Cell wall integrity and stress response component 4 precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38739 (WSC4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 80. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cell wall integrity and stress response component 4

Gene names

Name:	WSC4
Ordered Locus Names:	YHL028W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 WSC domain.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW protein targeting to ER Inferred from mutant phenotype. Source: SGD response to heat Inferred from genetic interaction. Source: SGD
Cellular component	endoplasmic reticulum membrane Inferred from direct assay. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transmembrane signaling receptor activity Inferred from genetic interaction. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSB3	P43603	1	EBI-20558,EBI-22980
YSC84	P32793	1	EBI-20558,EBI-24460

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

26

Potential

Chain

579

Cell wall integrity and stress response component 4

PRO_0000041486

Regions

Transmembrane

21

Helical; Potential

Domain

84

WSC

Compositional bias

202

Ser/Thr-rich

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P38739 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C9DF8CBAA9553811
Show »

605

63,808

        10         20         30         40         50         60 
MQTSMVSAKV SIWLVCSVIC SSLVRATQSV CSSQNTATTD GVRNQFQSNG WCSNNCAGHQ 

        70         80         90        100        110        120 
FAIVQGFMCW CSDSEPSTQT SVGDCSGTCP GYGYEDCGNA DKDLFGYIYL GQTPLSSVQS 

       130        140        150        160        170        180 
VETSTESSVY VSSSSITSSS STSIVDTTTI SPTLTSTSTT PLTTASTSTT PSTDITSALP 

       190        200        210        220        230        240 
TTTSTKLSTS IPTSTTSSTS TTTSTSSSTS TTVSVTSSTS TTTSTTSSTL ISTSTSSSSS 

       250        260        270        280        290        300 
STPTTTSSAP ISTSTTSSTS TSTSTTSPTS SSAPTSSSNT TPTSTTFTTT SPSTAPSSTT 

       310        320        330        340        350        360 
VTYTSTTASP ITSTITSVNL QTSLKYSVIT VTSVHTMDTN ISEITSRYLT MKKVITQIYS 

       370        380        390        400        410        420 
STLGATPTSA VATTSASVGG RITNNNNSNT TNSNTPTNKS TEKKGYWDSP GKIAATFVVV 

       430        440        450        460        470        480 
GVVCLVIICI LIYLIHHYRT RPARKAQDFE NEYQSKFYQS KYPNEVTTTT LHTPSPSSNS 

       490        500        510        520        530        540 
TFSTPRLIYT DEKGQIMSES PSPRQSTYSL TAGSPPNDPS TLASPFHDPI LPRRTSTFLH 

       550        560        570        580        590        600 
SPIQKQHEKM ESNVTLGEDT VLVDQRLDPS KMLNTLANDD ATNHSTISLS DNVDYSRRVL 


RLMNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11583 Genomic DNA. Translation: AAB65040.1. BK006934 Genomic DNA. Translation: DAA06657.1.
PIR	S48940.
RefSeq	NP_011835.1. NM_001179108.1.
3D structure databases
ProteinModelPortal	P38739.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38739. 3 interactions.
MINT	MINT-1552783.
STRING	P38739.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL028W; YHL028W; YHL028W.
GeneID	856357.
KEGG	sce:YHL028W.
NMPDR	fig\|4932.3.peg.2973.
Organism-specific databases
CYGD	YHL028w.
SGD	S000001020. WSC4.
Phylogenomic databases
eggNOG	fuNOG12241.
GeneTree	EFGT00070000008721.
OMA	ISSEMCA.
OrthoDB	EOG49PF7T.
Gene expression databases
ArrayExpress	P38739.
Genevestigator	P38739.
GermOnline	YHL028W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002889. WSC_carb-bd. [Graphical view]
PROSITE	PS51212. WSC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981808.

Entry information

Entry name

WSC4_YEAST

Accession

Primary (citable) accession number: P38739
Secondary accession number(s): D3DKU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents