P38760 (MIP6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding protein MIP6

Alternative name(s):
MEX67-interacting protein 6

Gene names

Name:	MIP6
Ordered Locus Names:	YHR015W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	659 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with MEX67. Ref.3
Subcellular location	Cytoplasm Ref.4.
Miscellaneous	Present with 98 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mRNA export from nucleus Inferred from physical interaction Ref.3. Source: SGD
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from physical interaction Ref.3. Source: SGD
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 659	659	RNA-binding protein MIP6		PRO_0000082032
Regions
	Domain	111 – 189	79	RRM 1
	Domain	199 – 267	69	RRM 2
	Domain	313 – 389	77	RRM 3

Sequences

	Sequence		Length	Mass (Da)
	P38760 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: DF8E3F4D12A63871	FASTA	659	75,920
	10 20 30 40 50 60 MPNSHGNVLN NISLNSKQNP RSISKSCPND KDARQKSFKT ISAQALVRVQ GAGYKLGDVK 70 80 90 100 110 120 LKDAEVKEKN SLKKYDCKNA TQEKKEQEQV FEKTVAKGSV QKYITKTSKT NSLFIGNLKS 130 140 150 160 170 180 TVTEEMLRKI FKRYQSFESA KVCRDFLTKK SLGYGYLNFK DKNDAESARK EFNYTVFFGQ 190 200 210 220 230 240 EVKIMPSMKN TLFRKNIGTN VFFSNLPLEN PQLTTRSFYL IMIEYGNVLS CLLERRKNIG 250 260 270 280 290 300 FVYFDNDISA RNVIKKYNNQ EFFGNKIICG LHFDKEVRTR PEFTKRKKMI GSDIVIEDEL 310 320 330 340 350 360 LASNNLSDNA RSKTILVKNL PSDTTQEEVL DYFSTIGPIK SVFISEKQAN TPHKAFVTYK 370 380 390 400 410 420 NEEESKKAQK CLNKTIFKNH TIWVGPGKDK PVHNQIGTNK KTKVYLKNLS FNCNKEFISQ 430 440 450 460 470 480 LCLQEKIRFS EIKITNYNSL NWTFCGHVEC FSRSDAERLF NILDRRLIGS SLVEASWSKN 490 500 510 520 530 540 NDNILNEIDY DDGNNNENYK KLINISSMMR FRTQELSAHQ KGLTSQFQQV VSPFSSYSNS 550 560 570 580 590 600 YTNMNSLVAT PMKPHPAFNL ITNTVDEKLH QPKRTKQENA EILESLKKII NRNLQRISIS 610 620 630 640 650 GLNKEENLRS ISEFIFDVFW EHDSERLSHF LLMTNTSLES QKILQKQVTR AAESLGFTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores." Segref A., Sharma K., Doye V., Hellwig A., Huber J., Luehrmann R., Hurt E. EMBO J. 16:3256-3271(1997) [PubMed: 9214641] [Abstract] Cited for: INTERACTION WITH MEX67.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10400 Genomic DNA. Translation: AAB68942.1. BK006934 Genomic DNA. Translation: DAA06704.1.
PIR	S46788.
RefSeq	NP_011879.1. NM_001179145.1.
3D structure databases
ProteinModelPortal	P38760.
SMR	P38760. Positions 108-191, 197-271, 312-390.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6647N.
IntAct	P38760. 2 interactions.
MINT	MINT-644353.
STRING	P38760.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR015W; YHR015W; YHR015W.
GeneID	856408.
KEGG	sce:YHR015W.
NMPDR	fig|4932.3.peg.3024.
Organism-specific databases
CYGD	YHR015w.
SGD	S000001057. MIP6.
Phylogenomic databases
eggNOG	fuNOG04633.
GeneTree	EFGT00050000000240.
HOGENOM	HBG203847.
OrthoDB	EOG45HW68.
Gene expression databases
ArrayExpress	P38760.
Genevestigator	P38760.
GermOnline	YHR015W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits.
Pfam	PF00076. RRM_1. 3 hits. [Graphical view]
SMART	SM00360. RRM. 3 hits. [Graphical view]
PROSITE	PS50102. RRM. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	981953.

Entry information

Entry name

MIP6_YEAST

Accession

Primary (citable) accession number: P38760
Secondary accession number(s): D3DKW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program