P38736 (GOS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein transport protein GOS1

Alternative name(s):
Golgi SNAP receptor complex member 1
Golgi SNARE protein 1

Gene names

Name:	GOS1
Ordered Locus Names:	YHL031C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nonessential SNARE involved in retrograde transport within the Golgi complex. Ref.3 Ref.4
Subunit structure	Component of a SNARE complex consisting of SED5, GOS1, YKT6, and SFT1.
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein Ref.3.
Sequence similarities	Belongs to the GOSR1 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ER to Golgi vesicle-mediated transport Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle fusion Inferred from direct assay. Source: SGD
Cellular component	Golgi medial cisterna Inferred from direct assay. Source: SGD Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell SNARE complex Inferred from direct assay. Source: SGD cis-Golgi network Inferred from electronic annotation. Source: InterPro integral to membrane Non-traceable author statement Ref.3. Source: SGD
Molecular function	SNAP receptor activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SED5	Q01590	4	EBI-24365,EBI-16930

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Protein transport protein GOS1		PRO_0000212557
Regions
	Topological domain	1 – 204	204	Cytoplasmic Potential
	Transmembrane	205 – 222	18	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	223	1	Vesicular Potential
Amino acid modifications
	Modified residue	164	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P38736 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 1E833249CCC306C2	FASTA	223	25,395
	10 20 30 40 50 60 MSSQPSFVTI RGKAISLETQ TESLLSKYST FAQTTSSEQT GQEKKIDKQL EGILGQRQDV 70 80 90 100 110 120 IDSLTQICDS NPAISASKLS QLHRHKEILQ DHWKSFRNIR SSIQQERNRL NLLFSVKNDI 130 140 150 160 170 180 ANSTTDAPAP IGDADEYIQN ETRRIDQSNN VVDRLISQAW ETRSQFHSQS NVLNTANNKV 190 200 210 220 LQTLQRIPGV NQLIMKINTR RKKNAFVLAT ITTLCILFLF FTW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport." McNew J.A., Coe J.G.S., Sogaard M., Zemelman B.V., Wimmer C., Hong W., Soellner T.H. FEBS Lett. 435:89-95(1998) [PubMed: 9755865] [Abstract] Cited for: FUNCTION, INTERACTION WITH SED5, SUBCELLULAR LOCATION.
[4]	"Topological restriction of SNARE-dependent membrane fusion." Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E. Nature 407:194-198(2000) [PubMed: 11001058] [Abstract] Cited for: FUNCTION, INTERACTION WITH SED5; YKT6 AND SFT1.
[5]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, MASS SPECTROMETRY. Strain: ADR376.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11583 Genomic DNA. Translation: AAB65043.1. BK006934 Genomic DNA. Translation: DAA06654.1.
PIR	S48937.
RefSeq	NP_011832.1. NM_001179111.1.
3D structure databases
ProteinModelPortal	P38736.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2490N.
IntAct	P38736. 8 interactions.
STRING	P38736.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL031C; YHL031C; YHL031C.
GeneID	856354.
KEGG	sce:YHL031C.
NMPDR	fig|4932.3.peg.2969.
Organism-specific databases
CYGD	YHL031c.
SGD	S000001023. GOS1.
Phylogenomic databases
eggNOG	fuNOG09363.
GeneTree	EFGT00050000004546.
HOGENOM	HBG382530.
OMA	MDVPSSW.
OrthoDB	EOG444PVQ.
Gene expression databases
ArrayExpress	P38736.
Genevestigator	P38736.
GermOnline	YHL031C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR023601. Golgi_SNAP_su1. [Graphical view]
KO	K08495.
PANTHER	PTHR21094. PTHR21094. 1 hit.
PIRSF	PIRSF027109. Golgi_SNARE. 1 hit.
ProtoNet	Search...
Other
NextBio	981799.

Entry information

Entry name

GOS1_YEAST

Accession

Primary (citable) accession number: P38736
Secondary accession number(s): D3DKT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program