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Protein

ABC transporter ATP-binding protein/permease VMR1

Gene

VMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi702 – 709ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1357 – 1364ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • drug transport Source: SGD
  • response to drug Source: SGD
  • response to metal ion Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein/permease VMR1
Alternative name(s):
Vacuolar multidrug resistance protein 1
Gene namesi
Name:VMR1
Ordered Locus Names:YHL035C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL035C.
SGDiS000001027. VMR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33VacuolarBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100VacuolarBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 131CytoplasmicBy similarity10
Transmembranei132 – 152Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini153 – 170VacuolarBy similarityAdd BLAST18
Transmembranei171 – 191Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini192 – 329CytoplasmicBy similarityAdd BLAST138
Transmembranei330 – 350Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini351 – 379VacuolarBy similarityAdd BLAST29
Transmembranei380 – 400Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini401 – 465CytoplasmicBy similarityAdd BLAST65
Transmembranei466 – 486Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini487 – 489VacuolarBy similarity3
Transmembranei490 – 510Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini511 – 572CytoplasmicBy similarityAdd BLAST62
Transmembranei573 – 593Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini594 – 614VacuolarBy similarityAdd BLAST21
Transmembranei615 – 635Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini636 – 989CytoplasmicBy similarityAdd BLAST354
Transmembranei990 – 1010Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1011 – 1051VacuolarBy similarityAdd BLAST41
Transmembranei1052 – 1072Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1073 – 1115CytoplasmicBy similarityAdd BLAST43
Transmembranei1116 – 1136Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1137VacuolarBy similarity1
Transmembranei1138 – 1158Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1159 – 1229CytoplasmicBy similarityAdd BLAST71
Transmembranei1230 – 1250Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1251 – 1252VacuolarBy similarity2
Transmembranei1253 – 1273Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1274 – 1592CytoplasmicBy similarityAdd BLAST319

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934651 – 1592ABC transporter ATP-binding protein/permease VMR1Add BLAST1592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38735.
PRIDEiP38735.

Expressioni

Inductioni

Under the control of the iron homeostasis regulating AFT1 and AFT2 transcription factors. Up-regulated upon SUB2 overexpression.3 Publications

Interactioni

Subunit structurei

ABC transporter which may be involved in multidrug resistance.By similarity

Protein-protein interaction databases

BioGridi36387. 16 interactors.
DIPiDIP-6477N.
IntActiP38735. 3 interactors.
MINTiMINT-635362.

Structurei

3D structure databases

ProteinModelPortaliP38735.
SMRiP38735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini338 – 632ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST295
Domaini664 – 908ABC transporter 1PROSITE-ProRule annotationAdd BLAST245
Domaini981 – 1282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST302
Domaini1323 – 1572ABC transporter 2PROSITE-ProRule annotationAdd BLAST250

