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P38734 (MUP3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Low-affinity methionine permease
Gene names
Name:MUP3
Ordered Locus Names:YHL036W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Very low affinity permease for methionine.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

To yeast high affinity methionine permease (MUP1).

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionL-methionine transmembrane transporter activity

Inferred from mutant phenotype Ref.3. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Low-affinity methionine permease
PRO_0000096649

Regions

Topological domain1 – 7070Extracellular Potential
Transmembrane71 – 9121Helical; Potential
Topological domain92 – 987Cytoplasmic Potential
Transmembrane99 – 11921Helical; Potential
Topological domain120 – 14829Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 18819Cytoplasmic Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 2134Extracellular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 25420Cytoplasmic Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 29722Extracellular Potential
Transmembrane298 – 31821Helical; Potential
Topological domain3191Cytoplasmic Potential
Transmembrane320 – 34021Helical; Potential
Topological domain341 – 3466Extracellular Potential
Transmembrane347 – 36721Helical; Potential
Topological domain368 – 39326Cytoplasmic Potential
Transmembrane394 – 41421Helical; Potential
Topological domain415 – 4239Extracellular Potential
Transmembrane424 – 44421Helical; Potential
Topological domain445 – 45915Cytoplasmic Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 49414Extracellular Potential
Transmembrane495 – 51521Helical; Potential
Topological domain516 – 54631Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38734 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9C9767A181FDDCAE

FASTA54660,620
        10         20         30         40         50         60 
MEPLLFNSGK ANPSQDVFID VEVGDITTKY GSTNTGSFSS MDTVEAQAIK AETARFMEVP 

        70         80         90        100        110        120 
QGRHLGVFST VVLFVSRIMG SGIFAVPSVI LLNTGGNKLI YFAIWVFSAA IAFAGLYLFL 

       130        140        150        160        170        180 
EFGSWIPKSG GRKNFLERSF ERPRLLISVV FSCYSVLTGY ALTGSIVFGK YVLSAFGVTD 

       190        200        210        220        230        240 
DSWSKYVSIS FIIFAVLIHG VSVRHGVFIQ NALGGLKLIM IVLMCFAGLY TLFFYKSTGQ 

       250        260        270        280        290        300 
VAWDLPVTQV EKDSLLSVSS IATAFISSFF CFSGWDTVHT VTSEIKNPVK TLKVSGPLSL 

       310        320        330        340        350        360 
IICFVCYTMM NVAYLKVLTY EEIVSAGPLV GSVLFTKLFG PRVGGKFIAF SIAISAASNI 

       370        380        390        400        410        420 
LVVIYSISRV NQEIFKEGYL PFSIHMSKNW PFDAPLPSIS LCGFITIAWI LILPKEGESF 

       430        440        450        460        470        480 
NYLVSMDGYG NQFFLLLVAI GLFIWRFKHK NEVPEIRAST FGVLAIITLS LYMLMAPFFA 

       490        500        510        520        530        540 
DPSLNRVGFL PPYQIMSLLV IVACFFFWLV KFVLLPKFFH YKLLPKITYL HDGLIVTEWV 


KKPCLC

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases."
Isnard A.D., Thomas D., Surdin-Kerjan Y.
J. Mol. Biol. 262:473-484(1996) [PubMed: 8893857] [Abstract]
Cited for: CHARACTERIZATION.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U11583 Genomic DNA. Translation: AAB65048.1.
BK006934 Genomic DNA. Translation: DAA06649.1.
PIRS48932.
RefSeqNP_011827.1. NM_001179116.1.

3D structure databases

ProteinModelPortalP38734.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5572N.
IntActP38734. 1 interaction.
MINTMINT-486480.
STRINGP38734.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL036W; YHL036W; YHL036W.
GeneID856349.
KEGGsce:YHL036W.
NMPDRfig|4932.3.peg.2963.

Organism-specific databases

CYGDYHL036w.
SGDS000001028. MUP3.

Phylogenomic databases

eggNOGfuNOG07779.
GeneTreeEFGT00050000001133.
HOGENOMHBG396662.
OMAITIAWIL.
OrthoDBEOG45XC4N.

Gene expression databases

ArrayExpressP38734.
GenevestigatorP38734.
GermOnlineYHL036W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004841. AA-permease_dom.
IPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. AA/rel_permease1. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio981784.

Entry information

Entry nameMUP3_YEAST
AccessionPrimary (citable) accession number: P38734
Secondary accession number(s): D3DKT2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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