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Protein

Box C/D snoRNA protein 1

Gene

BCD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 3935HIT-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: SGD

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. snoRNA metabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Box C/D snoRNA protein 1
Gene namesi
Name:BCD1
Ordered Locus Names:YHR040W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR040w.
SGDiS000001082. BCD1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Box C/D snoRNA protein 1PRO_0000173558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei330 – 3301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38772.
PaxDbiP38772.
PeptideAtlasiP38772.

Expressioni

Gene expression databases

GenevestigatoriP38772.

Interactioni

Protein-protein interaction databases

BioGridi36472. 7 interactions.
DIPiDIP-3862N.
IntActiP38772. 7 interactions.
MINTiMINT-512945.
STRINGi4932.YHR040W.

Structurei

3D structure databases

ProteinModelPortaliP38772.
SMRiP38772. Positions 2-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCD1 family.Curated
Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 3935HIT-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG279669.
GeneTreeiENSGT00390000017201.
HOGENOMiHOG000000870.
InParanoidiP38772.
OMAiISNATEY.
OrthoDBiEOG7ZSJ63.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLCGVCGI KEFKYKCPRC LVQTCSLECS KKHKTRDNCS GQTHDPKEYI
60 70 80 90 100
SSEALKQADD DKHERNAYVQ RDYNYLTQLK RMVHVQKMDA RMKNKRVLGP
110 120 130 140 150
VGGHNSNFKK RRYDIDEDDR DSTECQRIIR RGVNCLMLPK GMQRSSQNRS
160 170 180 190 200
KWDKTMDLFV WSVEWILCPM QEKGEKKELF KHVSHRIKET DFLVQGMGKN
210 220 230 240 250
VFQKCCEFYR LAGTSSCIEG EDGSETKEER TQILQKSGLK FYTKTFPYNT
260 270 280 290 300
THIMDSKKLV ELAIHEKCIG ELLKNTTVIE FPTIFVAMTE ADLPEGYEVL
310 320 330 340 350
HQEPRPLEHT STLNKFIDNA REEEDAEEDS QPTEEPVQKE TQDASDSDSD
360
SDDDYNPGLS MDFLTA
Length:366
Mass (Da):42,334
Last modified:February 1, 1995 - v1
Checksum:iEE8BDAF489EC1F12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68905.1.
BK006934 Genomic DNA. Translation: DAA06732.1.
PIRiS46736.
RefSeqiNP_011906.1. NM_001179170.1.

Genome annotation databases

EnsemblFungiiYHR040W; YHR040W; YHR040W.
GeneIDi856436.
KEGGisce:YHR040W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68905.1.
BK006934 Genomic DNA. Translation: DAA06732.1.
PIRiS46736.
RefSeqiNP_011906.1. NM_001179170.1.

3D structure databases

ProteinModelPortaliP38772.
SMRiP38772. Positions 2-48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36472. 7 interactions.
DIPiDIP-3862N.
IntActiP38772. 7 interactions.
MINTiMINT-512945.
STRINGi4932.YHR040W.

Proteomic databases

MaxQBiP38772.
PaxDbiP38772.
PeptideAtlasiP38772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR040W; YHR040W; YHR040W.
GeneIDi856436.
KEGGisce:YHR040W.

Organism-specific databases

CYGDiYHR040w.
SGDiS000001082. BCD1.

Phylogenomic databases

eggNOGiNOG279669.
GeneTreeiENSGT00390000017201.
HOGENOMiHOG000000870.
InParanoidiP38772.
OMAiISNATEY.
OrthoDBiEOG7ZSJ63.

Enzyme and pathway databases

BioCyciYEAST:G3O-31099-MONOMER.

Miscellaneous databases

NextBioi982036.

Gene expression databases

GenevestigatoriP38772.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCD1_YEAST
AccessioniPrimary (citable) accession number: P38772
Secondary accession number(s): D3DKY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.