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P38749

- YAP3_YEAST

UniProt

P38749 - YAP3_YEAST

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Protein
AP-1-like transcription factor YAP3
Gene
YAP3, YHL009C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) By similarity. Preferentially binds 5'-TTACTAA-3'.4 Publications

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: SGD

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: SGD
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31031-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1-like transcription factor YAP3
Gene namesi
Name:YAP3
Ordered Locus Names:YHL009C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL009c.
SGDiS000001001. YAP3.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330AP-1-like transcription factor YAP3
PRO_0000076523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38749.
PaxDbiP38749.
PRIDEiP38749.

Expressioni

Gene expression databases

GenevestigatoriP38749.

Interactioni

Subunit structurei

Homodimer By similarity. Interacts with the C-terminal, cytoplasmic tail of the multidrug resistance ABC transporter PDR5.1 Publication

Protein-protein interaction databases

BioGridi36414. 44 interactions.
DIPiDIP-1668N.
IntActiP38749. 10 interactions.
MINTiMINT-411090.
STRINGi4932.YHL009C.

Structurei

3D structure databases

ProteinModelPortaliP38749.
SMRiP38749. Positions 149-195.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 20764bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni147 – 16822Basic motif By similarity
Add
BLAST
Regioni172 – 20736Leucine-zipper By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi107 – 1126Poly-Asn

Sequence similaritiesi

Belongs to the bZIP family. YAP subfamily.

Phylogenomic databases

eggNOGiNOG40061.
OMAiQECCHTH.
OrthoDBiEOG7ZGXCV.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38749-1 [UniParc]FASTAAdd to Basket

« Hide

MTPSNMDDNT SGFMKFINPQ CQEEDCCIRN SLFQEDSKCI KQQPDLLSEQ    50
TAPFPILEDQ CPALNLDRSN NDLLLQNNIS FPKGSDLQAI QLTPISGDYS 100
TYVMADNNNN DNDSYSNTNY FSKNNGISPS SRSPSVAHNE NVPDDSKAKK 150
KAQNRAAQKA FRERKEARMK ELQDKLLESE RNRQSLLKEI EELRKANTEI 200
NAENRLLLRS GNENFSKDIE DDTNYKYSFP TKDEFFTSMV LESKLNHKGK 250
YSLKDNEIMK RNTQYTDEAG RHVLTVPATW EYLYKLSEER DFDVTYVMSK 300
LQGQECCHTH GPAYPRSLID FLVEEATLNE 330
Length:330
Mass (Da):37,955
Last modified:February 1, 1995 - v1
Checksum:i9868389698623A27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11581 Genomic DNA. Translation: AAB69745.1.
BK006934 Genomic DNA. Translation: DAA06677.1.
PIRiS46819.
RefSeqiNP_011854.1. NM_001179089.1.

Genome annotation databases

EnsemblFungiiYHL009C; YHL009C; YHL009C.
GeneIDi856377.
KEGGisce:YHL009C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11581 Genomic DNA. Translation: AAB69745.1 .
BK006934 Genomic DNA. Translation: DAA06677.1 .
PIRi S46819.
RefSeqi NP_011854.1. NM_001179089.1.

3D structure databases

ProteinModelPortali P38749.
SMRi P38749. Positions 149-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36414. 44 interactions.
DIPi DIP-1668N.
IntActi P38749. 10 interactions.
MINTi MINT-411090.
STRINGi 4932.YHL009C.

Proteomic databases

MaxQBi P38749.
PaxDbi P38749.
PRIDEi P38749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL009C ; YHL009C ; YHL009C .
GeneIDi 856377.
KEGGi sce:YHL009C.

Organism-specific databases

CYGDi YHL009c.
SGDi S000001001. YAP3.

Phylogenomic databases

eggNOGi NOG40061.
OMAi QECCHTH.
OrthoDBi EOG7ZGXCV.

Enzyme and pathway databases

BioCyci YEAST:G3O-31031-MONOMER.

Miscellaneous databases

NextBioi 981867.

Gene expression databases

Genevestigatori P38749.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions."
    Fernandes L., Rodrigues-Pousada C., Struhl K.
    Mol. Cell. Biol. 17:6982-6993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ISOLATION OF YAP FAMILY PROTEINS.
  4. "Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae."
    Talibi D., Raymond M.
    J. Bacteriol. 181:231-240(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MULTIDRUG RESISTANCE.
  5. "Functional isolation of the Candida albicans FCR3 gene encoding a bZip transcription factor homologous to Saccharomyces cerevisiae Yap3p."
    Yang X., Talibi D., Weber S., Poisson G., Raymond M.
    Yeast 18:1217-1225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MULTIDRUG RESISTANCE.
  6. "Two-hybrid-based analysis of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p."
    Subba Rao G., Bachhawat A.K., Gupta C.M.
    Funct. Integr. Genomics 1:357-366(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PDR5.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYAP3_YEAST
AccessioniPrimary (citable) accession number: P38749
Secondary accession number(s): D3DKQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
Present with 1700 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi