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Protein

Putative pterin-4-alpha-carbinolamine dehydratase

Gene

YHL018W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

GO - Molecular functioni

  1. 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. tetrahydrobiopterin biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciYEAST:G3O-31038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Ordered Locus Names:YHL018W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHL018w.
SGDiS000001010. YHL018W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Putative pterin-4-alpha-carbinolamine dehydratasePRO_0000063064Add
BLAST

Proteomic databases

MaxQBiP38744.
PaxDbiP38744.

Expressioni

Gene expression databases

GenevestigatoriP38744.

Interactioni

Protein-protein interaction databases

BioGridi36405. 15 interactions.
DIPiDIP-1872N.
IntActiP38744. 13 interactions.
MINTiMINT-404879.
STRINGi4932.YHL018W.

Structurei

3D structure databases

SMRiP38744. Positions 8-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2154.
HOGENOMiHOG000007680.
InParanoidiP38744.
OrthoDBiEOG79GTM1.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Complete.

P38744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNKIVRIAS SALTGGKLLE KLKPLTRWEV QWDPNKTKCL GITREVTFKD
60 70 80 90 100
YETTWAFLTR VSMRSHLWGH HPLIHTSYTW VKLELHTHDI DPKDGAHSQL
110 120
SDIDVRMAKR IDSYIDEMTT
Length:120
Mass (Da):14,026
Last modified:January 31, 1995 - v1
Checksum:i4265E895BD5CDB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65071.1.
AY558391 Genomic DNA. Translation: AAS56717.1.
BK006934 Genomic DNA. Translation: DAA06667.1.
PIRiS46832.
RefSeqiNP_011845.1. NM_001179098.1.

Genome annotation databases

EnsemblFungiiYHL018W; YHL018W; YHL018W.
GeneIDi856368.
KEGGisce:YHL018W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65071.1.
AY558391 Genomic DNA. Translation: AAS56717.1.
BK006934 Genomic DNA. Translation: DAA06667.1.
PIRiS46832.
RefSeqiNP_011845.1. NM_001179098.1.

3D structure databases

SMRiP38744. Positions 8-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36405. 15 interactions.
DIPiDIP-1872N.
IntActiP38744. 13 interactions.
MINTiMINT-404879.
STRINGi4932.YHL018W.

Proteomic databases

MaxQBiP38744.
PaxDbiP38744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL018W; YHL018W; YHL018W.
GeneIDi856368.
KEGGisce:YHL018W.

Organism-specific databases

CYGDiYHL018w.
SGDiS000001010. YHL018W.

Phylogenomic databases

eggNOGiCOG2154.
HOGENOMiHOG000007680.
InParanoidiP38744.
OrthoDBiEOG79GTM1.

Enzyme and pathway databases

BioCyciYEAST:G3O-31038-MONOMER.

Miscellaneous databases

NextBioi981840.
PROiP38744.

Gene expression databases

GenevestigatoriP38744.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPHS_YEAST
AccessioniPrimary (citable) accession number: P38744
Secondary accession number(s): D3DKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: January 31, 1995
Last modified: March 31, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.