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P38770

- BRL1_YEAST

UniProt

P38770 - BRL1_YEAST

Protein

Nucleus export protein BRL1

Gene

BRL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in mRNA and protein export from nucleus.1 Publication

    GO - Biological processi

    1. mRNA export from nucleus Source: SGD
    2. nuclear envelope organization Source: SGD
    3. protein export from nucleus Source: SGD

    Keywords - Biological processi

    mRNA transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31096-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleus export protein BRL1
    Alternative name(s):
    BRR6-like protein 1
    Gene namesi
    Name:BRL1
    Ordered Locus Names:YHR036W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR036w.
    SGDiS000001078. BRL1.

    Subcellular locationi

    Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear envelope Source: SGD
    4. nuclear membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Nucleus export protein BRL1PRO_0000202892Add
    BLAST

    Proteomic databases

    MaxQBiP38770.
    PaxDbiP38770.

    Expressioni

    Gene expression databases

    GenevestigatoriP38770.

    Interactioni

    Subunit structurei

    Interacts with BRR6.1 Publication

    Protein-protein interaction databases

    BioGridi36467. 13 interactions.
    DIPiDIP-5580N.
    IntActiP38770. 12 interactions.
    MINTiMINT-526264.
    STRINGi4932.YHR036W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38770.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 299299CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini321 – 40787Perinuclear spaceSequence AnalysisAdd
    BLAST
    Topological domaini429 – 47143CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei300 – 32021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BRL1/BRR6 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5085.
    HOGENOMiHOG000095263.
    OMAiTHTEATE.
    OrthoDBiEOG7RRFK5.

    Family and domain databases

    InterProiIPR018767. Brl1/Brr6_dom.
    [Graphical view]
    PfamiPF10104. Brr6_like_C_C. 1 hit.
    [Graphical view]
    SMARTiSM01042. Brr6_like_C_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38770-1 [UniParc]FASTAAdd to Basket

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    MESFENLSIR DSFTSGMEHV DEELGGLSDL SISKQGPTLS PQLINRFMPH    50
    FPSSPSPLRN TLDFSAAKAD EEEDDRMEID EVDDTSFEEE YNNEPIETHT 100
    EATENAVVEE IEATPEERQK QEKNESQDQS VEEVENIVSP HRSTVIKALL 150
    SPTDLGVAAA TKVEGVVPLP PSANQDDNES SNNNAEGEDI IRNEEVEDEI 200
    KSSLGNHKSS QYANAFDSEI IKRELRSRSK YQPIQVSFNT HNYFYSDKDG 250
    IKTYSLTKPN HNKIDEFYDQ NEAFKLPKPW SPNSHPASRA SYALMSYLQL 300
    FLNAITTVVI FSFILSFIIA LQKDLKSTWE QRKHELQYES RICQEQYLTN 350
    RCNQTPGLPA LGEQCAIWKQ CMDRNNDIFF RARSTLSAKL FGDIINSFID 400
    PLNWKTLFVI FCGVITWCFS SNFLLGFVRA KSYYGNGIKT YPLPSSPKSP 450
    TSEETHSSMT ASGEDSHLLK Q 471
    Length:471
    Mass (Da):53,385
    Last modified:February 1, 1995 - v1
    Checksum:i732209EC74DE3463
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68908.1.
    BK006934 Genomic DNA. Translation: DAA06727.1.
    PIRiS46739.
    RefSeqiNP_011901.1. NM_001179166.1.

    Genome annotation databases

    EnsemblFungiiYHR036W; YHR036W; YHR036W.
    GeneIDi856431.
    KEGGisce:YHR036W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68908.1 .
    BK006934 Genomic DNA. Translation: DAA06727.1 .
    PIRi S46739.
    RefSeqi NP_011901.1. NM_001179166.1.

    3D structure databases

    ProteinModelPortali P38770.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36467. 13 interactions.
    DIPi DIP-5580N.
    IntActi P38770. 12 interactions.
    MINTi MINT-526264.
    STRINGi 4932.YHR036W.

    Proteomic databases

    MaxQBi P38770.
    PaxDbi P38770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR036W ; YHR036W ; YHR036W .
    GeneIDi 856431.
    KEGGi sce:YHR036W.

    Organism-specific databases

    CYGDi YHR036w.
    SGDi S000001078. BRL1.

    Phylogenomic databases

    eggNOGi COG5085.
    HOGENOMi HOG000095263.
    OMAi THTEATE.
    OrthoDBi EOG7RRFK5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31096-MONOMER.

    Miscellaneous databases

    NextBioi 982021.

    Gene expression databases

    Genevestigatori P38770.

    Family and domain databases

    InterProi IPR018767. Brl1/Brr6_dom.
    [Graphical view ]
    Pfami PF10104. Brr6_like_C_C. 1 hit.
    [Graphical view ]
    SMARTi SM01042. Brr6_like_C_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. "Brl1p - a novel nuclear envelope protein required for nuclear transport."
      Saitoh Y.-H., Ogawa K., Nishimoto T.
      Traffic 6:502-517(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BRR6.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBRL1_YEAST
    AccessioniPrimary (citable) accession number: P38770
    Secondary accession number(s): D3DKY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1280 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3