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P38751

- SHU1_YEAST

UniProt

P38751 - SHU1_YEAST

Protein

Suppressor of HU sensitivity involved in recombination protein 1

Gene

SHU1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (30 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. maintenance of rDNA Source: SGD
    2. recombinational repair Source: SGD

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31028-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor of HU sensitivity involved in recombination protein 1
    Gene namesi
    Name:SHU1
    Ordered Locus Names:YHL006C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL006c.
    SGDiS000000998. SHU1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. Shu complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Suppressor of HU sensitivity involved in recombination protein 1PRO_0000097742Add
    BLAST

    Proteomic databases

    PaxDbiP38751.

    Expressioni

    Gene expression databases

    GenevestigatoriP38751.

    Interactioni

    Subunit structurei

    Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SHU2P389573EBI-24305,EBI-22154

    Protein-protein interaction databases

    BioGridi36420. 31 interactions.
    DIPiDIP-1874N.
    IntActiP38751. 7 interactions.
    MINTiMINT-385326.
    STRINGi4932.YHL006C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG77801.
    OMAiWIAAPAR.
    OrthoDBiEOG71ZPF8.

    Sequencei

    Sequence statusi: Complete.

    P38751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT    50
    VAGHVASRER VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT 100
    ATQDGPQQLR LLSLVLRQCL SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR 150
    Length:150
    Mass (Da):17,121
    Last modified:July 30, 2004 - v2
    Checksum:i8B17700BDAA2367F
    GO

    Sequence cautioni

    The sequence AAA35196.1 differs from that shown. Reason: Frameshift at position 106.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381P → A in AAA35196. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11581 Genomic DNA. Translation: AAB69748.2.
    L09261 Genomic DNA. Translation: AAA35196.1. Frameshift.
    BK006934 Genomic DNA. Translation: DAA06682.1.
    PIRiS46822.
    RefSeqiNP_011857.2. NM_001179086.1.

    Genome annotation databases

    EnsemblFungiiYHL006C; YHL006C; YHL006C.
    GeneIDi856383.
    KEGGisce:YHL006C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11581 Genomic DNA. Translation: AAB69748.2 .
    L09261 Genomic DNA. Translation: AAA35196.1 . Frameshift.
    BK006934 Genomic DNA. Translation: DAA06682.1 .
    PIRi S46822.
    RefSeqi NP_011857.2. NM_001179086.1.

    3D structure databases

    ProteinModelPortali P38751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36420. 31 interactions.
    DIPi DIP-1874N.
    IntActi P38751. 7 interactions.
    MINTi MINT-385326.
    STRINGi 4932.YHL006C.

    Proteomic databases

    PaxDbi P38751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL006C ; YHL006C ; YHL006C .
    GeneIDi 856383.
    KEGGi sce:YHL006C.

    Organism-specific databases

    CYGDi YHL006c.
    SGDi S000000998. SHU1.

    Phylogenomic databases

    eggNOGi NOG77801.
    OMAi WIAAPAR.
    OrthoDBi EOG71ZPF8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31028-MONOMER.

    Miscellaneous databases

    NextBioi 981884.

    Gene expression databases

    Genevestigatori P38751.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Fisk D., Cherry J.M.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Dignard D.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair."
      Shor E., Weinstein J., Rothstein R.
      Genetics 169:1275-1289(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
    6. "The yeast Shu complex couples error-free post-replication repair to homologous recombination."
      Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.
      Mol. Microbiol. 73:89-102(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SHU COMPLEX, FUNCTION.

    Entry informationi

    Entry nameiSHU1_YEAST
    AccessioniPrimary (citable) accession number: P38751
    Secondary accession number(s): D3DKQ9, Q07190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: July 30, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3