB68917.1 .
AY558516 Genomic DNA. Translation: AAS56842.1 .
BK006934 Genomic DNA. Translation: DAA06736.1 .
PIRi S46604.
RefSeqi NP_011910.1. NM_001179174.1.

3D structure databases

ProteinModelPortali P38774.
SMRi P38774. Positions 10-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36476. 26 interactions.
DIPi DIP-6336N.
IntActi P38774. 1 interaction.
MINTi MINT-690583.
STRINGi 4932.YHR044C.

Proteomic databases

MaxQBi P38774.
PaxDbi P38774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR044C ; YHR044C ; YHR044C .
GeneIDi 856440.
KEGGi sce:YHR044C.

Organism-specific databases

CYGDi YHR044c.
SGDi S000001086. DOG1.

Phylogenomic databases

eggNOGi COG0637.
GeneTreei ENSGT00530000065392.
HOGENOMi HOG000248341.
KOi K01111.
OMAi LSKIHIT.
OrthoDBi EOG72JWT8.

Enzyme and pathway databases

BioCyci YEAST:YHR044C-MONOMER.

Miscellaneous databases

NextBioi 982048.

Gene expression databases

Genevestigatori P38774.

Family and domain databases

Gene3Di 1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view ]
Pfami PF13419. HAD_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast."
    Sanz P., Randez-Gil F., Prieto J.A.
    Yeast 10:1195-1202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed."
    Randez-Gil F., Blasco A., Prieto J.A., Sanz P.
    Yeast 11:1233-1240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDOG1_YEAST
AccessioniPrimary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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