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Protein

Low-affinity methionine permease

Gene

MUP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Very low affinity permease for methionine.

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-methionine transmembrane transporter activity Source: SGD

GO - Biological processi

  • methionine import Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31055-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.16. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity methionine permease
Gene namesi
Name:MUP3
Ordered Locus Names:YHL036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL036W.
SGDiS000001028. MUP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 987CytoplasmicSequence analysis
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 14829ExtracellularSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 18819CytoplasmicSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 2134ExtracellularSequence analysis
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Topological domaini235 – 25420CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Topological domaini276 – 29722ExtracellularSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Topological domaini319 – 3191CytoplasmicSequence analysis
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Topological domaini341 – 3466ExtracellularSequence analysis
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Topological domaini368 – 39326CytoplasmicSequence analysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence analysisAdd
BLAST
Topological domaini415 – 4239ExtracellularSequence analysis
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Topological domaini445 – 45915CytoplasmicSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 49414ExtracellularSequence analysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence analysisAdd
BLAST
Topological domaini516 – 54631CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Low-affinity methionine permeasePRO_0000096649Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi36386. 27 interactions.
DIPiDIP-5572N.
IntActiP38734. 1 interaction.
MINTiMINT-486480.

Structurei

3D structure databases

ProteinModelPortaliP38734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast high affinity methionine permease (MUP1).Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119037.
HOGENOMiHOG000187297.
InParanoidiP38734.
OMAiITIAWIL.
OrthoDBiEOG7SFJ67.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P38734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLLFNSGK ANPSQDVFID VEVGDITTKY GSTNTGSFSS MDTVEAQAIK
60 70 80 90 100
AETARFMEVP QGRHLGVFST VVLFVSRIMG SGIFAVPSVI LLNTGGNKLI
110 120 130 140 150
YFAIWVFSAA IAFAGLYLFL EFGSWIPKSG GRKNFLERSF ERPRLLISVV
160 170 180 190 200
FSCYSVLTGY ALTGSIVFGK YVLSAFGVTD DSWSKYVSIS FIIFAVLIHG
210 220 230 240 250
VSVRHGVFIQ NALGGLKLIM IVLMCFAGLY TLFFYKSTGQ VAWDLPVTQV
260 270 280 290 300
EKDSLLSVSS IATAFISSFF CFSGWDTVHT VTSEIKNPVK TLKVSGPLSL
310 320 330 340 350
IICFVCYTMM NVAYLKVLTY EEIVSAGPLV GSVLFTKLFG PRVGGKFIAF
360 370 380 390 400
SIAISAASNI LVVIYSISRV NQEIFKEGYL PFSIHMSKNW PFDAPLPSIS
410 420 430 440 450
LCGFITIAWI LILPKEGESF NYLVSMDGYG NQFFLLLVAI GLFIWRFKHK
460 470 480 490 500
NEVPEIRAST FGVLAIITLS LYMLMAPFFA DPSLNRVGFL PPYQIMSLLV
510 520 530 540
IVACFFFWLV KFVLLPKFFH YKLLPKITYL HDGLIVTEWV KKPCLC
Length:546
Mass (Da):60,620
Last modified:February 1, 1995 - v1
Checksum:i9C9767A181FDDCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65048.1.
BK006934 Genomic DNA. Translation: DAA06649.1.
PIRiS48932.
RefSeqiNP_011827.1. NM_001179116.1.

Genome annotation databases

EnsemblFungiiYHL036W; YHL036W; YHL036W.
GeneIDi856349.
KEGGisce:YHL036W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65048.1.
BK006934 Genomic DNA. Translation: DAA06649.1.
PIRiS48932.
RefSeqiNP_011827.1. NM_001179116.1.

3D structure databases

ProteinModelPortaliP38734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36386. 27 interactions.
DIPiDIP-5572N.
IntActiP38734. 1 interaction.
MINTiMINT-486480.

Protein family/group databases

TCDBi2.A.3.8.16. the amino acid-polyamine-organocation (apc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL036W; YHL036W; YHL036W.
GeneIDi856349.
KEGGisce:YHL036W.

Organism-specific databases

EuPathDBiFungiDB:YHL036W.
SGDiS000001028. MUP3.

Phylogenomic databases

GeneTreeiENSGT00760000119037.
HOGENOMiHOG000187297.
InParanoidiP38734.
OMAiITIAWIL.
OrthoDBiEOG7SFJ67.

Enzyme and pathway databases

BioCyciYEAST:G3O-31055-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiP38734.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases."
    Isnard A.D., Thomas D., Surdin-Kerjan Y.
    J. Mol. Biol. 262:473-484(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiMUP3_YEAST
AccessioniPrimary (citable) accession number: P38734
Secondary accession number(s): D3DKT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.