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P38735 (VMR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter ATP-binding protein/permease VMR1
Alternative name(s):
Vacuolar multidrug resistance protein 1
Gene names
Name:VMR1
Ordered Locus Names:YHL035C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length1592 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

ABC transporter which may be involved in multidrug resistance By similarity.

Subcellular location

Vacuole membrane; Multi-pass membrane protein Probable.

Induction

Under the controle of the iron homeostasis regulating AFT1 and AFT2 transcription factors. Up-regulated upon SUB2 overexpression. Ref.4 Ref.5 Ref.6

Sequence similarities

Belongs to the ABC transporter superfamily.

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15921592ABC transporter ATP-binding protein/permease VMR1
PRO_0000093465

Regions

Topological domain1 – 3333Vacuolar By similarity
Transmembrane34 – 5421Helical; Name=1; By similarity
Topological domain55 – 7420Cytoplasmic By similarity
Transmembrane75 – 9521Helical; Name=2; By similarity
Topological domain96 – 1005Vacuolar By similarity
Transmembrane101 – 12121Helical; Name=3; By similarity
Topological domain122 – 13110Cytoplasmic By similarity
Transmembrane132 – 15221Helical; Name=4; By similarity
Topological domain153 – 17018Vacuolar By similarity
Transmembrane171 – 19121Helical; Name=5; By similarity
Topological domain192 – 329138Cytoplasmic By similarity
Transmembrane330 – 35021Helical; Name=6; By similarity
Topological domain351 – 37929Vacuolar By similarity
Transmembrane380 – 40021Helical; Name=7; By similarity
Topological domain401 – 46565Cytoplasmic By similarity
Transmembrane466 – 48621Helical; Name=8; By similarity
Topological domain487 – 4893Vacuolar By similarity
Transmembrane490 – 51021Helical; Name=9; By similarity
Topological domain511 – 57262Cytoplasmic By similarity
Transmembrane573 – 59321Helical; Name=10; By similarity
Topological domain594 – 61421Vacuolar By similarity
Transmembrane615 – 63521Helical; Name=11; By similarity
Topological domain636 – 989354Cytoplasmic By similarity
Transmembrane990 – 101021Helical; Name=12; By similarity
Topological domain1011 – 105141Vacuolar By similarity
Transmembrane1052 – 107221Helical; Name=13; By similarity
Topological domain1073 – 111543Cytoplasmic By similarity
Transmembrane1116 – 113621Helical; Name=14; By similarity
Topological domain11371Vacuolar By similarity
Transmembrane1138 – 115821Helical; Name=15; By similarity
Topological domain1159 – 122971Cytoplasmic By similarity
Transmembrane1230 – 125021Helical; Name=16; By similarity
Topological domain1251 – 12522Vacuolar By similarity
Transmembrane1253 – 127321Helical; Name=17; By similarity
Topological domain1274 – 1592319Cytoplasmic By similarity
Domain338 – 632295ABC transmembrane type-1 1
Domain664 – 908245ABC transporter 1
Domain981 – 1282302ABC transmembrane type-1 2
Domain1323 – 1572250ABC transporter 2
Nucleotide binding702 – 7098ATP 1 Potential
Nucleotide binding1357 – 13648ATP 2 Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation3701N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38735 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 055FB0399992ACE8

FASTA1,592180,926
        10         20         30         40         50         60 
MGTDPLIIRN NGSFWEVDDF TRLGRTQLLS YYLPLAIIAS IGIFALCRSG LSRYVRSAEC 

        70         80         90        100        110        120 
DLVNEYLFGA QEERKEDNSI ERLLRNSNTQ ANYVNVKKQG RILKLRHFDI TTIDVKQIDA 

       130        140        150        160        170        180 
KNHGGLTFSR PSTSDHLRKS SEIVLMSLQI IGLSFLRVTK INIELTNRDV TTLLLFWLIL 

       190        200        210        220        230        240 
LSLSILRVYK RSTNLWAICF TAHTTIWIST WIPIRSVYIG NIDDVPSQIF YIFEFVITST 

       250        260        270        280        290        300 
LQPIKLTSPI KDNSSIIYVR DDHTSPSREH ISSILSCITW SWITNFIWEA QKNTIKLKDI 

       310        320        330        340        350        360 
WGLSMEDYSI FILKGFTRRN KHINNLTLAL FESFKTYLLI GMLWVLVNSI VNLLPTILMK 

       370        380        390        400        410        420 
RFLEIVDNPN RSSSCMNLAW LYIIGMFICR LTLAICNSQG QFVSDKICLR IRAILIGEIY 

       430        440        450        460        470        480 
AKGLRRRLFT SPKTSSDSDS ISANLGTIIN LISIDSFKVS ELANYLYVTV QAVIMIIVVV 

       490        500        510        520        530        540 
GLLFNFLGVS AFAGISIILV MFPLNFLLAN LLGKFQKQTL KCTDQRISKL NECLQNIRIV 

       550        560        570        580        590        600 
KYFAWERNII NEIKSIRQKE LRSLLKKSLV WSVTSFLWFV TPTLVTGVTF AICTFVQHED 

