SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38732

- EFM1_YEAST

UniProt

P38732 - EFM1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
N-lysine methyltransferase EFM1
Gene
EFM1, YHL039W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Lysine methyltransferase that probably monomethylates TEF1/eEF1A at 'Lys-30' and/or 'Lys-390'.1 Publication

GO - Molecular functioni

  1. protein-lysine N-methyltransferase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. peptidyl-lysine monomethylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31057-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-lysine methyltransferase EFM1 (EC:2.1.1.-)
Alternative name(s):
Elongation factor methyltransferase 1
Gene namesi
Name:EFM1
Ordered Locus Names:YHL039W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL039w.
SGDiS000001031. EFM1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585N-lysine methyltransferase EFM1
PRO_0000202879Add
BLAST

Proteomic databases

MaxQBiP38732.
PaxDbiP38732.
PeptideAtlasiP38732.

Expressioni

Gene expression databases

GenevestigatoriP38732.

Interactioni

Protein-protein interaction databases

BioGridi36384. 24 interactions.
DIPiDIP-6582N.
IntActiP38732. 1 interaction.
MINTiMINT-705797.
STRINGi4932.YHL039W.

Structurei

3D structure databases

ProteinModelPortaliP38732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 281259SET
Add
BLAST

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiNOG265033.
GeneTreeiENSGT00630000090454.
HOGENOMiHOG000141878.
OMAiYNNYGDK.
OrthoDBiEOG7XSTQQ.

Family and domain databases

InterProiIPR017119. Ribosomal_Lys-MeTrfase-1.
IPR001214. SET_dom.
[Graphical view]
PIRSFiPIRSF037136. Ribosomal_Lys-mtfrase-1. 1 hit.
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38732-1 [UniParc]FASTAAdd to Basket

« Hide

MITQTELDNC LQWAQNNGAF IDPKISFRIT EDAGVSAFVN EKFSPKPDQA    50
LIRVPETLLI TSQQALSEFS QAANERSLLN SVTQLYLSKL KFGTDAVHLK 100
SFYKPYLDVL PLHLPQPYFW STDEVMNLHG TDVYLTMRDT LNKLVKEWRM 150
LFQALSIEHS SQDKQFLSLF QENKDSAVVP LEQFCAHING CKLEDSEWNS 200
FVAYLWSYCI FNSRAFPRVI LGRAGTDRTN LNEGFLYPIV DLLNHKNDVP 250
VRWEMNEQNE LCFMSQTTTF SAQDELFNNY GNISNEKCLL NYGFWDSSNK 300
FDFSRLTLKL PSTLVSGLPV DFNKSGNFVT DDGETTILQF SLKISEPLPP 350
VLLALFAYLS KLKSEETPTV RSVLEGIDQL TSVVSQRLLF YKNFKIKTSS 400
TQKLRPHVIK LIKLYYQDNK KILNATTEKL SVLQKKIYSN NKEFSLSFKT 450
IFKNDKIFAN SLLLVFGAIN YEDLITKDCL NDALLLWIVK LINDKSNNQG 500
GFIKQTFKEV SDSIVIEKED VMEFLPFYKK YFPNLSERIP EIYSVGDWGI 550
RQFIVADTAI DRLVWIRKSN KEPIFLMKKA YDLQI 585
Length:585
Mass (Da):67,452
Last modified:February 1, 1995 - v1
Checksum:i84BC2D3A204D9D29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11583 Genomic DNA. Translation: AAB65051.1.
BK006934 Genomic DNA. Translation: DAA06647.1.
PIRiS48929.
RefSeqiNP_011824.1. NM_001179119.1.

Genome annotation databases

EnsemblFungiiYHL039W; YHL039W; YHL039W.
GeneIDi856346.
KEGGisce:YHL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11583 Genomic DNA. Translation: AAB65051.1 .
BK006934 Genomic DNA. Translation: DAA06647.1 .
PIRi S48929.
RefSeqi NP_011824.1. NM_001179119.1.

3D structure databases

ProteinModelPortali P38732.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36384. 24 interactions.
DIPi DIP-6582N.
IntActi P38732. 1 interaction.
MINTi MINT-705797.
STRINGi 4932.YHL039W.

Proteomic databases

MaxQBi P38732.
PaxDbi P38732.
PeptideAtlasi P38732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL039W ; YHL039W ; YHL039W .
GeneIDi 856346.
KEGGi sce:YHL039W.

Organism-specific databases

CYGDi YHL039w.
SGDi S000001031. EFM1.

Phylogenomic databases

eggNOGi NOG265033.
GeneTreei ENSGT00630000090454.
HOGENOMi HOG000141878.
OMAi YNNYGDK.
OrthoDBi EOG7XSTQQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-31057-MONOMER.

Miscellaneous databases

NextBioi 981778.
PROi P38732.

Gene expression databases

Genevestigatori P38732.

Family and domain databases

InterProi IPR017119. Ribosomal_Lys-MeTrfase-1.
IPR001214. SET_dom.
[Graphical view ]
PIRSFi PIRSF037136. Ribosomal_Lys-mtfrase-1. 1 hit.
PROSITEi PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae."
    Lipson R.S., Webb K.J., Clarke S.G.
    Arch. Biochem. Biophys. 500:137-143(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEFM1_YEAST
AccessioniPrimary (citable) accession number: P38732
Secondary accession number(s): D3DKT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5170 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi