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Protein

RNA-binding protein MIP6

Gene

MIP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: SGD

GO - Biological processi

  • mRNA export from nucleus Source: SGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31077-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MIP6
Alternative name(s):
MEX67-interacting protein 6
Gene namesi
Name:MIP6
Ordered Locus Names:YHR015W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR015W.
SGDiS000001057. MIP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659RNA-binding protein MIP6PRO_0000082032Add
BLAST

Interactioni

Subunit structurei

Interacts with MEX67.1 Publication

Protein-protein interaction databases

BioGridi36444. 18 interactions.
DIPiDIP-6647N.
IntActiP38760. 2 interactions.
MINTiMINT-644353.

Structurei

3D structure databases

ProteinModelPortaliP38760.
SMRiP38760. Positions 108-262, 312-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 18979RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini199 – 26769RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini313 – 38977RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00790000123919.
HOGENOMiHOG000000869.
InParanoidiP38760.
OMAiTEWIARE.
OrthoDBiEOG092C3WHA.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNSHGNVLN NISLNSKQNP RSISKSCPND KDARQKSFKT ISAQALVRVQ
60 70 80 90 100
GAGYKLGDVK LKDAEVKEKN SLKKYDCKNA TQEKKEQEQV FEKTVAKGSV
110 120 130 140 150
QKYITKTSKT NSLFIGNLKS TVTEEMLRKI FKRYQSFESA KVCRDFLTKK
160 170 180 190 200
SLGYGYLNFK DKNDAESARK EFNYTVFFGQ EVKIMPSMKN TLFRKNIGTN
210 220 230 240 250
VFFSNLPLEN PQLTTRSFYL IMIEYGNVLS CLLERRKNIG FVYFDNDISA
260 270 280 290 300
RNVIKKYNNQ EFFGNKIICG LHFDKEVRTR PEFTKRKKMI GSDIVIEDEL
310 320 330 340 350
LASNNLSDNA RSKTILVKNL PSDTTQEEVL DYFSTIGPIK SVFISEKQAN
360 370 380 390 400
TPHKAFVTYK NEEESKKAQK CLNKTIFKNH TIWVGPGKDK PVHNQIGTNK
410 420 430 440 450
KTKVYLKNLS FNCNKEFISQ LCLQEKIRFS EIKITNYNSL NWTFCGHVEC
460 470 480 490 500
FSRSDAERLF NILDRRLIGS SLVEASWSKN NDNILNEIDY DDGNNNENYK
510 520 530 540 550
KLINISSMMR FRTQELSAHQ KGLTSQFQQV VSPFSSYSNS YTNMNSLVAT
560 570 580 590 600
PMKPHPAFNL ITNTVDEKLH QPKRTKQENA EILESLKKII NRNLQRISIS
610 620 630 640 650
GLNKEENLRS ISEFIFDVFW EHDSERLSHF LLMTNTSLES QKILQKQVTR

AAESLGFTV
Length:659
Mass (Da):75,920
Last modified:February 1, 1995 - v1
Checksum:iDF8E3F4D12A63871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10400 Genomic DNA. Translation: AAB68942.1.
BK006934 Genomic DNA. Translation: DAA06704.1.
PIRiS46788.
RefSeqiNP_011879.1. NM_001179145.1.

Genome annotation databases

EnsemblFungiiYHR015W; YHR015W; YHR015W.
GeneIDi856408.
KEGGisce:YHR015W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10400 Genomic DNA. Translation: AAB68942.1.
BK006934 Genomic DNA. Translation: DAA06704.1.
PIRiS46788.
RefSeqiNP_011879.1. NM_001179145.1.

3D structure databases

ProteinModelPortaliP38760.
SMRiP38760. Positions 108-262, 312-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36444. 18 interactions.
DIPiDIP-6647N.
IntActiP38760. 2 interactions.
MINTiMINT-644353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR015W; YHR015W; YHR015W.
GeneIDi856408.
KEGGisce:YHR015W.

Organism-specific databases

EuPathDBiFungiDB:YHR015W.
SGDiS000001057. MIP6.

Phylogenomic databases

GeneTreeiENSGT00790000123919.
HOGENOMiHOG000000869.
InParanoidiP38760.
OMAiTEWIARE.
OrthoDBiEOG092C3WHA.

Enzyme and pathway databases

BioCyciYEAST:G3O-31077-MONOMER.

Miscellaneous databases

PROiP38760.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIP6_YEAST
AccessioniPrimary (citable) accession number: P38760
Secondary accession number(s): D3DKW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.