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P38724 (ARN2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Siderophore iron transporter ARN2
Alternative name(s):
Triacetylfusarinine C permease
Triacetylfusarinine C transporter 1
Gene names
Name:ARN2
Synonyms:TAF1
Ordered Locus Names:YHL047C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis. Ref.3 Ref.4

Subcellular location

Endosome membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence caution

The sequence AAB65059.1 differs from that shown. Reason: Frameshift at position 619.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Siderophore iron transporter ARN2
PRO_0000084863

Regions

Transmembrane71 – 9323Helical; Potential
Transmembrane106 – 12823Helical; Potential
Transmembrane135 – 15218Helical; Potential
Transmembrane162 – 18423Helical; Potential
Transmembrane191 – 21323Helical; Potential
Transmembrane223 – 24523Helical; Potential
Transmembrane286 – 30823Helical; Potential
Transmembrane318 – 33518Helical; Potential
Transmembrane355 – 37723Helical; Potential
Transmembrane392 – 41423Helical; Potential
Transmembrane421 – 43818Helical; Potential
Transmembrane448 – 47023Helical; Potential
Transmembrane491 – 51323Helical; Potential
Transmembrane561 – 57818Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P38724 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 19C3DDF83A1FC760

FASTA62069,566
        10         20         30         40         50         60 
MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS LIIRKSELMA 

        70         80         90        100        110        120 
KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS YSAHSLISTV SVIVLMISAV 

       130        140        150        160        170        180 
SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV 

       190        200        210        220        230        240 
LMLSDNSSLK WRLFYTLIPS WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP 

       250        260        270        280        290        300 
LILCMLHMRW KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL 

       310        320        330        340        350        360 
VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL KDRGVWAPLG 

       370        380        390        400        410        420 
IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF VTAVVAPFLG LIVTRSSRLK 

       430        440        450        460        470        480 
SYIIFGGSLY FITMGLFYRY RSGQDADGGI IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN 

       490        500        510        520        530        540 
MATVTALNYT VFRIGGAVAA AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP 

       550        560        570        580        590        600 
WGTPVRSAMV EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK 

       610        620 
EDDPINDWIA KRFAKALGRS

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 619.
Strain: ATCC 204508 / S288c.
[3]"Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily."
Heymann P., Ernst J.F., Winkelmann G.
BioMetals 12:301-306(1999) [PubMed: 10816729] [Abstract]
Cited for: FUNCTION.
[4]"Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
J. Biol. Chem. 275:10709-10715(2000) [PubMed: 10744769] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U11583 Genomic DNA. Translation: AAB65059.1. Frameshift.
BK006934 Genomic DNA. Translation: DAA06641.2.
PIRS48921.
RefSeqNP_011816.2. NM_001179127.2.

3D structure databases

ProteinModelPortalP38724.
SMRP38724. Positions 112-151.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-7479N.
STRINGP38724.

Protein family/group databases

TCDB2.A.1.16.3. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID856338.
KEGGsce:YHL047C.
NMPDRfig|4932.3.peg.2951.

Organism-specific databases

CYGDYHL047c.
SGDS000001039. ARN2.

Phylogenomic databases

eggNOGfuNOG13891.
GeneTreeEFGT00050000000289.
HOGENOMHBG325340.
OMAFWKLDVV.
OrthoDBEOG4N07PH.

Gene expression databases

ArrayExpressP38724.
GenevestigatorP38724.
GermOnlineYHL047C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
KOK08197.
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981760.

Entry information

Entry nameARN2_YEAST
AccessionPrimary (citable) accession number: P38724
Secondary accession number(s): D3DKS4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: December 14, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

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