Reviewed, UniProtKB/Swiss-Prot P38773 (DOG2_YEAST)

Names and origin

Protein names

Recommended name:
    2-deoxyglucose-6-phosphate phosphatase 2
      Short name=2-DOG-6-P 2
      Short name=2-deoxyglucose-6-phosphatase 2
    EC=3.1.3.68

Gene names

Name:	DOG2
Ordered Locus Names:	YHR043C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Active on 2-DOG-6P, not very active on fructose-1p.
Catalytic activity	2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
Miscellaneous	Present with 2400 molecules/cell in log phase SD medium. Ref.3
biophysicochemical properties	pH dependence: Optimum pH is 6. Temperature dependence: Optimum temperature is 40 degrees Celsius.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ER-associated protein catabolic process Inferred from mutant phenotype. Source: SGD response to stress Inferred from expression pattern. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	2-deoxyglucose-6-phosphatase activity Ref.1 Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P43582	1	EBI-6028,EBI-22766
ESS1	P22696	1	EBI-6028,EBI-6679
PRP40	P33203	1	EBI-6028,EBI-701

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	2-deoxyglucose-6-phosphate phosphatase 2		PRO_0000079975

Sequences

	Sequence		Length	Mass (Da)
	P38773-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 1F44B940C48E5E0B	FASTA	246	27,165
	10 20 30 40 50 60 MPQFSVDLCL FDLDGTIVST TTAAESAWKK LCRQHGVDPV ELFKHSHGAR SQEMMKKFFP 70 80 90 100 110 120 KLDNTDNKGV LALEKDMADN YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS 130 140 150 160 170 180 PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV 190 200 210 220 230 240 FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed." Randez-Gil F., Blasco A., Prieto J.A., Sanz P. Yeast 11:1233-1240(1995) [PubMed: 8553694] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00062 Genomic DNA. Translation: AAB68916.1.
PIR	S46747.
RefSeq	NP_011909.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5586N.
IntAct	P38773. 9 interactions.
Genome annotation databases
Ensembl	YHR043C. Saccharomyces cerevisiae. [Contig view]
GeneID	856439.
GenomeReviews	Gene locus YHR043C in contig U00093_GR.
KEGG	sce:YHR043C.
NMPDR	fig|4932.3.peg.3058.
Organism-specific databases
CYGD	YHR043c.
SGD	S000001085. DOG2.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38773.
OMA	P38773. ITRGKPD.
Enzyme and pathway databases
BRENDA	3.1.3.68. 250.
Gene expression databases
GermOnline	YHR043C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	982045.

Entry information

Entry name

DOG2_YEAST

Accession

Primary (citable) accession number: P38773

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)