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Protein

Siderophore iron transporter ARN1

Gene

ARN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis.1 Publication

GO - Molecular functioni

  • siderophore transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: GO_Central
  • siderophore transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-31058-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter ARN1
Alternative name(s):
Ferrichrome permease
Gene namesi
Name:ARN1
Ordered Locus Names:YHL040C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL040C.
SGDiS000001032. ARN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70ExtracellularSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 110CytoplasmicSequence analysisAdd BLAST19
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 135ExtracellularSequence analysis4
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 167CytoplasmicSequence analysisAdd BLAST11
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 197ExtracellularSequence analysis9
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231CytoplasmicSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 290ExtracellularSequence analysisAdd BLAST38
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 323CytoplasmicSequence analysisAdd BLAST12
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 367ExtracellularSequence analysisAdd BLAST23
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 398CytoplasmicSequence analysis10
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 424ExtracellularSequence analysis5
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 454CytoplasmicSequence analysis9
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 563ExtracellularSequence analysisAdd BLAST88
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 627CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: SGD
  • endosome Source: SGD
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848621 – 627Siderophore iron transporter ARN1Add BLAST627

Proteomic databases

PRIDEiP38731.

Interactioni

Protein-protein interaction databases

BioGridi36383. 19 interactors.
MINTiMINT-4488358.

Structurei

3D structure databases

ProteinModelPortaliP38731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP38731.
KOiK08197.
OMAiINAYVAG.
OrthoDBiEOG092C2P9I.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P38731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL
60 70 80 90 100
RQNRSLIIQQ TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG
110 120 130 140 150
YATSSYSEHS LLSTINVINA VVSAASQIIY ARLSDVFGRL YLFISAVILY
160 170 180 190 200
VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV ILILLIILSD FSSLKWRLLY
210 220 230 240 250
QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP LSCVPIVLCM
260 270 280 290 300
LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS
310 320 330 340 350
LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL
360 370 380 390 400
PYRLVKDRAV WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA
410 420 430 440 450
TLSSFVSTVA SPFFALLVTR CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ
460 470 480 490 500
SHSGIIGALC VWGVGTTLFT YPVTVSVQSA VSHENMATVT ALNYTLYRIG
510 520 530 540 550
SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF IETYTWGTPQ
560 570 580 590 600
RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG
610 620
EYVDTKDNDP ILDWFEKLPS KFTFKRE
Length:627
Mass (Da):70,899
Last modified:February 1, 1995 - v1
Checksum:iFD06176163668174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65052.1.
BK006934 Genomic DNA. Translation: DAA06646.1.
PIRiS48928.
RefSeqiNP_011823.1. NM_001179120.1.

Genome annotation databases

EnsemblFungiiYHL040C; YHL040C; YHL040C.
GeneIDi856345.
KEGGisce:YHL040C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65052.1.
BK006934 Genomic DNA. Translation: DAA06646.1.
PIRiS48928.
RefSeqiNP_011823.1. NM_001179120.1.

3D structure databases

ProteinModelPortaliP38731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36383. 19 interactors.
MINTiMINT-4488358.

Protein family/group databases

TCDBi2.A.1.16.4. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP38731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL040C; YHL040C; YHL040C.
GeneIDi856345.
KEGGisce:YHL040C.

Organism-specific databases

EuPathDBiFungiDB:YHL040C.
SGDiS000001032. ARN1.

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP38731.
KOiK08197.
OMAiINAYVAG.
OrthoDBiEOG092C2P9I.

Enzyme and pathway databases

BioCyciYEAST:G3O-31058-MONOMER.

Miscellaneous databases

PROiP38731.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARN1_YEAST
AccessioniPrimary (citable) accession number: P38731
Secondary accession number(s): D3DKS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.