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000131000.
InParanoidiP38735.
OMAiTTIWIST.
OrthoDBiEOG092C0VET.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTDPLIIRN NGSFWEVDDF TRLGRTQLLS YYLPLAIIAS IGIFALCRSG
60 70 80 90 100
LSRYVRSAEC DLVNEYLFGA QEERKEDNSI ERLLRNSNTQ ANYVNVKKQG
110 120 130 140 150
RILKLRHFDI TTIDVKQIDA KNHGGLTFSR PSTSDHLRKS SEIVLMSLQI
160 170 180 190 200
IGLSFLRVTK INIELTNRDV TTLLLFWLIL LSLSILRVYK RSTNLWAICF
210 220 230 240 250
TAHTTIWIST WIPIRSVYIG NIDDVPSQIF YIFEFVITST LQPIKLTSPI
260 270 280 290 300
KDNSSIIYVR DDHTSPSREH ISSILSCITW SWITNFIWEA QKNTIKLKDI
310 320 330 340 350
WGLSMEDYSI FILKGFTRRN KHINNLTLAL FESFKTYLLI GMLWVLVNSI
360 370 380 390 400
VNLLPTILMK RFLEIVDNPN RSSSCMNLAW LYIIGMFICR LTLAICNSQG
410 420 430 440 450
QFVSDKICLR IRAILIGEIY AKGLRRRLFT SPKTSSDSDS ISANLGTIIN
460 470 480 490 500
LISIDSFKVS ELANYLYVTV QAVIMIIVVV GLLFNFLGVS AFAGISIILV
510 520 530 540 550
MFPLNFLLAN LLGKFQKQTL KCTDQRISKL NECLQNIRIV KYFAWERNII
560 570 580 590 600
NEIKSIRQKE LRSLLKKSLV WSVTSFLWFV TPTLVTGVTF AICTFVQHED
610 620 630 640 650
LNAPLAFTTL SLFTLLKTPL DQLSNMLSFI NQSKVSLKRI SDFLRMDDTE
660 670 680 690 700
KYNQLTISPD KNKIEFKNAT LTWNENDSDM NAFKLCGLNI KFQIGKLNLI
710 720 730 740 750
LGSTGSGKSA LLLGLLGELN LISGSIIVPS LEPKHDLIPD CEGLTNSFAY
760 770 780 790 800
CSQSAWLLND TVKNNIIFDN FYNEDRYNKV IDACGLKRDL EILPAGDLTE
810 820 830 840 850
IGEKGITLSG GQKQRISLAR AVYSSAKHVL LDDCLSAVDS HTAVWIYENC
860 870 880 890 900
ITGPLMKNRT CILVTHNVSL TLRNAHFAIV LENGKVKNQG TITELQSKGL
910 920 930 940 950
FKEKYVQLSS RDSINEKNAN RLKAPRKNDS QKIEPVTENI NFDANFVNDG
960 970 980 990 1000
QLIEEEEKSN GAISPDVYKW YLKFFGGFKA LTALFALYIT AQILFISQSW
1010 1020 1030 1040 1050
WIRHWVNDTN VRINAPGFAM DTLPLKGMTD SSKNKHNAFY YLTVYFLIGI
1060 1070 1080 1090 1100
IQAMLGGFKT MMTFLSGMRA SRKIFNNLLD LVLHAQIRFF DVTPVGRIMN
1110 1120 1130 1140 1150
RFSKDIEGVD QELIPYLEVT IFCLIQCASI IFLITVITPR FLTVAVIVFV
1160 1170 1180 1190 1200
LYFFVGKWYL TASRELKRLD SITKSPIFQH FSETLVGVCT IRAFGDERRF
1210 1220 1230 1240 1250
ILENMNKIDQ NNRAFFYLSV TVKWFSFRVD MIGAFIVLAS GSFILLNIAN
1260 1270 1280 1290 1300
IDSGLAGISL TYAILFTDGA LWLVRLYSTF EMNMNSVERL KEYSSIEQEN
1310 1320 1330 1340 1350
YLGHDEGRIL LLNEPSWPKD GEIEIENLSL RYAPNLPPVI RNVSFKVDPQ
1360 1370 1380 1390 1400
SKIGIVGRTG AGKSTIITAL FRLLEPITGC IKIDGQDISK IDLVTLRRSI
1410 1420 1430 1440 1450
TIIPQDPILF AGTIKSNVDP YDEYDEKKIF KALSQVNLIS SHEFEEVLNS
1460 1470 1480 1490 1500
EERFNSTHNK FLNLHTEIAE GGLNLSQGER QLLFIARSLL REPKIILLDE
1510 1520 1530 1540 1550
ATSSIDYDSD HLIQGIIRSE FNKSTILTIA HRLRSVIDYD RIIVMDAGEV
1560 1570 1580 1590
KEYDRPSELL KDERGIFYSM CRDSGGLELL KQIAKQSSKM MK
Length:1,592
Mass (Da):180,926
Last modified:February 1, 1995 - v1
Checksum:i055FB0399992ACE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65047.1.
BK006934 Genomic DNA. Translation: DAA06650.1.
PIRiS48933.
RefSeqiNP_011828.1. NM_001179115.1.

Genome annotation databases

EnsemblFungiiYHL035C; YHL035C; YHL035C.
GeneIDi856350.
KEGGisce:YHL035C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65047.1.
BK006934 Genomic DNA. Translation: DAA06650.1.
PIRiS48933.
RefSeqiNP_011828.1. NM_001179115.1.

3D structure databases

ProteinModelPortaliP38735.
SMRiP38735.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36387. 16 interactors.
DIPiDIP-6477N.
IntActiP38735. 3 interactors.
MINTiMINT-635362.

Proteomic databases

MaxQBiP38735.
PRIDEiP38735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL035C; YHL035C; YHL035C.
GeneIDi856350.
KEGGisce:YHL035C.

Organism-specific databases

EuPathDBiFungiDB:YHL035C.
SGDiS000001027. VMR1.

Phylogenomic databases

GeneTreeiENSGT00840000131000.
InParanoidiP38735.
OMAiTTIWIST.
OrthoDBiEOG092C0VET.

Enzyme and pathway databases

BioCyciYEAST:G3O-31054-MONOMER.

Miscellaneous databases

PROiP38735.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMR1_YEAST
AccessioniPrimary (citable) accession number: P38735
Secondary accession number(s): D3DKT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.