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Protein

Protein interacting with Hsp90 1

Gene

PIH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.1 Publication

GO - Biological processi

  • box C/D snoRNP assembly Source: SGD
  • mRNA processing Source: UniProtKB-KW
  • protein folding Source: SGD
  • RNA splicing Source: UniProtKB-KW
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein interacting with Hsp90 1
Alternative name(s):
Nucleolar protein 17
Gene namesi
Name:PIH1
Synonyms:NOP17
Ordered Locus Names:YHR034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR034C.
SGDiS000001076. PIH1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • R2TP complex Source: SGD
  • small nucleolar ribonucleoprotein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584401 – 344Protein interacting with Hsp90 1Add BLAST344

Proteomic databases

MaxQBiP38768.
PRIDEiP38768.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90, RRP43, NOP53 and NOP58.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRM4Q124983EBI-24499,EBI-32462
RRP43P253592EBI-24499,EBI-1773
RVB1Q0394010EBI-24499,EBI-30712
RVB2Q124647EBI-24499,EBI-31814
TAH1P2563811EBI-24499,EBI-21956

Protein-protein interaction databases

BioGridi36465. 101 interactors.
DIPiDIP-807N.
IntActiP38768. 16 interactors.
MINTiMINT-424616.

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Beta strandi35 – 47Combined sources13
Beta strandi49 – 51Combined sources3
Beta strandi58 – 66Combined sources9
Helixi78 – 86Combined sources9
Beta strandi100 – 103Combined sources4
Beta strandi109 – 118Combined sources10
Helixi119 – 127Combined sources9
Helixi129 – 147Combined sources19
Beta strandi149 – 151Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi160 – 162Combined sources3
Beta strandi164 – 167Combined sources4
Beta strandi171 – 174Combined sources4
Helixi175 – 177Combined sources3
Helixi180 – 182Combined sources3
Beta strandi262 – 264Combined sources3
Beta strandi267 – 273Combined sources7
Beta strandi275 – 278Combined sources4
Beta strandi280 – 287Combined sources8
Beta strandi289 – 291Combined sources3
Beta strandi300 – 302Combined sources3
Turni303 – 306Combined sources4
Beta strandi307 – 309Combined sources3
Beta strandi311 – 313Combined sources3
Beta strandi315 – 317Combined sources3
Turni326 – 328Combined sources3
Beta strandi330 – 334Combined sources5
Turni335 – 338Combined sources4
Beta strandi339 – 344Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MNJNMR-B257-344[»]
4CGUX-ray2.11B187-344[»]
4CHHX-ray2.03A/B1-185[»]
ProteinModelPortaliP38768.
SMRiP38768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

HOGENOMiHOG000094562.
InParanoidiP38768.
OMAiDNQWEIP.
OrthoDBiEOG092C3IMG.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFLLRPIK QRHRNEDKYV SVDAADGSVS KIEPIADFVI KTKLLSANGP
60 70 80 90 100
EKLQDGRKVF INVCHSPLVP KPEVDFNARI VFPLIIQNEW EIPIITSCYR
110 120 130 140 150
MDHDKKGQEC YVWDCCINSD CSRWICDDIQ LREILVEWCL ESCEIRDSVV
160 170 180 190 200
LCRDRIAFPK MKKKGAELPA LEVLNDELHQ DYKAKMHKII EEEAGDPMSI
210 220 230 240 250
LRGRNDDGDD NNDPDDGTLP PLFPIENKIS GAKIEEIDKN EIAHRNLKQA
260 270 280 290 300
PAPAPAPHEQ QEDVPEYEVK MKRFKGAAYK LRILIENKAP NSKPDRFSPS
310 320 330 340
YNFAENILYI NGKLSIPLPR DIVVNAADIK IFHIRKERTL YIYI
Length:344
Mass (Da):39,519
Last modified:February 1, 1995 - v1
Checksum:i02C06D0A113B1B3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1.
BK006934 Genomic DNA. Translation: DAA06725.1.
PIRiS46745.
RefSeqiNP_011899.1. NM_001179164.1.

Genome annotation databases

EnsemblFungiiYHR034C; YHR034C; YHR034C.
GeneIDi856429.
KEGGisce:YHR034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68914.1.
BK006934 Genomic DNA. Translation: DAA06725.1.
PIRiS46745.
RefSeqiNP_011899.1. NM_001179164.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MNJNMR-B257-344[»]
4CGUX-ray2.11B187-344[»]
4CHHX-ray2.03A/B1-185[»]
ProteinModelPortaliP38768.
SMRiP38768.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36465. 101 interactors.
DIPiDIP-807N.
IntActiP38768. 16 interactors.
MINTiMINT-424616.

Proteomic databases

MaxQBiP38768.
PRIDEiP38768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR034C; YHR034C; YHR034C.
GeneIDi856429.
KEGGisce:YHR034C.

Organism-specific databases

EuPathDBiFungiDB:YHR034C.
SGDiS000001076. PIH1.

Phylogenomic databases

HOGENOMiHOG000094562.
InParanoidiP38768.
OMAiDNQWEIP.
OrthoDBiEOG092C3IMG.

Enzyme and pathway databases

BioCyciYEAST:G3O-31094-MONOMER.

Miscellaneous databases

PROiP38768.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIH1_YEAST
AccessioniPrimary (citable) accession number: P38768
Secondary accession number(s): D3DKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.