P38751 (SHU1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor of HU sensitivity involved in recombination protein 1

Gene names

Name:	SHU1
Ordered Locus Names:	YHL006C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Ref.5 Ref.6
Subunit structure	Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2. Ref.5 Ref.6
Subcellular location	Nucleus Ref.5.
Sequence caution	The sequence AAA35196.1 differs from that shown. Reason: Frameshift at position 106.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	maintenance of rDNA Inferred from genetic interaction PubMed 21372173. Source: SGD recombinational repair Inferred from genetic interaction Ref.5. Source: SGD
Cellular_component	Shu complex Inferred from physical interaction Ref.5. Source: SGD nucleolus Inferred from direct assay PubMed 21372173. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SHU2	P38957	3	EBI-24305,EBI-22154

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 150	150	Suppressor of HU sensitivity involved in recombination protein 1		PRO_0000097742
Experimental info
	Sequence conflict	138	1	P → A in AAA35196. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P38751 [UniParc]. Last modified July 30, 2004. Version 2. Checksum: 8B17700BDAA2367F	FASTA	150	17,121
	10 20 30 40 50 60 MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT VAGHVASRER 70 80 90 100 110 120 VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT ATQDGPQQLR LLSLVLRQCL 130 140 150 SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Fisk D., Cherry J.M. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	Dignard D. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair." Shor E., Weinstein J., Rothstein R. Genetics 169:1275-1289(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
[6]	"The yeast Shu complex couples error-free post-replication repair to homologous recombination." Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W. Mol. Microbiol. 73:89-102(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE SHU COMPLEX, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11581 Genomic DNA. Translation: AAB69748.2. L09261 Genomic DNA. Translation: AAA35196.1. Frameshift. BK006934 Genomic DNA. Translation: DAA06682.1.
PIR	S46822.
RefSeq	NP_011857.2. NM_001179086.1.
3D structure databases
ProteinModelPortal	P38751.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1874N.
IntAct	P38751. 6 interactions.
MINT	MINT-385326.
STRING	4932.YHL006C.
Proteomic databases
PaxDb	P38751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL006C; YHL006C; YHL006C.
GeneID	856383.
KEGG	sce:YHL006C.
Organism-specific databases
CYGD	YHL006c.
SGD	S000000998. SHU1.
Phylogenomic databases
eggNOG	NOG77801.
OrthoDB	EOG4M68TF.
Gene expression databases
Genevestigator	P38751.
GermOnline	YHL006C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	981884.

Entry information

Entry name

SHU1_YEAST

Accession

Primary (citable) accession number: P38751
Secondary accession number(s): D3DKQ9, Q07190

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	July 30, 2004
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program