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Protein

Oxysterol-binding protein homolog 7

Gene

OSH7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner.2 Publications

Miscellaneous

Present with 2350 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei129PhosphatidylserineBy similarity1
Binding sitei183PhosphatidylserineBy similarity1
Binding sitei351Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei355Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei359Phosphatidylinositol 4-phosphateBy similarity1

GO - Molecular functioni

  • lipid binding Source: SGD
  • oxysterol binding Source: SGD
  • phosphatidylinositol-4-phosphate binding Source: UniProtKB
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid transporter activity Source: UniProtKB

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • late endosome to vacuole transport Source: SGD
  • maintenance of cell polarity Source: SGD
  • phospholipid transport Source: UniProtKB
  • piecemeal microautophagy of the nucleus Source: SGD
  • sterol metabolic process Source: SGD
  • sterol transport Source: SGD

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciYEAST:YHR001W-MONOMER
ReactomeiR-SCE-1482801 Acyl chain remodelling of PS
R-SCE-192105 Synthesis of bile acids and bile salts

Protein family/group databases

TCDBi2.D.1.1.4 the pi4p/ps counter transporter (p/p-ct) family

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein homolog 7
Gene namesi
Name:OSH7
Ordered Locus Names:YHR001W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR001W
SGDiS000001043 OSH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003911 – 437Oxysterol-binding protein homolog 7Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38755
PaxDbiP38755
PRIDEiP38755

PTM databases

iPTMnetiP38755

Interactioni

Protein-protein interaction databases

BioGridi36425, 110 interactors
DIPiDIP-6363N
IntActiP38755, 19 interactors
MINTiP38755
STRINGi4932.YHR001W

Structurei

3D structure databases

ProteinModelPortaliP38755
SMRiP38755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 69Phosphatidylinositol 4-phosphate bindingBy similarity6
Regioni64 – 69Phosphatidylserine bindingBy similarity6
Regioni126 – 129Phosphatidylinositol 4-phosphate bindingBy similarity4
Regioni157 – 158Phosphatidylinositol 4-phosphate bindingBy similarity2

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074515
HOGENOMiHOG000233871
InParanoidiP38755
KOiK22285
OMAiLSGWHIR
OrthoDBiEOG092C2XNN

Family and domain databases

InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit

Sequencei

Sequence statusi: Complete.

P38755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNKLKNIP SLTNSSHSSI NGIASNAANS KPSGADTDDI DENDESGQSI
60 70 80 90 100
LLNIISQLKP GCDLSRITLP TFILEKKSML ERITNQLQFP DVLLEAHSNK
110 120 130 140 150
DGLQRFVKVV AWYLAGWHIG PRAVKKPLNP ILGEHFTAYW DLPNKQQAFY
160 170 180 190 200
IAEQTSHHPP ESAYFYMIPE SNIRVDGVVV PKSKFLGNSS AAMMEGLTVL
210 220 230 240 250
QFLDIKDANG KPEKYTLSQP NVYARGILFG KMRIELGDHM VIMGPKYQVD
260 270 280 290 300
IEFKTKGFIS GTYDAIEGTI KDYDGKEYYQ ISGKWNDIMY IKDLREKSSK
310 320 330 340 350
KTVLFDTHQH FPLAPKVRPL EEQGEYESRR LWKKVTDALA VRDHEVATEE
360 370 380 390 400
KFQIENRQRE LAKKRAEDGV EFHSKLFRRA EPGEDLDYYI YKHIPEGTDK
410 420 430
HEEQIRSILE TAPILPGQTF TEKFSIPAYK KHGIQKN
Length:437
Mass (Da):49,805
Last modified:February 1, 1995 - v1
Checksum:i1C972ED6517D529B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA Translation: AAB68425.1
AY692903 Genomic DNA Translation: AAT92922.1
BK006934 Genomic DNA Translation: DAA06687.1
PIRiS46796
RefSeqiNP_011863.1, NM_001179131.1

Genome annotation databases

EnsemblFungiiYHR001W; YHR001W; YHR001W
GeneIDi856389
KEGGisce:YHR001W

Similar proteinsi

Entry informationi

Entry nameiOSH7_YEAST
AccessioniPrimary (citable) accession number: P38755
Secondary accession number(s): D3DKR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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