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P38751 (SHU1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Suppressor of HU sensitivity involved in recombination protein 1
Gene names
Name:SHU1
Ordered Locus Names:YHL006C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Ref.5 Ref.6

Subunit structure

Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2. Ref.5 Ref.6

Subcellular location

Nucleus Ref.5.

Sequence caution

The sequence AAA35196.1 differs from that shown. Reason: Frameshift at position 106.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SHU2P389573EBI-24305,EBI-22154

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150Suppressor of HU sensitivity involved in recombination protein 1
PRO_0000097742

Experimental info

Sequence conflict1381P → A in AAA35196. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P38751 [UniParc].

Last modified July 30, 2004. Version 2.
Checksum: 8B17700BDAA2367F

FASTA15017,121
        10         20         30         40         50         60 
MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT VAGHVASRER 

        70         80         90        100        110        120 
VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT ATQDGPQQLR LLSLVLRQCL 

       130        140        150 
SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Fisk D., Cherry J.M.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]Dignard D.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair."
Shor E., Weinstein J., Rothstein R.
Genetics 169:1275-1289(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
[6]"The yeast Shu complex couples error-free post-replication repair to homologous recombination."
Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.
Mol. Microbiol. 73:89-102(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SHU COMPLEX, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11581 Genomic DNA. Translation: AAB69748.2.
L09261 Genomic DNA. Translation: AAA35196.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06682.1.
PIRS46822.
RefSeqNP_011857.2. NM_001179086.1.

3D structure databases

ProteinModelPortalP38751.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36420. 30 interactions.
DIPDIP-1874N.
IntActP38751. 7 interactions.
MINTMINT-385326.
STRING4932.YHL006C.

Proteomic databases

PaxDbP38751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL006C; YHL006C; YHL006C.
GeneID856383.
KEGGsce:YHL006C.

Organism-specific databases

CYGDYHL006c.
SGDS000000998. SHU1.

Phylogenomic databases

eggNOGNOG77801.
OrthoDBEOG71ZPF8.

Enzyme and pathway databases

BioCycYEAST:G3O-31028-MONOMER.

Gene expression databases

GenevestigatorP38751.

Family and domain databases

ProtoNetSearch...

Other

NextBio981884.

Entry information

Entry nameSHU1_YEAST
AccessionPrimary (citable) accession number: P38751
Secondary accession number(s): D3DKQ9, Q07190
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 30, 2004
Last modified: February 19, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD