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P38731

- ARN1_YEAST

UniProt

P38731 - ARN1_YEAST

Protein

Siderophore iron transporter ARN1

Gene

ARN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis.1 Publication

    GO - Molecular functioni

    1. siderophore transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. siderophore transmembrane transport Source: GOC
    2. siderophore transport Source: SGD

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31058-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.16.4. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Siderophore iron transporter ARN1
    Alternative name(s):
    Ferrichrome permease
    Gene namesi
    Name:ARN1
    Ordered Locus Names:YHL040C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL040c.
    SGDiS000001032. ARN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: SGD
    2. endosome Source: SGD
    3. endosome membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Siderophore iron transporter ARN1PRO_0000084862Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP38731.

    Interactioni

    Protein-protein interaction databases

    BioGridi36383. 20 interactions.
    MINTiMINT-4488358.
    STRINGi4932.YHL040C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38731.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini92 – 11019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 1354ExtracellularSequence Analysis
    Topological domaini157 – 16711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 1979ExtracellularSequence Analysis
    Topological domaini219 – 23113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 29038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 36723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini389 – 39810CytoplasmicSequence Analysis
    Topological domaini420 – 4245ExtracellularSequence Analysis
    Topological domaini446 – 4549CytoplasmicSequence Analysis
    Topological domaini476 – 56388ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini585 – 62743CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei564 – 58421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281153.
    GeneTreeiENSGT00390000002930.
    HOGENOMiHOG000181235.
    KOiK08197.
    OMAiINTWIAG.
    OrthoDBiEOG7PZS6Z.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P38731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL    50
    RQNRSLIIQQ TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG 100
    YATSSYSEHS LLSTINVINA VVSAASQIIY ARLSDVFGRL YLFISAVILY 150
    VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV ILILLIILSD FSSLKWRLLY 200
    QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP LSCVPIVLCM 250
    LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS 300
    LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL 350
    PYRLVKDRAV WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA 400
    TLSSFVSTVA SPFFALLVTR CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ 450
    SHSGIIGALC VWGVGTTLFT YPVTVSVQSA VSHENMATVT ALNYTLYRIG 500
    SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF IETYTWGTPQ 550
    RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG 600
    EYVDTKDNDP ILDWFEKLPS KFTFKRE 627
    Length:627
    Mass (Da):70,899
    Last modified:February 1, 1995 - v1
    Checksum:iFD06176163668174
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11583 Genomic DNA. Translation: AAB65052.1.
    BK006934 Genomic DNA. Translation: DAA06646.1.
    PIRiS48928.
    RefSeqiNP_011823.1. NM_001179120.1.

    Genome annotation databases

    EnsemblFungiiYHL040C; YHL040C; YHL040C.
    GeneIDi856345.
    KEGGisce:YHL040C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11583 Genomic DNA. Translation: AAB65052.1 .
    BK006934 Genomic DNA. Translation: DAA06646.1 .
    PIRi S48928.
    RefSeqi NP_011823.1. NM_001179120.1.

    3D structure databases

    ProteinModelPortali P38731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36383. 20 interactions.
    MINTi MINT-4488358.
    STRINGi 4932.YHL040C.

    Protein family/group databases

    TCDBi 2.A.1.16.4. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL040C ; YHL040C ; YHL040C .
    GeneIDi 856345.
    KEGGi sce:YHL040C.

    Organism-specific databases

    CYGDi YHL040c.
    SGDi S000001032. ARN1.

    Phylogenomic databases

    eggNOGi NOG281153.
    GeneTreei ENSGT00390000002930.
    HOGENOMi HOG000181235.
    KOi K08197.
    OMAi INTWIAG.
    OrthoDBi EOG7PZS6Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31058-MONOMER.

    Miscellaneous databases

    NextBioi 981775.

    Gene expression databases

    Genevestigatori P38731.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
      Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
      J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae."
      Moore R.E., Kim Y., Philpott C.C.
      Proc. Natl. Acad. Sci. U.S.A. 100:5664-5669(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
      Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
      J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiARN1_YEAST
    AccessioniPrimary (citable) accession number: P38731
    Secondary accession number(s): D3DKS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3