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P38768

- PIH1_YEAST

UniProt

P38768 - PIH1_YEAST

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Protein
Protein interacting with Hsp90 1
Gene
PIH1, NOP17, YHR034C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. box C/D snoRNP assembly Source: SGD
  3. mRNA processing Source: UniProtKB-KW
  4. protein folding Source: SGD
  5. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein interacting with Hsp90 1
Alternative name(s):
Nucleolar protein 17
Gene namesi
Name:PIH1
Synonyms:NOP17
Ordered Locus Names:YHR034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR034c.
SGDiS000001076. PIH1.

Subcellular locationi

Cytoplasm. Nucleus 2 Publications

GO - Cellular componenti

  1. R2TP complex Source: SGD
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
  4. small nucleolar ribonucleoprotein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein interacting with Hsp90 1
PRO_0000058440Add
BLAST

Proteomic databases

MaxQBiP38768.
PaxDbiP38768.
PeptideAtlasiP38768.

Expressioni

Gene expression databases

GenevestigatoriP38768.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028292EBI-24499,EBI-8659
PRM4Q124983EBI-24499,EBI-32462
RRP43P253592EBI-24499,EBI-1773
RVB1Q039406EBI-24499,EBI-30712
TAH1P256388EBI-24499,EBI-21956

Protein-protein interaction databases

BioGridi36465. 99 interactions.
DIPiDIP-807N.
IntActiP38768. 12 interactions.
MINTiMINT-424616.
STRINGi4932.YHR034C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 324
Beta strandi35 – 4713
Beta strandi49 – 513
Beta strandi58 – 669
Helixi78 – 869
Beta strandi100 – 1034
Beta strandi109 – 11810
Helixi119 – 1279
Helixi129 – 14719
Beta strandi149 – 1513
Beta strandi153 – 1553
Beta strandi160 – 1623
Beta strandi164 – 1674
Beta strandi171 – 1744
Helixi175 – 1773
Helixi180 – 1823
Beta strandi267 – 2737
Beta strandi275 – 2784
Beta strandi280 – 2878
Beta strandi300 – 3023
Turni303 – 3064
Beta strandi307 – 3093
Beta strandi311 – 3133
Beta strandi315 – 3173
Turni326 – 3283
Beta strandi330 – 3345
Turni335 – 3384
Beta strandi339 – 3446

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CGUX-ray2.11B187-344[»]
4CHHX-ray2.03A/B1-185[»]
ProteinModelPortaliP38768.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family.

Phylogenomic databases

eggNOGiNOG295745.
HOGENOMiHOG000094562.
OMAiRSILIEW.
OrthoDBiEOG7QC867.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38768-1 [UniParc]FASTAAdd to Basket

« Hide

MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP    50
EKLQDGRKVF INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR 100
MDHDKKGQEC YVWDCCINSD CSRWICDDIQ LREILVEWCL ESCEIRDSVV 150
LCRDRIAFPK MKKKGAELPA LEVLNDELHQ DYKAKMHKII EEEAGDPMSI 200
LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN EIAHRNLKQA 250
PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS 300
YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI 344
Length:344
Mass (Da):39,519
Last modified:February 1, 1995 - v1
Checksum:i02C06D0A113B1B3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1.
BK006934 Genomic DNA. Translation: DAA06725.1.
PIRiS46745.
RefSeqiNP_011899.1. NM_001179164.1.

Genome annotation databases

EnsemblFungiiYHR034C; YHR034C; YHR034C.
GeneIDi856429.
KEGGisce:YHR034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1 .
BK006934 Genomic DNA. Translation: DAA06725.1 .
PIRi S46745.
RefSeqi NP_011899.1. NM_001179164.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CGU X-ray 2.11 B 187-344 [» ]
4CHH X-ray 2.03 A/B 1-185 [» ]
ProteinModelPortali P38768.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36465. 99 interactions.
DIPi DIP-807N.
IntActi P38768. 12 interactions.
MINTi MINT-424616.
STRINGi 4932.YHR034C.

Proteomic databases

MaxQBi P38768.
PaxDbi P38768.
PeptideAtlasi P38768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR034C ; YHR034C ; YHR034C .
GeneIDi 856429.
KEGGi sce:YHR034C.

Organism-specific databases

CYGDi YHR034c.
SGDi S000001076. PIH1.

Phylogenomic databases

eggNOGi NOG295745.
HOGENOMi HOG000094562.
OMAi RSILIEW.
OrthoDBi EOG7QC867.

Enzyme and pathway databases

BioCyci YEAST:G3O-31094-MONOMER.

Miscellaneous databases

NextBioi 982015.

Gene expression databases

Genevestigatori P38768.

Family and domain databases

InterProi IPR012981. PIH1.
[Graphical view ]
PANTHERi PTHR22997. PTHR22997. 1 hit.
Pfami PF08190. PIH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
    Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
    Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae."
    Granato D.C., Gonzales F.A., Luz J.S., Cassiola F., Machado-Santelli G.M., Oliveira C.C.
    FEBS J. 272:4450-4463(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOP53.
  7. "Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in pre-rRNA processing."
    Gonzales F.A., Zanchin N.I., Luz J.S., Oliveira C.C.
    J. Mol. Biol. 346:437-455(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RRP43 AND NOP58.

Entry informationi

Entry nameiPIH1_YEAST
AccessioniPrimary (citable) accession number: P38768
Secondary accession number(s): D3DKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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