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P38768

- PIH1_YEAST

UniProt

P38768 - PIH1_YEAST

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Protein

Protein interacting with Hsp90 1

Gene

PIH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.1 Publication

GO - Biological processi

  1. box C/D snoRNP assembly Source: SGD
  2. mRNA processing Source: UniProtKB-KW
  3. protein folding Source: SGD
  4. RNA splicing Source: UniProtKB-KW
  5. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein interacting with Hsp90 1
Alternative name(s):
Nucleolar protein 17
Gene namesi
Name:PIH1
Synonyms:NOP17
Ordered Locus Names:YHR034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR034c.
SGDiS000001076. PIH1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. R2TP complex Source: SGD
  4. small nucleolar ribonucleoprotein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein interacting with Hsp90 1PRO_0000058440Add
BLAST

Proteomic databases

MaxQBiP38768.
PaxDbiP38768.
PeptideAtlasiP38768.

Expressioni

Gene expression databases

GenevestigatoriP38768.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRM4Q124983EBI-24499,EBI-32462
RRP43P253592EBI-24499,EBI-1773
RVB1Q039406EBI-24499,EBI-30712
TAH1P256388EBI-24499,EBI-21956

Protein-protein interaction databases

BioGridi36465. 100 interactions.
DIPiDIP-807N.
IntActiP38768. 12 interactions.
MINTiMINT-424616.
STRINGi4932.YHR034C.

Structurei

Secondary structure

1
344
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 324Combined sources
Beta strandi35 – 4713Combined sources
Beta strandi49 – 513Combined sources
Beta strandi58 – 669Combined sources
Helixi78 – 869Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi109 – 11810Combined sources
Helixi119 – 1279Combined sources
Helixi129 – 14719Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi160 – 1623Combined sources
Beta strandi164 – 1674Combined sources
Beta strandi171 – 1744Combined sources
Helixi175 – 1773Combined sources
Helixi180 – 1823Combined sources
Beta strandi267 – 2737Combined sources
Beta strandi275 – 2784Combined sources
Beta strandi280 – 2878Combined sources
Beta strandi300 – 3023Combined sources
Turni303 – 3064Combined sources
Beta strandi307 – 3093Combined sources
Beta strandi311 – 3133Combined sources
Beta strandi315 – 3173Combined sources
Turni326 – 3283Combined sources
Beta strandi330 – 3345Combined sources
Turni335 – 3384Combined sources
Beta strandi339 – 3446Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CGUX-ray2.11B187-344[»]
4CHHX-ray2.03A/B1-185[»]
ProteinModelPortaliP38768.
SMRiP38768. Positions 28-185, 264-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

eggNOGiNOG295745.
HOGENOMiHOG000094562.
InParanoidiP38768.
OMAiRSILIEW.
OrthoDBiEOG7QC867.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38768-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP
60 70 80 90 100
EKLQDGRKVF INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR
110 120 130 140 150
MDHDKKGQEC YVWDCCINSD CSRWICDDIQ LREILVEWCL ESCEIRDSVV
160 170 180 190 200
LCRDRIAFPK MKKKGAELPA LEVLNDELHQ DYKAKMHKII EEEAGDPMSI
210 220 230 240 250
LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN EIAHRNLKQA
260 270 280 290 300
PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS
310 320 330 340
YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI
Length:344
Mass (Da):39,519
Last modified:February 1, 1995 - v1
Checksum:i02C06D0A113B1B3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1.
BK006934 Genomic DNA. Translation: DAA06725.1.
PIRiS46745.
RefSeqiNP_011899.1. NM_001179164.1.

Genome annotation databases

EnsemblFungiiYHR034C; YHR034C; YHR034C.
GeneIDi856429.
KEGGisce:YHR034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1 .
BK006934 Genomic DNA. Translation: DAA06725.1 .
PIRi S46745.
RefSeqi NP_011899.1. NM_001179164.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CGU X-ray 2.11 B 187-344 [» ]
4CHH X-ray 2.03 A/B 1-185 [» ]
ProteinModelPortali P38768.
SMRi P38768. Positions 28-185, 264-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36465. 100 interactions.
DIPi DIP-807N.
IntActi P38768. 12 interactions.
MINTi MINT-424616.
STRINGi 4932.YHR034C.

Proteomic databases

MaxQBi P38768.
PaxDbi P38768.
PeptideAtlasi P38768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR034C ; YHR034C ; YHR034C .
GeneIDi 856429.
KEGGi sce:YHR034C.

Organism-specific databases

CYGDi YHR034c.
SGDi S000001076. PIH1.

Phylogenomic databases

eggNOGi NOG295745.
HOGENOMi HOG000094562.
InParanoidi P38768.
OMAi RSILIEW.
OrthoDBi EOG7QC867.

Enzyme and pathway databases

BioCyci YEAST:G3O-31094-MONOMER.

Miscellaneous databases

NextBioi 982015.

Gene expression databases

Genevestigatori P38768.

Family and domain databases

InterProi IPR012981. PIH1.
[Graphical view ]
PANTHERi PTHR22997. PTHR22997. 1 hit.
Pfami PF08190. PIH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
    Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
    Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae."
    Granato D.C., Gonzales F.A., Luz J.S., Cassiola F., Machado-Santelli G.M., Oliveira C.C.
    FEBS J. 272:4450-4463(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOP53.
  7. "Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in pre-rRNA processing."
    Gonzales F.A., Zanchin N.I., Luz J.S., Oliveira C.C.
    J. Mol. Biol. 346:437-455(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RRP43 AND NOP58.

Entry informationi

Entry nameiPIH1_YEAST
AccessioniPrimary (citable) accession number: P38768
Secondary accession number(s): D3DKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3