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Protein

Protein-lysine N-methyltransferase EFM1

Gene

EFM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at 'Lys-30'.2 Publications

Miscellaneous

Present with 5170 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei280S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31057-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine N-methyltransferase EFM11 Publication (EC:2.1.1.-2 Publications)
Alternative name(s):
Elongation factor methyltransferase 11 Publication
Gene namesi
Name:EFM11 Publication
Ordered Locus Names:YHL039WImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL039W
SGDiS000001031 EFM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028791 – 585Protein-lysine N-methyltransferase EFM1Add BLAST585

Proteomic databases

MaxQBiP38732
PaxDbiP38732
PRIDEiP38732

PTM databases

iPTMnetiP38732

Interactioni

Protein-protein interaction databases

BioGridi36384, 52 interactors
DIPiDIP-6582N
IntActiP38732, 2 interactors
MINTiP38732
STRINGi4932.YHL039W

Structurei

3D structure databases

ProteinModelPortaliP38732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 281SETPROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.PROSITE-ProRule annotationCurated

Phylogenomic databases

GeneTreeiENSGT00630000090454
HOGENOMiHOG000141878
InParanoidiP38732
OMAiDLITKDC
OrthoDBiEOG092C2Z81

Family and domain databases

InterProiView protein in InterPro
IPR017119 Efm1/Rkm1
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PIRSFiPIRSF037136 Ribosomal_Lys-mtfrase-1, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

P38732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITQTELDNC LQWAQNNGAF IDPKISFRIT EDAGVSAFVN EKFSPKPDQA
60 70 80 90 100
LIRVPETLLI TSQQALSEFS QAANERSLLN SVTQLYLSKL KFGTDAVHLK
110 120 130 140 150
SFYKPYLDVL PLHLPQPYFW STDEVMNLHG TDVYLTMRDT LNKLVKEWRM
160 170 180 190 200
LFQALSIEHS SQDKQFLSLF QENKDSAVVP LEQFCAHING CKLEDSEWNS
210 220 230 240 250
FVAYLWSYCI FNSRAFPRVI LGRAGTDRTN LNEGFLYPIV DLLNHKNDVP
260 270 280 290 300
VRWEMNEQNE LCFMSQTTTF SAQDELFNNY GNISNEKCLL NYGFWDSSNK
310 320 330 340 350
FDFSRLTLKL PSTLVSGLPV DFNKSGNFVT DDGETTILQF SLKISEPLPP
360 370 380 390 400
VLLALFAYLS KLKSEETPTV RSVLEGIDQL TSVVSQRLLF YKNFKIKTSS
410 420 430 440 450
TQKLRPHVIK LIKLYYQDNK KILNATTEKL SVLQKKIYSN NKEFSLSFKT
460 470 480 490 500
IFKNDKIFAN SLLLVFGAIN YEDLITKDCL NDALLLWIVK LINDKSNNQG
510 520 530 540 550
GFIKQTFKEV SDSIVIEKED VMEFLPFYKK YFPNLSERIP EIYSVGDWGI
560 570 580
RQFIVADTAI DRLVWIRKSN KEPIFLMKKA YDLQI
Length:585
Mass (Da):67,452
Last modified:February 1, 1995 - v1
Checksum:i84BC2D3A204D9D29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA Translation: AAB65051.1
BK006934 Genomic DNA Translation: DAA06647.1
PIRiS48929
RefSeqiNP_011824.1, NM_001179119.1

Genome annotation databases

EnsemblFungiiYHL039W; YHL039W; YHL039W
GeneIDi856346
KEGGisce:YHL039W

Similar proteinsi

Entry informationi

Entry nameiEFM1_YEAST
AccessioniPrimary (citable) accession number: P38732
Secondary accession number(s): D3DKT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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