P38745 (YHB7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized membrane protein YHL071W

Gene names

Ordered Locus Names:

YHL017W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein Ref.3.
Miscellaneous	Present with 14600 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the LU7TM family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 532	512	Uncharacterized membrane protein YHL071W		PRO_0000014326
Regions
	Topological domain	21 – 193	173	Lumenal Potential
	Transmembrane	194 – 214	21	Helical; Name=1; Potential
	Topological domain	215 – 226	12	Cytoplasmic Potential
	Transmembrane	227 – 247	21	Helical; Name=2; Potential
	Topological domain	248 – 262	15	Lumenal Potential
	Transmembrane	263 – 283	21	Helical; Name=3; Potential
	Topological domain	284 – 301	18	Cytoplasmic Potential
	Transmembrane	302 – 322	21	Helical; Name=4; Potential
	Topological domain	323 – 330	8	Lumenal Potential
	Transmembrane	331 – 351	21	Helical; Name=5; Potential
	Topological domain	352 – 375	24	Cytoplasmic Potential
	Transmembrane	376 – 396	21	Helical; Name=6; Potential
	Topological domain	397 – 414	18	Lumenal Potential
	Transmembrane	415 – 435	21	Helical; Name=7; Potential
	Topological domain	436 – 532	97	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P38745 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: EF2CB7CB74006503	FASTA	532	61,206
	10 20 30 40 50 60 MDRTWLLLTW LLLLCGVVQG NQESINQKYH DVCSGMYSKE DFNGKVDPYI SFTLEELSLA 70 80 90 100 110 120 DEDDDGEGVS VAVFDFQDYE HIGVRLPNGE IQYICDDYAL DLGLCEDSSE GQFIIQETAI 130 140 150 160 170 180 DPFTSKEHKL TSQILTFTQQ ELGTNDKVYS INKTGYYCVT TSSFISSSSK FKATVNFRNA 190 200 210 220 230 240 YGQLDASEAY KMPIYAFLAV AYAVCTLVYS WLCWKHRHEL LPLQRYILVF CIFLTADTIF 250 260 270 280 290 300 VWMYYIIENQ KGNSSVALHV YMVFISIFSA GKMTFTLLLA LLISLGYGIV YPKLDRTLLR 310 320 330 340 350 360 RCQIFAIFTF AVCVAFLVQK YSQNSESLSN LILITAIPLV LCLFAFYYLT LSSMNKTMTY 370 380 390 400 410 420 LREQNQVVKL NMYRKLIILC YISLFILFLG LLVSTFAYVG MDTVDMIEQY WKTEFLITDT 430 440 450 460 470 480 WPSFVYFLVF VIFAFFWRPT STSYLLACSH QLPTDMENVS EFDLDDINSL SDEALPNREP 490 500 510 520 530 RNDYQEHDHN MDIDLASDFE EVPSVNANTN ANNDVLFDVD YDRDAKNDRS TT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11582 Genomic DNA. Translation: AAB65070.1. BK006934 Genomic DNA. Translation: DAA06668.1.
PIR	S46831.
RefSeq	NP_011846.1. NM_001179097.1.
3D structure databases
ProteinModelPortal	P38745.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4577N.
IntAct	P38745. 4 interactions.
MINT	MINT-541074.
Proteomic databases
PeptideAtlas	P38745.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL017W; YHL017W; YHL017W.
GeneID	856369.
KEGG	sce:YHL017W.
NMPDR	fig|4932.3.peg.2985.
Organism-specific databases
CYGD	YHL017w.
SGD	S000001009. YHL017W.
Phylogenomic databases
eggNOG	fuNOG05245.
GeneTree	EFGT00050000005371.
HOGENOM	HBG327762.
OMA	VYMVFIS.
OrthoDB	EOG43XZCR.
Gene expression databases
ArrayExpress	P38745.
Genevestigator	P38745.
GermOnline	YHL017W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009637. TM_rcpt_euk. [Graphical view]
PANTHER	PTHR21229. Lung7_TM_rcpt. 1 hit.
Pfam	PF06814. Lung_7-TM_R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981843.

Entry information

Entry name

YHB7_YEAST

Accession

Primary (citable) accession number: P38745
Secondary accession number(s): D3DKR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program