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P38774 (DOG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-deoxyglucose-6-phosphate phosphatase 1

Short name=2-DOG-6-P 1
Short name=2-deoxyglucose-6-phosphatase 1
EC=3.1.3.68
Gene names
Name:DOG1
Ordered Locus Names:YHR044C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Active on 2-DOG-6P, also very active on fructose-1P.

Catalytic activity

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactor

Magnesium By similarity.

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.

Biophysicochemical properties

pH dependence:

Optimum pH is 6.

Temperature dependence:

Optimum temperature is 30 degrees Celsius.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2462462-deoxyglucose-6-phosphate phosphatase 1
PRO_0000079974

Sites

Active site121Nucleophile By similarity
Active site141Proton donor By similarity
Metal binding121Magnesium By similarity
Metal binding141Magnesium By similarity
Metal binding1831Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P38774 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 0682527802373EAD

FASTA24627,100
        10         20         30         40         50         60 
MAEFSADLCL FDLDGTIVST TVAAEKAWTK LCYEYGVDPS ELFKHSHGAR TQEVLRRFFP 

        70         80         90        100        110        120 
KLDDTDNKGV LALEKDIAHS YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS 

       130        140        150        160        170        180 
PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV 

       190        200        210        220        230        240 
FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN 


NPLTRA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast."
Sanz P., Randez-Gil F., Prieto J.A.
Yeast 10:1195-1202(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed."
Randez-Gil F., Blasco A., Prieto J.A., Sanz P.
Yeast 11:1233-1240(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03107 Genomic DNA. Translation: AAC48923.1.
U00062 Genomic DNA. Translation: AAB68917.1.
AY558516 Genomic DNA. Translation: AAS56842.1.
BK006934 Genomic DNA. Translation: DAA06736.1.
PIRS46604.
RefSeqNP_011910.1. NM_001179174.1.

3D structure databases

ProteinModelPortalP38774.
SMRP38774. Positions 10-231.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36476. 26 interactions.
DIPDIP-6336N.
IntActP38774. 1 interaction.
MINTMINT-690583.
STRING4932.YHR044C.

Proteomic databases

PaxDbP38774.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR044C; YHR044C; YHR044C.
GeneID856440.
KEGGsce:YHR044C.

Organism-specific databases

CYGDYHR044c.
SGDS000001086. DOG1.

Phylogenomic databases

eggNOGCOG0637.
GeneTreeENSGT00530000065392.
HOGENOMHOG000248341.
KOK01111.
OrthoDBEOG72JWT8.

Enzyme and pathway databases

BioCycYEAST:YHR044C-MONOMER.

Gene expression databases

GenevestigatorP38774.

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNetSearch...

Other

NextBio982048.

Entry information

Entry nameDOG1_YEAST
AccessionPrimary (citable) accession number: P38774
Secondary accession number(s): D3DKZ2, P38923
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families