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Protein

Oxysterol-binding protein homolog 7

Gene

OSH7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291PhosphatidylserineBy similarity
Binding sitei183 – 1831PhosphatidylserineBy similarity
Binding sitei351 – 3511Phosphatidylinositol 4-phosphateBy similarity
Binding sitei355 – 3551Phosphatidylinositol 4-phosphateBy similarity
Binding sitei359 – 3591Phosphatidylinositol 4-phosphateBy similarity

GO - Molecular functioni

  • lipid binding Source: SGD
  • oxysterol binding Source: SGD
  • phosphatidylinositol-4-phosphate binding Source: UniProtKB
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid transporter activity Source: UniProtKB

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • late endosome to vacuole transport Source: SGD
  • maintenance of cell polarity Source: SGD
  • phospholipid transport Source: UniProtKB
  • piecemeal microautophagy of nucleus Source: SGD
  • sterol metabolic process Source: SGD
  • sterol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Protein family/group databases

TCDBi2.D.1.1.4. the pi4p/ps counter transporter (p/p-ct) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein homolog 7
Gene namesi
Name:OSH7
Ordered Locus Names:YHR001W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR001W.
SGDiS000001043. OSH7.

Subcellular locationi

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: UniProtKB
  • cytoplasm Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Oxysterol-binding protein homolog 7PRO_0000100391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki276 – 276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38755.

Interactioni

Protein-protein interaction databases

BioGridi36425. 34 interactions.
DIPiDIP-6363N.
IntActiP38755. 17 interactions.
MINTiMINT-681243.

Structurei

3D structure databases

ProteinModelPortaliP38755.
SMRiP38755. Positions 36-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 696Phosphatidylinositol 4-phosphate bindingBy similarity
Regioni64 – 696Phosphatidylserine bindingBy similarity
Regioni126 – 1294Phosphatidylinositol 4-phosphate bindingBy similarity
Regioni157 – 1582Phosphatidylinositol 4-phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233871.
InParanoidiP38755.
OMAiWIINAQI.
OrthoDBiEOG092C2XNN.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNKLKNIP SLTNSSHSSI NGIASNAANS KPSGADTDDI DENDESGQSI
60 70 80 90 100
LLNIISQLKP GCDLSRITLP TFILEKKSML ERITNQLQFP DVLLEAHSNK
110 120 130 140 150
DGLQRFVKVV AWYLAGWHIG PRAVKKPLNP ILGEHFTAYW DLPNKQQAFY
160 170 180 190 200
IAEQTSHHPP ESAYFYMIPE SNIRVDGVVV PKSKFLGNSS AAMMEGLTVL
210 220 230 240 250
QFLDIKDANG KPEKYTLSQP NVYARGILFG KMRIELGDHM VIMGPKYQVD
260 270 280 290 300
IEFKTKGFIS GTYDAIEGTI KDYDGKEYYQ ISGKWNDIMY IKDLREKSSK
310 320 330 340 350
KTVLFDTHQH FPLAPKVRPL EEQGEYESRR LWKKVTDALA VRDHEVATEE
360 370 380 390 400
KFQIENRQRE LAKKRAEDGV EFHSKLFRRA EPGEDLDYYI YKHIPEGTDK
410 420 430
HEEQIRSILE TAPILPGQTF TEKFSIPAYK KHGIQKN
Length:437
Mass (Da):49,805
Last modified:February 1, 1995 - v1
Checksum:i1C972ED6517D529B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA. Translation: AAB68425.1.
AY692903 Genomic DNA. Translation: AAT92922.1.
BK006934 Genomic DNA. Translation: DAA06687.1.
PIRiS46796.
RefSeqiNP_011863.1. NM_001179131.1.

Genome annotation databases

EnsemblFungiiYHR001W; YHR001W; YHR001W.
GeneIDi856389.
KEGGisce:YHR001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA. Translation: AAB68425.1.
AY692903 Genomic DNA. Translation: AAT92922.1.
BK006934 Genomic DNA. Translation: DAA06687.1.
PIRiS46796.
RefSeqiNP_011863.1. NM_001179131.1.

3D structure databases

ProteinModelPortaliP38755.
SMRiP38755. Positions 36-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36425. 34 interactions.
DIPiDIP-6363N.
IntActiP38755. 17 interactions.
MINTiMINT-681243.

Protein family/group databases

TCDBi2.D.1.1.4. the pi4p/ps counter transporter (p/p-ct) family.

Proteomic databases

MaxQBiP38755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR001W; YHR001W; YHR001W.
GeneIDi856389.
KEGGisce:YHR001W.

Organism-specific databases

EuPathDBiFungiDB:YHR001W.
SGDiS000001043. OSH7.

Phylogenomic databases

GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233871.
InParanoidiP38755.
OMAiWIINAQI.
OrthoDBiEOG092C2XNN.

Miscellaneous databases

PROiP38755.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSH7_YEAST
AccessioniPrimary (citable) accession number: P38755
Secondary accession number(s): D3DKR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.