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P38731 (ARN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Siderophore iron transporter ARN1
Alternative name(s):
Ferrichrome permease
Gene names
Name:ARN1
Ordered Locus Names:YHL040C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein Ref.4 Ref.5.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Siderophore iron transporter ARN1
PRO_0000084862

Regions

Topological domain1 – 7070Extracellular Potential
Transmembrane71 – 9121Helical; Potential
Topological domain92 – 11019Cytoplasmic Potential
Transmembrane111 – 13121Helical; Potential
Topological domain132 – 1354Extracellular Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 16711Cytoplasmic Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 1979Extracellular Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 23113Cytoplasmic Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 29038Extracellular Potential
Transmembrane291 – 31121Helical; Potential
Topological domain312 – 32312Cytoplasmic Potential
Transmembrane324 – 34421Helical; Potential
Topological domain345 – 36723Extracellular Potential
Transmembrane368 – 38821Helical; Potential
Topological domain389 – 39810Cytoplasmic Potential
Transmembrane399 – 41921Helical; Potential
Topological domain420 – 4245Extracellular Potential
Transmembrane425 – 44521Helical; Potential
Topological domain446 – 4549Cytoplasmic Potential
Transmembrane455 – 47521Helical; Potential
Topological domain476 – 56388Extracellular Potential
Transmembrane564 – 58421Helical; Potential
Topological domain585 – 62743Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38731 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: FD06176163668174

FASTA62770,899
        10         20         30         40         50         60 
MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL RQNRSLIIQQ 

        70         80         90        100        110        120 
TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG YATSSYSEHS LLSTINVINA 

       130        140        150        160        170        180 
VVSAASQIIY ARLSDVFGRL YLFISAVILY VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV 

       190        200        210        220        230        240 
ILILLIILSD FSSLKWRLLY QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP 

       250        260        270        280        290        300 
LSCVPIVLCM LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS 

       310        320        330        340        350        360 
LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL PYRLVKDRAV 

       370        380        390        400        410        420 
WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA TLSSFVSTVA SPFFALLVTR 

       430        440        450        460        470        480 
CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ SHSGIIGALC VWGVGTTLFT YPVTVSVQSA 

       490        500        510        520        530        540 
VSHENMATVT ALNYTLYRIG SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF 

       550        560        570        580        590        600 
IETYTWGTPQ RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG 

       610        620 
EYVDTKDNDP ILDWFEKLPS KFTFKRE 

« Hide

References

« Hide 'large scale' references
[1]"Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae."
Moore R.E., Kim Y., Philpott C.C.
Proc. Natl. Acad. Sci. U.S.A. 100:5664-5669(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11583 Genomic DNA. Translation: AAB65052.1.
BK006934 Genomic DNA. Translation: DAA06646.1.
PIRS48928.
RefSeqNP_011823.1. NM_001179120.1.

3D structure databases

ProteinModelPortalP38731.
SMRP38731. Positions 120-153.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36383. 20 interactions.
MINTMINT-4488358.
STRING4932.YHL040C.

Protein family/group databases

TCDB2.A.1.16.4. the major facilitator superfamily (mfs).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL040C; YHL040C; YHL040C.
GeneID856345.
KEGGsce:YHL040C.

Organism-specific databases

CYGDYHL040c.
SGDS000001032. ARN1.

Phylogenomic databases

eggNOGNOG281153.
GeneTreeENSGT00390000002930.
HOGENOMHOG000181235.
KOK08197.
OMAINAYVAG.
OrthoDBEOG7PZS6Z.

Enzyme and pathway databases

BioCycYEAST:G3O-31058-MONOMER.

Gene expression databases

GenevestigatorP38731.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
ProtoNetSearch...

Other

NextBio981775.

Entry information

Entry nameARN1_YEAST
AccessionPrimary (citable) accession number: P38731
Secondary accession number(s): D3DKS9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families