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Protein

Ethionine resistance-conferring protein 1

Gene

ERC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter involved in ethionine resistance. Overproduction leads to accumulation of S-adenosylmethionine.2 Publications

GO - Molecular functioni

GO - Biological processi

  • S-adenosylmethionine biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31092-MONOMER.
ReactomeiR-SCE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.66.1.5. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethionine resistance-conferring protein 1
Gene namesi
Name:ERC1
Ordered Locus Names:YHR032W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR032W.
SGDiS000001074. ERC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 172172ExtracellularSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Topological domaini194 – 24855CytoplasmicSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 28112ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 34543CytoplasmicSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Topological domaini367 – 471105ExtracellularSequence analysisAdd
BLAST
Transmembranei472 – 49221HelicalSequence analysisAdd
BLAST
Topological domaini493 – 58189CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Ethionine resistance-conferring protein 1PRO_0000164256Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi36463. 11 interactions.
DIPiDIP-1785N.
IntActiP38767. 1 interaction.
MINTiMINT-395733.

Structurei

3D structure databases

ProteinModelPortaliP38767.
SMRiP38767. Positions 161-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000015713.
HOGENOMiHOG000177026.
InParanoidiP38767.
KOiK03327.
OMAiIANTWES.
OrthoDBiEOG75TMMN.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

P38767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQFSHTTN DRRSSIIYST SVGKAGLFTP ADYIPQESEE NLIEGEEQEG
60 70 80 90 100
SEEEPSYTGN DDETEREGEY HSLLDANNSR TLQQEAWQQG YDSHDRKRLL
110 120 130 140 150
DEERDLLIDN KLLSQHGNGG GDIESHGHGQ AIGPDEEERP AEIANTWESA
160 170 180 190 200
IESGQKISTT FKRETQVITM NALPLIFTFI LQNSLSLASI FSVSHLGTKE
210 220 230 240 250
LGGVTLGSMT ANITGLAAIQ GLCTCLDTLC AQAYGAKNYH LVGVLVQRCA
260 270 280 290 300
VITILAFLPM MYVWFVWSEK ILALMIPERE LCALAANYLR VTAFGVPGFI
310 320 330 340 350
LFECGKRFLQ CQGIFHASTI VLFVCAPLNA LMNYLLVWND KIGIGYLGAP
360 370 380 390 400
LSVVINYWLM TLGLLIYAMT TKHKERPLKC WNGIIPKEQA FKNWRKMINL
410 420 430 440 450
AIPGVVMVEA EFLGFEVLTI FASHLGTDAL GAQSIVATIA SLAYQVPFSI
460 470 480 490 500
SVSTSTRVAN FIGASLYDSC MITCRVSLLL SFVCSSMNMF VICRYKEQIA
510 520 530 540 550
SLFSTESAVV KMVVDTLPLL AFMQLFDAFN ASTAGCLRGQ GRQKNRWVHQ
560 570 580
PSRILLPRCA HGICVSIPVS SGCRRLMVGY N
Length:581
Mass (Da):64,209
Last modified:February 1, 1995 - v1
Checksum:iB0592C480589319B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68911.1.
BK006934 Genomic DNA. Translation: DAA06723.1.
PIRiS46742.
RefSeqiNP_011897.1. NM_001179162.1.

Genome annotation databases

EnsemblFungiiYHR032W; YHR032W; YHR032W.
GeneIDi856427.
KEGGisce:YHR032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68911.1.
BK006934 Genomic DNA. Translation: DAA06723.1.
PIRiS46742.
RefSeqiNP_011897.1. NM_001179162.1.

3D structure databases

ProteinModelPortaliP38767.
SMRiP38767. Positions 161-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36463. 11 interactions.
DIPiDIP-1785N.
IntActiP38767. 1 interaction.
MINTiMINT-395733.

Protein family/group databases

TCDBi2.A.66.1.5. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR032W; YHR032W; YHR032W.
GeneIDi856427.
KEGGisce:YHR032W.

Organism-specific databases

EuPathDBiFungiDB:YHR032W.
SGDiS000001074. ERC1.

Phylogenomic databases

GeneTreeiENSGT00390000015713.
HOGENOMiHOG000177026.
InParanoidiP38767.
KOiK03327.
OMAiIANTWES.
OrthoDBiEOG75TMMN.

Enzyme and pathway databases

BioCyciYEAST:G3O-31092-MONOMER.
ReactomeiR-SCE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

PROiP38767.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Production of S-adenosyl-L-methionine by Saccharomyces cerevisiae cells carrying a gene for ethionine resistance."
    Shiomi N., Fukuda H., Fukuda Y., Murata K., Kimura A.
    Biotechnol. Bioeng. 35:1120-1124(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Improvement of S-adenosylmethionine production by integration of the ethionine-resistance gene into chromosomes of the yeast Saccharomyces cerevisiae."
    Shiomi N., Fukuda H., Murata K., Kimura A.
    Appl. Microbiol. Biotechnol. 42:730-733(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiERC1_YEAST
AccessioniPrimary (citable) accession number: P38767
Secondary accession number(s): D3DKX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.