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Protein

Nucleus export protein BRL1

Gene

BRL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mRNA and protein export from nucleus.1 Publication

GO - Biological processi

  1. mRNA export from nucleus Source: SGD
  2. nuclear envelope organization Source: SGD
  3. protein export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus export protein BRL1
Alternative name(s):
BRR6-like protein 1
Gene namesi
Name:BRL1
Ordered Locus Names:YHR036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR036w.
SGDiS000001078. BRL1.

Subcellular locationi

Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 299299CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST
Topological domaini321 – 40787Perinuclear spaceSequence AnalysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence AnalysisAdd
BLAST
Topological domaini429 – 47143CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear envelope Source: SGD
  4. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Nucleus export protein BRL1PRO_0000202892Add
BLAST

Proteomic databases

MaxQBiP38770.
PaxDbiP38770.

Expressioni

Gene expression databases

GenevestigatoriP38770.

Interactioni

Subunit structurei

Interacts with BRR6.1 Publication

Protein-protein interaction databases

BioGridi36467. 13 interactions.
DIPiDIP-5580N.
IntActiP38770. 12 interactions.
MINTiMINT-526264.
STRINGi4932.YHR036W.

Structurei

3D structure databases

ProteinModelPortaliP38770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BRL1/BRR6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5085.
HOGENOMiHOG000095263.
InParanoidiP38770.
OMAiTHTEATE.
OrthoDBiEOG7RRFK5.

Family and domain databases

InterProiIPR018767. Brl1/Brr6_dom.
[Graphical view]
PfamiPF10104. Brr6_like_C_C. 1 hit.
[Graphical view]
SMARTiSM01042. Brr6_like_C_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFENLSIR DSFTSGMEHV DEELGGLSDL SISKQGPTLS PQLINRFMPH
60 70 80 90 100
FPSSPSPLRN TLDFSAAKAD EEEDDRMEID EVDDTSFEEE YNNEPIETHT
110 120 130 140 150
EATENAVVEE IEATPEERQK QEKNESQDQS VEEVENIVSP HRSTVIKALL
160 170 180 190 200
SPTDLGVAAA TKVEGVVPLP PSANQDDNES SNNNAEGEDI IRNEEVEDEI
210 220 230 240 250
KSSLGNHKSS QYANAFDSEI IKRELRSRSK YQPIQVSFNT HNYFYSDKDG
260 270 280 290 300
IKTYSLTKPN HNKIDEFYDQ NEAFKLPKPW SPNSHPASRA SYALMSYLQL
310 320 330 340 350
FLNAITTVVI FSFILSFIIA LQKDLKSTWE QRKHELQYES RICQEQYLTN
360 370 380 390 400
RCNQTPGLPA LGEQCAIWKQ CMDRNNDIFF RARSTLSAKL FGDIINSFID
410 420 430 440 450
PLNWKTLFVI FCGVITWCFS SNFLLGFVRA KSYYGNGIKT YPLPSSPKSP
460 470
TSEETHSSMT ASGEDSHLLK Q
Length:471
Mass (Da):53,385
Last modified:January 31, 1995 - v1
Checksum:i732209EC74DE3463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68908.1.
BK006934 Genomic DNA. Translation: DAA06727.1.
PIRiS46739.
RefSeqiNP_011901.1. NM_001179166.1.

Genome annotation databases

EnsemblFungiiYHR036W; YHR036W; YHR036W.
GeneIDi856431.
KEGGisce:YHR036W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68908.1.
BK006934 Genomic DNA. Translation: DAA06727.1.
PIRiS46739.
RefSeqiNP_011901.1. NM_001179166.1.

3D structure databases

ProteinModelPortaliP38770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36467. 13 interactions.
DIPiDIP-5580N.
IntActiP38770. 12 interactions.
MINTiMINT-526264.
STRINGi4932.YHR036W.

Proteomic databases

MaxQBiP38770.
PaxDbiP38770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR036W; YHR036W; YHR036W.
GeneIDi856431.
KEGGisce:YHR036W.

Organism-specific databases

CYGDiYHR036w.
SGDiS000001078. BRL1.

Phylogenomic databases

eggNOGiCOG5085.
HOGENOMiHOG000095263.
InParanoidiP38770.
OMAiTHTEATE.
OrthoDBiEOG7RRFK5.

Enzyme and pathway databases

BioCyciYEAST:G3O-31096-MONOMER.

Miscellaneous databases

NextBioi982021.

Gene expression databases

GenevestigatoriP38770.

Family and domain databases

InterProiIPR018767. Brl1/Brr6_dom.
[Graphical view]
PfamiPF10104. Brr6_like_C_C. 1 hit.
[Graphical view]
SMARTiSM01042. Brr6_like_C_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Brl1p - a novel nuclear envelope protein required for nuclear transport."
    Saitoh Y.-H., Ogawa K., Nishimoto T.
    Traffic 6:502-517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BRR6.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBRL1_YEAST
AccessioniPrimary (citable) accession number: P38770
Secondary accession number(s): D3DKY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: January 31, 1995
Last modified: January 6, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.