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Protein

AP-1-like transcription factor YAP3

Gene

YAP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity). Preferentially binds 5'-TTACTAA-3'.By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31031-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1-like transcription factor YAP3
Gene namesi
Name:YAP3
Ordered Locus Names:YHL009C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL009C.
SGDiS000001001. YAP3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765231 – 330AP-1-like transcription factor YAP3Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38749.
PRIDEiP38749.

PTM databases

iPTMnetiP38749.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with the C-terminal, cytoplasmic tail of the multidrug resistance ABC transporter PDR5.By similarity1 Publication

Protein-protein interaction databases

BioGridi36414. 45 interactors.
DIPiDIP-1668N.
IntActiP38749. 10 interactors.
MINTiMINT-411090.

Structurei

3D structure databases

ProteinModelPortaliP38749.
SMRiP38749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 207bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 168Basic motifPROSITE-ProRule annotationAdd BLAST22
Regioni172 – 207Leucine-zipperPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi107 – 112Poly-Asn6

Sequence similaritiesi

Belongs to the bZIP family. YAP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP38749.
OMAiMEINAEN.
OrthoDBiEOG092C3R9V.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSNMDDNT SGFMKFINPQ CQEEDCCIRN SLFQEDSKCI KQQPDLLSEQ
60 70 80 90 100
TAPFPILEDQ CPALNLDRSN NDLLLQNNIS FPKGSDLQAI QLTPISGDYS
110 120 130 140 150
TYVMADNNNN DNDSYSNTNY FSKNNGISPS SRSPSVAHNE NVPDDSKAKK
160 170 180 190 200
KAQNRAAQKA FRERKEARMK ELQDKLLESE RNRQSLLKEI EELRKANTEI
210 220 230 240 250
NAENRLLLRS GNENFSKDIE DDTNYKYSFP TKDEFFTSMV LESKLNHKGK
260 270 280 290 300
YSLKDNEIMK RNTQYTDEAG RHVLTVPATW EYLYKLSEER DFDVTYVMSK
310 320 330
LQGQECCHTH GPAYPRSLID FLVEEATLNE
Length:330
Mass (Da):37,955
Last modified:February 1, 1995 - v1
Checksum:i9868389698623A27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11581 Genomic DNA. Translation: AAB69745.1.
BK006934 Genomic DNA. Translation: DAA06677.1.
PIRiS46819.
RefSeqiNP_011854.1. NM_001179089.1.

Genome annotation databases

EnsemblFungiiYHL009C; YHL009C; YHL009C.
GeneIDi856377.
KEGGisce:YHL009C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11581 Genomic DNA. Translation: AAB69745.1.
BK006934 Genomic DNA. Translation: DAA06677.1.
PIRiS46819.
RefSeqiNP_011854.1. NM_001179089.1.

3D structure databases

ProteinModelPortaliP38749.
SMRiP38749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36414. 45 interactors.
DIPiDIP-1668N.
IntActiP38749. 10 interactors.
MINTiMINT-411090.

PTM databases

iPTMnetiP38749.

Proteomic databases

MaxQBiP38749.
PRIDEiP38749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL009C; YHL009C; YHL009C.
GeneIDi856377.
KEGGisce:YHL009C.

Organism-specific databases

EuPathDBiFungiDB:YHL009C.
SGDiS000001001. YAP3.

Phylogenomic databases

InParanoidiP38749.
OMAiMEINAEN.
OrthoDBiEOG092C3R9V.

Enzyme and pathway databases

BioCyciYEAST:G3O-31031-MONOMER.

Miscellaneous databases

PROiP38749.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYAP3_YEAST
AccessioniPrimary (citable) accession number: P38749
Secondary accession number(s): D3DKQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
Present with 1700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.