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P38749

- YAP3_YEAST

UniProt

P38749 - YAP3_YEAST

Protein

AP-1-like transcription factor YAP3

Gene

YAP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) By similarity. Preferentially binds 5'-TTACTAA-3'.By similarity4 Publications

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: SGD

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: SGD
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31031-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1-like transcription factor YAP3
    Gene namesi
    Name:YAP3
    Ordered Locus Names:YHL009C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL009c.
    SGDiS000001001. YAP3.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330AP-1-like transcription factor YAP3PRO_0000076523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei135 – 1351Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38749.
    PaxDbiP38749.
    PRIDEiP38749.

    Expressioni

    Gene expression databases

    GenevestigatoriP38749.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with the C-terminal, cytoplasmic tail of the multidrug resistance ABC transporter PDR5.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi36414. 44 interactions.
    DIPiDIP-1668N.
    IntActiP38749. 10 interactions.
    MINTiMINT-411090.
    STRINGi4932.YHL009C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38749.
    SMRiP38749. Positions 149-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini144 – 20764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni147 – 16822Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni172 – 20736Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi107 – 1126Poly-Asn

    Sequence similaritiesi

    Belongs to the bZIP family. YAP subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG40061.
    OMAiQECCHTH.
    OrthoDBiEOG7ZGXCV.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPSNMDDNT SGFMKFINPQ CQEEDCCIRN SLFQEDSKCI KQQPDLLSEQ    50
    TAPFPILEDQ CPALNLDRSN NDLLLQNNIS FPKGSDLQAI QLTPISGDYS 100
    TYVMADNNNN DNDSYSNTNY FSKNNGISPS SRSPSVAHNE NVPDDSKAKK 150
    KAQNRAAQKA FRERKEARMK ELQDKLLESE RNRQSLLKEI EELRKANTEI 200
    NAENRLLLRS GNENFSKDIE DDTNYKYSFP TKDEFFTSMV LESKLNHKGK 250
    YSLKDNEIMK RNTQYTDEAG RHVLTVPATW EYLYKLSEER DFDVTYVMSK 300
    LQGQECCHTH GPAYPRSLID FLVEEATLNE 330
    Length:330
    Mass (Da):37,955
    Last modified:February 1, 1995 - v1
    Checksum:i9868389698623A27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11581 Genomic DNA. Translation: AAB69745.1.
    BK006934 Genomic DNA. Translation: DAA06677.1.
    PIRiS46819.
    RefSeqiNP_011854.1. NM_001179089.1.

    Genome annotation databases

    EnsemblFungiiYHL009C; YHL009C; YHL009C.
    GeneIDi856377.
    KEGGisce:YHL009C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11581 Genomic DNA. Translation: AAB69745.1 .
    BK006934 Genomic DNA. Translation: DAA06677.1 .
    PIRi S46819.
    RefSeqi NP_011854.1. NM_001179089.1.

    3D structure databases

    ProteinModelPortali P38749.
    SMRi P38749. Positions 149-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36414. 44 interactions.
    DIPi DIP-1668N.
    IntActi P38749. 10 interactions.
    MINTi MINT-411090.
    STRINGi 4932.YHL009C.

    Proteomic databases

    MaxQBi P38749.
    PaxDbi P38749.
    PRIDEi P38749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL009C ; YHL009C ; YHL009C .
    GeneIDi 856377.
    KEGGi sce:YHL009C.

    Organism-specific databases

    CYGDi YHL009c.
    SGDi S000001001. YAP3.

    Phylogenomic databases

    eggNOGi NOG40061.
    OMAi QECCHTH.
    OrthoDBi EOG7ZGXCV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31031-MONOMER.

    Miscellaneous databases

    NextBioi 981867.

    Gene expression databases

    Genevestigatori P38749.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions."
      Fernandes L., Rodrigues-Pousada C., Struhl K.
      Mol. Cell. Biol. 17:6982-6993(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ISOLATION OF YAP FAMILY PROTEINS.
    4. "Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae."
      Talibi D., Raymond M.
      J. Bacteriol. 181:231-240(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MULTIDRUG RESISTANCE.
    5. "Functional isolation of the Candida albicans FCR3 gene encoding a bZip transcription factor homologous to Saccharomyces cerevisiae Yap3p."
      Yang X., Talibi D., Weber S., Poisson G., Raymond M.
      Yeast 18:1217-1225(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MULTIDRUG RESISTANCE.
    6. "Two-hybrid-based analysis of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p."
      Subba Rao G., Bachhawat A.K., Gupta C.M.
      Funct. Integr. Genomics 1:357-366(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PDR5.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYAP3_YEAST
    AccessioniPrimary (citable) accession number: P38749
    Secondary accession number(s): D3DKQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
    Present with 1700 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3