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Protein

Mitochondrial pyruvate carrier 2

Gene

Mpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Protein 0-44
Gene namesi
Name:Mpc2
Synonyms:Brp44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1563422. Mpc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9018HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Mitochondrial pyruvate carrier 2PRO_0000212796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP38718.
PRIDEiP38718.

PTM databases

iPTMnetiP38718.

Expressioni

Tissue specificityi

Liver, kidney, and brain.

Gene expression databases

GenevisibleiP38718. RN.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.By similarity

Protein-protein interaction databases

MINTiMINT-4565724.
STRINGi10116.ENSRNOP00000004206.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1589. Eukaryota.
ENOG4111UER. LUCA.
GeneTreeiENSGT00510000047120.
HOVERGENiHBG023934.
InParanoidiP38718.
OMAiASYHRIL.
OrthoDBiEOG7W155Q.
PhylomeDBiP38718.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P38718-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGARGLR ATYHRLMDKV ELLLPKKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSTVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGSAGASQ LFRIWKYNQE LKSKGIQ
Length:127
Mass (Da):14,258
Last modified:February 1, 1995 - v1
Checksum:iBE8AEC82CA4405A6
GO
Isoform Short (identifier: P38718-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-127: Missing.

Show »
Length:116
Mass (Da):12,968
Checksum:i2BCCC26ED37CE531
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 12711Missing in isoform Short. CuratedVSP_006719Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13095, M13094 Genomic DNA. Translation: AAA40791.1.
RefSeqiNP_001071111.1. NM_001077643.2. [P38718-1]
XP_006250188.1. XM_006250126.2. [P38718-2]
UniGeneiRn.2487.

Genome annotation databases

EnsembliENSRNOT00000004206; ENSRNOP00000004206; ENSRNOG00000003150. [P38718-1]
GeneIDi100359982.
KEGGirno:100359982.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13095, M13094 Genomic DNA. Translation: AAA40791.1.
RefSeqiNP_001071111.1. NM_001077643.2. [P38718-1]
XP_006250188.1. XM_006250126.2. [P38718-2]
UniGeneiRn.2487.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4565724.
STRINGi10116.ENSRNOP00000004206.

PTM databases

iPTMnetiP38718.

Proteomic databases

PaxDbiP38718.
PRIDEiP38718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004206; ENSRNOP00000004206; ENSRNOG00000003150. [P38718-1]
GeneIDi100359982.
KEGGirno:100359982.

Organism-specific databases

CTDi25874.
RGDi1563422. Mpc2.

Phylogenomic databases

eggNOGiKOG1589. Eukaryota.
ENOG4111UER. LUCA.
GeneTreeiENSGT00510000047120.
HOVERGENiHBG023934.
InParanoidiP38718.
OMAiASYHRIL.
OrthoDBiEOG7W155Q.
PhylomeDBiP38718.

Miscellaneous databases

PROiP38718.

Gene expression databases

GenevisibleiP38718. RN.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural characterization of a heterogeneous family of rat brain mRNAs."
    Tsou A.-P., Lai C., Danielson P., Noonan D.J., Sutcliffe J.G.
    Mol. Cell. Biol. 6:768-778(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiMPC2_RAT
AccessioniPrimary (citable) accession number: P38718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.