Protein interacting with Hsp90 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38768 (PIH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein interacting with Hsp90 1

Alternative name(s):
Nucleolar protein 17

Gene names

Name:	PIH1
Synonyms:	NOP17
Ordered Locus Names:	YHR034C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction. Ref.7
Subunit structure	Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58. Ref.5 Ref.6 Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.3 Ref.7.
Miscellaneous	Present with 2610 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the PIH1 family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW box C/D snoRNP assembly Inferred from mutant phenotype PubMed 18268103. Source: SGD mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from mutant phenotype Ref.5. Source: SGD rRNA processing Inferred from genetic interaction Ref.7. Source: SGD regulation of cell size Inferred from mutant phenotype PubMed 12089449. Source: SGD
Cellular_component	R2TP complex Inferred from direct assay Ref.5. Source: SGD cytoplasm Inferred from direct assay Ref.3. Source: SGD nucleus Inferred from direct assay Ref.3. Source: SGD small nucleolar ribonucleoprotein complex Inferred from physical interaction Ref.7. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
HSP82	P02829	2	EBI-24499,EBI-8659
PRM4	Q12498	3	EBI-24499,EBI-32462
RRP43	P25359	2	EBI-24499,EBI-1773
RVB1	Q03940	6	EBI-24499,EBI-30712
TAH1	P25638	8	EBI-24499,EBI-21956

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 344

344

Protein interacting with Hsp90 1

PRO_0000058440

Sequences

Sequence

Length

Mass (Da)

Tools

P38768 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 02C06D0A113B1B3B
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FASTA

344

39,519

        10         20         30         40         50         60 
MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP EKLQDGRKVF 

        70         80         90        100        110        120 
INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR MDHDKKGQEC YVWDCCINSD 

       130        140        150        160        170        180 
CSRWICDDIQ LREILVEWCL ESCEIRDSVV LCRDRIAFPK MKKKGAELPA LEVLNDELHQ 

       190        200        210        220        230        240 
DYKAKMHKII EEEAGDPMSI LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN 

       250        260        270        280        290        300 
EIAHRNLKQA PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS 

       310        320        330        340 
YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A. Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, MASS SPECTROMETRY.
[6]	"Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae." Granato D.C., Gonzales F.A., Luz J.S., Cassiola F., Machado-Santelli G.M., Oliveira C.C. FEBS J. 272:4450-4463(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NOP53.
[7]	"Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in pre-rRNA processing." Gonzales F.A., Zanchin N.I., Luz J.S., Oliveira C.C. J. Mol. Biol. 346:437-455(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RRP43 AND NOP58.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00062 Genomic DNA. Translation: AAB68914.1. BK006934 Genomic DNA. Translation: DAA06725.1.
PIR	S46745.
RefSeq	NP_011899.1. NM_001179164.1.
3D structure databases
ProteinModelPortal	P38768.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-807N.
IntAct	P38768. 11 interactions.
MINT	MINT-424616.
STRING	4932.YHR034C.
Proteomic databases
PaxDb	P38768.
PeptideAtlas	P38768.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR034C; YHR034C; YHR034C.
GeneID	856429.
KEGG	sce:YHR034C.
Organism-specific databases
CYGD	YHR034c.
SGD	S000001076. PIH1.
Phylogenomic databases
eggNOG	NOG295745.
HOGENOM	HOG000094562.
OMA	RSILIEW.
OrthoDB	EOG49W5QT.
Gene expression databases
Genevestigator	P38768.
GermOnline	YHR034C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012981. PIH. [Graphical view]
PANTHER	PTHR22997. PTHR22997. 1 hit.
Pfam	PF08190. PIH1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982015.

Entry information

Entry name

PIH1_YEAST

Accession

Primary (citable) accession number: P38768
Secondary accession number(s): D3DKY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents