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Protein

Uncharacterized membrane protein YHL071W

Gene

YHL017W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31037-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YHL071W
Gene namesi
Ordered Locus Names:YHL017W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL017w.
SGDiS000001009. YHL017W.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 193173LumenalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini215 – 22612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini248 – 26215LumenalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini284 – 30118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini323 – 3308LumenalSequence Analysis
Transmembranei331 – 35121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini352 – 37524CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei376 – 39621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini397 – 41418LumenalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini436 – 53297CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 532512Uncharacterized membrane protein YHL071WPRO_0000014326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Modified residuei497 – 4971Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP38745.
PaxDbiP38745.
PeptideAtlasiP38745.

Expressioni

Gene expression databases

GenevestigatoriP38745.

Interactioni

Protein-protein interaction databases

BioGridi36406. 9 interactions.
DIPiDIP-4577N.
IntActiP38745. 4 interactions.
MINTiMINT-541074.
STRINGi4932.YHL017W.

Structurei

3D structure databases

ProteinModelPortaliP38745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302490.
GeneTreeiENSGT00390000015417.
HOGENOMiHOG000176489.
InParanoidiP38745.
OMAiVYMVFIS.
OrthoDBiEOG70ZZWZ.

Family and domain databases

InterProiIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38745-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRTWLLLTW LLLLCGVVQG NQESINQKYH DVCSGMYSKE DFNGKVDPYI
60 70 80 90 100
SFTLEELSLA DEDDDGEGVS VAVFDFQDYE HIGVRLPNGE IQYICDDYAL
110 120 130 140 150
DLGLCEDSSE GQFIIQETAI DPFTSKEHKL TSQILTFTQQ ELGTNDKVYS
160 170 180 190 200
INKTGYYCVT TSSFISSSSK FKATVNFRNA YGQLDASEAY KMPIYAFLAV
210 220 230 240 250
AYAVCTLVYS WLCWKHRHEL LPLQRYILVF CIFLTADTIF VWMYYIIENQ
260 270 280 290 300
KGNSSVALHV YMVFISIFSA GKMTFTLLLA LLISLGYGIV YPKLDRTLLR
310 320 330 340 350
RCQIFAIFTF AVCVAFLVQK YSQNSESLSN LILITAIPLV LCLFAFYYLT
360 370 380 390 400
LSSMNKTMTY LREQNQVVKL NMYRKLIILC YISLFILFLG LLVSTFAYVG
410 420 430 440 450
MDTVDMIEQY WKTEFLITDT WPSFVYFLVF VIFAFFWRPT STSYLLACSH
460 470 480 490 500
QLPTDMENVS EFDLDDINSL SDEALPNREP RNDYQEHDHN MDIDLASDFE
510 520 530
EVPSVNANTN ANNDVLFDVD YDRDAKNDRS TT
Length:532
Mass (Da):61,206
Last modified:February 1, 1995 - v1
Checksum:iEF2CB7CB74006503
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65070.1.
BK006934 Genomic DNA. Translation: DAA06668.1.
PIRiS46831.
RefSeqiNP_011846.1. NM_001179097.1.

Genome annotation databases

EnsemblFungiiYHL017W; YHL017W; YHL017W.
GeneIDi856369.
KEGGisce:YHL017W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65070.1.
BK006934 Genomic DNA. Translation: DAA06668.1.
PIRiS46831.
RefSeqiNP_011846.1. NM_001179097.1.

3D structure databases

ProteinModelPortaliP38745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36406. 9 interactions.
DIPiDIP-4577N.
IntActiP38745. 4 interactions.
MINTiMINT-541074.
STRINGi4932.YHL017W.

Proteomic databases

MaxQBiP38745.
PaxDbiP38745.
PeptideAtlasiP38745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL017W; YHL017W; YHL017W.
GeneIDi856369.
KEGGisce:YHL017W.

Organism-specific databases

CYGDiYHL017w.
SGDiS000001009. YHL017W.

Phylogenomic databases

eggNOGiNOG302490.
GeneTreeiENSGT00390000015417.
HOGENOMiHOG000176489.
InParanoidiP38745.
OMAiVYMVFIS.
OrthoDBiEOG70ZZWZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31037-MONOMER.

Miscellaneous databases

NextBioi981843.
PROiP38745.

Gene expression databases

GenevestigatoriP38745.

Family and domain databases

InterProiIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYHB7_YEAST
AccessioniPrimary (citable) accession number: P38745
Secondary accession number(s): D3DKR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 14600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.