Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38768

- PIH1_YEAST

UniProt

P38768 - PIH1_YEAST

Protein

Protein interacting with Hsp90 1

Gene

PIH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. box C/D snoRNP assembly Source: SGD
    2. mRNA processing Source: UniProtKB-KW
    3. protein folding Source: SGD
    4. RNA splicing Source: UniProtKB-KW
    5. rRNA processing Source: SGD

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31094-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein interacting with Hsp90 1
    Alternative name(s):
    Nucleolar protein 17
    Gene namesi
    Name:PIH1
    Synonyms:NOP17
    Ordered Locus Names:YHR034C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR034c.
    SGDiS000001076. PIH1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. R2TP complex Source: SGD
    4. small nucleolar ribonucleoprotein complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Protein interacting with Hsp90 1PRO_0000058440Add
    BLAST

    Proteomic databases

    MaxQBiP38768.
    PaxDbiP38768.
    PeptideAtlasiP38768.

    Expressioni

    Gene expression databases

    GenevestigatoriP38768.

    Interactioni

    Subunit structurei

    Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP82P028292EBI-24499,EBI-8659
    PRM4Q124983EBI-24499,EBI-32462
    RRP43P253592EBI-24499,EBI-1773
    RVB1Q039406EBI-24499,EBI-30712
    TAH1P256388EBI-24499,EBI-21956

    Protein-protein interaction databases

    BioGridi36465. 99 interactions.
    DIPiDIP-807N.
    IntActiP38768. 12 interactions.
    MINTiMINT-424616.
    STRINGi4932.YHR034C.

    Structurei

    Secondary structure

    1
    344
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 324
    Beta strandi35 – 4713
    Beta strandi49 – 513
    Beta strandi58 – 669
    Helixi78 – 869
    Beta strandi100 – 1034
    Beta strandi109 – 11810
    Helixi119 – 1279
    Helixi129 – 14719
    Beta strandi149 – 1513
    Beta strandi153 – 1553
    Beta strandi160 – 1623
    Beta strandi164 – 1674
    Beta strandi171 – 1744
    Helixi175 – 1773
    Helixi180 – 1823
    Beta strandi267 – 2737
    Beta strandi275 – 2784
    Beta strandi280 – 2878
    Beta strandi300 – 3023
    Turni303 – 3064
    Beta strandi307 – 3093
    Beta strandi311 – 3133
    Beta strandi315 – 3173
    Turni326 – 3283
    Beta strandi330 – 3345
    Turni335 – 3384
    Beta strandi339 – 3446

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CGUX-ray2.11B187-344[»]
    4CHHX-ray2.03A/B1-185[»]
    ProteinModelPortaliP38768.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIH1 family.Curated

    Phylogenomic databases

    eggNOGiNOG295745.
    HOGENOMiHOG000094562.
    OMAiRSILIEW.
    OrthoDBiEOG7QC867.

    Family and domain databases

    InterProiIPR012981. PIH1.
    [Graphical view]
    PANTHERiPTHR22997. PTHR22997. 1 hit.
    PfamiPF08190. PIH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38768-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP    50
    EKLQDGRKVF INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR 100
    MDHDKKGQEC YVWDCCINSD CSRWICDDIQ LREILVEWCL ESCEIRDSVV 150
    LCRDRIAFPK MKKKGAELPA LEVLNDELHQ DYKAKMHKII EEEAGDPMSI 200
    LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN EIAHRNLKQA 250
    PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS 300
    YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI 344
    Length:344
    Mass (Da):39,519
    Last modified:February 1, 1995 - v1
    Checksum:i02C06D0A113B1B3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68914.1.
    BK006934 Genomic DNA. Translation: DAA06725.1.
    PIRiS46745.
    RefSeqiNP_011899.1. NM_001179164.1.

    Genome annotation databases

    EnsemblFungiiYHR034C; YHR034C; YHR034C.
    GeneIDi856429.
    KEGGisce:YHR034C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68914.1 .
    BK006934 Genomic DNA. Translation: DAA06725.1 .
    PIRi S46745.
    RefSeqi NP_011899.1. NM_001179164.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CGU X-ray 2.11 B 187-344 [» ]
    4CHH X-ray 2.03 A/B 1-185 [» ]
    ProteinModelPortali P38768.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36465. 99 interactions.
    DIPi DIP-807N.
    IntActi P38768. 12 interactions.
    MINTi MINT-424616.
    STRINGi 4932.YHR034C.

    Proteomic databases

    MaxQBi P38768.
    PaxDbi P38768.
    PeptideAtlasi P38768.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR034C ; YHR034C ; YHR034C .
    GeneIDi 856429.
    KEGGi sce:YHR034C.

    Organism-specific databases

    CYGDi YHR034c.
    SGDi S000001076. PIH1.

    Phylogenomic databases

    eggNOGi NOG295745.
    HOGENOMi HOG000094562.
    OMAi RSILIEW.
    OrthoDBi EOG7QC867.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31094-MONOMER.

    Miscellaneous databases

    NextBioi 982015.

    Gene expression databases

    Genevestigatori P38768.

    Family and domain databases

    InterProi IPR012981. PIH1.
    [Graphical view ]
    PANTHERi PTHR22997. PTHR22997. 1 hit.
    Pfami PF08190. PIH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
      Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
      Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae."
      Granato D.C., Gonzales F.A., Luz J.S., Cassiola F., Machado-Santelli G.M., Oliveira C.C.
      FEBS J. 272:4450-4463(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NOP53.
    7. "Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in pre-rRNA processing."
      Gonzales F.A., Zanchin N.I., Luz J.S., Oliveira C.C.
      J. Mol. Biol. 346:437-455(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RRP43 AND NOP58.

    Entry informationi

    Entry nameiPIH1_YEAST
    AccessioniPrimary (citable) accession number: P38768
    Secondary accession number(s): D3DKY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2610 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3