DUP240 protein YHL044W - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38727 (YHE4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
DUP240 protein YHL044W

Gene names

Ordered Locus Names:

YHL044W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts according to large scale protein interaction studies with BZZ1, SRB4 and SUA7 Potential. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.5.
Miscellaneous	Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
Sequence similarities	Belongs to the DUP/COS family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from mutant phenotype Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SSP120	P39931	1	EBI-24403,EBI-16366

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 235

235

DUP240 protein YHL044W

PRO_0000207533

Regions

Topological domain

1 – 44

Cytoplasmic Potential

Transmembrane

45 – 65

Helical; Potential

Topological domain

66 – 72

Extracellular Potential

Transmembrane

73 – 93

Helical; Potential

Topological domain

94 – 235

142

Cytoplasmic Potential

Natural variations

Natural variant

N → D in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. Ref.1

Natural variant

F → L in strain: CLIB 219, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. Ref.1

Natural variant

I → V in strain: CLIB 95, CLIB 382, CLIB 556 haplotype Ha1, K1, R12, R13, YIIc12 haplotype Ha1 and YIIc17 haplotype Ha1. Ref.1

Natural variant

L → F in strain: CLIB 388.

Natural variant

L → P in strain: CLIB 388. Ref.1

Natural variant

S → N in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. Ref.1

Natural variant

103

R → T in strain: CLIB 388, CLIB 410, CLIB 556 haplotype Ha2, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. Ref.1

Natural variant

124

M → V in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. Ref.1

Natural variant

145

I → M in strain: R12 haplotype Ha2. Ref.1

Natural variant

157

Y → S in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. Ref.1

Natural variant

160

Q → R in strain: CLIB 556 haplotype Ha1. Ref.1

Natural variant

180

Y → D in strain: CLIB 95, CLIB 382, K1, R12, R13, YIIc12 haplotype Ha1 and YIIc17 haplotype Ha1. Ref.1

Natural variant

189

G → A in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. Ref.1

Natural variant

225 – 235

EDKYPEMGVTV → RISIQRWGTQF in strain: CLIB 630.

Natural variant

233

V → D in strain: CLIB 219, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. Ref.1

Natural variant

234

T → I in strain: CLIB 413 haplotype Ha1. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P38727 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2A789B602087D928
Show »

FASTA

235

26,972

        10         20         30         40         50         60 
MSSELLISNS KPRPEGLRKL CEGETVILPR DITPSKCAYF LKQNIVFISY IFIHIIITII 

        70         80         90        100        110        120 
LNRLALSAHG NTLIIILAAL LITISLFLLL LLPYLSCSRY KLRCLDDDCK FKLLAEVITH 

       130        140        150        160        170        180 
KPNMDLSTWD RIAYDMNQFV YDRRICADRS FFYDGSYCYQ VFKKLVATPY LVNSNMNSIY 

       190        200        210        220        230 
ADLEMRSNGA TNINDSGNSS LHIELGTYIF KALAVFRNSV DKYWEDKYPE MGVTV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny." Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L. Nucleic Acids Res. 32:2069-2078(2004) [PubMed: 15087486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-9; LEU-47; VAL-75; PRO-86; ASN-96; THR-103; VAL-124; MET-145; SER-157; ARG-160; ASP-180; ALA-189; ASP-233 AND ILE-234. Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"A comprehensive two-hybrid analysis to explore the yeast protein interactome." Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y. Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed: 11283351] [Abstract] Cited for: INTERACTION WITH BZZ1; SRB4 AND SUA7.
[5]	"Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability." Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C. Microbiology 148:2111-2123(2002) [PubMed: 12101299] [Abstract] Cited for: NULL MUTANT, SUBCELLULAR LOCATION.
[6]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ585565 Genomic DNA. Translation: CAE52085.1. AJ585566 Genomic DNA. Translation: CAE52086.1. AJ585567 Genomic DNA. Translation: CAE52087.1. AJ585568 Genomic DNA. Translation: CAE52088.1. AJ585569 Genomic DNA. Translation: CAE52089.1. AJ585570 Genomic DNA. Translation: CAE52090.1. AJ585571 Genomic DNA. Translation: CAE52091.1. AJ585572 Genomic DNA. Translation: CAE52092.1. AJ585573 Genomic DNA. Translation: CAE52093.1. AJ585574 Genomic DNA. Translation: CAE52094.1. AJ585575 Genomic DNA. Translation: CAE52095.1. AJ585576 Genomic DNA. Translation: CAE52096.1. AJ585577 Genomic DNA. Translation: CAE52097.1. AJ585578 Genomic DNA. Translation: CAE52098.1. AJ585579 Genomic DNA. Translation: CAE52099.1. AJ585580 Genomic DNA. Translation: CAE52100.1. AJ585581 Genomic DNA. Translation: CAE52101.1. AJ585582 Genomic DNA. Translation: CAE52102.1. AJ585755 Genomic DNA. Translation: CAE52275.1. U11583 Genomic DNA. Translation: AAB65056.1. BK006934 Genomic DNA. Translation: DAA06643.1.
PIR	S48924.
RefSeq	NP_011819.1. NM_001179124.1.
3D structure databases
ProteinModelPortal	P38727.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2089N.
IntAct	P38727. 1 interaction.
MINT	MINT-507303.
STRING	P38727.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL044W; YHL044W; YHL044W.
GeneID	856341.
KEGG	sce:YHL044W.
NMPDR	fig\|4932.3.peg.2955.
Organism-specific databases
CYGD	YHL044w.
SGD	S000001036. YHL044W.
Phylogenomic databases
GeneTree	EFGT00050000008558.
Gene expression databases
ArrayExpress	P38727.
Genevestigator	P38727.
GermOnline	YHL044W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001142. DUP. [Graphical view]
Pfam	PF00674. DUP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981766.

Entry information

Entry name

YHE4_YEAST

Accession

Primary (citable) accession number: P38727
Secondary accession number(s): D3DKS6

Q70DG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents