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Protein

Suppressor of HU sensitivity involved in recombination protein 1

Gene

SHU1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.2 Publications

GO - Biological processi

  • DNA recombinase assembly Source: SGD
  • maintenance of rDNA Source: SGD
  • recombinational repair Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-31028-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of HU sensitivity involved in recombination protein 1
Gene namesi
Name:SHU1
Ordered Locus Names:YHL006C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHL006c.
EuPathDBiFungiDB:YHL006C.
SGDiS000000998. SHU1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleolus Source: SGD
  • Shu complex Source: SGD
  • site of double-strand break Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Suppressor of HU sensitivity involved in recombination protein 1PRO_0000097742Add
BLAST

Proteomic databases

PaxDbiP38751.

Expressioni

Gene expression databases

GenevestigatoriP38751.

Interactioni

Subunit structurei

Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SHU2P389573EBI-24305,EBI-22154

Protein-protein interaction databases

BioGridi36420. 32 interactions.
DIPiDIP-1874N.
IntActiP38751. 7 interactions.
MINTiMINT-385326.
STRINGi4932.YHL006C.

Structurei

3D structure databases

ProteinModelPortaliP38751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG77801.
InParanoidiP38751.
OrthoDBiEOG71ZPF8.

Sequencei

Sequence statusi: Complete.

P38751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT
60 70 80 90 100
VAGHVASRER VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT
110 120 130 140 150
ATQDGPQQLR LLSLVLRQCL SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR
Length:150
Mass (Da):17,121
Last modified:July 30, 2004 - v2
Checksum:i8B17700BDAA2367F
GO

Sequence cautioni

The sequence AAA35196.1 differs from that shown. Reason: Frameshift at position 106. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381P → A in AAA35196 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11581 Genomic DNA. Translation: AAB69748.2.
L09261 Genomic DNA. Translation: AAA35196.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06682.1.
PIRiS46822.
RefSeqiNP_011857.2. NM_001179086.1.

Genome annotation databases

EnsemblFungiiYHL006C; YHL006C; YHL006C.
GeneIDi856383.
KEGGisce:YHL006C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11581 Genomic DNA. Translation: AAB69748.2.
L09261 Genomic DNA. Translation: AAA35196.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06682.1.
PIRiS46822.
RefSeqiNP_011857.2. NM_001179086.1.

3D structure databases

ProteinModelPortaliP38751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36420. 32 interactions.
DIPiDIP-1874N.
IntActiP38751. 7 interactions.
MINTiMINT-385326.
STRINGi4932.YHL006C.

Proteomic databases

PaxDbiP38751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL006C; YHL006C; YHL006C.
GeneIDi856383.
KEGGisce:YHL006C.

Organism-specific databases

CYGDiYHL006c.
EuPathDBiFungiDB:YHL006C.
SGDiS000000998. SHU1.

Phylogenomic databases

eggNOGiNOG77801.
InParanoidiP38751.
OrthoDBiEOG71ZPF8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31028-MONOMER.

Miscellaneous databases

NextBioi981884.
PROiP38751.

Gene expression databases

GenevestigatoriP38751.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Fisk D., Cherry J.M.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Dignard D.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair."
    Shor E., Weinstein J., Rothstein R.
    Genetics 169:1275-1289(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
  6. "The yeast Shu complex couples error-free post-replication repair to homologous recombination."
    Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.
    Mol. Microbiol. 73:89-102(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SHU COMPLEX, FUNCTION.

Entry informationi

Entry nameiSHU1_YEAST
AccessioniPrimary (citable) accession number: P38751
Secondary accession number(s): D3DKQ9, Q07190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 30, 2004
Last modified: May 27, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.