Reviewed, UniProtKB/Swiss-Prot P38774 (DOG1_YEAST)

Names and origin

Protein names

Recommended name:
    2-deoxyglucose-6-phosphate phosphatase 1
      Short name=2-DOG-6-P 1
      Short name=2-deoxyglucose-6-phosphatase 1
    EC=3.1.3.68

Gene names

Name:	DOG1
Ordered Locus Names:	YHR044C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Active on 2-DOG-6P, also very active on fructose-1P.
Catalytic activity	2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
Miscellaneous	Present with 752 molecules/cell in log phase SD medium. Ref.5
biophysicochemical properties	pH dependence: Optimum pH is 6. Temperature dependence: Optimum temperature is 30 degrees Celsius.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-deoxyglucose-6-phosphatase activity Ref.4 Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	2-deoxyglucose-6-phosphate phosphatase 1		PRO_0000079974

Sequences

	Sequence		Length	Mass (Da)
	P38774-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 0682527802373EAD	FASTA	246	27,100
	10 20 30 40 50 60 MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR TQEVLRRFFP 70 80 90 100 110 120 KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS 130 140 150 160 170 180 PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV 190 200 210 220 230 240 FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast." Sanz P., Randez-Gil F., Prieto J.A. Yeast 10:1195-1202(1994) [PubMed: 7754708] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed." Randez-Gil F., Blasco A., Prieto J.A., Sanz P. Yeast 11:1233-1240(1995) [PubMed: 8553694] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U03107 Genomic DNA. Translation: AAC48923.1. U00062 Genomic DNA. Translation: AAB68917.1. AY558516 Genomic DNA. Translation: AAS56842.1.
PIR	S46604.
RefSeq	NP_011910.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6336N.
IntAct	P38774. 5 interactions.
Genome annotation databases
Ensembl	YHR044C. Saccharomyces cerevisiae. [Contig view]
GeneID	856440.
GenomeReviews	Gene locus YHR044C in contig U00093_GR.
KEGG	sce:YHR044C.
NMPDR	fig|4932.3.peg.3059.
Organism-specific databases
CYGD	YHR044c.
SGD	S000001086. DOG1.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38774.
OMA	P38774. VFEDEAD.
Enzyme and pathway databases
BRENDA	3.1.3.68. 250.
Gene expression databases
GermOnline	YHR044C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	982048.

Entry information

Entry name

DOG1_YEAST

Accession

Primary (citable) accession number: P38774
Secondary accession number(s): P38923

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)