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P38768 (PIH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein interacting with Hsp90 1
Alternative name(s):
Nucleolar protein 17
Gene names
Name:PIH1
Synonyms:NOP17
Ordered Locus Names:YHR034C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction. Ref.7

Subunit structure

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58. Ref.5 Ref.6 Ref.7

Subcellular location

Cytoplasm. Nucleus Ref.3 Ref.7.

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PIH1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Protein interacting with Hsp90 1
PRO_0000058440

Sequences

Sequence LengthMass (Da)Tools
P38768 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 02C06D0A113B1B3B

FASTA34439,519
        10         20         30         40         50         60 
MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP EKLQDGRKVF 

        70         80         90        100        110        120 
INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR MDHDKKGQEC YVWDCCINSD 

       130        140        150        160        170        180 
CSRWICDDIQ LREILVEWCL ESCEIRDSVV LCRDRIAFPK MKKKGAELPA LEVLNDELHQ 

       190        200        210        220        230        240 
DYKAKMHKII EEEAGDPMSI LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN 

       250        260        270        280        290        300 
EIAHRNLKQA PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS 

       310        320        330        340 
YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae."
Granato D.C., Gonzales F.A., Luz J.S., Cassiola F., Machado-Santelli G.M., Oliveira C.C.
FEBS J. 272:4450-4463(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NOP53.
[7]"Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in pre-rRNA processing."
Gonzales F.A., Zanchin N.I., Luz J.S., Oliveira C.C.
J. Mol. Biol. 346:437-455(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RRP43 AND NOP58.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00062 Genomic DNA. Translation: AAB68914.1.
BK006934 Genomic DNA. Translation: DAA06725.1.
PIRS46745.
RefSeqNP_011899.1. NM_001179164.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4CGUX-ray2.11B187-344[»]
4CHHX-ray2.03A/B1-185[»]
ProteinModelPortalP38768.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36465. 99 interactions.
DIPDIP-807N.
IntActP38768. 12 interactions.
MINTMINT-424616.
STRING4932.YHR034C.

Proteomic databases

MaxQBP38768.
PaxDbP38768.
PeptideAtlasP38768.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR034C; YHR034C; YHR034C.
GeneID856429.
KEGGsce:YHR034C.

Organism-specific databases

CYGDYHR034c.
SGDS000001076. PIH1.

Phylogenomic databases

eggNOGNOG295745.
HOGENOMHOG000094562.
OMARSILIEW.
OrthoDBEOG7QC867.

Enzyme and pathway databases

BioCycYEAST:G3O-31094-MONOMER.

Gene expression databases

GenevestigatorP38768.

Family and domain databases

InterProIPR012981. PIH1.
[Graphical view]
PANTHERPTHR22997. PTHR22997. 1 hit.
PfamPF08190. PIH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982015.

Entry information

Entry namePIH1_YEAST
AccessionPrimary (citable) accession number: P38768
Secondary accession number(s): D3DKY1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references