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Reviewed, UniProtKB/Swiss-Prot P38750 (YHA8_YEAST)

Last modified November 24, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uncharacterized transporter YHL008C
Gene names
Ordered Locus Names: YHL008C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the FNT transporter (TC 2.A.44) family. [View classification]

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Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processchloride transport

Inferred from mutant phenotype. Source: SGD

   Cellular componentfungal-type vacuole

Inferred from direct assay. Source: SGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Uncharacterized transporter YHL008C
PRO_0000094729

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5321 Potential
Topological domain54 – 6613Cytoplasmic Potential
Transmembrane67 – 8721 Potential
Topological domain88 – 11326Extracellular Potential
Transmembrane114 – 13421 Potential
Topological domain135 – 16531Cytoplasmic Potential
Transmembrane166 – 18621 Potential
Topological domain187 – 1926Extracellular Potential
Transmembrane193 – 21321 Potential
Topological domain214 – 2185Cytoplasmic Potential
Transmembrane219 – 23921 Potential
Topological domain240 – 2456Extracellular Potential
Transmembrane246 – 26621 Potential
Topological domain267 – 627361Cytoplasmic Potential

Amino acid modifications

Modified residue201Phosphothreonine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P38750-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4413C989A6673FE1

FASTA62769,969
        10         20         30         40         50         60 
MVDDSNYLTP HETALAVVAT AMKKARLQLD TLLINSILGG VLFSSGSFLL VAVYSEDPDI 

        70         80         90        100        110        120 
VARNPGIVNL ITGVNFAMGL FYVVMMGADL FNSNILFFSV GVLRKAVTIY DLMISWVVSW 

       130        140        150        160        170        180 
LGNIAGSLFV SYLFGHLSGI SSQKLWIIGS RQIIEQKVSY SFVQTFLKGI ACNFFVCLAI 

       190        200        210        220        230        240 
YLQLMAKPIH VKFILMSFPI IDFIGIGFTH VVGDMSASFI AMLNGANVSV GKYIWKLLIP 

       250        260        270        280        290        300 
ASLGNIVGGL FFSAVVPFYL HLVVVERDRK RLSLPEYEAR DEQPELNMDS RVVRIQKNEC 

       310        320        330        340        350        360 
DDDATETGED LENLTEKGFA SIYNTNHDNS SYFTGRSLNS LRSIPSSVIT SDNVTMESDL 

       370        380        390        400        410        420 
GEPVQFIPKS NSTTRSPHLG LPHNLPHNHS IKSINRHRIN KRHSLRSPPG VFPVRGMGEP 

       430        440        450        460        470        480 
LEREKTIEDA TYDPKENELF LRRAETHNSA YVKNKKKEDD NLLRLVKTEE DREQKEYEKN 

       490        500        510        520        530        540 
GGYNILENKP GTRLEKIITH LAENVSSREV TPPILPRTTQ DTFPHNAPAS SPAYTDDAHS 

       550        560        570        580        590        600 
LRKANSTTLG GLFRAVSKEF HSSKDAESPD DLLKKMAAVG INRNARITAN NVAGIVNLNK 

       610        620 
EDLDSTTRRQ KITEPKNFYN RHTSPQL

« Hide

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References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U11581 Genomic DNA. Translation: AAB69746.1.
AY558102 Genomic DNA. Translation: AAS56428.1.
PIRS46820.
RefSeqNP_011855.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2601N.
IntActP38750. 1 interaction.
STRINGP38750.

Genome annotation databases

EnsemblYHL008C; YHL008C; YHL008C; Saccharomyces cerevisiae. [Genome view]
GeneID856381.
KEGGsce:YHL008C.
NMPDRfig|4932.3.peg.2997.

Organism-specific databases

CYGDYHL008c.
SGDS000001000. YHL008C.

Phylogenomic databases

HOGENOMP38750.
OMAYITPHET
OrthoDBEOG91ZGTG

Gene expression databases

ArrayExpressP38750.
GenevestigatorP38750.
GermOnlineYHL008C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000292. For/Nit_transpt.
[Graphical view]
PfamPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsTIGR00790. fnt. 1 hit.
PROSITEPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio981878.

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Entry information

Entry nameYHA8_YEAST
AccessionPrimary (citable) accession number: P38750
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents