Reviewed, UniProtKB/Swiss-Prot P38724 (ARN2_YEAST)

Names and origin

Protein names

Recommended name:
    Siderophore iron transporter ARN2
Alternative name(s):
    Triacetylfusarinine C transporter 1
    Triacetylfusarinine C permease

Gene names

Name:	ARN2
Synonyms:	TAF1
Ordered Locus Names:	YHL047C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis. Ref.3
Subcellular location	Endosome membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the major facilitator superfamily.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Endosome Membrane
Domain	Transmembrane
Ligand	Iron
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	siderophore metabolic process Ref.3 Inferred from mutant phenotype. Source: SGD siderophore-iron transport Ref.3 Inferred from direct assay. Source: SGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasmic membrane-bounded vesicle Traceable author statement. Source: SGD endosome Traceable author statement. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW siderophore-iron transmembrane transporter activity Ref.3 Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	Siderophore iron transporter ARN2		PRO_0000084863
Regions
	Transmembrane	71 – 93	23	Potential
	Transmembrane	106 – 128	23	Potential
	Transmembrane	135 – 152	18	Potential
	Transmembrane	162 – 184	23	Potential
	Transmembrane	191 – 213	23	Potential
	Transmembrane	223 – 245	23	Potential
	Transmembrane	286 – 308	23	Potential
	Transmembrane	318 – 335	18	Potential
	Transmembrane	355 – 377	23	Potential
	Transmembrane	392 – 414	23	Potential
	Transmembrane	421 – 438	18	Potential
	Transmembrane	448 – 470	23	Potential
	Transmembrane	491 – 513	23	Potential
	Transmembrane	561 – 578	18	Potential

Sequences

	Sequence		Length	Mass (Da)
	P38724-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: C47AD0F80A35ACEA	FASTA	637	71,554
	10 20 30 40 50 60 MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS LIIRKSELMA 70 80 90 100 110 120 KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS YSAHSLISTV SVIVLMISAV 130 140 150 160 170 180 SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV 190 200 210 220 230 240 LMLSDNSSLK WRLFYTLIPS WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP 250 260 270 280 290 300 LILCMLHMRW KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL 310 320 330 340 350 360 VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL KDRGVWAPLG 370 380 390 400 410 420 IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF VTAVVAPFLG LIVTRSSRLK 430 440 450 460 470 480 SYIIFGGSLY FITMGLFYRY RSGQDADGGI IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN 490 500 510 520 530 540 MATVTALNYT VFRIGGAVAA AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP 550 560 570 580 590 600 WGTPVRSAMV EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK 610 620 630 EDDPINDWIA KRFAKALGGH KKDLQNPNRI CVRKNDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake." Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C. J. Biol. Chem. 275:10709-10715(2000) [PubMed: 10744769] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily." Heymann P., Ernst J.F., Winkelmann G. BioMetals 12:301-306(1999) [PubMed: 10816729] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U11583 Genomic DNA. Translation: AAB65059.1.
PIR	S48921.
RefSeq	NP_011816.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:7479N.
STRING	P38724.
Protein family/group databases
TCDB	2.A.1.16.3. major facilitator superfamily (MFS).
Genome annotation databases
Ensembl	YHL047C; YHL047C; YHL047C; Saccharomyces cerevisiae. [Genome view]
GeneID	856338.
KEGG	sce:YHL047C.
NMPDR	fig|4932.3.peg.2951.
Organism-specific databases
CYGD	YHL047c.
SGD	S000001039. ARN2.
Phylogenomic databases
HOGENOM	P38724.
OMA	QQIFIAD
OrthoDB	EOG97STWX
Gene expression databases
ArrayExpress	P38724.
Genevestigator	P38724.
GermOnline	YHL047C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011701. MFS_1. IPR016196. MFS_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	981760.

Entry information

Entry name

ARN2_YEAST

Accession

Primary (citable) accession number: P38724

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)