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Protein

Siderophore iron transporter ARN2

Gene

ARN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.2 Publications

GO - Molecular functioni

  • siderophore transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • ion transport Source: UniProtKB-KW
  • iron assimilation by chelation and transport Source: GO_Central
  • siderophore metabolic process Source: SGD
  • siderophore transport Source: SGD

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciYEAST:G3O-31063-MONOMER

Protein family/group databases

TCDBi2.A.1.16.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter ARN2
Alternative name(s):
Triacetylfusarinine C permease
Triacetylfusarinine C transporter 1
Gene namesi
Name:ARN2
Synonyms:TAF1
Ordered Locus Names:YHL047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL047C
SGDiS000001039 ARN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 93HelicalSequence analysisAdd BLAST23
Transmembranei106 – 128HelicalSequence analysisAdd BLAST23
Transmembranei135 – 152HelicalSequence analysisAdd BLAST18
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23
Transmembranei191 – 213HelicalSequence analysisAdd BLAST23
Transmembranei223 – 245HelicalSequence analysisAdd BLAST23
Transmembranei286 – 308HelicalSequence analysisAdd BLAST23
Transmembranei318 – 335HelicalSequence analysisAdd BLAST18
Transmembranei355 – 377HelicalSequence analysisAdd BLAST23
Transmembranei392 – 414HelicalSequence analysisAdd BLAST23
Transmembranei421 – 438HelicalSequence analysisAdd BLAST18
Transmembranei448 – 470HelicalSequence analysisAdd BLAST23
Transmembranei491 – 513HelicalSequence analysisAdd BLAST23
Transmembranei561 – 578HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848631 – 620Siderophore iron transporter ARN2Add BLAST620

Proteomic databases

PaxDbiP38724
PRIDEiP38724

Interactioni

Protein-protein interaction databases

BioGridi36378, 20 interactors
DIPiDIP-7479N
STRINGi4932.YHL047C

Structurei

3D structure databases

ProteinModelPortaliP38724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930
HOGENOMiHOG000181235
InParanoidiP38724
KOiK08197
OMAiNSSLKWR
OrthoDBiEOG092C2P9I

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P38724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS
60 70 80 90 100
LIIRKSELMA KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS
110 120 130 140 150
YSAHSLISTV SVIVLMISAV SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI
160 170 180 190 200
IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV LMLSDNSSLK WRLFYTLIPS
210 220 230 240 250
WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP LILCMLHMRW
260 270 280 290 300
KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL
310 320 330 340 350
VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL
360 370 380 390 400
KDRGVWAPLG IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF
410 420 430 440 450
VTAVVAPFLG LIVTRSSRLK SYIIFGGSLY FITMGLFYRY RSGQDADGGI
460 470 480 490 500
IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN MATVTALNYT VFRIGGAVAA
510 520 530 540 550
AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP WGTPVRSAMV
560 570 580 590 600
EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK
610 620
EDDPINDWIA KRFAKALGRS
Length:620
Mass (Da):69,566
Last modified:July 27, 2011 - v2
Checksum:i19C3DDF83A1FC760
GO

Sequence cautioni

The sequence AAB65059 differs from that shown. Reason: Frameshift at position 619.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA Translation: AAB65059.1 Frameshift.
BK006934 Genomic DNA Translation: DAA06641.2
PIRiS48921
RefSeqiNP_011816.2, NM_001179127.2

Genome annotation databases

EnsemblFungiiYHL047C; YHL047C; YHL047C
GeneIDi856338
KEGGisce:YHL047C

Similar proteinsi

Entry informationi

Entry nameiARN2_YEAST
AccessioniPrimary (citable) accession number: P38724
Secondary accession number(s): D3DKS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health