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P38731

- ARN1_YEAST

UniProt

P38731 - ARN1_YEAST

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Protein

Siderophore iron transporter ARN1

Gene

ARN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis.1 Publication

GO - Molecular functioni

  1. siderophore transmembrane transporter activity Source: SGD

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
  2. siderophore transmembrane transport Source: GOC
  3. siderophore transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-31058-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter ARN1
Alternative name(s):
Ferrichrome permease
Gene namesi
Name:ARN1
Ordered Locus Names:YHL040C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL040c.
SGDiS000001032. ARN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070ExtracellularSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Topological domaini92 – 11019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 1354ExtracellularSequence Analysis
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Topological domaini157 – 16711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 1979ExtracellularSequence Analysis
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 23113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 29038ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Topological domaini312 – 32312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Topological domaini345 – 36723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Topological domaini389 – 39810CytoplasmicSequence Analysis
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Topological domaini420 – 4245ExtracellularSequence Analysis
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST
Topological domaini446 – 4549CytoplasmicSequence Analysis
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 56388ExtracellularSequence AnalysisAdd
BLAST
Transmembranei564 – 58421HelicalSequence AnalysisAdd
BLAST
Topological domaini585 – 62743CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: SGD
  2. endosome Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Siderophore iron transporter ARN1PRO_0000084862Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP38731.

Interactioni

Protein-protein interaction databases

BioGridi36383. 20 interactions.
MINTiMINT-4488358.
STRINGi4932.YHL040C.

Structurei

3D structure databases

ProteinModelPortaliP38731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281153.
GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP38731.
KOiK08197.
OMAiINTWIAG.
OrthoDBiEOG7PZS6Z.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P38731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL
60 70 80 90 100
RQNRSLIIQQ TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG
110 120 130 140 150
YATSSYSEHS LLSTINVINA VVSAASQIIY ARLSDVFGRL YLFISAVILY
160 170 180 190 200
VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV ILILLIILSD FSSLKWRLLY
210 220 230 240 250
QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP LSCVPIVLCM
260 270 280 290 300
LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS
310 320 330 340 350
LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL
360 370 380 390 400
PYRLVKDRAV WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA
410 420 430 440 450
TLSSFVSTVA SPFFALLVTR CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ
460 470 480 490 500
SHSGIIGALC VWGVGTTLFT YPVTVSVQSA VSHENMATVT ALNYTLYRIG
510 520 530 540 550
SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF IETYTWGTPQ
560 570 580 590 600
RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG
610 620
EYVDTKDNDP ILDWFEKLPS KFTFKRE
Length:627
Mass (Da):70,899
Last modified:February 1, 1995 - v1
Checksum:iFD06176163668174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65052.1.
BK006934 Genomic DNA. Translation: DAA06646.1.
PIRiS48928.
RefSeqiNP_011823.1. NM_001179120.1.

Genome annotation databases

EnsemblFungiiYHL040C; YHL040C; YHL040C.
GeneIDi856345.
KEGGisce:YHL040C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65052.1 .
BK006934 Genomic DNA. Translation: DAA06646.1 .
PIRi S48928.
RefSeqi NP_011823.1. NM_001179120.1.

3D structure databases

ProteinModelPortali P38731.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36383. 20 interactions.
MINTi MINT-4488358.
STRINGi 4932.YHL040C.

Protein family/group databases

TCDBi 2.A.1.16.4. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL040C ; YHL040C ; YHL040C .
GeneIDi 856345.
KEGGi sce:YHL040C.

Organism-specific databases

CYGDi YHL040c.
SGDi S000001032. ARN1.

Phylogenomic databases

eggNOGi NOG281153.
GeneTreei ENSGT00390000002930.
HOGENOMi HOG000181235.
InParanoidi P38731.
KOi K08197.
OMAi INTWIAG.
OrthoDBi EOG7PZS6Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-31058-MONOMER.

Miscellaneous databases

NextBioi 981775.

Gene expression databases

Genevestigatori P38731.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
    Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
    J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae."
    Moore R.E., Kim Y., Philpott C.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:5664-5669(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
    Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
    J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiARN1_YEAST
AccessioniPrimary (citable) accession number: P38731
Secondary accession number(s): D3DKS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3