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P38770 (BRL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleus export protein BRL1
Alternative name(s):
BRR6-like protein 1
Gene names
Name:BRL1
Ordered Locus Names:YHR036W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mRNA and protein export from nucleus. Ref.4

Subunit structure

Interacts with BRR6. Ref.4

Subcellular location

Nucleus membrane; Multi-pass membrane protein Ref.4.

Miscellaneous

Present with 1280 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the BRL1/BRR6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Nucleus export protein BRL1
PRO_0000202892

Regions

Topological domain1 – 299299Cytoplasmic Potential
Transmembrane300 – 32021Helical; Potential
Topological domain321 – 40787Perinuclear space Potential
Transmembrane408 – 42821Helical; Potential
Topological domain429 – 47143Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38770 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 732209EC74DE3463

FASTA47153,385
        10         20         30         40         50         60 
MESFENLSIR DSFTSGMEHV DEELGGLSDL SISKQGPTLS PQLINRFMPH FPSSPSPLRN 

        70         80         90        100        110        120 
TLDFSAAKAD EEEDDRMEID EVDDTSFEEE YNNEPIETHT EATENAVVEE IEATPEERQK 

       130        140        150        160        170        180 
QEKNESQDQS VEEVENIVSP HRSTVIKALL SPTDLGVAAA TKVEGVVPLP PSANQDDNES 

       190        200        210        220        230        240 
SNNNAEGEDI IRNEEVEDEI KSSLGNHKSS QYANAFDSEI IKRELRSRSK YQPIQVSFNT 

       250        260        270        280        290        300 
HNYFYSDKDG IKTYSLTKPN HNKIDEFYDQ NEAFKLPKPW SPNSHPASRA SYALMSYLQL 

       310        320        330        340        350        360 
FLNAITTVVI FSFILSFIIA LQKDLKSTWE QRKHELQYES RICQEQYLTN RCNQTPGLPA 

       370        380        390        400        410        420 
LGEQCAIWKQ CMDRNNDIFF RARSTLSAKL FGDIINSFID PLNWKTLFVI FCGVITWCFS 

       430        440        450        460        470 
SNFLLGFVRA KSYYGNGIKT YPLPSSPKSP TSEETHSSMT ASGEDSHLLK Q 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Brl1p - a novel nuclear envelope protein required for nuclear transport."
Saitoh Y.-H., Ogawa K., Nishimoto T.
Traffic 6:502-517(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BRR6.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00062 Genomic DNA. Translation: AAB68908.1.
BK006934 Genomic DNA. Translation: DAA06727.1.
PIRS46739.
RefSeqNP_011901.1. NM_001179166.1.

3D structure databases

ProteinModelPortalP38770.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36467. 13 interactions.
DIPDIP-5580N.
IntActP38770. 12 interactions.
MINTMINT-526264.
STRING4932.YHR036W.

Proteomic databases

PaxDbP38770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR036W; YHR036W; YHR036W.
GeneID856431.
KEGGsce:YHR036W.

Organism-specific databases

CYGDYHR036w.
SGDS000001078. BRL1.

Phylogenomic databases

eggNOGCOG5085.
HOGENOMHOG000095263.
OMATHTEATE.
OrthoDBEOG7RRFK5.

Enzyme and pathway databases

BioCycYEAST:G3O-31096-MONOMER.

Gene expression databases

GenevestigatorP38770.

Family and domain databases

InterProIPR018767. Brl1/Brr6_dom.
[Graphical view]
PfamPF10104. Brr6_like_C_C. 1 hit.
[Graphical view]
SMARTSM01042. Brr6_like_C_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982021.

Entry information

Entry nameBRL1_YEAST
AccessionPrimary (citable) accession number: P38770
Secondary accession number(s): D3DKY3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families