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Protein

Ethionine resistance-conferring protein 1

Gene

ERC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter involved in ethionine resistance. Overproduction leads to accumulation of S-adenosylmethionine.2 Publications

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: GO_Central
  • S-adenosylmethionine biosynthetic process Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31092-MONOMER
ReactomeiR-SCE-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

TCDBi2.A.66.1.5 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Ethionine resistance-conferring protein 1
Gene namesi
Name:ERC1
Ordered Locus Names:YHR032W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR032W
SGDiS000001074 ERC1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 172ExtracellularSequence analysisAdd BLAST172
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 248CytoplasmicSequence analysisAdd BLAST55
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 281ExtracellularSequence analysisAdd BLAST12
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 345CytoplasmicSequence analysisAdd BLAST43
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 471ExtracellularSequence analysisAdd BLAST105
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 581CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001642561 – 581Ethionine resistance-conferring protein 1Add BLAST581

Proteomic databases

PaxDbiP38767

Interactioni

Protein-protein interaction databases

BioGridi36463, 48 interactors
DIPiDIP-1785N
IntActiP38767, 1 interactor
MINTiP38767
STRINGi4932.YHR032W

Structurei

3D structure databases

ProteinModelPortaliP38767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000015713
HOGENOMiHOG000177026
InParanoidiP38767
KOiK03327
OMAiVCVRVGT
OrthoDBiEOG092C45A3

Family and domain databases

InterProiView protein in InterPro
IPR002528 MATE_fam
PfamiView protein in Pfam
PF01554 MatE, 2 hits
TIGRFAMsiTIGR00797 matE, 1 hit

Sequencei

Sequence statusi: Complete.

P38767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQFSHTTN DRRSSIIYST SVGKAGLFTP ADYIPQESEE NLIEGEEQEG
60 70 80 90 100
SEEEPSYTGN DDETEREGEY HSLLDANNSR TLQQEAWQQG YDSHDRKRLL
110 120 130 140 150
DEERDLLIDN KLLSQHGNGG GDIESHGHGQ AIGPDEEERP AEIANTWESA
160 170 180 190 200
IESGQKISTT FKRETQVITM NALPLIFTFI LQNSLSLASI FSVSHLGTKE
210 220 230 240 250
LGGVTLGSMT ANITGLAAIQ GLCTCLDTLC AQAYGAKNYH LVGVLVQRCA
260 270 280 290 300
VITILAFLPM MYVWFVWSEK ILALMIPERE LCALAANYLR VTAFGVPGFI
310 320 330 340 350
LFECGKRFLQ CQGIFHASTI VLFVCAPLNA LMNYLLVWND KIGIGYLGAP
360 370 380 390 400
LSVVINYWLM TLGLLIYAMT TKHKERPLKC WNGIIPKEQA FKNWRKMINL
410 420 430 440 450
AIPGVVMVEA EFLGFEVLTI FASHLGTDAL GAQSIVATIA SLAYQVPFSI
460 470 480 490 500
SVSTSTRVAN FIGASLYDSC MITCRVSLLL SFVCSSMNMF VICRYKEQIA
510 520 530 540 550
SLFSTESAVV KMVVDTLPLL AFMQLFDAFN ASTAGCLRGQ GRQKNRWVHQ
560 570 580
PSRILLPRCA HGICVSIPVS SGCRRLMVGY N
Length:581
Mass (Da):64,209
Last modified:February 1, 1995 - v1
Checksum:iB0592C480589319B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA Translation: AAB68911.1
BK006934 Genomic DNA Translation: DAA06723.1
PIRiS46742
RefSeqiNP_011897.1, NM_001179162.1

Genome annotation databases

EnsemblFungiiYHR032W; YHR032W; YHR032W
GeneIDi856427
KEGGisce:YHR032W

Similar proteinsi

Entry informationi

Entry nameiERC1_YEAST
AccessioniPrimary (citable) accession number: P38767
Secondary accession number(s): D3DKX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health