P38738 (OCA5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxidant-induced cell-cycle arrest protein 5

Gene names

Name:	OCA5
Ordered Locus Names:	YHL029C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	679 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for replication of brome mosaic virus (BMV), a positive-strand RNA virus. Ref.5
Subcellular location	Cytoplasm Ref.3.
Miscellaneous	Present with 12500 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the OCA5 family. Contains 1 Rab-GAP TBC domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.3. Source: SGD
Molecular function	Rab GTPase activator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
OCA4	P25366	3	EBI-24355,EBI-22021

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 679	679	Oxidant-induced cell-cycle arrest protein 5		PRO_0000202881
Regions
	Domain	50 – 441	392	Rab-GAP TBC
	Compositional bias	263 – 271	9	Poly-Asn
	Compositional bias	609 – 637	29	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	P38738 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: AA2C5434FFDD881A	FASTA	679	77,756
	10 20 30 40 50 60 MHDKKSPMAN SHYLKNLKQQ FRNKNLIETT IHLVKCNDHD SLAFLARTYG VPPQLRHVVW 70 80 90 100 110 120 PILLKYHPMC ISPNITSNTI SWDPITNDFI LNDPFLKSKA PTDKQDKSDD ENILPYDIES 130 140 150 160 170 180 IILHDLKKYF HSRSNPAGSS SNANTTNIAT PTPVSSSDAS TISSMEVLSP SLDYEFQIIE 190 200 210 220 230 240 TLKNAIVKFL LKWSKIFKYE SGLAWIALGL AEWYPIYPYE TMSPFNETHS FYEVEDYVVL 250 260 270 280 290 300 SGRKHALLST NNGNNGNSNS SSNNTNNNNT NITSGMHNLS INTNTSLHNS PYISHTLSYL 310 320 330 340 350 360 YKEYPLPFEL RSKLPTKPIF SFSALFERLA LVILHCPDTI LAHKQLKNDS NASSSSKANS 370 380 390 400 410 420 NFNTNYFPII SGGDLSFQTQ VFFKVFSSIL PELYQPLTEE SSLQPSSSRN SWIYWWLKCS 430 440 450 460 470 480 GAKALQRQDR GRVWDLLLGW RPKPNMDTIN FFLNYNDKKM DHLYHDTPQC DNEQYWMKDW 490 500 510 520 530 540 IALYNNDPFW FPDLDSMALG SKKFPYDYSV FKELILRNRY GGTQSKAQKD NTVPSPGSDS 550 560 570 580 590 600 NDKSELKLPF SSIDPHMQLI FIFIAILQFN EFKLLEFEEA EISEFLNNVP LLTKFDDSSY 610 620 630 640 650 660 RKLYENTESS ITSLPSSPTT STMASLQSSS NSSAHISNYH MLIEVGNDAK ASHCFDDLLN 670 MAGDIWRKWL WRELEESSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus." Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P. Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed: 14671320] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11583 Genomic DNA. Translation: AAB65041.1. BK006934 Genomic DNA. Translation: DAA06656.1.
PIR	S48939.
RefSeq	NP_011834.1. NM_001179109.1.
3D structure databases
ProteinModelPortal	P38738.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5006N.
IntAct	P38738. 8 interactions.
MINT	MINT-532502.
STRING	P38738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL029C; YHL029C; YHL029C.
GeneID	856356.
KEGG	sce:YHL029C.
NMPDR	fig|4932.3.peg.2972.
Organism-specific databases
CYGD	YHL029c.
SGD	S000001021. OCA5.
Phylogenomic databases
eggNOG	fuNOG08132.
HOGENOM	HBG203791.
OMA	DRGRIWD.
OrthoDB	EOG4T4H3Z.
Gene expression databases
ArrayExpress	P38738.
Genevestigator	P38738.
GermOnline	YHL029C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000195. RabGAP/TBC_dom. [Graphical view]
SMART	SM00164. TBC. 1 hit. [Graphical view]
SUPFAM	SSF47923. RabGAP_TBC. 1 hit.
PROSITE	PS50086. TBC_RABGAP. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	981805.

Entry information

Entry name

OCA5_YEAST

Accession

Primary (citable) accession number: P38738
Secondary accession number(s): D3DKT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program