       610        620        630        640        650        660 
LNAPLAFTTL SLFTLLKTPL DQLSNMLSFI NQSKVSLKRI SDFLRMDDTE KYNQLTISPD 

       670        680        690        700        710        720 
KNKIEFKNAT LTWNENDSDM NAFKLCGLNI KFQIGKLNLI LGSTGSGKSA LLLGLLGELN 

       730        740        750        760        770        780 
LISGSIIVPS LEPKHDLIPD CEGLTNSFAY CSQSAWLLND TVKNNIIFDN FYNEDRYNKV 

       790        800        810        820        830        840 
IDACGLKRDL EILPAGDLTE IGEKGITLSG GQKQRISLAR AVYSSAKHVL LDDCLSAVDS 

       850        860        870        880        890        900 
HTAVWIYENC ITGPLMKNRT CILVTHNVSL TLRNAHFAIV LENGKVKNQG TITELQSKGL 

       910        920        930        940        950        960 
FKEKYVQLSS RDSINEKNAN RLKAPRKNDS QKIEPVTENI NFDANFVNDG QLIEEEEKSN 

       970        980        990       1000       1010       1020 
GAISPDVYKW YLKFFGGFKA LTALFALYIT AQILFISQSW WIRHWVNDTN VRINAPGFAM 

      1030       1040       1050       1060       1070       1080 
DTLPLKGMTD SSKNKHNAFY YLTVYFLIGI IQAMLGGFKT MMTFLSGMRA SRKIFNNLLD 

      1090       1100       1110       1120       1130       1140 
LVLHAQIRFF DVTPVGRIMN RFSKDIEGVD QELIPYLEVT IFCLIQCASI IFLITVITPR 

      1150       1160       1170       1180       1190       1200 
FLTVAVIVFV LYFFVGKWYL TASRELKRLD SITKSPIFQH FSETLVGVCT IRAFGDERRF 

      1210       1220       1230       1240       1250       1260 
ILENMNKIDQ NNRAFFYLSV TVKWFSFRVD MIGAFIVLAS GSFILLNIAN IDSGLAGISL 

      1270       1280       1290       1300       1310       1320 
TYAILFTDGA LWLVRLYSTF EMNMNSVERL KEYSSIEQEN YLGHDEGRIL LLNEPSWPKD 

      1330       1340       1350       1360       1370       1380 
GEIEIENLSL RYAPNLPPVI RNVSFKVDPQ SKIGIVGRTG AGKSTIITAL FRLLEPITGC 

      1390       1400       1410       1420       1430       1440 
IKIDGQDISK IDLVTLRRSI TIIPQDPILF AGTIKSNVDP YDEYDEKKIF KALSQVNLIS 

      1450       1460       1470       1480       1490       1500 
SHEFEEVLNS EERFNSTHNK FLNLHTEIAE GGLNLSQGER QLLFIARSLL REPKIILLDE 

      1510       1520       1530       1540       1550       1560 
ATSSIDYDSD HLIQGIIRSE FNKSTILTIA HRLRSVIDYD RIIVMDAGEV KEYDRPSELL 

      1570       1580       1590 
KDERGIFYSM CRDSGGLELL KQIAKQSSKM MK

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Complete inventory of the yeast ABC proteins."
Decottignies A., Goffeau A.
Nat. Genet. 15:137-145(1997) [PubMed: 9020838] [Abstract]
Cited for: PROTEIN FAMILY.
[4]"Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements."
Rutherford J.C., Jaron S., Winge D.R.
J. Biol. Chem. 278:27636-27643(2003) [PubMed: 12756250] [Abstract]
Cited for: INDUCTION.
[5]"Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism."
van Bakel H., Strengman E., Wijmenga C., Holstege F.C.P.
Physiol. Genomics 22:356-367(2005) [PubMed: 15886332] [Abstract]
Cited for: INDUCTION.
[6]"The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes."
Lahue E., Heckathorn J., Meyer Z., Smith J., Wolfe C.
Yeast 22:537-551(2005) [PubMed: 15942929] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U11583 Genomic DNA. Translation: AAB65047.1.
BK006934 Genomic DNA. Translation: DAA06650.1.
PIRS48933.
RefSeqNP_011828.1. NM_001179115.1.

3D structure databases

ProteinModelPortalP38735.
SMRP38735. Positions 326-908, 966-1574.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6477N.
IntActP38735. 3 interactions.
MINTMINT-635362.
STRINGP38735.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL035C; YHL035C; YHL035C.
GeneID856350.
KEGGsce:YHL035C.
NMPDRfig|4932.3.peg.2964.

Organism-specific databases

CYGDYHL035c.
SGDS000001027. VMR1.

Phylogenomic databases

eggNOGfuNOG05955.
GeneTreeEFGT00050000001686.
HOGENOMHBG734884.
OMALISSHEF.
OrthoDBEOG4P5PJ6.

Gene expression databases

ArrayExpressP38735.
GenevestigatorP38735.
GermOnlineYHL035C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio981787.

Entry information

Entry nameVMR1_YEAST
AccessionPrimary (citable) accession number: P38735
Secondary accession number(s): D3DKT3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents