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P38751

- SHU1_YEAST

UniProt

P38751 - SHU1_YEAST

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Protein
Suppressor of HU sensitivity involved in recombination protein 1
Gene
SHU1, YHL006C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. maintenance of rDNA Source: SGD
  2. recombinational repair Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-31028-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of HU sensitivity involved in recombination protein 1
Gene namesi
Name:SHU1
Ordered Locus Names:YHL006C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL006c.
SGDiS000000998. SHU1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Shu complex Source: SGD
  2. nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Suppressor of HU sensitivity involved in recombination protein 1
PRO_0000097742Add
BLAST

Proteomic databases

PaxDbiP38751.

Expressioni

Gene expression databases

GenevestigatoriP38751.

Interactioni

Subunit structurei

Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SHU2P389573EBI-24305,EBI-22154

Protein-protein interaction databases

BioGridi36420. 31 interactions.
DIPiDIP-1874N.
IntActiP38751. 7 interactions.
MINTiMINT-385326.
STRINGi4932.YHL006C.

Structurei

3D structure databases

ProteinModelPortaliP38751.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG77801.
OMAiWIAAPAR.
OrthoDBiEOG71ZPF8.

Sequencei

Sequence statusi: Complete.

P38751-1 [UniParc]FASTAAdd to Basket

« Hide

MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT    50
VAGHVASRER VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT 100
ATQDGPQQLR LLSLVLRQCL SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR 150
Length:150
Mass (Da):17,121
Last modified:July 30, 2004 - v2
Checksum:i8B17700BDAA2367F
GO

Sequence cautioni

The sequence AAA35196.1 differs from that shown. Reason: Frameshift at position 106.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381P → A in AAA35196. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11581 Genomic DNA. Translation: AAB69748.2.
L09261 Genomic DNA. Translation: AAA35196.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06682.1.
PIRiS46822.
RefSeqiNP_011857.2. NM_001179086.1.

Genome annotation databases

EnsemblFungiiYHL006C; YHL006C; YHL006C.
GeneIDi856383.
KEGGisce:YHL006C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11581 Genomic DNA. Translation: AAB69748.2 .
L09261 Genomic DNA. Translation: AAA35196.1 . Frameshift.
BK006934 Genomic DNA. Translation: DAA06682.1 .
PIRi S46822.
RefSeqi NP_011857.2. NM_001179086.1.

3D structure databases

ProteinModelPortali P38751.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36420. 31 interactions.
DIPi DIP-1874N.
IntActi P38751. 7 interactions.
MINTi MINT-385326.
STRINGi 4932.YHL006C.

Proteomic databases

PaxDbi P38751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL006C ; YHL006C ; YHL006C .
GeneIDi 856383.
KEGGi sce:YHL006C.

Organism-specific databases

CYGDi YHL006c.
SGDi S000000998. SHU1.

Phylogenomic databases

eggNOGi NOG77801.
OMAi WIAAPAR.
OrthoDBi EOG71ZPF8.

Enzyme and pathway databases

BioCyci YEAST:G3O-31028-MONOMER.

Miscellaneous databases

NextBioi 981884.

Gene expression databases

Genevestigatori P38751.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Fisk D., Cherry J.M.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Dignard D.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair."
    Shor E., Weinstein J., Rothstein R.
    Genetics 169:1275-1289(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
  6. "The yeast Shu complex couples error-free post-replication repair to homologous recombination."
    Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.
    Mol. Microbiol. 73:89-102(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SHU COMPLEX, FUNCTION.

Entry informationi

Entry nameiSHU1_YEAST
AccessioniPrimary (citable) accession number: P38751
Secondary accession number(s): D3DKQ9, Q07190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 30, 2004
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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