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P38744 (PHS_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative pterin-4-alpha-carbinolamine dehydratase

Short name=PHS
EC=4.2.1.96
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase
Short name=PCD
Gene names
Ordered Locus Names:YHL018W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtetrahydrobiopterin biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_function4-alpha-hydroxytetrahydrobiopterin dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Putative pterin-4-alpha-carbinolamine dehydratase
PRO_0000063064

Sequences

Sequence LengthMass (Da)Tools
P38744 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4265E895BD5CDB02

FASTA12014,026
        10         20         30         40         50         60 
MHNKIVRIAS SALTGGKLLE KLKPLTRWEV QWDPNKTKCL GITREVTFKD YETTWAFLTR 

        70         80         90        100        110        120 
VSMRSHLWGH HPLIHTSYTW VKLELHTHDI DPKDGAHSQL SDIDVRMAKR IDSYIDEMTT 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11582 Genomic DNA. Translation: AAB65071.1.
AY558391 Genomic DNA. Translation: AAS56717.1.
BK006934 Genomic DNA. Translation: DAA06667.1.
PIRS46832.
RefSeqNP_011845.1. NM_001179098.1.

3D structure databases

ProteinModelPortalP38744.
SMRP38744. Positions 8-112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36405. 15 interactions.
DIPDIP-1872N.
IntActP38744. 13 interactions.
MINTMINT-404879.
STRING4932.YHL018W.

Proteomic databases

PaxDbP38744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL018W; YHL018W; YHL018W.
GeneID856368.
KEGGsce:YHL018W.

Organism-specific databases

CYGDYHL018w.
SGDS000001010. YHL018W.

Phylogenomic databases

eggNOGCOG2154.
HOGENOMHOG000007680.
OrthoDBEOG79GTM1.

Enzyme and pathway databases

BioCycYEAST:G3O-31038-MONOMER.

Gene expression databases

GenevestigatorP38744.

Family and domain databases

Gene3D3.30.1360.20. 1 hit.
InterProIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERPTHR12599. PTHR12599. 1 hit.
PfamPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMSSF55248. SSF55248. 1 hit.
ProtoNetSearch...

Other

NextBio981840.
PROP38744.

Entry information

Entry namePHS_YEAST
AccessionPrimary (citable) accession number: P38744
Secondary accession number(s): D3DKR5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families