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Protein

Siderophore iron transporter ARN2

Gene

ARN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.2 Publications

GO - Molecular functioni

  • siderophore transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • siderophore metabolic process Source: SGD
  • siderophore transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-31063-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter ARN2
Alternative name(s):
Triacetylfusarinine C permease
Triacetylfusarinine C transporter 1
Gene namesi
Name:ARN2
Synonyms:TAF1
Ordered Locus Names:YHL047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL047C.
SGDiS000001039. ARN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei71 – 9323HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12823HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15218HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18423HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21323HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24523HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30823HelicalSequence analysisAdd
BLAST
Transmembranei318 – 33518HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37723HelicalSequence analysisAdd
BLAST
Transmembranei392 – 41423HelicalSequence analysisAdd
BLAST
Transmembranei421 – 43818HelicalSequence analysisAdd
BLAST
Transmembranei448 – 47023HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51323HelicalSequence analysisAdd
BLAST
Transmembranei561 – 57818HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endosome Source: GO_Central
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Siderophore iron transporter ARN2PRO_0000084863Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi36378. 12 interactions.
DIPiDIP-7479N.

Structurei

3D structure databases

ProteinModelPortaliP38724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP38724.
KOiK08197.
OMAiFWKLDVV.
OrthoDBiEOG7PZS6Z.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS
60 70 80 90 100
LIIRKSELMA KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS
110 120 130 140 150
YSAHSLISTV SVIVLMISAV SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI
160 170 180 190 200
IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV LMLSDNSSLK WRLFYTLIPS
210 220 230 240 250
WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP LILCMLHMRW
260 270 280 290 300
KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL
310 320 330 340 350
VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL
360 370 380 390 400
KDRGVWAPLG IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF
410 420 430 440 450
VTAVVAPFLG LIVTRSSRLK SYIIFGGSLY FITMGLFYRY RSGQDADGGI
460 470 480 490 500
IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN MATVTALNYT VFRIGGAVAA
510 520 530 540 550
AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP WGTPVRSAMV
560 570 580 590 600
EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK
610 620
EDDPINDWIA KRFAKALGRS
Length:620
Mass (Da):69,566
Last modified:July 27, 2011 - v2
Checksum:i19C3DDF83A1FC760
GO

Sequence cautioni

The sequence AAB65059.1 differs from that shown. Reason: Frameshift at position 619. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65059.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06641.2.
PIRiS48921.
RefSeqiNP_011816.2. NM_001179127.2.

Genome annotation databases

EnsemblFungiiYHL047C; YHL047C; YHL047C.
GeneIDi856338.
KEGGisce:YHL047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11583 Genomic DNA. Translation: AAB65059.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06641.2.
PIRiS48921.
RefSeqiNP_011816.2. NM_001179127.2.

3D structure databases

ProteinModelPortaliP38724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36378. 12 interactions.
DIPiDIP-7479N.

Protein family/group databases

TCDBi2.A.1.16.3. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL047C; YHL047C; YHL047C.
GeneIDi856338.
KEGGisce:YHL047C.

Organism-specific databases

EuPathDBiFungiDB:YHL047C.
SGDiS000001039. ARN2.

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP38724.
KOiK08197.
OMAiFWKLDVV.
OrthoDBiEOG7PZS6Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-31063-MONOMER.

Miscellaneous databases

PROiP38724.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 619.
    Strain: ATCC 204508 / S288c.
  3. "Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily."
    Heymann P., Ernst J.F., Winkelmann G.
    BioMetals 12:301-306(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
    Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
    J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiARN2_YEAST
AccessioniPrimary (citable) accession number: P38724
Secondary accession number(s): D3DKS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.