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P38745

- YHB7_YEAST

UniProt

P38745 - YHB7_YEAST

Protein

Uncharacterized membrane protein YHL071W

Gene

YHL017W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31037-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized membrane protein YHL071W
    Gene namesi
    Ordered Locus Names:YHL017W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL017w.
    SGDiS000001009. YHL017W.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 532512Uncharacterized membrane protein YHL071WPRO_0000014326Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Modified residuei497 – 4971Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP38745.
    PaxDbiP38745.
    PeptideAtlasiP38745.

    Expressioni

    Gene expression databases

    GenevestigatoriP38745.

    Interactioni

    Protein-protein interaction databases

    BioGridi36406. 9 interactions.
    DIPiDIP-4577N.
    IntActiP38745. 4 interactions.
    MINTiMINT-541074.
    STRINGi4932.YHL017W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38745.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 193173LumenalSequence AnalysisAdd
    BLAST
    Topological domaini215 – 22612CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26215LumenalSequence AnalysisAdd
    BLAST
    Topological domaini284 – 30118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 3308LumenalSequence Analysis
    Topological domaini352 – 37524CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini397 – 41418LumenalSequence AnalysisAdd
    BLAST
    Topological domaini436 – 53297CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei194 – 21421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LU7TM family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302490.
    GeneTreeiENSGT00390000015417.
    HOGENOMiHOG000176489.
    OMAiCEDSSEG.
    OrthoDBiEOG70ZZWZ.

    Family and domain databases

    InterProiIPR009637. TM_rcpt_euk.
    [Graphical view]
    PANTHERiPTHR21229. PTHR21229. 1 hit.
    PfamiPF06814. Lung_7-TM_R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRTWLLLTW LLLLCGVVQG NQESINQKYH DVCSGMYSKE DFNGKVDPYI    50
    SFTLEELSLA DEDDDGEGVS VAVFDFQDYE HIGVRLPNGE IQYICDDYAL 100
    DLGLCEDSSE GQFIIQETAI DPFTSKEHKL TSQILTFTQQ ELGTNDKVYS 150
    INKTGYYCVT TSSFISSSSK FKATVNFRNA YGQLDASEAY KMPIYAFLAV 200
    AYAVCTLVYS WLCWKHRHEL LPLQRYILVF CIFLTADTIF VWMYYIIENQ 250
    KGNSSVALHV YMVFISIFSA GKMTFTLLLA LLISLGYGIV YPKLDRTLLR 300
    RCQIFAIFTF AVCVAFLVQK YSQNSESLSN LILITAIPLV LCLFAFYYLT 350
    LSSMNKTMTY LREQNQVVKL NMYRKLIILC YISLFILFLG LLVSTFAYVG 400
    MDTVDMIEQY WKTEFLITDT WPSFVYFLVF VIFAFFWRPT STSYLLACSH 450
    QLPTDMENVS EFDLDDINSL SDEALPNREP RNDYQEHDHN MDIDLASDFE 500
    EVPSVNANTN ANNDVLFDVD YDRDAKNDRS TT 532
    Length:532
    Mass (Da):61,206
    Last modified:February 1, 1995 - v1
    Checksum:iEF2CB7CB74006503
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11582 Genomic DNA. Translation: AAB65070.1.
    BK006934 Genomic DNA. Translation: DAA06668.1.
    PIRiS46831.
    RefSeqiNP_011846.1. NM_001179097.1.

    Genome annotation databases

    EnsemblFungiiYHL017W; YHL017W; YHL017W.
    GeneIDi856369.
    KEGGisce:YHL017W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11582 Genomic DNA. Translation: AAB65070.1 .
    BK006934 Genomic DNA. Translation: DAA06668.1 .
    PIRi S46831.
    RefSeqi NP_011846.1. NM_001179097.1.

    3D structure databases

    ProteinModelPortali P38745.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36406. 9 interactions.
    DIPi DIP-4577N.
    IntActi P38745. 4 interactions.
    MINTi MINT-541074.
    STRINGi 4932.YHL017W.

    Proteomic databases

    MaxQBi P38745.
    PaxDbi P38745.
    PeptideAtlasi P38745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL017W ; YHL017W ; YHL017W .
    GeneIDi 856369.
    KEGGi sce:YHL017W.

    Organism-specific databases

    CYGDi YHL017w.
    SGDi S000001009. YHL017W.

    Phylogenomic databases

    eggNOGi NOG302490.
    GeneTreei ENSGT00390000015417.
    HOGENOMi HOG000176489.
    OMAi CEDSSEG.
    OrthoDBi EOG70ZZWZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31037-MONOMER.

    Miscellaneous databases

    NextBioi 981843.
    PROi P38745.

    Gene expression databases

    Genevestigatori P38745.

    Family and domain databases

    InterProi IPR009637. TM_rcpt_euk.
    [Graphical view ]
    PANTHERi PTHR21229. PTHR21229. 1 hit.
    Pfami PF06814. Lung_7-TM_R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYHB7_YEAST
    AccessioniPrimary (citable) accession number: P38745
    Secondary accession number(s): D3DKR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 14600 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3