Reviewed, UniProtKB/Swiss-Prot P38745 (YHB7_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized membrane protein YHL071W

Gene names

Ordered Locus Names:

YHL017W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein.
Miscellaneous	Present with 14600 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the LU7TM family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 532	512	Uncharacterized membrane protein YHL071W		PRO_0000014326
Regions
	Topological domain	21 – 193	173	Lumenal Potential
	Transmembrane	194 – 214	21	1 Potential
	Topological domain	215 – 226	12	Cytoplasmic Potential
	Transmembrane	227 – 247	21	2 Potential
	Topological domain	248 – 262	15	Lumenal Potential
	Transmembrane	263 – 283	21	3 Potential
	Topological domain	284 – 301	18	Cytoplasmic Potential
	Transmembrane	302 – 322	21	4 Potential
	Topological domain	323 – 330	8	Lumenal Potential
	Transmembrane	331 – 351	21	5 Potential
	Topological domain	352 – 375	24	Cytoplasmic Potential
	Transmembrane	376 – 396	21	6 Potential
	Topological domain	397 – 414	18	Lumenal Potential
	Transmembrane	415 – 435	21	7 Potential
	Topological domain	436 – 532	97	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P38745-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: EF2CB7CB74006503	FASTA	532	61,206
	10 20 30 40 50 60 MDRTWLLLTW LLLLCGVVQG NQESINQKYH DVCSGMYSKE DFNGKVDPYI SFTLEELSLA 70 80 90 100 110 120 DEDDDGEGVS VAVFDFQDYE HIGVRLPNGE IQYICDDYAL DLGLCEDSSE GQFIIQETAI 130 140 150 160 170 180 DPFTSKEHKL TSQILTFTQQ ELGTNDKVYS INKTGYYCVT TSSFISSSSK FKATVNFRNA 190 200 210 220 230 240 YGQLDASEAY KMPIYAFLAV AYAVCTLVYS WLCWKHRHEL LPLQRYILVF CIFLTADTIF 250 260 270 280 290 300 VWMYYIIENQ KGNSSVALHV YMVFISIFSA GKMTFTLLLA LLISLGYGIV YPKLDRTLLR 310 320 330 340 350 360 RCQIFAIFTF AVCVAFLVQK YSQNSESLSN LILITAIPLV LCLFAFYYLT LSSMNKTMTY 370 380 390 400 410 420 LREQNQVVKL NMYRKLIILC YISLFILFLG LLVSTFAYVG MDTVDMIEQY WKTEFLITDT 430 440 450 460 470 480 WPSFVYFLVF VIFAFFWRPT STSYLLACSH QLPTDMENVS EFDLDDINSL SDEALPNREP 490 500 510 520 530 RNDYQEHDHN MDIDLASDFE EVPSVNANTN ANNDVLFDVD YDRDAKNDRS TT

References

[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U11582 Genomic DNA. Translation: AAB65070.1.
PIR	S46831.
RefSeq	NP_011846.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4577N.
IntAct	P38745. 5 interactions.
Proteomic databases
PeptideAtlas	P38745.
Genome annotation databases
Ensembl	YHL017W; YHL017W; YHL017W; Saccharomyces cerevisiae. [Genome view]
GeneID	856369.
KEGG	sce:YHL017W.
NMPDR	fig|4932.3.peg.2985.
Organism-specific databases
CYGD	YHL017w.
SGD	S000001009. YHL017W.
Phylogenomic databases
HOGENOM	P38745.
OMA	VYMVFIS
OrthoDB	EOG9G4J74
Gene expression databases
ArrayExpress	P38745.
Genevestigator	P38745.
GermOnline	YHL017W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009637. TM_rcpt_euk. [Graphical view]
PANTHER	PTHR21229. Lung7_TM_rcpt. 1 hit.
Pfam	PF06814. Lung_7-TM_R. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	981843.

Entry information

Entry name

YHB7_YEAST

Accession

Primary (citable) accession number: P38745

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)