Reviewed, UniProtKB/Swiss-Prot P38758 (YHG9_YEAST)

Names and origin

Protein names

Recommended name:
    UPF0673 membrane protein YHR009C

Gene names

Ordered Locus Names:

YHR009C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Miscellaneous	Present with 5240 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the UPF0673 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Ref.2 Inferred from direct assay. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ESS1	P22696	1	EBI-24443,EBI-6679
PRP40	P33203	1	EBI-24443,EBI-701
RSP5	P39940	1	EBI-24443,EBI-16219
SSM4	P40318	1	EBI-24443,EBI-18208
URN1	Q06525	1	EBI-24443,EBI-35138
VTS1	Q08831	1	EBI-24443,EBI-36342

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	UPF0673 membrane protein YHR009C		PRO_0000202886
Regions
	Transmembrane	24 – 40	17	Potential
	Compositional bias	156 – 212	57	Ser-rich
Amino acid modifications
	Modified residue	158	1	Phosphoserine Ref.8
	Modified residue	159	1	Phosphoserine Ref.8
	Modified residue	184	1	Phosphoserine Ref.8
	Modified residue	200	1	Phosphoserine Ref.8 Ref.7
	Modified residue	202	1	Phosphothreonine Ref.8 Ref.7
	Modified residue	204	1	Phosphoserine Ref.8 Ref.7
	Modified residue	206	1	Phosphoserine Ref.8 Ref.7
	Modified residue	210	1	Phosphoserine Ref.8
	Modified residue	212	1	Phosphoserine Ref.8 Ref.7
	Modified residue	306	1	Phosphoserine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P38758-1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 7D02A4C731758B6D	FASTA	523	57,614
	10 20 30 40 50 60 MGEDFMHPPF QTYPSKNSEG KKHIVIVGGG IIGCCTAYYL TQHPSFSPST HHITIIESRR 70 80 90 100 110 120 IAGGASGKAG GLLASWAFPH QIVPLSFQLH QELSDEYDGE NNWDYRRLTT VSLEADVREE 130 140 150 160 170 180 VIENYERLSK KAYNLNVPPP KKRPGYISNK FNIGDSNSSL SSSGSSLKND SASNEEEGSD 190 200 210 220 230 240 IHVSSSVPSL HSLTNERMRS HTNSASDLDS VSPVEQLRET NIHNPLPADL DWIRRELVND 250 260 270 280 290 300 WSSLGGTDTT AQLHPYKFTH FILSKAMETG AVDLLLGKVV GLKCDEMDCV HSLKYLPSVV 310 320 330 340 350 360 KNRRNSRGHA ENPDIKLGTI FNDENAKPIE INDIQQIVLS MGPWTSKILK DCPISGLRAH 370 380 390 400 410 420 SVTIKPSEKT VSPYAILAEL KVNDREFFSP EMYARKDEVY VCGEGDTLVN IPESSDDVEV 430 440 450 460 470 480 VSEKCDELYH YVSKLSPTLS KGHLLRKQAC FLPVLNVPTS SGPLIGETNV KDLYIASGHS 490 500 510 520 CWGINNAPAT GKLMAEILLD GEATSAEISS LDPKLYFDAT ILS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The yeast nuclear pore complex: composition, architecture, and transport mechanism." Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T. J. Cell Biol. 148:635-651(2000) [PubMed: 10684247] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[3]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, MASS SPECTROMETRY.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; THR-202; SER-204; SER-206 AND SER-212, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158; SER-159; SER-184; SER-200; THR-202; SER-204; SER-206; SER-210 AND SER-212, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10400 Genomic DNA. Translation: AAB68938.1. Different initiation.
PIR	S46784.
RefSeq	NP_011873.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4617N.
IntAct	P38758. 13 interactions.
Proteomic databases
PeptideAtlas	P38758.
Genome annotation databases
Ensembl	YHR009C. Saccharomyces cerevisiae. [Contig view]
GeneID	856400.
GenomeReviews	Gene locus YHR009C in contig U00093_GR.
KEGG	sce:YHR009C.
NMPDR	fig|4932.3.peg.3018.
Organism-specific databases
CYGD	YHR009c.
SGD	S000001051. YHR009C.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38758.
OMA	P38758. TTAQVHP.
Gene expression databases
ArrayExpress	P38758.
GermOnline	YHR009C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	981931.

Entry information

Entry name

YHG9_YEAST

Accession

Primary (citable) accession number: P38758

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)