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Protein

RING finger protein ETP1

Gene

ETP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 280RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri299 – 360UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

  • nuclear localization sequence binding Source: SGD
  • ubiquitin binding Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • response to ethanol Source: SGD

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31032-MONOMER.
ReactomeiR-SCE-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein ETP1
Alternative name(s):
BRAP2 homolog
Ethanol tolerance protein 1
Gene namesi
Name:ETP1
Ordered Locus Names:YHL010C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL010C.
SGDiS000001002. ETP1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563371 – 585RING finger protein ETP1Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki369Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei376PhosphoserineCombined sources1
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38748.
PRIDEiP38748.

PTM databases

iPTMnetiP38748.

Interactioni

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi36413. 75 interactors.
DIPiDIP-2987N.
IntActiP38748. 1 interactor.
MINTiMINT-436947.
STRINGi4932.YHL010C.

Structurei

3D structure databases

ProteinModelPortaliP38748.
SMRiP38748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 280RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri299 – 360UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00500000044909.
HOGENOMiHOG000190616.
InParanoidiP38748.
KOiK10632.
OMAiNQYMALI.
OrthoDBiEOG092C15N3.

Family and domain databases

CDDicd12717. RRM_ETP1. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR011422. BRAP2.
IPR034931. ETP1_RRM.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PfamiView protein in Pfam
PF07576. BRAP2. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF02148. zf-UBP. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017029. BRAP2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SM00290. ZnF_UBP. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

P38748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQFEYIITL EFGNQNQVES AYQIFKSIPK KLKAKSIGEE SIKSNNQDWQ
60 70 80 90 100
DWRVCDLEID MITDFKNQTS KEEESDLITS QYLGHGIIRL FKLSNANNTL
110 120 130 140 150
NEKEILTIPG DDTMICILFV PTYFTVHDLL HFYIGDDIVN KQVSNFRILR
160 170 180 190 200
NQQKGMGFNF TVLIKFRNAL DAKNFKEEFN GKSFSRMDPE TCHVISVKEI
210 220 230 240 250
VFQKKLFQRP AANEDFPYLL TDPFTVKKKK ELVKVELPTC PVCLERMDSE
260 270 280 290 300
TTGLVTIPCQ HTFHCQCLNK WKNSRCPVCR HSSLRLSRES LLKQAGDSAH
310 320 330 340 350
CATCGSTDNL WICLICGNVG CGRYNSKHAI KHYEETLHCF AMDIRTQRVW
360 370 380 390 400
DYAGDNYVHR LVQNEVDGKL VEVGGSGDDD NNDIGNSDEL QNVVYGNRSK
410 420 430 440 450
NGEKSNSNKK DGELAANFLR HREYHLEYVQ VLISQLESQR EYYELKLQEK
460 470 480 490 500
DQTASDSSNV ESLKKSMEDL KLQFQVTQKE WQKREMAQKS KLEEDMLVIE
510 520 530 540 550
GLQANLDHLS KKQEQLEREN KALEESKQDL EEQVKDLMFY LDSQEKFKDA
560 570 580
DESVKEGTIL IQQPHGAAQA SKSKKKRNKN KKAGK
Length:585
Mass (Da):67,503
Last modified:February 1, 1995 - v1
Checksum:i88FF670CC73A1263
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti558T → I in AAS56441 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65064.1.
AY558115 Genomic DNA. Translation: AAS56441.1.
BK006934 Genomic DNA. Translation: DAA06676.1.
PIRiS46825.
RefSeqiNP_011853.1. NM_001179090.1.

Genome annotation databases

EnsemblFungiiYHL010C; YHL010C; YHL010C.
GeneIDi856376.
KEGGisce:YHL010C.

Similar proteinsi

Entry informationi

Entry nameiETP1_YEAST
AccessioniPrimary (citable) accession number: P38748
Secondary accession number(s): D3DKQ3, Q6Q5F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names